Michael H Gollob

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. doi request reprint Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper
    Michael H Gollob
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 27:232-45. 2011
  2. doi request reprint The short QT syndrome: proposed diagnostic criteria
    Michael H Gollob
    Inherited Arrhythmia Clinic and Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 57:802-12. 2011
  3. ncbi request reprint Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada
    N Engl J Med 354:2677-88. 2006
  4. ncbi request reprint Cardiac connexins as candidate genes for idiopathic atrial fibrillation
    Michael H Gollob
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 21:155-8. 2006
  5. ncbi request reprint Genetic profiling as a marker for risk of sudden cardiac death
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 21:42-6. 2006
  6. doi request reprint Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissue
    Isabelle L Thibodeau
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Circulation 122:236-44. 2010
  7. doi request reprint Sentinel symptoms in patients with unexplained cardiac arrest: from the cardiac arrest survivors with preserved ejection fraction registry (CASPER)
    Andrew D Krahn
    University of Western Ontario, London, Ontario, Canada Hamilton Health Sciences Center, Hamilton, Ontario, Canada
    J Cardiovasc Electrophysiol 23:60-6. 2012
  8. doi request reprint Arrhythmia characterization and long-term outcomes in catecholaminergic polymorphic ventricular tachycardia
    Raymond W Sy
    University of Western Ontario, Ontario, Canada
    Heart Rhythm 8:864-71. 2011
  9. doi request reprint Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model
    Stephanie L Thorn
    Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 54:1637-44. 2013
  10. pmc Frequency and predictors of tachycardia-induced cardiomyopathy in patients with persistent atrial flutter
    Stephen Pizzale
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 25:469-72. 2009

Collaborators

Detail Information

Publications51

  1. doi request reprint Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper
    Michael H Gollob
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 27:232-45. 2011
    ....
  2. doi request reprint The short QT syndrome: proposed diagnostic criteria
    Michael H Gollob
    Inherited Arrhythmia Clinic and Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 57:802-12. 2011
    ..We aimed to develop diagnostic criteria for the short QT syndrome (SQTS) to facilitate clinical evaluation of suspected cases...
  3. ncbi request reprint Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada
    N Engl J Med 354:2677-88. 2006
    ..We hypothesized that idiopathic atrial fibrillation has a genetic basis and that tissue-specific mutations in GJA5, the gene encoding connexin 40, may predispose the atria to fibrillation...
  4. ncbi request reprint Cardiac connexins as candidate genes for idiopathic atrial fibrillation
    Michael H Gollob
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 21:155-8. 2006
    ..This review discusses the role of cardiac connexins in the heart and suggests that genetic defects in cardiac connexins may predispose to arrhythmia vulnerability...
  5. ncbi request reprint Genetic profiling as a marker for risk of sudden cardiac death
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 21:42-6. 2006
    ..This review discusses the prospect of genomic medicine as an approach to assess genetic susceptibility to sudden arrhythmic death in at-risk populations...
  6. doi request reprint Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissue
    Isabelle L Thibodeau
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Circulation 122:236-44. 2010
    ..In this study, we provide data supporting a novel paradigm that atrial tissue-specific genetic defects may be associated with sporadic cases of lone AF...
  7. doi request reprint Sentinel symptoms in patients with unexplained cardiac arrest: from the cardiac arrest survivors with preserved ejection fraction registry (CASPER)
    Andrew D Krahn
    University of Western Ontario, London, Ontario, Canada Hamilton Health Sciences Center, Hamilton, Ontario, Canada
    J Cardiovasc Electrophysiol 23:60-6. 2012
    ..We explored the symptom history of patients with apparently unexplained cardiac arrest to determine the frequency of sentinel symptoms...
  8. doi request reprint Arrhythmia characterization and long-term outcomes in catecholaminergic polymorphic ventricular tachycardia
    Raymond W Sy
    University of Western Ontario, Ontario, Canada
    Heart Rhythm 8:864-71. 2011
    ..Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by adrenergically induced ventricular tachycardia (VT) associated with syncope and sudden death...
  9. doi request reprint Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model
    Stephanie L Thorn
    Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 54:1637-44. 2013
    ..A noninvasive and repeatable method for assessing mouse myocardial glucose uptake with (18)F-FDG PET and Patlak kinetic analysis was systematically assessed using the vena cava image-derived blood input function (IDIF)...
  10. pmc Frequency and predictors of tachycardia-induced cardiomyopathy in patients with persistent atrial flutter
    Stephen Pizzale
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 25:469-72. 2009
    ..There are few data on the frequency and predictors of tachycardia-induced cardiomyopathy (TICM) in patients with persistent atrial flutter...
  11. doi request reprint Psychological adjustment in ICD patients living with advisory fidelis leads
    Arieh Keren
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada Department of Psychology Department of Cardiovascular Sciences, East Carolina University, Greenville, North Carolina, USA
    J Cardiovasc Electrophysiol 22:57-63. 2011
    ..Second, patients who had experienced an ICD lead fracture had adverse psychological morbidity compared to control patients, and this appeared, primarily, to be related to receiving inappropriate shock(s) at the time of the fracture...
  12. doi request reprint Remote magnetic navigation-assisted catheter ablation enhances catheter stability and ablation success with lower catheter temperatures
    Darryl R Davis
    Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Pacing Clin Electrophysiol 31:893-8. 2008
    ..Accordingly, we compared the characteristics of the successful ablation of atrioventricular reentry tachycardia (AVNRT) using RMN with a matched population ablated using a conventional (CON) manual approach...
  13. ncbi request reprint Influence of gender on ICD implantation for primary and secondary prevention of sudden cardiac death
    Darryl R Davis
    Division of Cardiology, University of Ottawa Heart Institute, H145 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Europace 8:1054-6. 2006
    ..This study sought to investigate the influence of gender on access to ICD therapy and examine the influence of gender on subsequent ICD shock experience...
  14. doi request reprint Derivation and validation of a simple exercise-based algorithm for prediction of genetic testing in relatives of LQTS probands
    Raymond W Sy
    University of Western Ontario, London, Canada
    Circulation 124:2187-94. 2011
    ..The accuracy of a simple algorithm that incorporates resting and exercise ECG parameters for screening LQTS in asymptomatic relatives was evaluated, with genetic testing as the gold standard...
  15. pmc Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation
    Jason D Roberts
    Arrhythmia Research Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada
    Europace 12:1078-83. 2010
    ..We sought to examine the associations of both rs5063 and rs5065 with AF in two separate North American cohorts of European ancestry...
  16. doi request reprint Predictors of fracture risk of a small caliber implantable cardioverter defibrillator lead
    Andrew C T Ha
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Pacing Clin Electrophysiol 33:437-43. 2010
    ..We sought to determine if there are clinical, procedural, or radiological features associated with a greater risk of subsequent lead fracture...
  17. pmc Molecular autopsy in the sudden cardiac death of a young woman: a first Canadian report
    Julie Rutberg
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 23:904-6. 2007
    ..Molecular genetic analysis of tissue retrieved from the regional coroner's office identified a novel missense mutation in the KCNH2 gene, a gene known to cause the long QT syndrome...
  18. doi request reprint Exercise testing in asymptomatic gene carriers exposes a latent electrical substrate of arrhythmogenic right ventricular cardiomyopathy
    Mark J Perrin
    Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 62:1772-9. 2013
    ..The aim of this study was to determine if exercise testing could expose a latent electrical substrate of arrhythmogenic right ventricular cardiomyopathy (ARVC) in asymptomatic gene carriers...
  19. doi request reprint A novel mutation in the RYR2 gene leading to catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation: dose-dependent arrhythmia-event suppression by β-blocker therapy
    Pedram Kazemian
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 27:870.e7-10. 2011
    ..Titration of β-blocker to a much higher dose suppressed further episodes of ventricular arrhythmia and paroxysmal atrial fibrillation, resulting in reduction in device therapies...
  20. doi request reprint Discrepant DNA analysis in three patients with inherited arrhythmia: molecular genetic test results deserve a second glance
    Christina R Honeywell
    Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Am J Med Genet A 146:1466-9. 2008
    ....
  21. doi request reprint Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation
    Stephen Pizzale
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Cardiovasc Electrophysiol 19:1319-21. 2008
    ..Our patient died after probably initially receiving inappropriate ICD shocks for atrial fibrillation. We recommend that utmost efforts should be made to prevent shocks including repeated exercise testing to confirm suppression of PVT...
  22. doi request reprint Accelerating risk of Fidelis lead fracture
    David Farwell
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Heart Rhythm 5:1375-9. 2008
    ..In October 2007 the manufacturer suspended distribution of Sprint Fidelis leads secondary to high early fracture rates. Reprogramming of lead impedance alerts was recommended to try to reduce inappropriate shocks...
  23. doi request reprint Inherited cardiomyopathies mimicking arrhythmogenic right ventricular cardiomyopathy
    Jason D Roberts
    Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Cardiovasc Pathol 19:316-20. 2010
    ..This report represents the first documentation of inherited cardiomyopathies mimicking ARVC and highlights the concept that other cardiac conditions can be associated with fibrofatty replacement of the myocardium...
  24. doi request reprint Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER)
    Andrew D Krahn
    University of Western Ontario, London, Ontario, Canada
    Circulation 120:278-85. 2009
    ..Provocative testing to unmask a phenotype is often necessary to detect primary electrical disease, direct genetic testing, and perform family screening...
  25. pmc Rapid genetic testing facilitating the diagnosis of short QT syndrome
    Calum J Redpath
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 25:e133-5. 2009
    ..Consequently, the patient was diagnosed with SQTS and the recommendation of implantable cardioverter defibrillator implantation was accepted by the patient before discharge from the hospital...
  26. ncbi request reprint Successful ablation of a concealed parahisian accessory pathway using a remote magnetic navigation system following failure by conventional methods
    Darryl R Davis
    University of Ottawa Heart Institute, Rm H350 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada
    J Interv Card Electrophysiol 16:149-51. 2006
    ..Using conventional catheters, ablation of concealed parahisian accessory pathways may be difficult and high risk for heart block...
  27. doi request reprint Gain-of-function mutation of Nav1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing
    Qiuju Li
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ont, Canada
    Biochem Biophys Res Commun 380:132-7. 2009
    ..These novel biophysical observations provide molecular evidence linking cellular "hyperexcitability" as a mechanism inducing vulnerability to this common arrhythmia...
  28. ncbi request reprint Transient left ventricular apical ballooning following a prolonged ablation
    Darryl R Davis
    University of Ottawa Heart Institute, Rm H123, 40 Ruskin St, Ottawa, ON, Canada
    J Interv Card Electrophysiol 17:47-9. 2006
    ..The authors report a case of transient left ventricular apical ballooning after a prolonged electrophysiology procedure. Interventional electrophysiologists should be aware of this syndrome as a potential complication...
  29. pmc Electrical heart disease: Genetic and molecular basis of cardiac arrhythmias in normal structural hearts
    David Farwell
    Arrhythmia Service, University of Ottawa Heart Institute, Ottawa, Ontario
    Can J Cardiol 23:16A-22A. 2007
    ..The present paper reviews the current clinical and molecular understanding of the electrical diseases of the heart associated with sudden cardiac death...
  30. doi request reprint Ventricular tachycardia following tube thoracotomy
    Benjamin Hibbert
    1Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Europace 12:1504-6. 2010
    ..Identification of the chest tube as an arrhythmic trigger following tube thoracotomy is essential in definitive management of refractory arrhythmias...
  31. doi request reprint Ten-year follow-up of cardiac sympathectomy in a young woman with catecholaminergic polymorphic ventricular tachycardia and an implantable cardioverter defibrillator
    Bhavanesh Makanjee
    Arrhythmia Service, Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    J Cardiovasc Electrophysiol 20:1167-9. 2009
    ..We report a young woman with CPVT who received frequent ICD shocks despite beta blockade, who subsequently underwent cardiac sympathectomy with a dramatic reduction in shocks over 10 years of follow-up...
  32. ncbi request reprint Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia
    Uwais Mohamed
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Heart Rhythm 3:1486-9. 2006
  33. doi request reprint No long-term psychological morbidity living with an implantable cardioverter defibrillator under advisory: the Medtronic Marquis experience
    David H Birnie
    University of Ottawa Heart Institute, 40 Ruskin Road, Ottawa, ON, Canada
    Europace 11:26-30. 2009
    ..It is unclear whether there is important psychological morbidity associated with living with an implantable cardioverter defibrillator (ICD) under advisory and whether this should be factored into decision-making...
  34. pmc Use of implantable cardioverter defibrillators in Canadian and US survivors of out-of-hospital cardiac arrest
    David H Birnie
    Ottawa Heart Institute, Ottawa, Ont
    CMAJ 177:41-6. 2007
    ..We compared and contrasted the use of implantable cardioverter defibrillator therapy in Canada and the United States among adults who survived a cardiac arrest...
  35. doi request reprint Early repolarization: a rare primary arrhythmic syndrome and common modifier of arrhythmic risk
    Jason D Roberts
    Inherited Arrhythmia Clinic and Arrhythmia Research Laboratory, University of Ottawa, Heart Institute, Ottawa, Ontario, Canada
    J Cardiovasc Electrophysiol 24:837-43. 2013
    ..The challenge ahead lies in discerning when early repolarization may represent an ominous ECG marker, as opposed to a benign entity. ..
  36. doi request reprint Genetics of cardiac electrical disease
    Mark J Perrin
    Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 29:89-99. 2013
    ..This review summarizes the diagnosis and management of each of the listed syndromes in the context of currently available genetic testing...
  37. doi request reprint The genetics of cardiac disease associated with sudden cardiac death: a paper from the 2011 William Beaumont Hospital Symposium on molecular pathology
    Mark J Perrin
    Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Mol Diagn 14:424-36. 2012
    ....
  38. doi request reprint The role of atrial natriuretic peptide in modulating cardiac electrophysiology
    Mark J Perrin
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Heart Rhythm 9:610-5. 2012
    ..This review examines our current understanding of the electrophysiological effects of ANP, and their physiological relationship to clinical studies linking ANP and atrial fibrillation...
  39. doi request reprint Reduced septal glucose metabolism predicts response to cardiac resynchronization therapy
    David Birnie
    University of Ottawa Heart Institute, 40 Ruskin Road, Ottawa, ON K1Y 4W7, Canada
    J Nucl Cardiol 19:73-83. 2012
    ..Therefore, this study's objective was to assess whether greater septal R-MM pattern predicts response to CRT...
  40. ncbi request reprint Appropriate result from an inappropriate ICD shock
    Darryl R Davis
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Pacing Clin Electrophysiol 29:1183-4. 2006
    ..The resultant ICD shock dislodged the patient from the electrical source, thus preventing injury or electrocution...
  41. ncbi request reprint An unusual accessory pathway: anteroseptal to ventricular outflow region connection
    Basilios Petrellis
    University of Western Ontario, Arrhythmia Service, London, Ontario, Canada
    J Cardiovasc Electrophysiol 16:546-51. 2005
    ..This is the second such pathway observed at our institution over a 20-year period...
  42. ncbi request reprint Isorhythmic interaction between a dual-chamber pacemaker and an intrinsic rhythm: pacemaker malfunctioning or not?
    Ernest W Lau
    University of Ottawa Heart Institute, Ontario, Canada
    Heart Rhythm 1:752-5. 2004
    ..The different patterns possible for the phenomenon and the necessary conditions for their occurrence are elucidated...
  43. doi request reprint The genetic and clinical features of cardiac channelopathies
    Jason D Roberts
    Arrhythmia Research Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada
    Future Cardiol 6:491-506. 2010
    ....
  44. doi request reprint Begetting atrial fibrillation: Connexins and arrhythmogenesis
    Michael H Gollob
    Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Heart Rhythm 5:888-91. 2008
  45. doi request reprint Impact of genetic discoveries on the classification of lone atrial fibrillation
    Jason D Roberts
    Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 55:705-12. 2010
    ..Proper identification of the culprit pathophysiology may permit administration of a targeted form of therapy that carries maximal efficacy and minimal risk in a manner consistent with the vision of pharmacogenomics...
  46. doi request reprint Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial
    Jason D Roberts
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada
    Lancet 379:1705-11. 2012
    ..We used a novel point-of-care genetic test to identify carriers of the CYP2C19*2 allele and aimed to assess a pharmacogenetic approach to dual antiplatelet treatment after PCI...
  47. ncbi request reprint PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy
    Michael H Gollob
    Division of Cardiology, University of Western Ontario, London Health Sciences Center, Ontario, Canada
    Curr Opin Cardiol 17:229-34. 2002
    ..The role of AMP-activated protein kinase in the regulation of the glucose metabolic pathway in muscle suggests that genetic defects in PRKAG2 may induce a previously undescribed cardiac glycogenosis syndrome...
  48. doi request reprint In vivo assessment of myocardial glucose uptake by positron emission tomography in adults with the PRKAG2 cardiac syndrome
    Andrew C T Ha
    Division of Cardiology, University of Ottawa Heart Institute, and the Department of Cellular and Molecular Medicine at the University of Ottawa, Ottawa, Ontario K1Y 4W7, Canada
    Circ Cardiovasc Imaging 2:485-91. 2009
    ..The biochemical alterations associated with this condition remain controversial and have not previously been studied in affected humans...
  49. pmc Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome
    Jasvinder S Sidhu
    Baylor College of Medicine, Houston, Tex, USA
    Circulation 111:21-9. 2005
    ..The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertrophy...
  50. ncbi request reprint Frequency of peripartum cardiomyopathy
    Lisa M Mielniczuk
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 97:1765-8. 2006
    ..The estimated mortality of 1.36% to 2.05% (95% confidence interval 0.29% to 10.8%) is less than previously reported from most case series...
  51. ncbi request reprint Genetic determinants of atrial fibrillation: SNPs are riding the wave(lets)
    Michael H Gollob
    Heart Rhythm 3:813-4. 2006