Gregory B Gloor

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc ANOVA-like differential expression (ALDEx) analysis for mixed population RNA-Seq
    Andrew D Fernandes
    YouKaryote Genomics, London, Ontario, Canada
    PLoS ONE 8:e67019. 2013
  2. pmc Identifying and seeing beyond multiple sequence alignment errors using intra-molecular protein covariation
    Russell J Dickson
    Department of Biochemistry, The University of Western Ontario, London, Canada
    PLoS ONE 5:e11082. 2010
  3. pmc Protein sequence alignment analysis by local covariation: coevolution statistics detect benchmark alignment errors
    Russell J Dickson
    Department of Biochemistry, The University of Western Ontario, London, Canada
    PLoS ONE 7:e37645. 2012
  4. doi request reprint Functionally compensating coevolving positions are neither homoplasic nor conserved in clades
    Gregory B Gloor
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Mol Biol Evol 27:1181-91. 2010
  5. pmc Microbiome profiling by illumina sequencing of combinatorial sequence-tagged PCR products
    Gregory B Gloor
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 5:e15406. 2010
  6. ncbi request reprint Mutual information in protein multiple sequence alignments reveals two classes of coevolving positions
    Gregory B Gloor
    Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Biochemistry 44:7156-65. 2005
  7. ncbi request reprint The role of sequence homology in the repair of DNA double-strand breaks in Drosophila
    Gregory B Gloor
    Department of Biochemistry, The University of Western Ontario, London, Canada
    Adv Genet 46:91-117. 2002
  8. pmc Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1
    Julie Genereaux
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A5C1
    Genetics 191:765-80. 2012
  9. pmc Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1
    Stephanie Kvas
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London N6A5C1, Canada
    BMC Genet 13:19. 2012
  10. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010

Collaborators

Detail Information

Publications34

  1. pmc ANOVA-like differential expression (ALDEx) analysis for mixed population RNA-Seq
    Andrew D Fernandes
    YouKaryote Genomics, London, Ontario, Canada
    PLoS ONE 8:e67019. 2013
    ..We show that the presence of differential expression and the magnitude of these comparative differences can be reasonably estimated with even very small sample sizes. ..
  2. pmc Identifying and seeing beyond multiple sequence alignment errors using intra-molecular protein covariation
    Russell J Dickson
    Department of Biochemistry, The University of Western Ontario, London, Canada
    PLoS ONE 5:e11082. 2010
    ..We thus hypothesized that current criteria are insufficient to build alignments for use with covariation analyses...
  3. pmc Protein sequence alignment analysis by local covariation: coevolution statistics detect benchmark alignment errors
    Russell J Dickson
    Department of Biochemistry, The University of Western Ontario, London, Canada
    PLoS ONE 7:e37645. 2012
    ..We also show that local covariation identifies active site residues in a validated alignment of paralogous structures. Loco is available at https://sourceforge.net/projects/locoprotein/files/...
  4. doi request reprint Functionally compensating coevolving positions are neither homoplasic nor conserved in clades
    Gregory B Gloor
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Mol Biol Evol 27:1181-91. 2010
    ..The results show that nonconserved covarying positions that affect protein function can be identified with high precision...
  5. pmc Microbiome profiling by illumina sequencing of combinatorial sequence-tagged PCR products
    Gregory B Gloor
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 5:e15406. 2010
    ....
  6. ncbi request reprint Mutual information in protein multiple sequence alignments reveals two classes of coevolving positions
    Gregory B Gloor
    Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Biochemistry 44:7156-65. 2005
    ..We propose that these coevolving positions compose an important subset of the positions in an alignment, and may be as important to the structure and function of the protein family as are highly conserved positions...
  7. ncbi request reprint The role of sequence homology in the repair of DNA double-strand breaks in Drosophila
    Gregory B Gloor
    Department of Biochemistry, The University of Western Ontario, London, Canada
    Adv Genet 46:91-117. 2002
  8. pmc Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1
    Julie Genereaux
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A5C1
    Genetics 191:765-80. 2012
    ..Since an intragenic mutation of tra1-R3590I also suppressed F3744A, we propose that Tti2 is required for the folding/stability of the C-terminal FATC and PI3K domains of Tra1 into their functionally active form...
  9. pmc Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1
    Stephanie Kvas
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London N6A5C1, Canada
    BMC Genet 13:19. 2012
    ..To further define the regulatory interactions of Tra1 we isolated extragenic suppressors of the tra1-L3733A allele...
  10. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010
    ..It is poorly understood which bacterial communities constitute BV or the normal vaginal microbiota among this population and how the microbiota associated with BV responds to antibiotic treatment...
  11. pmc The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function
    Lance F Dasilva
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada N6A5C1
    G3 (Bethesda) 3:1661-74. 2013
    ..Our study supports a role for the C-terminus in Mec1 folding and stability, and suggests a role for the proteasome in regulating Mec1 levels. ..
  12. pmc Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1
    Stephen M T Hoke
    Department of Biochemistry, University of Western Ontario, London, Canada
    Curr Genet 56:447-65. 2010
    ..These findings demonstrate the regulatory potential of mechanisms targeting the FATC domains of PIKK proteins...
  13. pmc Persistence of the oral probiotic Streptococcus salivarius M18 is dose dependent and megaplasmid transfer can augment their bacteriocin production and adhesion characteristics
    Jeremy P Burton
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    PLoS ONE 8:e65991. 2013
    ..For candidate probiotic strains having relatively poor antimicrobial or adhesive properties, unique derivatives displaying improved probiotic performance may be engineered in vitro by megaplasmid transfer...
  14. pmc A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI
    Benjamin P Kleinstiver
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada
    Nucleic Acids Res 38:2411-27. 2010
    ....
  15. pmc Exploring a road map to counter misconceptions about the cervicovaginal microbiome and disease
    Jean M Macklaim
    Department of Biochemistry, The University of Western Ontario, London, Canada
    Reprod Sci 19:1154-62. 2012
    ....
  16. pmc Vaginal microbiome and epithelial gene array in post-menopausal women with moderate to severe dryness
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 6:e26602. 2011
    ....
  17. ncbi request reprint Gene targeting in Drosophila
    Gregory B Gloor
    Department of Biochemistry, The University of Western Ontario, London, Canada
    Methods Mol Biol 260:97-114. 2004
    ..It cannot be emphasized strongly enough that the investigator should be prepared to invest sufficient time into setting up and running these experiments properly...
  18. pmc Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster
    Angela M Holmes
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Genetics 172:2367-77. 2006
    ..We propose that esc and E(Pc) mutants enhance homologous recombination by modulating the histone acetylation status of histone H4 at the double-strand break...
  19. doi request reprint Mutual information is critically dependent on prior assumptions: would the correct estimate of mutual information please identify itself?
    Andrew D Fernandes
    Department of Biochemistry, The University of Western Ontario, London, ON, Canada
    Bioinformatics 26:1135-9. 2010
    ..These differences revealed that estimating the 'true' value of MI is not a straightforward procedure, and minor variations of assumptions yielded remarkably different estimates...
  20. pmc At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1
    Jean M Macklaim
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, ON, Canada
    Proc Natl Acad Sci U S A 108:4688-95. 2011
    ..L. iners is widely present in healthy females as well as those suffering from bacterial vaginosis or who have undergone antimicrobial therapy, suggesting that it is an important indigenous species of the vagina...
  21. pmc A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems
    Piya Lahiry
    Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Am J Hum Genet 84:134-47. 2009
    ..We also demonstrate that the R272Q mutant fails to localize at the nucleus and has diminished kinase activity. These findings suggest that ICK plays a key role in the development of multiple organ systems...
  22. pmc Influence of the vaginal microbiota on toxic shock syndrome toxin 1 production by Staphylococcus aureus
    Roderick A MacPhee
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    Appl Environ Microbiol 79:1835-42. 2013
    ..suppressed it. The findings suggest that women colonized by S. aureus and with AV, but not BV, may be more susceptible to menstrual TSS and would most benefit from prophylactic treatment...
  23. pmc Estimating the evidence of selection and the reliability of inference in unigenic evolution
    Andrew D Fernandes
    Department of Biochemistry, The University of Western Ontario, N6A 5C1 Canada
    Algorithms Mol Biol 5:35. 2010
    ..In addition, both methods require the questionable assumption of asymptotically-large sample size due to the presumption of approximate normality...
  24. pmc A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorder
    Piya Lahiry
    Robarts Research Institute, London, ON, Canada
    Orphanet J Rare Dis 8:126. 2013
    ..To elucidate the genetic basis of a novel neurodegenerative disorder in an Old Order Amish pedigree by combining homozygosity mapping with exome sequencing...
  25. pmc Genome sequence of Lactobacillus pentosus KCA1: vaginal isolate from a healthy premenopausal woman
    Kingsley C Anukam
    Department of Medical Laboratory Sciences, TWAS Research Unit, University of Benin, Benin City, Edo, Nigeria
    PLoS ONE 8:e59239. 2013
    ..These findings add crucial information for understanding the genomic and geographic diversity of vaginal lactobacilli...
  26. pmc Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues
    Thomas A McMurrough
    Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada N6A 5C1
    Proc Natl Acad Sci U S A 111:E2376-83. 2014
    ..Creation of optimal coevolving active-site networks is therefore an important consideration in engineering of LHEs and other enzymes. ..
  27. pmc Microbiota of human breast tissue
    Camilla Urbaniak
    Lawson Health Research Institute, London, Ontario, Canada
    Appl Environ Microbiol 80:3007-14. 2014
    ..3%). None of the subjects had signs or symptoms of infection, but the presence of viable bacteria was confirmed in some samples by culture. The extent to which these organisms play a role in health or disease remains to be determined. ..
  28. doi request reprint High throughput sequencing methods and analysis for microbiome research
    Julia M Di Bella
    Department of Microbiology and Immunology, The University of Western Ontario, London, ON, Canada
    J Microbiol Methods 95:401-14. 2013
    ..Additionally, we seek to stimulate others to solve the many problems that still exist with the sensitivity, specificity and interpretation of high throughput microbiome sequence analysis. ..
  29. doi request reprint Regulation of cell proliferation and survival: convergence of protein kinases and caspases
    James S Duncan
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario Canada N6A 5C1
    Biochim Biophys Acta 1804:505-10. 2010
    ....
  30. ncbi request reprint Solution NMR structure and X-ray absorption analysis of the C-terminal zinc-binding domain of the SecA ATPase
    Brian R Dempsey
    Department of Biochemistry, University of Western Ontario, London ON N6A 5C1, Ontario, Canada
    Biochemistry 43:9361-71. 2004
    ....
  31. pmc The effect of heterologous insertions on gene conversion in mitotically dividing cells in Drosophila melanogaster
    Angela M Coveny
    Department of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Genetics 161:249-58. 2002
    ..The results show that the repair of a double-strand break by gene conversion requires chromosome pairing in the local region of the double-strand break...
  32. ncbi request reprint Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat
    Xiaohong Tracey Gan
    From the Departments of Physiology and Pharmacology X T G, C X H, J V H, V R, M K, Microbiology and Immunology G E, J P B, G R, Surgery J P B, G R, and Biochemistry G B G, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada G E, J P B, G B G, G R and Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading, United Kingdom J E S, G M, J R S
    Circ Heart Fail 7:491-9. 2014
    ..Here, we determined whether oral probiotic administration can alter the progression of postinfarction heart failure...
  33. ncbi request reprint Bioinformatics identification of coevolving residues
    Russell J Dickson
    Department of Biochemistry, University of Western Ontario, London, ON, Canada
    Methods Mol Biol 1123:223-43. 2014
    ..Furthermore, it is important to understand common signs and sources of error. When confounding factors are accounted for, coevolution is a rich resource for protein engineering information. ..
  34. doi request reprint Microbiota restoration: natural and supplemented recovery of human microbial communities
    Gregor Reid
    Human Microbiology and Probiotics, F2 116, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Nat Rev Microbiol 9:27-38. 2011
    ....