Dafna D Gladman

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Radiological characteristics of the calcaneal spurs in psoriatic arthritis
    D D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Toronto, Canada
    Clin Exp Rheumatol 32:401-3. 2014
  2. pmc Risk factors for radiographic progression in psoriatic arthritis: subanalysis of the randomized controlled trial ADEPT
    Dafna D Gladman
    University of Toronto, 399 Bathurst Street, Room 1E 410B, Toronto, Ontario M5T 2S8, Canada
    Arthritis Res Ther 12:R113. 2010
  3. ncbi request reprint Killer-cell immunoglobulin-like receptor gene polymorphisms and susceptibility to psoriatic arthritis
    Vinod Chandran
    Psoriatic Arthritis Program, Toronto Western Research Institute, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, 399 Bathurst Street, Room 1E 410, Toronto, ON, Canada M5T 2S8
    Rheumatology (Oxford) 53:233-9. 2014
  4. ncbi request reprint Dermatology screening tools: project update from the GRAPPA 2012 annual meeting
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 40:1425-7. 2013
  5. ncbi request reprint Dactylitis in psoriatic arthritis: prevalence and response to therapy in the biologic era
    Dafna D Gladman
    University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 40:1357-9. 2013
  6. pmc UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family
    Mohammed Uddin
    Faculty of Medicine, Memorial University of Newfoundland, St John s, NF, Canada
    BMC Genet 14:67. 2013
  7. doi request reprint Biomarkers for comorbidities in psoriasis: a report from the GRAPPA 2011 annual meeting
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, and the Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 39:2193-5. 2012
  8. doi request reprint Recommendations for frequency of visits to monitor systemic lupus erythematosus in asymptomatic patients: data from an observational cohort study
    Dafna D Gladman
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 40:630-3. 2013
  9. doi request reprint Physician scores vs patient self-report of joint and skin manifestations in psoriatic arthritis
    Salman R Chaudhry
    Internal Medicine Department, McMaster University, Hamilton, Ontario, Canada
    Rheumatology (Oxford) 52:705-11. 2013
  10. ncbi request reprint Systemic lupus erythematosus disease activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months
    Zahi Touma
    Department of Medicine, Division of Rheumatology, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada
    Rheumatology (Oxford) 51:1814-9. 2012

Detail Information

Publications174 found, 100 shown here

  1. ncbi request reprint Radiological characteristics of the calcaneal spurs in psoriatic arthritis
    D D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Toronto, Canada
    Clin Exp Rheumatol 32:401-3. 2014
    ....
  2. pmc Risk factors for radiographic progression in psoriatic arthritis: subanalysis of the randomized controlled trial ADEPT
    Dafna D Gladman
    University of Toronto, 399 Bathurst Street, Room 1E 410B, Toronto, Ontario M5T 2S8, Canada
    Arthritis Res Ther 12:R113. 2010
    ..To identify independent predictors of radiographic progression in psoriatic arthritis (PsA) for patients treated with adalimumab or placebo in the Adalimumab Effectiveness in PsA Trial (ADEPT)...
  3. ncbi request reprint Killer-cell immunoglobulin-like receptor gene polymorphisms and susceptibility to psoriatic arthritis
    Vinod Chandran
    Psoriatic Arthritis Program, Toronto Western Research Institute, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, 399 Bathurst Street, Room 1E 410, Toronto, ON, Canada M5T 2S8
    Rheumatology (Oxford) 53:233-9. 2014
    ..We conducted a case-control study to determine the association between KIR2D and KIR3D gene polymorphisms and their interaction with HLA alleles in PsA...
  4. ncbi request reprint Dermatology screening tools: project update from the GRAPPA 2012 annual meeting
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 40:1425-7. 2013
    ..An additional study of the prevalence of PsA in a large cohort of psoriasis patients, the PREPARE study, which investigated the use of screening questionnaires, was also presented. ..
  5. ncbi request reprint Dactylitis in psoriatic arthritis: prevalence and response to therapy in the biologic era
    Dafna D Gladman
    University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 40:1357-9. 2013
    ....
  6. pmc UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family
    Mohammed Uddin
    Faculty of Medicine, Memorial University of Newfoundland, St John s, NF, Canada
    BMC Genet 14:67. 2013
    ..The frequency of copy number variation for the UGT2B17 gene was then performed on two well-defined AS cohorts. Fisher exact test was performed to quantify the association...
  7. doi request reprint Biomarkers for comorbidities in psoriasis: a report from the GRAPPA 2011 annual meeting
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, and the Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 39:2193-5. 2012
    ....
  8. doi request reprint Recommendations for frequency of visits to monitor systemic lupus erythematosus in asymptomatic patients: data from an observational cohort study
    Dafna D Gladman
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 40:630-3. 2013
    ..The aim of our study was to determine the optimal frequency of followup visits in patients with systemic lupus erythematosus (SLE)...
  9. doi request reprint Physician scores vs patient self-report of joint and skin manifestations in psoriatic arthritis
    Salman R Chaudhry
    Internal Medicine Department, McMaster University, Hamilton, Ontario, Canada
    Rheumatology (Oxford) 52:705-11. 2013
    ..We aimed to determine the degree of agreement between patient self-report and physician assessment of joint disease activity and damage and degree of skin disease...
  10. ncbi request reprint Systemic lupus erythematosus disease activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months
    Zahi Touma
    Department of Medicine, Division of Rheumatology, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada
    Rheumatology (Oxford) 51:1814-9. 2012
    ..We compared the performance of SRI-50 with that of SLEDAI-2K and SRI at 6 and 12 months in identifying responders...
  11. doi request reprint Early psoriatic arthritis
    Dafna D Gladman
    Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, 399 Bathurst Street 1E 410B, Toronto, Ontario, Canada
    Rheum Dis Clin North Am 38:373-86. 2012
    ..Psoriatic arthritis may lead to deformities, joint damage, reduced quality of life and function. Early detection and treatment may prevent untoward outcomes...
  12. ncbi request reprint Psoriatic arthritis in Canadian clinical practice: the PsA assessment in rheumatology
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, 1E 410B, Toronto, Ontario M5T 2S8, Canada
    J Rheumatol 39:1850-3. 2012
    ..We aimed to determine disease severity and treatment of patients with psoriatic arthritis (PsA) in rheumatology practices in Canada through the PsA Assessment in Rheumatology (PAIR) study...
  13. pmc Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Arthritis Res Ther 13:R156. 2011
    ....
  14. doi request reprint Does the change in season affect disease activity in patients with psoriatic arthritis?
    Zahi Touma
    Psoriatic Arthritis Clinic, Centre for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto Western Research Institute, Toronto, Canada
    Ann Rheum Dis 71:1370-3. 2012
    ..To determine whether there is seasonal variation in disease activity of patients with psoriatic arthritis (PsA)...
  15. doi request reprint Future trends in research in psoriatic arthritis
    Dafna D Gladman
    Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Rheumatol Suppl 89:106-10. 2012
    ..Early definition of PsA is crucial. Future research will concentrate on identifying genetic and other biomarkers for early diagnosis, disease expression, disease progression, and comorbidities. Newer therapies will be developed as well...
  16. doi request reprint Prevalence of monoclonal gammopathy among patients with psoriatic arthritis
    Lihi Eder
    Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 39:564-7. 2012
    ..There is limited information about the prevalence of monoclonal gammopathy in psoriatic arthritis (PsA). We investigated the prevalence, type, and associated features of monoclonal gammopathy in patients with PsA...
  17. doi request reprint Inflammatory spinal disease in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting
    Dafna D Gladman
    University of Toronto and The Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 39:418-20. 2012
    ....
  18. doi request reprint The path forward to biomarker discovery in psoriatic disease: a report from the GRAPPA 2010 annual meeting
    Dafna D Gladman
    University of Toronto and Toronto Western Research Institute, Toronto, Ontario, Canada
    J Rheumatol 39:434-6. 2012
    ..In this overview, we discuss the challenges of the clinical phenotype of PsA and review GRAPPA plans for developing a research program for biomarker discovery...
  19. pmc Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
    Christopher Butt
    Memorial University of Newfoundland, Hospital for Sick Children, Department of Public Health Sciences, University of Toronto, Toronto, Canada
    Arthritis Res Ther 8:R27. 2006
    ..Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted...
  20. pmc Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Arthritis Res Ther 12:R125. 2010
    ..The objective of this study was to describe and quantify variability over time of TC and BP among patients with SLE and to determine their correlates...
  21. pmc Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity
    Joan Wither
    Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada
    Arthritis Res Ther 10:R108. 2008
    ..Here, we used flow cytometry to investigate whether some of the immune abnormalities that are seen in the peripheral blood lymphocyte population of lupus patients are seen in their first-degree relatives...
  22. doi request reprint Cardiovascular morbidity in psoriatic arthritis
    D D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Rheum Dis 68:1131-5. 2009
    ..Increasing evidence for cardiovascular mortality among patients with psoriasis and psoriatic arthritis (PsA) has accumulated, together with evidence for increased prevalence of risk factors for cardiovascular disease (CVD)...
  23. doi request reprint Patient-reported outcome in psoriatic arthritis: a comparison of Web-based versus paper-completed questionnaires
    Heather MacKenzie
    Psoriatic Arthritis Program, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 38:2619-24. 2011
    ....
  24. doi request reprint Development and initial validation of a screening questionnaire for psoriatic arthritis: the Toronto Psoriatic Arthritis Screen (ToPAS)
    D D Gladman
    Toronto Western Research Institute, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Rheum Dis 68:497-501. 2009
    ..To develop and validate a psoriatic arthritis (PsA) screening questionnaire: the Toronto Psoriatic Arthritis Screen (ToPAS)...
  25. ncbi request reprint Axial disease in psoriatic arthritis
    Dafna D Gladman
    Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, 1E 410B, Toronto, Ontario, M5T 2S8, Canada
    Curr Rheumatol Rep 9:455-60. 2007
    ..This article reviews the prevalence, clinical and radiologic features, pathogenesis, prognosis, and treatment of psoriatic spondylitis...
  26. ncbi request reprint Biologic therapy of psoriatic arthritis
    D D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Reumatismo 59:85-7. 2007
    ..However, not all patients have responded, and the long-term safety of these drugs remains unknown...
  27. ncbi request reprint International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1740-5. 2007
    ..To determine whether the assessments of peripheral joints and enthesitis were reproducible for both AS and PsA with axial disease, and whether dactylitis assessment is reproducible in patients with PsA...
  28. ncbi request reprint International spondyloarthritis interobserver reliability exercise--the INSPIRE study: I. Assessment of spinal measures
    Dafna D Gladman
    Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1733-9. 2007
    ..To determine whether the axial measures used in primary ankylosing spondylitis (AS) were reproducible for both AS and psoriatic arthritis (PsA) with axial disease...
  29. ncbi request reprint Outcome measures in psoriatic arthritis
    Dafna D Gladman
    The University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 34:1159-66. 2007
    ..This article summarizes these features of PsA as well as current knowledge on the instruments available for the assessment of these domains...
  30. ncbi request reprint Adalimumab for long-term treatment of psoriatic arthritis: forty-eight week data from the adalimumab effectiveness in psoriatic arthritis trial
    Dafna D Gladman
    University of Toronto, and Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 56:476-88. 2007
    ..To evaluate the efficacy and safety of treatment with adalimumab, a fully human anti-tumor necrosis factor (anti-TNF) monoclonal antibody, over 48 weeks in patients with moderate to severe psoriatic arthritis (PsA)...
  31. pmc Adalimumab improves joint-related and skin-related functional impairment in patients with psoriatic arthritis: patient-reported outcomes of the Adalimumab Effectiveness in Psoriatic Arthritis Trial
    D D Gladman
    Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, 1E 410B, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Ann Rheum Dis 66:163-8. 2007
    ..To evaluate the effects of adalimumab on patient-reported outcomes of joint-related and skin-related functional impairment, health-related quality of life, fatigue and pain in patients with psoriatic arthritis (PsA)...
  32. pmc Clinical, radiological, and functional assessment in psoriatic arthritis: is it different from other inflammatory joint diseases?
    D D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, 1E 410B, Toronto, Ontario, M5T 2S8, Canada
    Ann Rheum Dis 65:iii22-4. 2006
  33. ncbi request reprint A novel, disease-specific quality-of-life instrument for patients with SLE
    Dafna D Gladman
    Division of Outcomes and Population Health, Toronto Western Research Institute, Toronto, ON, Canada
    Nat Clin Pract Rheumatol 2:132-3. 2006
  34. ncbi request reprint Clinical and genetic registries in psoriatic disease
    Dafna D Gladman
    University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 35:1458-63. 2008
    ..Proceedings of these meetings are summarized...
  35. ncbi request reprint Mortality in psoriatic arthritis
    D D Gladman
    University of Toronto, Toronto, Canada
    Clin Exp Rheumatol 26:S62-5. 2008
    ..Since disease activity is associated with progression of damage, and damage predicts mortality, it is important to treat patients aggressively to prevent these outcomes...
  36. doi request reprint Psoriatic arthritis
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Dermatol Ther 22:40-55. 2009
    ..New medications, including biologics, have emerged with potential to controlling the inflammation and arresting the progression of joint damage...
  37. doi request reprint Spondyloarthropathies: Targeted therapy for psoriatic arthritis
    Dafna D Gladman
    University of Toronto and Toronto Western Research Institute, Toronto, ON, Canada
    Nat Rev Rheumatol 5:241-2. 2009
    ..Tumor necrosis factor inhibitors are an effective treatment for psoriatic arthritis, but no single agent is effective in all patients. Novel therapies that target other cytokines have now been tested, with encouraging results...
  38. doi request reprint Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease?
    Dafna D Gladman
    Department of Medicine, University of Toronto, Ontario, Canada
    Ann Rheum Dis 70:2152-4. 2011
    ....
  39. doi request reprint Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis
    Lihi Eder
    Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Canada
    Ann Rheum Dis 71:50-5. 2012
    ..The authors aimed to identify human leucocyte antigen (HLA) alleles that are associated with the development of PsA in patients with psoriasis...
  40. doi request reprint Effectiveness and safety of etanercept in patients with psoriatic arthritis in a Canadian clinical practice setting: the REPArE trial
    Dafna D Gladman
    Toronto Western Hospital University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Rheumatol 38:1355-62. 2011
    ..To describe the longterm effectiveness and safety of etanercept in Canadian patients with psoriatic arthritis (PsA), treated over 24 months in clinical practice...
  41. doi request reprint The Spondyloarthritis Research Consortium of Canada registry for spondyloarthritis
    Dafna D Gladman
    Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 38:1343-8. 2011
    ..This article describes the SPARCC database and outlines difficulties and possible solutions for maintaining such a database...
  42. doi request reprint Review of clinical registries of psoriatic arthritis: lessons learned?: value for the future?
    Dafna D Gladman
    Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, University of Toronto, Ontario, Canada
    Curr Rheumatol Rep 13:346-52. 2011
    ..It is hoped that an international effort currently on the way will further enhance the contribution of PsA patient registries to address the etiology, pathogenesis, and outcome of this complex disease...
  43. doi request reprint Informing response criteria for psoriatic arthritis (PsA). II: Further considerations and a proposal--the PsA joint activity index
    Dafna D Gladman
    University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 37:2559-65. 2010
    ..To develop a recommended measure of response for use in psoriatic arthritis (PsA) clinical trials and observational cohort studies reflecting joint involvement...
  44. doi request reprint Observational cohort studies: lessons learnt from the University of Toronto Psoriatic Arthritis Program
    Dafna D Gladman
    Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada
    Rheumatology (Oxford) 50:25-31. 2011
    ..We also describe the development of an international collaboration based on this cohort, which will further be used to study the incidence, prevalence and predictive factors for the development of PsA among patients with psoriasis...
  45. doi request reprint Informing response criteria for psoriatic arthritis. I: discrimination models based on data from 3 anti-tumor necrosis factor randomized studies
    Dafna D Gladman
    Toronto Western Hospital, 399 Bathurst Street, 1E410B, Toronto, Ontario M5T 2S8, Canada
    J Rheumatol 37:1892-7. 2010
    ....
  46. doi request reprint Responses to adalimumab in patients with active psoriatic arthritis who have not adequately responded to prior therapy: effectiveness and safety results from an open-label study
    Dafna D Gladman
    Toronto Western Research Institute, 399 Bathurst Street, Room 1E 410B, Toronto, Ontario M5T 2S8, Canada
    J Rheumatol 37:1898-906. 2010
    ..To evaluate the effectiveness and safety of adalimumab in patients with active psoriatic arthritis (PsA) and an inadequate response to prior therapy...
  47. ncbi request reprint Pharmacoeconomics of adalimumab for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, 399 Bathurst St 1E 410B, Toronto, ON M5T 2S8, Canada
    Expert Rev Pharmacoecon Outcomes Res 8:111-25. 2008
    ..Cost-effectiveness data for newer indications of adalimumab, including ankylosing spondylitis and Crohn's disease, are needed. As longer term data for adalimumab become available, the cost-effectiveness data will have greater precision...
  48. doi request reprint The effect of lupus nephritis on pregnancy outcome and fetal and maternal complications
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 37:754-8. 2010
    ..To evaluate the effect of lupus nephritis on pregnancy with respect to fetal outcome, maternal complications, and lupus activity...
  49. doi request reprint Composite measures in psoriatic arthritis: GRAPPA 2008
    Dafna D Gladman
    University of Toronto, Ontario, Canada
    J Rheumatol 37:453-61. 2010
    ..e., in addition to assessment of peripheral joints, it should include assessment of sacroiliitis, spondylitis, enthesitis, and dactylitis, as well as skin and nail disease...
  50. doi request reprint Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2008
    Dafna D Gladman
    University of Toronto, Ontario, Canada
    J Rheumatol 37:446-7. 2010
    ..Summaries of those discussions are presented in this supplement...
  51. doi request reprint Psoriatic arthritis from Wright's era until today
    Dafna D Gladman
    Toronto Western Research Institute, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    J Rheumatol Suppl 83:4-8. 2009
    ..Since other presentations focus on pathogenesis and treatment, this article emphasizes the clinical features and prognosis, as well as development of outcome measures...
  52. doi request reprint The association between smoking and the development of psoriatic arthritis among psoriasis patients
    Lihi Eder
    Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, ON, Canada
    Ann Rheum Dis 71:219-24. 2012
    ..To investigate the association between smoking and psoriatic arthritis (PsA) among patients with psoriasis and its interaction with the HLA-C*06 allele...
  53. ncbi request reprint Effectiveness of psoriatic arthritis therapies
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    Semin Arthritis Rheum 33:29-37. 2003
    ..To review the effectiveness of systemic therapies for psoriatic arthritis (PsA)...
  54. ncbi request reprint HLA-DRB1*04 alleles in psoriatic arthritis: comparison with rheumatoid arthritis and healthy controls
    D D Gladman
    University of Toronto, Toronto, Canada
    Hum Immunol 62:1239-44. 2001
    ....
  55. ncbi request reprint Longitudinal cohort studies
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program UHN, Toronto, Canada
    J Rheumatol Suppl 72:30-2. 2005
    ..Analysis issues are highlighted and proposed mechanisms offered for keeping patients involved to ensure complete followup is maintained...
  56. ncbi request reprint Outcomes of symptomatic osteonecrosis in 95 patients with systemic lupus erythematosus
    D D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 28:2226-9. 2001
    ....
  57. pmc Consensus exercise on domains in psoriatic arthritis
    D D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario M5T 2S8, Canada
    Ann Rheum Dis 64:ii113-4. 2005
    ..These domains require further refining, and instruments to measure the items need to be developed...
  58. ncbi request reprint The nature and outcome of infection in systemic lupus erythematosus
    D D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    Lupus 11:234-9. 2002
    ..Until new medications which will control disease activity without predisposing to infection are developed, careful titration of steroids and cytotoxic drugs to control disease activity will remain crucial...
  59. ncbi request reprint The clinical assessment of patients with psoriatic arthritis: results of a reliability study of the spondyloarthritis research consortium of Canada
    Dafna D Gladman
    The Psoriatic Arthritis Program, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 31:1126-31. 2004
    ..To evaluate whether rheumatologists experienced in psoriatic arthritis (PsA) assess peripheral and axial involvement in the same way and to consider core clinical measurements that should be included in clinical trials in PsA...
  60. pmc Psoriatic arthritis clinical registries and genomics
    D D Gladman
    University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario M5T 2S8, Canada
    Ann Rheum Dis 64:ii103-5. 2005
    ..Careful collection and analysis of patient data through collaborative efforts will likely advance our knowledge of pathogenesis and provide new and much needed insights about the course and prognosis of the disease...
  61. ncbi request reprint Current concepts in psoriatic arthritis
    Dafna D Gladman
    University of Toronto, Ontario, Canada
    Curr Opin Rheumatol 14:361-6. 2002
    ..This review summarizes articles written about psoriatic arthritis in the past year. It concentrates on clinical and epidemiologic issues, pathogenesis and treatment, and updates the reader regarding new concepts in psoriatic arthritis...
  62. pmc Introduction/overview on clinical registries
    D D Gladman
    University of Toronto Western Research Institute, Psoriatic Arthritis Program, Toronto Western Hospital, Ontario M5T 2S8, Canada
    Ann Rheum Dis 64:ii101-2. 2005
  63. pmc Established criteria for disease controlling drugs in ankylosing spondylitis
    D D Gladman
    Centre for Prognosis Studies, Toronto Western Hospital, ECW 5 034B, Toronto, ON, Canada
    Ann Rheum Dis 62:793-4. 2003
  64. ncbi request reprint HLA markers for susceptibility and expression in scleroderma
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 32:1481-7. 2005
    ..Our objective was (1) to determine the role of HLA alleles in the susceptibility to scleroderma; and (2) to determine the role of HLA alleles in various aspects of disease expression...
  65. ncbi request reprint Psoriatic arthritis
    Dafna D Gladman
    Center for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario
    Dermatol Ther 17:350-63. 2004
    ..Traditional medications have not been effective in preventing the progression of joint damage. New medications, including biologics, have emerged with the potential to control the inflammation and arrest the progression of joint damage...
  66. pmc OMERACT 7 psoriatic arthritis workshop: synopsis
    D D Gladman
    University of Toronto, Western Research Institute, Psoriatic Arthritis Program, Toronto Western Hospital, Ontario M5T 2S8, Canada
    Ann Rheum Dis 64:ii115-6. 2005
    ....
  67. ncbi request reprint Traditional and newer therapeutic options for psoriatic arthritis: an evidence-based review
    Dafna D Gladman
    University of Toronto, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto, Ontario, Canada
    Drugs 65:1223-38. 2005
    ..Most of these medications have been found to be effective in both psoriasis and PsA. Recent randomised controlled trials suggest that at least anti-TNF agents may help prevent progression of joint destruction...
  68. ncbi request reprint Outcome measures in psoriatic arthritis
    Dafna D Gladman
    University of Toronto, Psoriatic Arthritis Program, University Health Network, Toronto, Canada
    J Rheumatol 32:2262-9. 2005
    ..A set of domains to be included in the assessment of patients with PsA was derived, and a research agenda was developed...
  69. ncbi request reprint Accurately describing changes in disease activity in Systemic Lupus Erythematosus
    D D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 27:377-9. 2000
    ..To determine whether Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores correlate with the clinician's impression of level of disease activity...
  70. ncbi request reprint HLA is a candidate region for psoriatic arthritis. evidence for excessive HLA sharing in sibling pairs
    Dafna D Gladman
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Hum Immunol 64:887-9. 2003
    ..04); whereas the haplotype sharing for the Ps affected sibling pairs was 12, 26, and 10, respectively (p = 0.38). In conclusion, the human leukocyte antigen region on chromosome 6p is implicated as one of the candidate regions in PsA...
  71. ncbi request reprint Psoriatic arthritis
    D D Gladman
    University of Toronto Psoriatic Arthritis Clinic and Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Expert Opin Investig Drugs 9:1511-22. 2000
    ..Any treatment for the arthritis must also help the skin. Greater understanding of psoriatic arthritis, its pathogenesis and natural history is required if we are to target these exciting but expensive therapies effectively...
  72. ncbi request reprint Clinical aspects of the spondyloarthropathies
    D D Gladman
    University of Toronto, The Centre for Prognosis Studies in the Rheumatic Diseases, The Toronto Hospital, Ontario, Canada
    Am J Med Sci 316:234-8. 1998
    ..Differences in response to medications and in prognosis are such that it is important to make the correct diagnosis in the individual patient...
  73. ncbi request reprint Summarizing disease features over time: I. Adjusted mean SLEDAI derivation and application to an index of disease activity in lupus
    Dominique Ibanez
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1977-82. 2003
    ..To develop a measurement of lupus disease activity over time...
  74. ncbi request reprint Changing patterns in mortality and disease outcomes for patients with systemic lupus erythematosus
    Murray B Urowitz
    Toronto Western Hospital, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Canada
    J Rheumatol 35:2152-8. 2008
    ..We examined changes in mortality and other outcomes over time in a large SLE cohort...
  75. doi request reprint Glomerular filtration rate predicts arterial events in women with systemic lupus erythematosus
    Wendy Zhang
    Arthritis Centre of Excellence, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada
    Rheumatology (Oxford) 50:799-805. 2011
    ..To determine whether renal function predicts the development of cardiovascular disease and other arterial vascular events in patients with SLE...
  76. doi request reprint Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis
    Janice A Husted
    University of Waterloo, Waterloo, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:1729-35. 2011
    ..To determine whether the presence of psoriatic arthritis (PsA) is associated with greater comorbidity, in particular cardiovascular morbidity, compared to psoriasis without arthritis...
  77. doi request reprint Clinical and serologic factors associated with lupus pleuritis
    Shikha Mittoo
    Department of Medicine, University of Manitoba, Manitoba, Canada
    J Rheumatol 37:747-53. 2010
    ..Pleuritis is a common manifestation and independent predictor of mortality in systemic lupus erythematosus (SLE). We examined the prevalence of pleuritis and factors associated with pleuritis in a multicenter Canadian SLE cohort...
  78. doi request reprint The burden of carotid artery plaques is higher in patients with psoriatic arthritis compared with those with psoriasis alone
    Lihi Eder
    Department of Rheumatology, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto Psoriatic Arthritis Program, Toronto, Ontario, Canada
    Ann Rheum Dis 72:715-20. 2013
    ..To compare the extent of atherosclerosis in patients with psoriatic arthritis (PsA) and patients with cutaneous psoriasis without arthritis (PsC)...
  79. doi request reprint Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study
    Lihi Eder
    Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto Psoriatic Arthritis Clinic, Toronto, Canada
    Ann Rheum Dis 71:1361-5. 2012
    ..A recent population-based study identified several HLA alleles as conferring a risk for psoriatic arthritis (PsA) among patients with psoriasis. The authors aimed to confirm these results using a family-based association study...
  80. ncbi request reprint Gender difference in disease expression, radiographic damage and disability among patients with psoriatic arthritis
    Lihi Eder
    Correspondence to Dafna D Gladman, University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Clinic, Centre for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto 97914, Canada
    Ann Rheum Dis 72:578-82. 2013
    ..The authors aimed to assess gender-related differences in severity of psoriatic arthritis (PsA) as reflected by measures of disease activity, joint damage, quality of life and disability...
  81. doi request reprint Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus
    Darryl Huang
    Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, Ontario, Canada
    J Rheumatol 39:254-61. 2012
    ....
  82. doi request reprint Patients with psoriatic arthritis have worse quality of life than those with psoriasis alone
    Cheryl F Rosen
    Toronto Western Hospital, Toronto, ON M5T 2S8, Canada
    Rheumatology (Oxford) 51:571-6. 2012
    ..Both conditions have a significant impact on quality of life (QoL). Our objective was to test the hypothesis that people with PsA have poorer QoL than patients with PsC because of the added burden of arthritis, age and comorbidities...
  83. ncbi request reprint Atherosclerotic vascular events in a single large lupus cohort: prevalence and risk factors
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 34:70-5. 2007
    ....
  84. ncbi request reprint Prolonged remission in systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Rheumatol 32:1467-72. 2005
    ..To also determine the frequency of remission utilizing less restrictive definitions, such as allowing shorter period of disease quiescence, persistence of serological activity, or treatment in the absence of clinical disease...
  85. ncbi request reprint Time and predictors of response to tumour necrosis factor-alpha blockers in psoriatic arthritis: an analysis of a longitudinal observational cohort
    Lihi Eder
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada
    Rheumatology (Oxford) 49:1361-6. 2010
    ..To determine predictors and time to response to treatment with TNF-alpha blockers in patients with PsA in a longitudinal observational cohort...
  86. ncbi request reprint Clinically active serologically quiescent systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1960-2. 2003
    ..To identify the frequency and characteristics of clinical activity with serological quiescence (CASQ) in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively at a single center...
  87. doi request reprint Incidence of arthritis in a prospective cohort of psoriasis patients
    Lihi Eder
    University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E 410B, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Arthritis Care Res (Hoboken) 63:619-22. 2011
    ..There are limited data regarding the incidence of PsA in patients with psoriasis. We aimed to determine the incidence of PsA among a prospective cohort of psoriasis patients...
  88. doi request reprint Folate pathway enzyme gene polymorphisms and the efficacy and toxicity of methotrexate in psoriatic arthritis
    Vinod Chandran
    University of Toronto, Toronto, Canada
    J Rheumatol 37:1508-12. 2010
    ..To determine the association between folate pathway gene polymorphisms and the effectiveness, toxicity, and drug survival of methotrexate (MTX) in psoriatic arthritis (PsA)...
  89. doi request reprint Serum albumin as a marker for disease activity in patients with systemic lupus erythematosus
    Jonathan Yip
    Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, Ontario, Canada
    J Rheumatol 37:1667-72. 2010
    ..There is currently no clinical "gold standard" in the assessment of disease activity in SLE...
  90. doi request reprint Myocardial perfusion imaging in assessing risk of coronary events in patients with systemic lupus erythematosus
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 36:288-94. 2009
    ..In this prospective cohort study we investigated whether myocardial perfusion defects in SLE are predictive of CAD events, independently of traditional Framingham risk factors...
  91. ncbi request reprint A longitudinal study of the effect of disease activity and clinical damage on physical function over the course of psoriatic arthritis: Does the effect change over time?
    Janice A Husted
    University of Waterloo, Waterloo, Ontario, Canada
    Arthritis Rheum 56:840-9. 2007
    ..To investigate whether there are differential effects of disease activity and damage on physical functioning as measured by the Health Assessment Questionnaire (HAQ) over the course of psoriatic arthritis (PsA)...
  92. ncbi request reprint Accrual of organ damage over time in patients with systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1955-9. 2003
    ....
  93. doi request reprint Risk factors for axial inflammatory arthritis in patients with psoriatic arthritis
    Vinod Chandran
    Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 37:809-15. 2010
    ..Axial involvement is an important manifestation of psoriatic arthritis (PsA). We aimed to identify risk factors associated with the presence of axial PsA (AxPsA) in patients with PsA...
  94. ncbi request reprint Ethnic variation in disease patterns and health outcomes in systemic lupus erythematosus
    Sindhu R Johnson
    Division of Rheumatology, Centre for Prognostic Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 33:1990-5. 2006
    ..In a single-center multiethnic lupus cohort, to investigate the influence of ethnicity on the prevalence of cumulative renal and central nervous system (CNS) lupus disease and damage, overall end-organ damage, and mortality...
  95. doi request reprint Mycophenolate mofetil for induction treatment of lupus nephritis: a systematic review and metaanalysis
    Zahi Touma
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 38:69-78. 2011
    ..to systematically review the efficacy and safety of mycophenolic acid and mycophenolate mofetil (MMF) compared to cyclophosphamide (CYC) for the induction treatment of lupus nephritis (LN)...
  96. doi request reprint Inflammation in an individual joint predicts damage to that joint in psoriatic arthritis
    Lynne Cresswell
    MRC Biostatistics Unit, Cambridge, UK
    Ann Rheum Dis 70:305-8. 2011
    ..The aim of this study was to identify key predictors of damage to individual joints in the hands and feet of patients with PsA, in particular those that capture previous activity...
  97. doi request reprint High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis
    Proton Rahman
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, 1E 410B, Toronto, Ontario M5T 2S8, Canada
    Ann Rheum Dis 70:690-4. 2011
    ..The study primary objective was to identify single nucleotide polymorphisms (SNPs) independent of known human leucocyte antigen (HLA) alleles within the MHC region that are associated with PsA using a high-density SNP map...
  98. doi request reprint Optimal frequency of visits for patients with systemic lupus erythematosus to measure disease activity over time
    Dominique Ibanez
    University of Toronto Lupus Clinic and Centre for Prognosis Studies in the Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 38:60-3. 2011
    ..adjusted mean Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; AMS) measures lupus disease activity over time. Our aim was to determine optimal visit frequency for calculating AMS...
  99. ncbi request reprint Reappraisal of the effectiveness of methotrexate in psoriatic arthritis: results from a longitudinal observational cohort
    Vinod Chandran
    University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 35:469-71. 2008
    ..Our aim was to determine if MTX is being used earlier in the course of PsA and in a higher dose and whether that has led to improved outcomes...
  100. doi request reprint IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients
    Lihi Eder
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Psoriatic Arthritis Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Rheum Dis 70:1594-8. 2011
    ..To study the association between smoking and IL13 gene polymorphisms with psoriatic arthritis (PsA) and psoriasis...
  101. doi request reprint Repair of radiographic joint damage following treatment with etanercept in psoriatic arthritis is demonstrable by 3 radiographic methods
    Lihi Eder
    Centre for Prognosis Studies in the Rheumatic Diseases, 1E 410B, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8
    J Rheumatol 38:1066-70. 2011
    ..We describe a patient with PsA with severe radiographic damage that improved significantly following treatment with etanercept. The improvement was documented by several methods of radiographic assessment...