Joana M Gil-Mohapel
Affiliation: University of Victoria
- Screening of therapeutic strategies for Huntington's disease in YAC128 transgenic miceJoana M Gil-Mohapel
Division of Medical Sciences, Island Medical Program, University of Victoria, British Columbia, Canada
CNS Neurosci Ther 18:77-86. 2012..The insights obtained from these and future studies will help identify potential candidates for clinical trials and will ultimately contribute to the discovery of a successful treatment for this devastating neurodegenerative disorder...
- The R6 lines of transgenic mice: a model for screening new therapies for Huntington's diseaseJoana M Gil
Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, BC, V8W 2Y2, Canada
Brain Res Rev 59:410-31. 2009..Although many of these treatments were beneficial in R6 mice, they may not be as effective in HD patients, and thus the search for a combination of therapies that will rescue the human condition continues...
- Neurogenesis in Huntington's disease: can studying adult neurogenesis lead to the development of new therapeutic strategies?Joana Gil-Mohapel
Division of Medical Sciences, Island Medical Program, University of Victoria, Canada
Brain Res 1406:84-105. 2011..Ultimately, the insights obtained from these and future studies will greatly improve our understanding of the cognitive impairment characteristic of HD...
- Mechanisms of neurodegeneration in Huntington's diseaseJoana M Gil
Island Medical Program, Division of Medical Sciences, University of Victoria, Victoria, BC, Canada
Eur J Neurosci 27:2803-20. 2008..This review presents an overview of the mechanisms that may contribute for HD pathogenesis. Ultimately, a better understanding of these mechanisms will lead to the development of more effective therapeutic targets...