T P George

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms
    Tony P George
    Program for Research in Smokers with Mental Illness PRISM, Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Schizophr Res 87:307-15. 2006
  2. pmc Monoamine oxidase inhibition for tobacco pharmacotherapy
    T P George
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Clin Pharmacol Ther 83:619-21. 2008
  3. doi request reprint Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study
    Tony P George
    Division of Substance Abuse, Department of Psychiatry, Program for Research in Smokers with Mental Illness, Yale University School of Medicine, New Haven, CT, USA
    J Clin Psychopharmacol 28:340-4. 2008
  4. ncbi request reprint Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization
    T P George
    Division of Substance Abuse, Yale University School of Medicine, New Haven, Connecticut, USA
    J Pharmacol Exp Ther 295:58-66. 2000
  5. ncbi request reprint Effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress
    T P George
    Division of Substance Abuse, Yale University School of Medicine, New Haven, CT 06520 8066, USA
    Brain Res 801:36-49. 1998
  6. ncbi request reprint Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects
    T P George
    Division of Substance Abuse, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Biol Psychiatry 49:300-6. 2001
  7. ncbi request reprint Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia
    T P George
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Center, New Haven, CT 06519, USA
    Am J Psychiatry 157:1835-42. 2000
  8. ncbi request reprint Nicotine receptor inactivation decreases sensitivity to cocaine
    V Zachariou
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 24:576-89. 2001
  9. ncbi request reprint Smoking cue reactivity in schizophrenia: effects of a nicotinic receptor antagonist
    Margaret A Fonder
    Program for Research in Smokers with Mental Illness PRISM, Connecticut Mental Health Center, and Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 57:802-8. 2005
  10. ncbi request reprint Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Arch Gen Psychiatry 62:649-59. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms
    Tony P George
    Program for Research in Smokers with Mental Illness PRISM, Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Schizophr Res 87:307-15. 2006
    ..We evaluated the effects of cigarette smoking on PPI deficits in schizophrenia, and the role of nicotinic acetylcholine receptors (nAChRs) in mediating cigarette smoking-related PPI enhancement...
  2. pmc Monoamine oxidase inhibition for tobacco pharmacotherapy
    T P George
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Clin Pharmacol Ther 83:619-21. 2008
    ..This article reviews the links between smoking and monoamine oxidase (MAO) inhibition, which could lead to the development of novel pharmacotherapies to treat tobacco dependence...
  3. doi request reprint Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study
    Tony P George
    Division of Substance Abuse, Department of Psychiatry, Program for Research in Smokers with Mental Illness, Yale University School of Medicine, New Haven, CT, USA
    J Clin Psychopharmacol 28:340-4. 2008
    ..We compared the nicotinic antagonist, mecamylamine hydrochloride (MEC), with placebo as an augmentation strategy for patients with MDD who were refractory to selective serotonin reuptake inhibitor (SSRI) treatment...
  4. ncbi request reprint Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization
    T P George
    Division of Substance Abuse, Yale University School of Medicine, New Haven, Connecticut, USA
    J Pharmacol Exp Ther 295:58-66. 2000
    ..Thus, complex regulation of mesoprefrontal DA neurons by nAChRs is suggested, which may have relevance to prefrontal cortical DA dysfunction and the high comorbid rates of nicotine dependence in schizophrenia...
  5. ncbi request reprint Effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress
    T P George
    Division of Substance Abuse, Yale University School of Medicine, New Haven, CT 06520 8066, USA
    Brain Res 801:36-49. 1998
    ....
  6. ncbi request reprint Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects
    T P George
    Division of Substance Abuse, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Biol Psychiatry 49:300-6. 2001
    ..Results are discussed within the clinical context of stress-related psychopathology syndromes and comorbid nicotine dependence...
  7. ncbi request reprint Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia
    T P George
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Center, New Haven, CT 06519, USA
    Am J Psychiatry 157:1835-42. 2000
    ....
  8. ncbi request reprint Nicotine receptor inactivation decreases sensitivity to cocaine
    V Zachariou
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 24:576-89. 2001
    ..These data indicate that activation of the high affinity nAChR may contribute to cocaine reinforcement...
  9. ncbi request reprint Smoking cue reactivity in schizophrenia: effects of a nicotinic receptor antagonist
    Margaret A Fonder
    Program for Research in Smokers with Mental Illness PRISM, Connecticut Mental Health Center, and Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 57:802-8. 2005
    ....
  10. ncbi request reprint Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Arch Gen Psychiatry 62:649-59. 2005
    ..Cigarette smoking rates in schizophrenia are higher than in the general population...
  11. ncbi request reprint Neuropsychological deficits in nonsmokers with schizophrenia: effects of a nicotinic antagonist
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness PRISM, Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 85:213-21. 2006
    ....
  12. ncbi request reprint Reliability of the Fagerström Test for Nicotine Dependence, Minnesota Nicotine Withdrawal Scale, and Tiffany Questionnaire for Smoking Urges in smokers with and without schizophrenia
    Andrea H Weinberger
    Program for Research on Smokers with Mental Illness, Yale University School of Medicine, New Haven, CT 06511, USA
    Drug Alcohol Depend 86:278-82. 2007
    ..65 versus 0.79), and TQSU Factor 2 (0.69 versus 0.81), but did not differ between diagnostic groups for M-NWS (0.58 versus 0.64). Our findings suggest that these measures may be reliable for use in smokers with schizophrenia...
  13. pmc Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia
    Andrea H Weinberger
    Program for Research on Smokers with Mental Illness PRISM, Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Res 91:217-25. 2007
    ....
  14. ncbi request reprint Adverse childhood experiences, smoking and mental illness in adulthood: a preliminary study
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness PRISM, Connecticut Mental Health Center, Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Ann Clin Psychiatry 19:89-97. 2007
    ..This study was designed to examine effects of ACE on the expression of smoking behavior and mental illness in adulthood...
  15. pmc A placebo-controlled trial of bupropion combined with nicotine patch for smoking cessation in schizophrenia
    Tony P George
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Ontario, Canada
    Biol Psychiatry 63:1092-6. 2008
    ..We determined whether the combination of sustained-release (SR) bupropion (BUP) with the transdermal nicotine patch (TNP) was well-tolerated and superior to placebo (PLO)+TNP for smoking cessation in schizophrenia...
  16. ncbi request reprint Characteristics of tobacco-smoking problem gamblers calling a gambling helpline
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Am J Addict 13:471-93. 2004
    ..The high proportion of callers reporting daily tobacco smoking highlights the need for enhanced smoking cessation efforts in problem gamblers...
  17. doi request reprint Effects of galantamine on cognitive deficits in smokers and non-smokers with schizophrenia
    Kristi A Sacco
    Schizophr Res 103:326-7. 2008
  18. ncbi request reprint A placebo controlled trial of bupropion for smoking cessation in schizophrenia
    Tony P George
    Program for Research in Smokers with Mental Illness and Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 52:53-61. 2002
    ..We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropion...
  19. ncbi request reprint Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
    Sara L Dolan
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, Rm S 109, Substance Abuse Center, New Haven, CT 06519, USA
    Schizophr Res 70:263-75. 2004
    ..These preliminary data suggest that in schizophrenics, neuropsychological deficits are associated with smoking cessation treatment failure...
  20. ncbi request reprint Smoking cessation and panic attacks: a report of 2 cases
    Jennifer C Vessicchio
    J Clin Psychiatry 63:594-5. 2002
  21. ncbi request reprint Current pharmacological treatments for nicotine dependence
    Tony P George
    Center for Nicotine and Tobacco Use Research at Yale, Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Room S 109, SAC, New Haven, CT 06519, USA
    Trends Pharmacol Sci 25:42-8. 2004
    ..Several existing medications are being tested as treatments for nicotine dependence and novel investigational agents are under development as effective treatments for nicotine dependence in the 'hard to treat' tobacco user...
  22. ncbi request reprint A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation
    Tony P George
    Program for Research in Smokers with Mental Illness PRISM, New Haven, Connecticut 06519, USA
    Biol Psychiatry 53:136-43. 2003
    ....
  23. ncbi request reprint The potential of dopamine agonists in drug addiction
    Thomas R Kosten
    Yale University School of Medicine, VA Connecticut Healthcare System, Department of Psychiatry, West Haven, CT 06516, USA
    Expert Opin Investig Drugs 11:491-9. 2002
    ..Animal studies also suggest that tailoring treatment to subgroups of patients based on genotype may improve responses...
  24. ncbi request reprint Acute tryptophan depletion in schizophrenic patients treated with clozapine
    Tony P George
    Arch Gen Psychiatry 59:291-2. 2002
  25. ncbi request reprint Neurocognitive performance among alcohol dependent men with and without physical violence toward their partners: a preliminary report
    Caroline J Easton
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine SATU, New Haven, Connecticut 06511, USA
    Am J Drug Alcohol Abuse 34:29-37. 2008
    ..The authors examined neurocognitive performance among treatment-seeking alcohol dependent men with (IPV+) and without reported physical violence (IPV-)...
  26. pmc Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar type
    Andrea H Weinberger
    J Clin Psychopharmacol 28:247-8. 2008
  27. ncbi request reprint Effects of smoking abstinence on visuospatial working memory function in schizophrenia
    Tony P George
    Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 26:75-85. 2002
    ..These results suggest that smoking abstinence differentially alters VSWM in schizophrenic vs. control smokers, and that cigarette smoking has beneficial effects on VSWM in schizophrenic, but not control, smokers...
  28. doi request reprint Survey of clinician attitudes toward smoking cessation for psychiatric and substance abusing clients
    Andrea H Weinberger
    Program for Research in Smokers with Mental Illness PRISM, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Addict Dis 27:55-63. 2008
    ..We suggest that mental health clinicians can be instrumental in providing information, encouragement, and opportunities for their patients to attempt smoking cessation...
  29. pmc Effects of acute tobacco abstinence in adolescent smokers compared with nonsmokers
    Anne E Smith
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Adolesc Health 43:46-54. 2008
    ..This study aimed to prospectively document tobacco abstinence-induced changes during the first 48 hours of abstinence in adolescent smokers compared with nonsmokers, to distinguish effects distinct from typical adolescent lability...
  30. pmc Comparing gain- and loss-framed messages for smoking cessation with sustained-release bupropion: a randomized controlled trial
    Benjamin A Toll
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06511, USA
    Psychol Addict Behav 21:534-44. 2007
    ..These data suggest that gain-framed messages may be more persuasive than loss-framed messages in promoting early success in smoking cessation for participants who are engaged in treatment...
  31. pmc Treatment of tobacco dependence: integrating recent progress into practice
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    CMAJ 177:1373-80. 2007
    ..Specifically, we discuss the use of nicotine replacement therapy, bupropion and varenicline in primary care settings...
  32. ncbi request reprint Treatment of patients with substance use disorders, second edition. American Psychiatric Association
    Herbert D Kleber
    Am J Psychiatry 164:5-123. 2007
  33. ncbi request reprint Age of onset of smoking among alcohol dependent men attending substance abuse treatment after a domestic violence arrest
    Caroline J Easton
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine SATU, Box 18, 1 Long Wharf, New Haven, CT 06511, USA
    Addict Behav 32:2020-31. 2007
    ..The implications of these findings are discussed...
  34. ncbi request reprint Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study
    Gerardo Gonzalez
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
    Addiction 98:1625-32. 2003
    ..We sought to evaluate the safety and efficacy of the GABAergic agent tiagabine in reducing cocaine use among methadone-treated patients...
  35. ncbi request reprint Cigarette smoking in Chinese male inpatients with schizophrenia: a cross-sectional analysis
    Yi lang Tang
    Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China
    J Psychiatr Res 41:43-8. 2007
    ..Accordingly, cigarette smoking may be associated with certain clinical features in schizophrenic patients, and should be carefully screened for when making treatment and rehabilitation plans...
  36. pmc Co-morbidity of smoking in patients with psychiatric and substance use disorders
    David Kalman
    Department of Psychiatry, Boston University School of Medicine, Massachusetts, USA
    Am J Addict 14:106-23. 2005
    ..Further research is needed to increase our understanding of nicotine addiction in PD and SUD and develop more effective treatment interventions...
  37. ncbi request reprint Non-nicotine pharmacotherapies for nicotine dependence
    Melissa M Dudas
    Program for Research in Smokers with Mental Illness PRISM, Connecticut Mental Health Center, New Haven, CT, USA
    Essent Psychopharmacol 6:158-72. 2005
    ..Studies summarizing the effectiveness (or lack thereof) of other (off-label) agents, such as tricyclic antidepressants, MAO-Inhibitors, SSRIs, and clonidine, are cited...
  38. pmc Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness, Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Psychopharmacol 18:457-74. 2004
    ..The potential benefits of nicotinic agents for therapeutic use in neuropsychiatric disorders is discussed, as well as directions for further research in this area...
  39. ncbi request reprint Daily patterns of alcohol, cigarette, and marijuana use in adolescent smokers and nonsmokers
    Amy M Duhig
    Department of Psychiatry, Yale University School of Medicine, CHMC, S 208, 34 Park Street, New Haven, CT 06519, USA
    Addict Behav 30:271-83. 2005
    ..There were no significant differences in the patterns of alcohol and marijuana use between female and male smokers, regardless of age. Implications for clinical interventions and future research are discussed...