Research Topics
| Graham N GeorgeSummaryAffiliation: University of Saskatchewan Country: Canada Publications
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Publications
Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercuryGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Chem Res Toxicol 17:999-1006. 2004..We discuss the design criteria for a mercuric specific chelator molecule or "custom chelator", which might form the basis for an improved clinical treatment...- Structure of the active site of sulfite dehydrogenase from Starkeya novellaChristian J Doonan
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 45:7488-92. 2006..73 A and three thiolate Mo-S ligands at 2.42 A, whereas the reduced enzyme has one oxo at 1.74 A, one long oxygen at 2.19 A (characteristic of Mo-OH2), and three Mo-S ligands at 2.40 A... 
X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samplesGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2
J Synchrotron Radiat 19:875-86. 2012..This paper reviews the origins of photo-reduction and photo-oxidation, the impact that they can have on active site structure, and the methods that can be used to provide relief from X-ray-induced photo-chemical artifacts...
The chemical forms of mercury and selenium in whale skeletal muscleGraham N George
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, SK S7N 5E2, Canada
Metallomics 3:1232-7. 2011....- X-ray absorption spectroscopy as a probe of microbial sulfur biochemistry: the nature of bacterial sulfur globules revisitedGraham N George
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
J Bacteriol 190:6376-83. 2008..We examine isolated sulfur globules of Allochromatium vinosum and intact cells of a strain of magnetotactic coccus and show that XAS indicates the presence of a chemical form of sulfur resembling S(8)... - The chemical forms of mercury in aged and fresh dental amalgam surfacesGraham N George
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
Chem Res Toxicol 22:1761-4. 2009..Whereas the fresh amalgam gives spectra that are typical of metallic mercury, the aged amalgam is predominantly beta-mercuric sulfide. The toxicological implications of these results are discussed... - Coordination chemistry at the molybdenum site of sulfite oxidase: redox-induced structural changes in the cysteine 207 to serine mutantGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 43:8456-60. 2004..The Mo(IV) species can be reoxidized to a mono-oxo Mo(V) species still coordinated to Ser207, which in turn can be further reoxidized to yield the initial tri-oxo Mo(VI) structure with loss of Ser207 ligation... - The chemical forms of mercury in human hair: a study using X-ray absorption spectroscopyGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK, Canada
J Biol Inorg Chem 15:709-15. 2010..No appreciable role was found for selenium in coordinating mercury in hair... - Chemical forms of mercury and selenium in fish following digestion with simulated gastric fluidGraham N George
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
Chem Res Toxicol 21:2106-10. 2008..We find that local chemical environments of mercury and selenium do not change upon digestion of the fish with simulated gastric fluid. We discuss the toxicological implications for humans consuming fish... - X-ray absorption spectroscopic characterization of the molybdenum site of Escherichia coli dimethyl sulfoxide reductaseGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 46:2-4. 2007..Furthermore, our results suggest that the form found in vivo is the monooxobis(molybdopterin) species... - Interaction of product analogues with the active site of rhodobacter sphaeroides dimethyl sulfoxide reductaseGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 46:3097-104. 2007.... - X-ray absorption spectroscopy of cuprous-thiolate clusters in Saccharomyces cerevisiae metallothioneinLimei Zhang
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon S7N5E2, Canada
Chem Biodivers 5:2042-9. 2008.... - MoV electron paramagnetic resonance of sulfite oxidase revisited: the low-pH chloride signalChristian J Doonan
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 47:2033-8. 2008..Here, we present a re-examination of the CW EPR spectroscopy of the sulfite oxidase low-pH chloride species and provide evidence for direct coordination of molybdenum by chloride... - Modified active site coordination in a clinical mutant of sulfite oxidaseChristian J Doonan
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
J Am Chem Soc 129:9421-8. 2007..This difference in the structure of the molybdenum site explains many of the properties of the mutant enzyme which have previously been reported... - Chemical form matters: differential accumulation of mercury following inorganic and organic mercury exposures in zebrafish larvaeMalgorzata Korbas
Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK, Canada
ACS Chem Biol 7:411-20. 2012..Our results clearly demonstrate that the common differentiation between organic and inorganic mercury is not sufficient to determine the toxicity of various mercury species... - Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvaeMalgorzata Korbas
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, SK, S7N 5E2, Canada
J Biol Inorg Chem 15:1137-45. 2010..The results indicate that mercury is redistributed from the original target tissue to the eye lens, identifying the developing lens as a major sink for methylmercury in early embryonic and larval stages... - Towards a custom chelator for mercury: evaluation of coordination environments by molecular modelingJuxia Fu
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, SK, Canada
J Biol Inorg Chem 16:15-24. 2011..Finally, we propose a new chelator "tripod" molecule, benzene-1,3,5-triamidopropanethiolate, or "Trithiopod," which is expected to bind Hg(2+) in three-coordinate geometry with very high affinity... - Arsenic K-edge X-ray absorption spectroscopy of arsenic in seafoodGraham N George
Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK, Canada
Mol Nutr Food Res 53:552-7. 2009..We find that three different chemical types of arsenic are present, consistent with arsenate, an arsenosugar or tetra-alkyl-arsonium species, and a trivalent arsenic species... - Molybdenum site structure of Escherichia coli YedY, a novel bacterial oxidoreductaseM Jake Pushie
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Inorg Chem 50:732-40. 2011..05 Å. Our results indicate that the YedY active site shows considerable similarity to but also important differences from that of reduced forms of sulfite oxidase... - Nature of halide binding to the molybdenum site of sulfite oxidaseM Jake Pushie
Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 50:9406-13. 2011..We show that there is no evidence of direct Mo-I coordination, and that the data are consistent with a structure in which the halide is bound at ∼5 Å from Mo... - Molecular mimicry in mercury toxicologyRuth E Hoffmeyer
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Canada
Chem Res Toxicol 19:753-9. 2006.... - The chemical form of mitochondrial iron in Friedreich's ataxiaBogdan F Gh Popescu
Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada S7N5E5
J Inorg Biochem 101:957-66. 2007..We conclude that most of the iron in fibroblast HMF from both affected and unaffected cells is ferrihydrite but only FRDA affected cells mineralize significant iron in mitochondrial ferritin... - Structure of the molybdenum site of Escherichia coli trimethylamine N-oxide reductaseLimei Zhang
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 47:1074-8. 2008..The presence of multiple active site structures provides a potential explanation for the anomalous features reported from the crystal structure... - Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular levelMalgorzata Korbas
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
Proc Natl Acad Sci U S A 105:12108-12. 2008..This novel approach is a powerful tool for directly investigating the molecular toxicology of heavy metals, and should be equally applicable to the study of a wide range of elements in developing embryos... - Localizing the chemical forms of sulfur in vivo using X-ray fluorescence spectroscopic imaging: application to onion (Allium cepa) tissuesIngrid J Pickering
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
Biochemistry 48:6846-53. 2009..In intact cells, X-ray fluorescence spectroscopic imaging showed elevated levels of sulfoxides in the cytosol and elevated levels of reduced sulfur in the central transport vessels and bundle sheath cells... - Chemical form of selenium in naturally selenium-rich lentils (Lens culinaris L.) from SaskatchewanDil Thavarajah
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan, Canada S7N 5E2
J Agric Food Chem 55:7337-41. 2007..As the toxicities of certain forms of arsenic and selenium are antagonistic, selenium-rich lentils may have a pivotal role to play in alleviating the chronic arsenic poisoning in Bangladesh... - High-resolution X-ray emission spectroscopy of molybdenum compoundsChristian J Doonan
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Inorg Chem 44:2579-81. 2005.... - Localizing the biochemical transformations of arsenate in a hyperaccumulating fernIngrid J Pickering
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Canada
Environ Sci Technol 40:5010-4. 2006..This study provides important insights into arsenic hyperaccumulation, which may prove useful for phytoremediating arsenic-contaminated sites, and demonstrates the strengths of XAS imaging for distinguishing highly localized species... - Tracing copper-thiomolybdate complexes in a prospective treatment for Wilson's diseaseLimei Zhang
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
Biochemistry 48:891-7. 2009..Our work allows new insights into metabolism of the metal complex in the diseased state... - Molybdenum speciation in uranium mine tailings using X-ray absorption spectroscopyJoseph Essilfie-Dughan
Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK, Canada
Environ Sci Technol 45:455-60. 2011..This suggests that the speciation of Mo in the tailings is dependent in part on the chemistry of the original ore... - X-ray absorption spectroscopy at a protein crystallography facility: the Canadian Light Source beamline 08B1-1Julien J H Cotelesage
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, SK, Canada S7N 5E2
J Synchrotron Radiat 19:887-91. 2012..Mainstream XAS data-processing software packages are available for the users; assistance with data processing and interpretation by staff is also available upon request... - The fictile coordination chemistry of cuprous-thiolate sites in copper chaperonesM Jake Pushie
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, SK, Canada S7N5E2
Biochim Biophys Acta 1817:938-47. 2012..This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes... - Nature of the catalytically labile oxygen at the active site of xanthine oxidaseChristian J Doonan
Department of Geological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
J Am Chem Soc 127:4518-22. 2005..These results support a mechanism initiated by base-assisted nucleophilic attack of the substrate by Mo-OH... - Structure of frataxin iron cores: an X-ray absorption spectroscopic studyHelen Nichol
Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada S7N 5E5
Biochemistry 42:5971-6. 2003..The extended X-ray absorption fine structure (EXAFS) analysis agrees with previous electron microscopy data showing that frataxin cores are composed of very small ferrihydrite crystallites... - Prion protein expression level alters regional copper, iron and zinc content in the mouse brainM Jake Pushie
Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada
Metallomics 3:206-14. 2011.... - Active-site dynamics and large-scale domain motions of sulfite oxidase: a molecular dynamics studyM Jake Pushie
Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada
J Phys Chem B 114:3266-75. 2010..Our simulations also probe the dynamics of the active site and surrounding residues, adding a further level of structural and thermodynamic detail in understanding sulfite oxidase function... - Metalloprotein active site structure determination: synergy between X-ray absorption spectroscopy and X-ray crystallographyJulien J H Cotelesage
Molecular and Environmental Sciences Research Group, Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E2
J Inorg Biochem 115:127-37. 2012.... - Development of a combined K-edge subtraction and fluorescence subtraction imaging system for small animalsBrian Bewer
Department of Physics, University of Saskatchewan, 116 Science Place, Saskatoon, SK S7N 5E2, Canada
Rev Sci Instrum 79:085102. 2008..A description of the system is given as well as preliminary results using an iodine test object... - Use of Soller slits to remove reference foil fluorescence from transmission spectraJustin J Tse
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan, Canada S7N 5E2
J Synchrotron Radiat 18:527-9. 2011..A comparison of blank and standard samples, measured with or without Soller slits or under a worst-case scenario, demonstrates the advantages of Soller slits when analyzing weak signal samples via transmission XAS... - Strong poison revisitedRoger C Prince
ExxonMobil Biomedical Sciences Inc, 1545 Route 22 East, Annandale, NJ 08801, USA
J Inorg Biochem 101:1891-3. 2007.... - C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper traffickingZhiguang Xiao
School of Chemistry, University of Melbourne, Victoria, 3010, Australia
J Am Chem Soc 126:3081-90. 2004..In addition, both Ctr1c and its copper-responsive transcription factor Mac1 contain similar clusters which may be important in signaling copper status in yeast... - Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) clusterXiaohua Chen
Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
Nucleic Acids Res 36:3128-38. 2008.... - Electronic structure description of the cis-MoOS unit in models for molybdenum hydroxylasesChristian J Doonan
The Department of Chemistry and Biological Chemistry, The University of New Mexico, MSC03 20601 University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
J Am Chem Soc 130:55-65. 2008.... - Spectroscopic studies of Pyrococcus furiosus superoxide reductase: implications for active-site structures and the catalytic mechanismMichael D Clay
Department of Chemistry and the Center for Metalloenzyme Studies, University of Georgia, Athens, Georgia 30602, USA
J Am Chem Soc 124:788-805. 2002..The structural and electronic properties of the SOR active site are discussed in relation to the role and bonding of the axial cysteine residue and the recent proposals for the catalytic mechanism... - Unraveling the substrate-metal binding site of ferrochelatase: an X-ray absorption spectroscopic studyGloria C Ferreira
Department of Biochemistry and Molecular Biology, College of Medicine, Institute for Biomolecular Science and H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
Biochemistry 41:4809-18. 2002..This is in marked disagreement with the conclusions from X-ray crystallographic studies of the human enzyme, and possible reasons for this are discussed... - Structures of the cuprous-thiolate clusters of the Mac1 and Ace1 transcriptional activatorsKenneth R Brown
University of Utah Health Sciences Center, 50 N. Medical Drive, 4C312, Salt Lake City, Utah 84132, USA
Biochemistry 41:6469-76. 2002.... - Yeast Cox11, a protein essential for cytochrome c oxidase assembly, is a Cu(I)-binding proteinHeather S Carr
University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
J Biol Chem 277:31237-42. 2002..Cytochrome c oxidase activity is reduced in these mutants. Thus, the residues important for Cu(I) binding correlate with in vivo function, suggesting that Cu(I) binding is important in Cox11 function... - Biliary excretion of [(GS)(2)AsSe](-) after intravenous injection of rabbits with arsenite and selenateJürgen Gailer
GSF National Research Center for Environment and Health, Institute for Ecological Chemistry, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Chem Res Toxicol 15:1466-71. 2002..The relevance of these results for the human toxicology of arsenic and selenium is discussed... - Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humansSilke Leimkuhler
Department of Plant Biology, Technical University Braunschweig, 38023 Braunschweig, Germany
J Biol Chem 278:20802-11. 2003..The active form contains a full complement of redox centers, whereas in the inactive form the FeSI center is likely to be missing... - The chemical form of mercury in fishHugh H Harris
Stanford Synchrotron Radiation Laboratory, SLAC, MS 69, 2575 Sand Hill Road, Menlo Park, CA 94025, USA
Science 301:1203. 2003 - X-ray absorption spectroscopy of selenate reductaseMegan J Maher
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
Inorg Chem 43:402-4. 2004..The enzyme was found to contain Se in a reduced form (probably organic) although the sequence does not indicate the presence of selenocysteine. The Se is coordinated to both a metal (probably Fe) and a lighter scatterer such as carbon... - High-resolution EXAFS of the active site of human sulfite oxidase: comparison with density functional theory and X-ray crystallographic resultsHugh H Harris
School of Chemistry, University of Sydney, New South Wales 2006, Australia
Inorg Chem 45:493-5. 2006..The reduced (Mo(IV)) enzyme shows two Mo-S bond lengths at 2.35 A and one at 2.41 A (assigned to cofactor dithiolene and cysteine, respectively, from DFT), together with one Mo=O at 1.72 A and one Mo-OH(2) at 2.30 A... - characterization of the cytochrome c oxidase assembly factor Cox19 of Saccharomyces cerevisiaeKevin Rigby
Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
J Biol Chem 282:10233-42. 2007..Cysteinyl residues important for Cu(I) binding are also shown to be important for the in vivo function of Cox19. Thus, a correlation exists in the ability to bind Cu(I) and in vivo function... - Reversed-phase high-performance liquid chromatographic separation of inorganic mercury and methylmercury driven by their different coordination chemistry towards thiolsAndrew J Percy
Department of Chemistry, University of Calgary, Calgary, Alberta, Canada
J Chromatogr A 1156:331-9. 2007..The developed method is compatible with inductively coupled plasma atomic emission spectrometry and was applied to analyze spiked human urine... - Synthesis, characterization, and biomimetic chemistry of cis-oxosulfidomolybdenum(VI) complexes stabilized by an intramolecular Mo(O)=S...S interactionLes J Laughlin
School of Chemistry, University of Melbourne, Victoria 3010, Australia
Inorg Chem 46:939-48. 2007..The presence of the Mo(O)=S...S interaction does not radically lengthen the Mo=S bond in the complexes or preclude them from reactions typical of unperturbed oxosulfidomolybdenum(VI) complexes... - The active site of arsenite oxidase from Alcaligenes faecalisThomas Conrads
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
J Am Chem Soc 124:11276-7. 2002.... - Removal of a cysteine ligand from rubredoxin: assembly of Fe(2)S(2) and Fe(S-Cys)(3)(OH) centresMaddalena Cross
School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
J Biol Inorg Chem 7:781-90. 2002..In addition to Fe(S-Cys)(3)(OH) centres, the C9G, C42G and C42A preparations contain a second four-coordinate Fe(III)form in which a ligand appears to be supplied by the protein chain... - X-ray absorption spectroscopy of bacterial sulfur globulesGraham N George
Stanford Synchrotron Radiation Laboratory, SLAC MS 69, 2575 Sand Hill Road, Menlo Park, California 94025, USA
Microbiology 148:2267-8; discussion 2268-70. 2002 - The seleno bis(S-glutathionyl) arsinium ion is assembled in erythrocyte lysateShawn A Manley
Department of Chemistry, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, T2N 1N4, Canada
Chem Res Toxicol 19:601-7. 2006..Combined, these results demonstrate that [(GS)2AsSe]- is rapidly formed in blood and that erythrocytes are an important site for the in vivo formation of this toxicologically important metabolite... - Sulfur X-ray absorption spectroscopy of living mammalian cells: an enabling tool for sulfur metabolomics. In situ observation of uptake of taurine into MDCK cellsManuel Gnida
Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
Biochemistry 46:14735-41. 2007..We also investigated the polarity of uptake of taurine into MDCK cells, and our results confirmed that uptake in situ is predominantly a function of the basolateral cell surface... - Copper transfer from the Cu(I) chaperone, CopZ, to the repressor, Zn(II)CopY: metal coordination environments and protein interactionsPaul A Cobine
National Research Center for Environmental Toxicology, University of Queensland, Coopers Plains, QLD 4108, Australia
Biochemistry 41:5822-9. 2002..Gain-of-function mutation of a CopZ homologue demonstrated the necessity of four lysine residues on the chaperone for the interaction with CopY. Taken together, these results suggest a mechanism for copper exchange between CopZ and CopY... - Solution structural studies of molybdate-nucleotide polyanionsLyndal M R Hill
School of Chemistry, University of Melbourne, Victoria 3010, Melbourne, Australia
J Inorg Biochem 88:274-83. 2002.... - Tetrathiomolybdate causes formation of hepatic copper-molybdenum clusters in an animal model of Wilson's diseaseGraham N George
Stanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center, 2575 Sand Hill Road, MS 69, Menlo Park, California 94025, USA
J Am Chem Soc 125:1704-5. 2003..70 A. Each Cu is coordinated to 3-4 sulfurs at 2.28 A with approximately one Mo neighbor at 2.70 A. These results indicate the formation of a biologically novel molybdenum-copper-sulfur cluster... - Chemical form and distribution of selenium and sulfur in the selenium hyperaccumulator Astragalus bisulcatusIngrid J Pickering
Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907, USA
Plant Physiol 131:1460-7. 2003..These results also indicate that sulfate and selenate reduction are developmentally correlated, and they suggest important differences between S and Se biochemistries... - The characterization and role of zinc binding in yeast Cox4H Jerome Coyne
University of Utah Health Sciences Center, Department of Medicine, Salt Lake City, Utah 84132, USA
J Biol Chem 282:8926-34. 2007..The Zn(II) ion is buried within the domain, consistent with its role in structural stability. Potential functions of this matrix-facing subunit are discussed... - Models for the molybdenum hydroxylases: synthesis, characterization and reactivity of cis-oxosulfido-Mo(VI) complexesChristian J Doonan
School of Chemistry, University of Melbourne, Victoria 3010, Australia
J Am Chem Soc 128:305-16. 2006..The oxosulfido-Mo(VI) complexes serve as precursors to biologically relevant Mo(V) and heterobimetallic MoO(mu-S)Cu species and undergo a range of biomimetic reactions... - Human Sco1 and Sco2 function as copper-binding proteinsYih Chern Horng
Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
J Biol Chem 280:34113-22. 2005..Both the mutant yeast and human proteins were nonfunctional, suggesting the importance of this aspartate for normal function. Taken together, these data suggest that both Cu(I) and Cu(II) binding are critical for normal Sco function... - Using softer X-ray absorption spectroscopy to probe biological systemsBarak Akabayov
Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
J Synchrotron Radiat 12:392-401. 2005..In addition, the required experimental set-up and the difficulties associated with conducting softer XAS experiments on biological samples are presented... - Biochemistry: a cadmium enzyme from a marine diatomTodd W Lane
Biosystems Research Department, Sandia National Laboratories, Livermore, California 94551-0969, USA
Nature 435:42. 2005.... - Selenium biotransformations in an insect ecosystem: effects of insects on phytoremediationDanel B Vickerman
Department of Entomology, University of California at Riverside, Riverside, California 92521, USA
Environ Sci Technol 38:3581-6. 2004..exigua damage to M. sativa being used to remove selenium from soils. Moreover, the presence of such insects may improve phytoremediation by increasing biotransformation of inorganic selenium and release of volatile selenium species... - Synthesis, purification, and structural characterization of the dimethyldiselenoarsinate anionJürgen Gailer
Institute for Ecological Chemistry, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
Inorg Chem 41:5426-32. 2002..943 A and two As-Se interactions at 2.279 A. On the basis of these results this novel solution species is identified as the dimethyldiselenoarsinate anion... - CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulatorTong Liu
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
Nat Chem Biol 3:60-8. 2007..Substitution of Cys36 or His61 with alanine abolishes Cu(I)- and CsoR-dependent regulation in vivo and in vitro. Potential roles of CsoR in Mtb pathogenesis are discussed... - Redox interplay of oxo-thio-tungsten centers with sulfur-donor co-ligandsSimon Thomas
School of Chemistry, University of Melbourne, Victoria 3010, Australia
Inorg Chem 42:5909-16. 2003..P.; Laughlin, L. J.; Gable, R. W.; Young, C. G. Inorg. Chem. 1996, 35, 3447)... - A new type of metal-binding site in cobalt- and zinc-containing adenylate kinases isolated from sulfate-reducers Desulfovibrio gigas and Desulfovibrio desulfuricans ATCC 27774Olga Yu Gavel
REQUIMTE, Departamento de Quimica, Centro de Quimica Fina e Biotecnologia, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
J Inorg Biochem 102:1380-95. 2008..gigas is involved in metal coordination and represents a new type of binding motif that differs from other known zinc-binding sites of AK. Cobalt and zinc play a structural role in stabilizing the LID domain... - Mercury speciation in piscivorous fish from mining-impacted reservoirsJames S Kuwabara
U S Geological Survey, 345 Middlefield Road, Mail Stop 439, Menlo Park, California 94025, USA
Environ Sci Technol 41:2745-9. 2007....