Research Topics
| Liisa A M GaleaSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Gonadal hormone modulation of hippocampal neurogenesis in the adultLiisa A M Galea
Program in Neuroscience, Department of Psychology and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Hippocampus 16:225-32. 2006..Clearly, more work needs to be done to elucidate the effects of gonadal hormones on neurogenesis in the DG of both male and female rodents...
Endocrine regulation of cognition and neuroplasticity: our pursuit to unveil the complex interaction between hormones, the brain, and behaviourLiisa A M Galea
Department of Psychology, Program in Neuroscience, University of British Columbia, Vancouver, Canada
Can J Exp Psychol 62:247-60. 2008..It is of the upmost importance to investigate the effects on neuroplasticity and behaviour in both the male and the female, particularly when modelling diseases that exhibit sex differences in incidence, etiology or treatment...- Prior sexual experience increases hippocampal cell proliferation and decreases risk assessment behavior in response to acute predator odor stress in the male ratMark D Spritzer
Department of Psychology, The University of British Columbia, 2136 West Mall, Vancouver, BC V6T1Z4, Canada
Behav Brain Res 200:106-12. 2009..The results demonstrate an influence of socio-sexual experience on the magnitude of the behavioral and neural responses to predator odor stress... - Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic mannerSusanne Brummelte
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropharmacology 62:406-18. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'... - Sleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormonesAnka D Mueller
Department of Psychology, Simon Fraser University, Burnaby, BC, Canada
Am J Physiol Regul Integr Comp Physiol 294:R1693-703. 2008..These results demonstrate that the Cort replacement method is critical for detecting an effect of SD on cell proliferation and support a significant role for sleep in adult neurogenesis... - Maternal care affects male and female offspring working memory and stress reactivityCindy K Barha
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Physiol Behav 92:939-50. 2007..Male offspring of low licking/grooming dams showed a flattened corticosterone response to stress. Thus variations in maternal care differentially affect working memory and stress reactivity in male and female offspring... - Hippocampus-dependent strategy choice predicts low levels of cell proliferation in the dentate gyrusJonathan R Epp
Department of Psychology, Graduate Program in Neuroscience, Brain Research Centre, University of British Columbia, BC, Canada
Neurobiol Learn Mem 91:437-46. 2009..These results suggest that low levels of cell proliferation in the dentate gyrus may be conducive or coincident with more efficient memory processing in the hippocampus... - Role of estradiol withdrawal in 'anhedonic' sucrose consumption: a model of postpartum depressionAmanda D Green
Department of Psychology, Neuroscience Program and Brain Research Centre, The University of British Columbia, Vancouver, Canada
Physiol Behav 97:259-65. 2009..Together, these results suggest an important, though complex, role for gonadal hormones in the behavioral changes accompanying this model of depression... 
Estradiol modulates effort-based decision making in female ratsKristina A Uban
Department of Psychology, Graduate Program in Neuroscience, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 37:390-401. 2012....- Males show stronger contextual fear conditioning than females after context pre-exposureJennifer M Barker
Graduate Program in Neuroscience, Brain Research Centre, Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Physiol Behav 99:82-90. 2010.... - First reproductive experience persistently affects spatial reference and working memory in the mother and these effects are not due to pregnancy or 'mothering' aloneJodi L Pawluski
Program in Neuroscience, Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4 Canada
Behav Brain Res 175:157-65. 2006..Clearly the combination of first pregnancy and first mothering experience has a significant impact on hippocampus-dependent learning and memory performance in the mother... - Activational levels of androgens influence risk assessment behaviour but do not influence stress-induced suppression in hippocampal cell proliferation in adult male ratsJaspreet S Kambo
Department of Psychology and Neuroscience Program, University of British Columbia, Vancouver, BC, Canada
Behav Brain Res 175:263-70. 2006.... - Activation and survival of immature neurons in the dentate gyrus with spatial memory is dependent on time of exposure to spatial learning and age of cells at examinationJonathan R Epp
Department of Psychology, Graduate Program in Neuroscience, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada
Neurobiol Learn Mem 95:316-25. 2011..These results suggest there is a gradual removal of older BrdU-labeled new neurons following spatial learning perhaps due to a competitive interaction with a population of younger BrdU-labeled new neurons... - Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behavioursMatthew N Hill
Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T1Z4
Eur J Neurosci 24:1845-9. 2006..They also suggest that endocannabinoids may play a complex role in the regulation of neurogenesis via cell proliferation in the hippocampus... - Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male ratsMark D Spritzer
Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
Dev Neurobiol 67:1321-33. 2007..020 mg/kg) resulted in a significant increase in hippocampal neurogenesis. These results suggest that testosterone enhances hippocampal neurogenesis via increased cell survival in the dentate gyrus through an androgen-dependent mechanism... - Reproductive experience alters corticosterone and CBG levels in the rat damJodi L Pawluski
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Physiol Behav 96:108-14. 2009.... - Estradiol does not influence strategy choice but place strategy choice is associated with increased cell proliferation in the hippocampus of female ratsJulia Rummel
Department of Psychology, Graduate Program in Neuroscience, Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada
Horm Behav 58:582-90. 2010..In summary the present results suggest that estradiol does not shift strategy use in this paradigm and that cell proliferation is related to strategy use with greater cell proliferation seen in place strategy users in female rats... - Offspring-exposure reduces depressive-like behaviour in the parturient female ratJodi L Pawluski
Program in Neuroscience, Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Behav Brain Res 197:55-61. 2009..Further research is needed to determine the extent of these changes and the neural and hormonal correlates of these events... - ERalpha, but not ERbeta, mediates the expression of sexual behavior in the female ratChristine A Mazzucco
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
Behav Brain Res 191:111-7. 2008..5mg dose resulted in reduced levels of proceptivity and receptivity, suggesting that ERbeta modulates ERalpha's ability to elicit receptive and proceptive sexual behavior... - Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the damSusanne Brummelte
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
Horm Behav 58:769-79. 2010..More research is needed to understand the effects of stress hormones during different phases of reproduction and how they affect the brain and behavior of the mother and her offspring... - Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and agingJodi L Pawluski
Department of Psychology, The University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
Front Neuroendocrinol 30:343-57. 2009..The present review will focus on current research investigating how hippocampal neurogenesis is altered in the adult female rodent across the lifespan... - Task difficulty in the Morris water task influences the survival of new neurons in the dentate gyrusJonathan R Epp
Department of Psychology, Graduate Program in Neuroscience, Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
Hippocampus 20:866-76. 2010..In conclusion, different types of hippocampus-dependent learning can differentially impact cell survival... - Chronic restraint stress in adolescence differentially influences hypothalamic-pituitary-adrenal axis function and adult hippocampal neurogenesis in male and female ratsCindy K Barha
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Hippocampus 21:1216-27. 2011..These results suggest that stress during adolescence can have effects on hypothalamic-pituitary-adrenal axis function and hippocampus plasticity in adulthood, particularly in female rats... - Prenatal alcohol exposure reduces the proportion of newly produced neurons and glia in the dentate gyrus of the hippocampus in female ratsKristina A Uban
Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada
Horm Behav 58:835-43. 2010..Alterations in hippocampal neurogenesis following PAE may contribute to learning and memory deficits seen in individuals with fetal alcohol spectrum disorders... - Motherhood alters the cellular response to estrogens in the hippocampus later in lifeCindy K Barha
Department of Psychology, and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada
Neurobiol Aging 32:2091-5. 2011..Together these findings may lead to the development of new therapeutic advances in the treatment of symptoms associated with menopause in women... - Reproductive experience differentially affects spatial reference and working memory performance in the motherJodi L Pawluski
Program in Neuroscience, Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Horm Behav 49:143-9. 2006.... - Adult hippocampal cell proliferation is suppressed with estrogen withdrawal after a hormone-simulated pregnancyAmanda D Green
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada
Horm Behav 54:203-11. 2008..Cell death (pyknotic cells) was decreased only in the 'postpartum' group. Together, these results suggest an important, though complex, role for gonadal hormones in the cellular changes accompanying this model of postpartum depression... - Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memoryKatia J Sinopoli
Department of Psychology, The Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neurobiol Learn Mem 86:293-304. 2006..These data provide further evidence for the notion that estradiol can dose-dependently alter memory processes and suggest that facilitation or disruptions of working memory by estradiol are site- and time-specific... - Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injuryCindy K Barha
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Exp Neurol 231:72-81. 2011..Together these findings suggest that progesterone treatment after TBI normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus... - Hypogonadism predisposes males to the development of behavioural and neuroplastic depressive phenotypesSteven R Wainwright
Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada
Psychoneuroendocrinology 36:1327-41. 2011..These findings indicate that testicular hormones confer resiliency to chronic stress in males therefore reducing the likelihood of developing putative physiological, behavioural or neurological depressive-like phenotypes... - Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effectsMelissa M Holmes
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurosci Res 76:216-22. 2004.... - Influence of different estrogens on neuroplasticity and cognition in the hippocampusCindy K Barha
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Biochim Biophys Acta 1800:1056-67. 2010..There are three main forms of estrogens found in mammals: estradiol, estrone, and estriol. The vast majority of studies have used estradiol to investigate the effects of estrogens on the brain... - Endocrine substrates of cognitive and affective changes during pregnancy and postpartumJoanna L Workman
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Behav Neurosci 126:54-72. 2012..Research in this area may reveal insight into how pregnancy and motherhood alter the likelihood of developing postpartum depression and related disorders... - Hippocampal morphology is differentially affected by reproductive experience in the motherJodi L Pawluski
Program in Neuroscience, Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
J Neurobiol 66:71-81. 2006..These findings point to the effect of reproductive experience and offspring on plasticity in the hippocampus, an area not traditionally associated with motherhood... - Sex and regional differences in estradiol content in the prefrontal cortex, amygdala and hippocampus of adult male and female ratsJennifer M Barker
Graduate Program in Neuroscience, Brain Research Centre, Department of Psychology, University of British Columbia, British Columbia, Canada
Gen Comp Endocrinol 164:77-84. 2009..Thus there are regional differences in estradiol concentration in the prefrontal cortex, amygdala and hippocampus that are influenced by sex and hormone status... - Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodentsLiisa A M Galea
Program in Neuroscience, Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Brain Res Rev 57:332-41. 2008.... - Everyday life memory deficits in pregnant womenCarrie Cuttler
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Can J Exp Psychol 65:27-37. 2011..The predominant use of laboratory tests may explain the myriad of previous failures to detect objective deficits in pregnant women's memory... - Castration differentially affects spatial working and reference memory in male ratsMark D Spritzer
Department of Psychology, Neuroscience Program, University of British Columbia, Vancouver, BC, Canada
Arch Sex Behav 37:19-29. 2008..Our results indicate that androgens improve working memory and may impair reference memory, but the effects of androgens on reference memory seem to be task dependent... - Sex differences in cell proliferation, cell death and defensive behavior following acute predator odor stress in adult ratsErin M Falconer
Department of Psychology, University of British Columbia, Vancouver, Canada
Brain Res 975:22-36. 2003..This is the first demonstration of a sex difference in cell proliferation and death in the adult dentate gyrus in response to stress... - Depression during pregnancy and postpartum: contribution of stress and ovarian hormonesS Brummelte
Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada, V6T 1Z4
Prog Neuropsychopharmacol Biol Psychiatry 34:766-76. 2010.... - Elevated corticosterone levels in stomach milk, serum, and brain of male and female offspring after maternal corticosterone treatment in the ratSusanne Brummelte
Department of Psychology, Brain Research Center, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada
Dev Neurobiol 70:714-25. 2010..Developmental exposure to high CORT could reprogram the HPA axis and contribute to the behavioral and neural changes seen in adult offspring... - Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitorsJodi L Pawluski
Department of Pediatrics, University of British Columbia, Vancouver, Canada
Pediatrics 124:e662-70. 2009..This study investigated neonatal S100B levels as a biomarker of prenatal selective serotonin reuptake inhibitor (SSRI) exposure... - Defensive behavior and hippocampal cell proliferation: differential modulation by naltrexone during stressMelissa M Holmes
Department of Psychology, University of British Columbia, Vancouver, Canada
Behav Neurosci 116:160-8. 2002..In addition, naltrexone administration suppressed CP in the absence of TMT. These results demonstrate a dissociation between DBs and regulation of CP in the DG... - High levels of estradiol impair spatial performance in the Morris water maze and increase 'depressive-like' behaviors in the female meadow voleLiisa A M Galea
Department of Psychology and Neuroscience Program, The University of British Columbia, Vancouver, British Columbia, Canada
Physiol Behav 77:217-25. 2002..To our knowledge, this is the first demonstration in rodents indicating that estradiol-mediated changes in behavior in the FST is not indicative of subsequent performance in the Morris water maze... - Low levels of estradiol facilitate, whereas high levels of estradiol impair, working memory performance on the radial arm mazeMelissa M Holmes
Department of Psychology, University of British Columbia, Vancouver, Canada
Behav Neurosci 116:928-34. 2002..32 microg EB (low physiological) facilitated performance by decreasing the number of WME. Taken together, these data demonstrate a dose-dependent effect of EB on working memory... - The hormone therapy, Premarin, impairs hippocampus-dependent spatial learning and memory and reduces activation of new granule neurons in response to memory in female ratsCindy K Barha
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Neurobiol Aging 34:986-1004. 2013..These results indicate that Premarin may be impairing hippocampus-dependent learning and memory by negatively altering the neurogenic environment in the dentate gyrus thus disrupting normal activity of new neurons... - 17β-Estradiol, but not estrone, increases the survival and activation of new neurons in the hippocampus in response to spatial memory in adult female ratsRobyn E S McClure
Department of Psychology, Graduate Program in Neuroscience, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada
Horm Behav 63:144-57. 2013..These results provide insight into how estrogens differentially influence the brain and behavior, and may provide insight into the development of hormone replacement therapies for women... - High level estradiol impairs and low level estradiol facilitates non-spatial working memoryJennifer K Wide
Department of Psychology and Neuroscience Program, The University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Behav Brain Res 155:45-53. 2004..These data suggest that estradiol's facilitatory effects on working memory may not be mediated through the PFC, while estradiols inhibitory effects on working memory may be mediated at least in part through the PFC... - High post-partum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behavior of offspring: A model of post-partum stress and possible depressionSusanne Brummelte
Department of Neuroanatomy, University of Bielefeld, 33501 Bielefeld, Germany
Horm Behav 50:370-82. 2006....