Anthony Fyles

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    A Fyles
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 20:680-7. 2002
  2. ncbi request reprint Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer
    Anthony Fyles
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, Canada
    Radiother Oncol 80:132-7. 2006
  3. ncbi request reprint Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer
    Anthony W Fyles
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    N Engl J Med 351:963-70. 2004
  4. ncbi request reprint The effect of smoking on tumour oxygenation and treatment outcome in cervical cancer
    A Fyles
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Clin Oncol (R Coll Radiol) 14:442-6. 2002
  5. ncbi request reprint Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice
    Anthony Fyles
    Department of Radiation Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada
    Gynecol Oncol 108:395-401. 2008
  6. doi request reprint Rapid automated treatment planning process to select breast cancer patients for active breathing control to achieve cardiac dose reduction
    Wei Wang
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 82:386-93. 2012
  7. doi request reprint Automated weekly replanning for intensity-modulated radiotherapy of cervix cancer
    James Stewart
    Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
    Int J Radiat Oncol Biol Phys 78:350-8. 2010
  8. doi request reprint Magnetic resonance imaging-guided intracavitary brachytherapy for cancer of the cervix
    Daniel Zwahlen
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 74:1157-64. 2009
  9. ncbi request reprint Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia
    Karen Lim
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 70:126-33. 2008
  10. doi request reprint Role of adjuvant radiotherapy in granulosa cell tumors of the ovary
    Jan Hauspy
    Juravinski Cancer Centre, Department of Gynecologic Oncology, Hamilton Health Sciences Centre and McMaster University, Hamilton, ON, Canada
    Int J Radiat Oncol Biol Phys 79:770-4. 2011

Detail Information

Publications57

  1. ncbi request reprint Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    A Fyles
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 20:680-7. 2002
    ..This prospective clinical study was begun in 1994 to validate the independent prognostic impact of tumor hypoxia in patients with cervix cancer treated with definitive radiation therapy...
  2. ncbi request reprint Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer
    Anthony Fyles
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, Canada
    Radiother Oncol 80:132-7. 2006
    ..Using data from our prospective trial, we updated a cohort of patients treated with definitive radiation alone without chemotherapy, to assess the long-term prognostic impact of these microenvironmental features...
  3. ncbi request reprint Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer
    Anthony W Fyles
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    N Engl J Med 351:963-70. 2004
    ..We determined the effect of breast irradiation plus tamoxifen on disease-free survival and local relapse in women 50 years of age or older who had T1 or T2 node-negative breast cancer...
  4. ncbi request reprint The effect of smoking on tumour oxygenation and treatment outcome in cervical cancer
    A Fyles
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Clin Oncol (R Coll Radiol) 14:442-6. 2002
    ..We hypothesized that there is an association between smoking and tumour hypoxia, and that smoking adversely affects radiation response and survival...
  5. ncbi request reprint Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice
    Anthony Fyles
    Department of Radiation Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada
    Gynecol Oncol 108:395-401. 2008
    ..Our objective was to test whether ovariectomy, or ovariectomy followed by progestin treatment prevents the development of endometrial lesions in the pten+/- mouse model of endometrial cancer...
  6. doi request reprint Rapid automated treatment planning process to select breast cancer patients for active breathing control to achieve cardiac dose reduction
    Wei Wang
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 82:386-93. 2012
    ....
  7. doi request reprint Automated weekly replanning for intensity-modulated radiotherapy of cervix cancer
    James Stewart
    Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
    Int J Radiat Oncol Biol Phys 78:350-8. 2010
    ..In addition, the dosimetric consequences of organ and tumor motion are modeled using a combination of deformable registration and fractional dose accumulation techniques...
  8. doi request reprint Magnetic resonance imaging-guided intracavitary brachytherapy for cancer of the cervix
    Daniel Zwahlen
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 74:1157-64. 2009
    ..To determine the feasibility and benefits of optimized magnetic resonance imaging (MRI)-guided brachytherapy (BT) for cancer of the cervix...
  9. ncbi request reprint Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia
    Karen Lim
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 70:126-33. 2008
    ....
  10. doi request reprint Role of adjuvant radiotherapy in granulosa cell tumors of the ovary
    Jan Hauspy
    Juravinski Cancer Centre, Department of Gynecologic Oncology, Hamilton Health Sciences Centre and McMaster University, Hamilton, ON, Canada
    Int J Radiat Oncol Biol Phys 79:770-4. 2011
    ..To review the role of adjuvant radiotherapy (RT) in the outcome and recurrence patterns of granulosa cell tumors (GCTs) of the ovary...
  11. ncbi request reprint A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment
    Fernanda G Herrera
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 67:97-103. 2007
    ..To evaluate the toxicity and effectiveness of celecoxib in combination with definitive chemoradiotherapy (CRT) in women with locally advanced cervical cancer...
  12. ncbi request reprint Use of alternative therapy in postmenopausal breast cancer patients treated with tamoxifen after surgery
    Karen P L Yap
    Department of Surgical Oncology, Princess Margaret Hospital, 610 University Ave, Toronto, Ontario M5G 2M9, Canada
    Breast J 10:481-6. 2004
    ..In conclusion, 27% of patients with early stage breast cancer used alternative therapy. Users were more likely to be younger and to experience shoulder or arm symptoms after breast-conserving surgery with radiation...
  13. doi request reprint Inter- and intrafractional tumor and organ movement in patients with cervical cancer undergoing radiotherapy: a cinematic-MRI point-of-interest study
    Philip Chan
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 70:1507-15. 2008
    ..In this study, the internal movement of the tumor, cervix, and uterus were examined using serial cinematic magnetic resonance imaging scans and point-of-interest analysis...
  14. pmc Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis
    David Hedley
    Department of Medical Oncology and Hematology, Ontario Cancer Institute Princess Margaret Hospital, and Department of Medical Biophysics, University of Toronto, Canada
    Am J Pathol 164:557-65. 2004
    ..Elevated expression of thioredoxin and APE/ref-1 might promote cancer cell survival in hypoxic microenvironments of cervical carcinomas...
  15. doi request reprint Pelvic lymph node topography for radiotherapy treatment planning from ferumoxtran-10 contrast-enhanced magnetic resonance imaging
    Robert Dinniwell
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
    Int J Radiat Oncol Biol Phys 74:844-51. 2009
    ..To define a population-based pelvic lymph node clinical target volume (CTV) for radiotherapy treatment planning using magnetic resonance (MR) imaging and the ultrasmall superparamagnetic iron oxide lymph node contrast agent ferumoxtran-10...
  16. pmc MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer
    Christine How
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e67846. 2013
    ....
  17. doi request reprint Interstitial permeability and elasticity in human cervix cancer
    Michael Milosevic
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
    Microvasc Res 75:381-90. 2008
    ..Serial evaluation of these parameters may provide a means of clinically monitoring response to treatments that specifically target the tumor microenvironment...
  18. ncbi request reprint Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use
    William Chu
    Department of Radiation Oncology, Princess Margaret Hospital University Health Network, Toronto, Ontario, Canada
    Carcinogenesis 28:2139-42. 2007
    ..004). These findings suggest that a subgroup of breast cancer patients who carry the CYP3A4*1B allele and take tamoxifen may be at increased risk of developing endometrial cancer...
  19. doi request reprint Long-term results of hypofractionated radiation therapy for breast cancer
    Timothy J Whelan
    McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada
    N Engl J Med 362:513-20. 2010
    ..The optimal fractionation schedule for whole-breast irradiation after breast-conserving surgery is unknown...
  20. doi request reprint Concomitant intensity modulated boost during whole breast hypofractionated radiotherapy--a feasibility and toxicity study
    Amy Yuen Meei Teh
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Radiother Oncol 102:89-95. 2012
    ....
  21. ncbi request reprint Consolidative abdominopelvic radiotherapy after surgery and carboplatin/paclitaxel chemotherapy for epithelial ovarian cancer
    Robert Dinniwell
    Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 62:104-10. 2005
    ..To assess the feasibility and morbidity of sequential cytoreductive surgery, carboplatin/paclitaxel chemotherapy, and consolidative abdominopelvic radiotherapy (APRT) in ovarian cancer...
  22. doi request reprint Tumor and normal tissue dosimetry changes during MR-guided pulsed-dose-rate (PDR) brachytherapy for cervical cancer
    Marita Morgia
    Radiation Medicine Program, Princess Margaret Cancer Centre University Health Network, Toronto, Canada
    Radiother Oncol 107:46-51. 2013
    ..To analyze systematic changes in tumor and normal tissue anatomy and dosimetry using serial MR imaging during pulsed dose rate brachytherapy (PDR BT) for cervical cancer...
  23. ncbi request reprint Comparison of late toxicity between continuous low-dose-rate and pulsed-dose-rate brachytherapy in cervical cancer patients
    Barbara Bachtiary
    Department of Radiation Oncology, Princess Margaret Hospital, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 63:1077-82. 2005
    ..To compare survival and severe late radiation toxicity between patients who received continuous low-dose-rate (LDR) brachytherapy (BT) and pulsed-dose-rate (PDR) BT for cervical cancer...
  24. doi request reprint Heterogeneity and power in clinical biomarker studies
    Melania Pintilie
    Department of Biostatistics, Radiation Medicine Program, and the Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Canada
    J Clin Oncol 27:1517-21. 2009
    ..Due to this heterogeneous distribution of the biomarker, the association sought may appear weak or nonexistent. Thus, there is a wide range of conclusions in the literature on the association between a biomarker and an outcome...
  25. doi request reprint Pelvic radiotherapy for cancer of the cervix: is what you plan actually what you deliver?
    Karen Lim
    Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 74:304-12. 2009
    ..This study explored the effect of internal anatomic changes on the dose delivered to the tumor and organs at risk using a strategy integrating deformable soft-tissue modeling with simulated dose accumulation...
  26. doi request reprint Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis
    Sarah Jane Lunt
    Division of Applied Molecular Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Future Oncol 4:793-802. 2008
    ..Pretreatment interstitial fluid pressure and the change in pressure during treatment may provide important predictive information that in the future will be used to optimize therapy in individual patients...
  27. ncbi request reprint Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas
    David Hedley
    Division of Experimental Therapeutics and Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Cancer Res 9:5666-74. 2003
    ..Recent studies suggest that carbonic anhydrase IX (CA IX), which is regulated via hypoxia-inducible factor 1, is a useful intrinsic marker of tumor hypoxia...
  28. ncbi request reprint Adjuvant radiotherapy in women with stage I endometrial cancer: a systematic review
    Himu Lukka
    Juravinski Regional Cancer Centre, Ontario, Canada
    Gynecol Oncol 102:361-8. 2006
    ..To review the literature regarding the role of adjuvant radiotherapy (RT) in women with stage I endometrial cancer in terms of survival and pelvic control...
  29. doi request reprint Trends in the utilization of brachytherapy in cervical cancer in the United States
    Kathy Han
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 87:111-9. 2013
    ..To determine the trends in brachytherapy use in cervical cancer in the United States and to identify factors and survival benefits associated with brachytherapy treatment...
  30. pmc Dosimetric comparison of intensity-modulated, conformal, and four-field pelvic radiotherapy boost plans for gynecologic cancer: a retrospective planning study
    Philip Chan
    Department of Radiation Oncology, Princess Margaret Hospital University Health Network, Toronto, Canada
    Radiat Oncol 1:13. 2006
    ....
  31. ncbi request reprint The rapid uptake of concurrent chemotherapy for cervix cancer patients treated with curative radiation
    Lisa Barbera
    Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 64:1389-94. 2006
    ..The purpose of this study is to examine the rate of chemotherapy use, in the province of Ontario, before and after these publications...
  32. ncbi request reprint The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure
    Michael Milosevic
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Semin Radiat Oncol 14:249-58. 2004
    ..The pathophysiology of elevated IFP is discussed, along with possible explanations for the strong influence on patient outcome and directions for future research...
  33. ncbi request reprint Adenocarcinoma involving the uterine cervix: magnetic resonance imaging findings in tumours of endometrial, compared with cervical, origin
    Masoom A Haider
    Department of Medical Imaging, University Health Network, Mount Sinai Hospital, University of Toronto, Toronto, ON
    Can Assoc Radiol J 57:43-8. 2006
    ..To determine the distinctive magnetic resonance imaging (MRI) features of cervical and endometrial adenocarcinoma that present clinically as a cervical mass...
  34. ncbi request reprint Correlations between dynamic contrast-enhanced magnetic resonance imaging-derived measures of tumor microvasculature and interstitial fluid pressure in patients with cervical cancer
    Masoom A Haider
    Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Ontario, Canada
    J Magn Reson Imaging 25:153-9. 2007
    ....
  35. ncbi request reprint A phase III randomized study of misonidazole plus radiation vs. radiation alone for cervix cancer
    Philip Chan
    Department of Radiation Oncology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Radiother Oncol 70:295-9. 2004
    ..A randomized-controlled study of radical radiotherapy for cervical cancer with or without the hypoxic sensitizer, misonidazole was conducted from 1981 to 1984 to investigate its therapeutic benefit...
  36. doi request reprint Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer
    Karen Lim
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 79:348-55. 2011
    ..The aim of this study was to develop a consensus CTV definition in preparation for a Phase 2 clinical trial being planned by the Radiation Therapy Oncology Group...
  37. doi request reprint Diffusion-weighted MRI in cervical cancer
    Patrick Z McVeigh
    Department of Medical Imaging, University of Toronto, University Health Network, Princess Margaret Hospital, 610 University Ave, Toronto, ON, M5G 2M9, Canada
    Eur Radiol 18:1058-64. 2008
    ..05). Median ADC in cervix carcinoma is significantly lower compared to normal cervix. ADC may have predictive value in squamous tumors, but further long-term study will determine the ultimate clinical utility...
  38. ncbi request reprint Factors influencing arm and axillary symptoms after treatment for node negative breast carcinoma
    Karen P L Yap
    Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Cancer 97:1369-75. 2003
    ..The purpose of the current study was to identify the factors that contribute to postoperative arm symptoms following breast conserving surgery in a well-defined cohort of node negative breast carcinoma patients...
  39. doi request reprint MicroRNA-301 mediates proliferation and invasion in human breast cancer
    Wei Shi
    Department of Medical Biophysics, Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Canada
    Cancer Res 71:2926-37. 2011
    ..In summary, our findings define miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses...
  40. ncbi request reprint Assessment of the tumor microenvironment in cervix cancer using dynamic contrast enhanced CT, interstitial fluid pressure and oxygen measurements
    Masoom A Haider
    The Joint Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Int J Radiat Oncol Biol Phys 62:1100-7. 2005
    ..The purpose of this study was to determine the relationship between IFP and oxygenation and parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT)...
  41. ncbi request reprint Dysregulated PTEN-PKB and negative receptor status in human breast cancer
    Wei Shi
    Department of Experimental Therapeutics, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario
    Int J Cancer 104:195-203. 2003
    ..These observations support the contention that dysregulation in PTEN-PKB contributes to disease progression and hormone resistance of human breast cancer...
  42. doi request reprint Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148
    Amit M Oza
    Princess Margaret Hospital, University Health Network, Bras Family Drug Development Program, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 26:4319-25. 2008
    ..Epidermal growth factor receptor (EGFR) overexpression is common in endometrial cancers and may have a major role in tumor growth and progression. Erlotinib is an orally active, selective inhibitor of EGFR tyrosine kinase activity...
  43. doi request reprint The effect of local breast radiotherapy on circulating CD34(+) cells
    Nehad M Alajez
    Ontario Cancer Institute, Toronto, Canada
    Radiother Oncol 100:304-7. 2011
    ..These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications...
  44. ncbi request reprint Relations between non-protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinoma
    David W Hedley
    Department of Medical Oncology and Hematology, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 61:137-44. 2005
    ..The levels of NPSH in the nucleus are predicted to be more important than those in cytoplasm. We, therefore, investigated the relation between nuclear NPSH and the clinical outcome of radical radiotherapy (RT)...
  45. doi request reprint Quantitative coronary angiography findings of patients who received previous breast radiotherapy
    Wei Wang
    Department of Radiation Oncology, University Health Network, University of Toronto, Canada
    Radiother Oncol 100:184-8. 2011
    ..To compare the coronary angiographic findings between patients who had previous left sided versus right sided breast cancer radiotherapy (RT)...
  46. ncbi request reprint Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer
    Timothy Whelan
    T Whelan, M Levine, McMaster University, and Cancer Care Ontario CCO Hamilton Regional Cancer Centre, Hamilton, Ontario, Canada
    J Natl Cancer Inst 94:1143-50. 2002
    ....
  47. ncbi request reprint 5-hydroxytryptamine-3 receptor antagonist with or without short-course dexamethasone in the prophylaxis of radiation induced emesis: a placebo-controlled randomized trial of the National Cancer Institute of Canada Clinical Trials Group (SC19)
    Rebecca K S Wong
    National Cancer Institute of Canada Clinical Trials Group, Canada
    J Clin Oncol 24:3458-64. 2006
    ....
  48. doi request reprint Technological advances in radiotherapy for cervical cancer
    Lorraine Walsh
    Department of Radiation Oncology, University of Toronto and Radiation Medicine Program, Princess Margaret Hospital University Health Network, Toronto, Ontario, Canada
    Curr Opin Oncol 23:512-8. 2011
    ....
  49. ncbi request reprint Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity
    Barbara Bachtiary
    Department of Radiation Oncology, Clinical Study Coordination and Biostatistics, Division of Cancer Genomics and Proteomics, Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Cancer Res 12:5632-40. 2006
    ..To explore intratumor heterogeneity in gene expression profiles from patients with cervical cancer...
  50. doi request reprint Excellence in Radiation Research for the 21st Century (EIRR21): description of an innovative research training program
    Christine P'ng
    Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 83:e563-70. 2012
    ....
  51. ncbi request reprint Stage II endometrial carcinoma: prognostic factors and risk classification in 170 patients
    Graham Pitson
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 53:862-7. 2002
    ..The purpose of this study was to determine prognostic factors in a series of patients treated according to standardized protocols at a single institution...
  52. doi request reprint Follow-up for women after treatment for cervical cancer: a systematic review
    Laurie Elit
    Juravinski Regional Cancer Centre, Hamilton, ON, Canada
    Gynecol Oncol 114:528-35. 2009
    ..To determine the optimal recommended program for the follow-up of patients who are disease free after completed primary therapy for cervical cancer...
  53. ncbi request reprint Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2
    Mario E Beiner
    Centre for Research in Women s Health, 790 Bay Street, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 15:1636-40. 2006
    ..4; 95% CI, 1.7-6.6; P = 0.0005). In summary, two common variant alleles of the MLH1 and MSH2 genes make a substantial contribution to endometrial cancer incidence in Ontario...
  54. ncbi request reprint Systematic review of adjuvant care for women with Stage I ovarian carcinoma
    Laurie Elit
    Division of Gynecologic Oncology, Juravinski Regional Cancer Centre, Hamilton, Ontario, Canada
    Cancer 101:1926-35. 2004
    ..Several adjuvant care interventions to treat women with Stage I ovarian carcinoma have been studied. The aim of the current systematic review was to determine the optimal strategy for adjuvant care for women with Stage I ovarian carcinoma...
  55. doi request reprint Treating vulvar cancer in the new millennium: are patients receiving optimal care?
    Lisa Barbera
    Sunnybrook and Women s College Health Science Center, Canada
    Gynecol Oncol 109:71-5. 2008
    ..Our ultimate goal is to improve vulvar cancer care by understanding variations in care and their impact on outcome. In this pilot study, we specifically evaluate the use of groin node dissection (GND)...
  56. ncbi request reprint Do single and partnered women with gynecologic cancer differ in types and intensities of illness- and treatment-related psychosocial concerns? A pilot study
    Janet M de Groot
    Department of Psychiatry, Foothills Medical Centre, Calgary, Alberta, Canada
    J Psychosom Res 63:241-5. 2007
    ..We compared the psychosocial and psychosexual concerns of single and partnered women with gynecologic cancer, since relationship status and psychosocial context are known to affect sexuality, a life domain commonly affected by this cancer...
  57. ncbi request reprint In regard to Ishikawa et al.: Cyclooxygenase-2 impairs treatment effect of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis (Int J Radiat Oncol Biol Phys 2006;66:1347-1355)
    Fernanda G Herrera
    Int J Radiat Oncol Biol Phys 68:959-60; author reply 960. 2007