Jan O Friedrich

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death
    Jan O Friedrich
    St Michael s Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 142:510-24. 2005
  2. pmc Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
  3. doi request reprint Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    Stat Med 31:1857-86. 2012
  4. pmc Drotrecogin alfa (activated): down and not out, but not really in either
    Jan O Friedrich
    Crit Care 10:420. 2006
  5. pmc Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death
    Jan O Friedrich
    Crit Care 10:427. 2006
  6. pmc Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data
    Jan O Friedrich
    Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, R, Fraser Elliot Building, 3rd Floor, South Wing, 3S 805, 190 Elizabeth Street, Toronto, Ontario, Canada
    Crit Care 14:324. 2010
  7. pmc The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 8:32. 2008
  8. doi request reprint Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 64:556-64. 2011
  9. pmc Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 7:5. 2007
  10. pmc Rosiglitazone: can meta-analysis accurately estimate excess cardiovascular risk given the available data? Re-analysis of randomized trials using various methodologic approaches
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Res Notes 2:5. 2009

Detail Information

Publications42

  1. ncbi request reprint Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death
    Jan O Friedrich
    St Michael s Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 142:510-24. 2005
    ..Surveys have documented the continued popularity of low-dose dopamine to influence renal dysfunction even though few data support it and editorials and reviews have discouraged its use...
  2. pmc Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
    ....
  3. doi request reprint Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    Stat Med 31:1857-86. 2012
    ....
  4. pmc Drotrecogin alfa (activated): down and not out, but not really in either
    Jan O Friedrich
    Crit Care 10:420. 2006
  5. pmc Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death
    Jan O Friedrich
    Crit Care 10:427. 2006
  6. pmc Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data
    Jan O Friedrich
    Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, R, Fraser Elliot Building, 3rd Floor, South Wing, 3S 805, 190 Elizabeth Street, Toronto, Ontario, Canada
    Crit Care 14:324. 2010
    ..Further insights may come from individual patient data meta-analyses or from future large multicenter RCTs in more narrowly defined subgroups of surgical patients...
  7. pmc The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 8:32. 2008
    ..SMD and RoM allow pooling of outcomes expressed in different units and comparisons of effect sizes across interventions, but RoM interpretation does not require knowledge of the pooled SD, a quantity generally unknown to clinicians...
  8. doi request reprint Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 64:556-64. 2011
    ..Ratio of means (RoM) is an alternative effect measure that performs comparably in simulation. We compared treatment effects and heterogeneity for RoM, MD, and SMD using empiric data...
  9. pmc Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 7:5. 2007
    ..This study examined the influence of such trials on pooled treatment effects...
  10. pmc Rosiglitazone: can meta-analysis accurately estimate excess cardiovascular risk given the available data? Re-analysis of randomized trials using various methodologic approaches
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Res Notes 2:5. 2009
    ..The objective of this study was to assess the robustness of the rosiglitazone results by using alternative reasonable methodologic approaches and by analyzing additional related outcomes...
  11. pmc Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Crit Care 10:145. 2006
    ..Consequently, further randomised trials of this agent in prospectively defined high-risk patients are required to clarify its role in the management of severe sepsis...
  12. pmc Long-term outcomes and clinical predictors of hospital mortality in very long stay intensive care unit patients: a cohort study
    Jan O Friedrich
    Critical Care Department, St, Michael s Hospital, University of Toronto, Toronto, Canada
    Crit Care 10:R59. 2006
    ..The purpose of this study was to identify long-term outcomes after hospital discharge and readily available clinical predictors of hospital mortality for patients requiring prolonged care in the ICU...
  13. ncbi request reprint Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
    ..To examine the attitudes and preferences of surrogate decision makers (SDMs) regarding their involvement in the consent to research process for ICU patients...
  14. doi request reprint Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies
    Clarence Chant
    Leslie Dan Faculty of Pharmacy, University of Toronto and Pharmacy Department, St Michael s Hospital, Toronto, Canada
    Crit Care Med 39:1167-73. 2011
    ..To determine whether catheter-associated urinary tract infections are associated with increased morbidity and mortality in critically ill patients...
  15. ncbi request reprint The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study*
    Ron Wald
    1Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, ON, Canada 2Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada 3Institute for Clinical Evaluative Sciences, Toronto, ON, Canada 4Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 5Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada 6Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada 7Departments of Critical Care and Medicine, St Michael s Hospital, Toronto, ON, Canada 8Division of Nephrology, London Health Sciences Centre, London, ON, Canada 9Division of General Internal Medicine, St Michael s Hospital, Toronto, ON, Canada
    Crit Care Med 42:868-77. 2014
    ..Our objective was to determine whether continuous renal replacement therapy was associated with a lower risk of chronic dialysis as compared with intermittent hemodialysis, among survivors of acute kidney injury...
  16. ncbi request reprint Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis
    Sachin Sud
    Institute for Better Health and Division of Critical Care S Sud, Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont Interdepartmental Division of Critical Care S Sud, Friedrich, Adhikari, University of Toronto, Toronto, Ont Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute Friedrich, St Michael s Hospital, Toronto, Ont Dipartimento di Anestesia e Rianimazione Taccone, Gattinoni, Polli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy Istituto di Anestesiologia e Rianimazione Polli, Gattinoni, Universita degli Studi di Milano, Milan, Italy Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti Gattinoni, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy Department of Critical Care Medicine Adhikari, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont Department of Cardiovascular Research Latini, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Dipartimento di Medicina Perioperatoria e Terapie Intensive Pesenti, Azienda Ospedaliera San Gerardo, Monza, Italy Dipartimento di Medicina Sperimentale Pesenti, Universita degli Studi di Milano Bicocca, USA
    CMAJ 186:E381-90. 2014
    ..We sought to determine the effect of prone positioning on mortality among patients with ARDS receiving protective lung ventilation...
  17. doi request reprint High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
    Sachin Sud
    Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
    BMJ 340:c2327. 2010
    ..To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS)...
  18. doi request reprint High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome
    Sachin Sud
    Division of Critical Care, Department of Medicine, Trillium Health Center, University of Toronto, Mississauga, Canada
    Cochrane Database Syst Rev 2:CD004085. 2013
    ..This review was originally published in 2004 and was updated in 2011...
  19. ncbi request reprint Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study
    Ayodele Odutayo
    Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Can J Anaesth 59:934-42. 2012
    ..We undertook this study to characterize the epidemiology of acute kidney injury (AKI) in Canadian critical care units. We aimed to identify predictors of mortality for patients diagnosed with AKI...
  20. doi request reprint Nurse- vs nomogram-directed glucose control in a cardiovascular intensive care unit
    Clarence Chant
    Pharmacy Department, Critical Care Department at St Michael s Hospital, Toronto, Canada
    Am J Crit Care 21:270-8. 2012
    ..Paper-based nomograms are reasonably effective for achieving glycemic control but have low adherence and are less adaptive than nurses' judgment...
  21. doi request reprint Risk of chronic dialysis and death following acute kidney injury
    Ron Wald
    Division of Nephrology, St Michael s Hospital and University of Toronto, Ontario, Canada
    Am J Med 125:585-93. 2012
    ..Acute kidney injury frequently arises within an acute care hospitalization. Outcomes among acute kidney injury survivors following hospital discharge are poorly documented...
  22. pmc Anemia, transfusion, and phlebotomy practices in critically ill patients with prolonged ICU length of stay: a cohort study
    Clarence Chant
    Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2
    Crit Care 10:R140. 2006
    ..This study was performed to characterize anemia, transfusion, and phlebotomy practices in patients with prolonged ICU LOS...
  23. doi request reprint Patients' preferences for enrolment into critical-care trials
    Damon C Scales
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 35:1703-12. 2009
    ..Most critically ill patients are incapable of providing informed consent for research...
  24. doi request reprint Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis
    Sachin Sud
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Intensive Care Med 36:585-99. 2010
    ..Prone position ventilation for acute hypoxemic respiratory failure (AHRF) improves oxygenation but not survival, except possibly when AHRF is severe...
  25. doi request reprint Knowledge translation interventions for critically ill patients: a systematic review*
    Tasnim Sinuff
    1Department of Critical Care Medicine, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 2Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada 3Department of Medicine, Queen s University, Kingston, ON, Canada 4Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada 5Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada 6Department of Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada 7Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada 8Institute of Public Health, University of Calgary, Calgary, AB, Canada 9Center for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada 10Department of Medicine, Providence Health Care and University of British Columbia, Vancouver, BC, Canada 11Department of Medicine, McMaster University, Hamilton, ON, Canada 12Department of Clinical Epidemiology and Biostatistics, Japan
    Crit Care Med 41:2627-40. 2013
    ..We systematically reviewed ICU-based knowledge translation studies to assess the impact of knowledge translation interventions on processes and outcomes of care...
  26. pmc The hemodynamic tolerability and feasibility of sustained low efficiency dialysis in the management of critically ill patients with acute kidney injury
    Heather E Fieghen
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    BMC Nephrol 11:32. 2010
    ..We also compared the feasibility of SLED administration with that of CRRT and intermittent hemodialysis (IHD)...
  27. doi request reprint Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis
    Neill K J Adhikari
    1Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada 2Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, NJ 3Department of Anesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden 4Department of Critical Care and Anesthesiology and SAMU, Hopital Lariboisiere, Universite Paris 7 Denis Diderot, Paris, France 5Department of Anesthesiology and Intensive Care Medicine, University Hospital of Lille, Lille, France 6Departments for Anesthesia, Intensive Care Medicine, and Pain Management, Vivantes Klinikum Neukoelln, Berlin, Germany 7Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, South Korea 8Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto ON, Canada 9The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto ON, Canada 10Departments of Critical Care and Medicine, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, ON, Canada
    Crit Care Med 42:404-12. 2014
    ....
  28. doi request reprint High-frequency oscillation in adults: a utilization review
    Neill K J Adhikari
    Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Crit Care Med 39:2631-44. 2011
    ..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes...
  29. doi request reprint Prolonged time to alarm in infusion devices operated at low flow rates
    Roy Ilan
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Crit Care Med 36:2763-5. 2008
    ..To evaluate the time to occlusion alarm for peristaltic infusion devices used in Toronto adult critical care units...
  30. ncbi request reprint Validation of an insulin infusion nomogram for intensive glucose control in critically ill patients
    Clarence Chant
    Perioperative and Critical Care Services, Department of Pharmacy, St Michael s Hospital, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharmacotherapy 25:352-9. 2005
    ..To evaluate the effectiveness, safety, and associated patient outcomes of a simplified, nurse-directed insulin nomogram designed to achieve intensive blood glucose level control (target range 90-144 mg/dl)...
  31. pmc The use of wireless e-mail to improve healthcare team communication
    Chris O'Connor
    Department of Critical Care Medicine, Room D1 08, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N3M5
    J Am Med Inform Assoc 16:705-13. 2009
    ..To assess the impact of using wireless e-mail for clinical communication in an intensive care unit (ICU)...
  32. doi request reprint High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis
    Ryan Van Wert
    Department of Medicine, University of Toronto, Toronto, Canada
    Crit Care Med 38:1360-9. 2010
    ..To determine the effect of renal replacement therapy dose on mortality and dialysis dependence in patients with acute kidney injury...
  33. doi request reprint Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review
    Jason Phua
    F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
    Am J Respir Crit Care Med 179:220-7. 2009
    ..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing...
  34. pmc Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis
    Sachin Sud
    Interdepartmental Division of Critical Care, University of Toronto, Faculty of Science, Toronto, Ont
    CMAJ 178:1153-61. 2008
    ..We sought to determine the effect of mechanical ventilation in the prone position on mortality, oxygenation, duration of ventilation and adverse events in patients with acute hypoxemic respiratory failure...
  35. doi request reprint Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: secondary analysis from a randomized trial
    Kevin M Sanders
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    J Crit Care 23:58-63. 2008
    ..To examine the predictive validity of prior cultures at predicting the microorganism isolated at the time of suspicion of ventilator-associated pneumonia (VAP)...
  36. doi request reprint Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician survey
    Clarence Chant
    Pharmacy Department, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 36:1158-67. 2008
    ..To determine physician practice and perception about the management of intensive care unit (ICU)-acquired bacteriuria and funguria...
  37. doi request reprint Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults
    Karen E A Burns
    Interdepartmental Division of Critical Care and the University of Toronto, Keenan Research Centre Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Rm 4 045 Queen Wing, Toronto, Ontario, Canada, M5B 1WB
    Cochrane Database Syst Rev 2:CD008639. 2014
    ....
  38. doi request reprint Medical admission order sets to improve deep vein thrombosis prophylaxis rates and other outcomes
    Chris O'Connor
    Department of Medicine, Trillium Health Centre, Mississauga, Ontario, Canada
    J Hosp Med 4:81-9. 2009
    ..The value of order sets for clinical decision support has not been established...
  39. ncbi request reprint Drotrecogin alfa (activated) in severe sepsis
    Jan O Friedrich
    N Engl J Med 354:94-6; author reply 94-6. 2006
  40. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage
    Jan O Friedrich
    N Engl J Med 352:2133-4; author reply 2133-4. 2005
  41. doi request reprint Effect of prone positioning in patients with acute respiratory distress syndrome and high Simplified Acute Physiology Score II
    Sachin Sud
    Crit Care Med 36:2711-2; author reply 2712-3. 2008