Jan O Friedrich

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death
    Jan O Friedrich
    St Michael s Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 142:510-24. 2005
  2. ncbi Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
  3. ncbi Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    Stat Med 31:1857-86. 2012
  4. ncbi Drotrecogin alfa (activated): down and not out, but not really in either
    Jan O Friedrich
    Crit Care 10:420. 2006
  5. ncbi Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death
    Jan O Friedrich
    Crit Care 10:427. 2006
  6. ncbi Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 64:556-64. 2011
  7. ncbi Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 7:5. 2007
  8. ncbi The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 8:32. 2008
  9. ncbi Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Crit Care 10:145. 2006
  10. ncbi Long-term outcomes and clinical predictors of hospital mortality in very long stay intensive care unit patients: a cohort study
    Jan O Friedrich
    Critical Care Department, St, Michael s Hospital, University of Toronto, Toronto, Canada
    Crit Care 10:R59. 2006

Collaborators

Detail Information

Publications35

  1. ncbi Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death
    Jan O Friedrich
    St Michael s Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 142:510-24. 2005
    ..Surveys have documented the continued popularity of low-dose dopamine to influence renal dysfunction even though few data support it and editorials and reviews have discouraged its use...
  2. ncbi Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
    ....
  3. ncbi Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    Stat Med 31:1857-86. 2012
    ....
  4. ncbi Drotrecogin alfa (activated): down and not out, but not really in either
    Jan O Friedrich
    Crit Care 10:420. 2006
  5. ncbi Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death
    Jan O Friedrich
    Crit Care 10:427. 2006
  6. ncbi Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 64:556-64. 2011
    ..Ratio of means (RoM) is an alternative effect measure that performs comparably in simulation. We compared treatment effects and heterogeneity for RoM, MD, and SMD using empiric data...
  7. ncbi Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 7:5. 2007
    ..This study examined the influence of such trials on pooled treatment effects...
  8. ncbi The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 8:32. 2008
    ..SMD and RoM allow pooling of outcomes expressed in different units and comparisons of effect sizes across interventions, but RoM interpretation does not require knowledge of the pooled SD, a quantity generally unknown to clinicians...
  9. ncbi Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?
    Jan O Friedrich
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Crit Care 10:145. 2006
    ..Consequently, further randomised trials of this agent in prospectively defined high-risk patients are required to clarify its role in the management of severe sepsis...
  10. ncbi Long-term outcomes and clinical predictors of hospital mortality in very long stay intensive care unit patients: a cohort study
    Jan O Friedrich
    Critical Care Department, St, Michael s Hospital, University of Toronto, Toronto, Canada
    Crit Care 10:R59. 2006
    ..The purpose of this study was to identify long-term outcomes after hospital discharge and readily available clinical predictors of hospital mortality for patients requiring prolonged care in the ICU...
  11. ncbi Rosiglitazone: can meta-analysis accurately estimate excess cardiovascular risk given the available data? Re-analysis of randomized trials using various methodologic approaches
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Res Notes 2:5. 2009
    ..The objective of this study was to assess the robustness of the rosiglitazone results by using alternative reasonable methodologic approaches and by analyzing additional related outcomes...
  12. ncbi Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data
    Jan O Friedrich
    Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, R, Fraser Elliot Building, 3rd Floor, South Wing, 3S 805, 190 Elizabeth Street, Toronto, Ontario, Canada
    Crit Care 14:324. 2010
    ..Further insights may come from individual patient data meta-analyses or from future large multicenter RCTs in more narrowly defined subgroups of surgical patients...
  13. ncbi Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies
    Clarence Chant
    Leslie Dan Faculty of Pharmacy, University of Toronto and Pharmacy Department, St Michael s Hospital, Toronto, Canada
    Crit Care Med 39:1167-73. 2011
    ..To determine whether catheter-associated urinary tract infections are associated with increased morbidity and mortality in critically ill patients...
  14. ncbi High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
    Sachin Sud
    Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
    BMJ 340:c2327. 2010
    ..To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS)...
  15. ncbi Nurse- vs nomogram-directed glucose control in a cardiovascular intensive care unit
    Clarence Chant
    Pharmacy Department, Critical Care Department at St Michael s Hospital, Toronto, Canada
    Am J Crit Care 21:270-8. 2012
    ..Paper-based nomograms are reasonably effective for achieving glycemic control but have low adherence and are less adaptive than nurses' judgment...
  16. ncbi Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
    ..To examine the attitudes and preferences of surrogate decision makers (SDMs) regarding their involvement in the consent to research process for ICU patients...
  17. ncbi Risk of chronic dialysis and death following acute kidney injury
    Ron Wald
    Division of Nephrology, St Michael s Hospital and University of Toronto, Ontario, Canada
    Am J Med 125:585-93. 2012
    ..Acute kidney injury frequently arises within an acute care hospitalization. Outcomes among acute kidney injury survivors following hospital discharge are poorly documented...
  18. ncbi Anemia, transfusion, and phlebotomy practices in critically ill patients with prolonged ICU length of stay: a cohort study
    Clarence Chant
    Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2
    Crit Care 10:R140. 2006
    ..This study was performed to characterize anemia, transfusion, and phlebotomy practices in patients with prolonged ICU LOS...
  19. ncbi Patients' preferences for enrolment into critical-care trials
    Damon C Scales
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 35:1703-12. 2009
    ..Most critically ill patients are incapable of providing informed consent for research...
  20. ncbi Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis
    Sachin Sud
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Intensive Care Med 36:585-99. 2010
    ..Prone position ventilation for acute hypoxemic respiratory failure (AHRF) improves oxygenation but not survival, except possibly when AHRF is severe...
  21. ncbi The hemodynamic tolerability and feasibility of sustained low efficiency dialysis in the management of critically ill patients with acute kidney injury
    Heather E Fieghen
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    BMC Nephrol 11:32. 2010
    ..We also compared the feasibility of SLED administration with that of CRRT and intermittent hemodialysis (IHD)...
  22. ncbi Prolonged time to alarm in infusion devices operated at low flow rates
    Roy Ilan
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Crit Care Med 36:2763-5. 2008
    ..To evaluate the time to occlusion alarm for peristaltic infusion devices used in Toronto adult critical care units...
  23. ncbi Validation of an insulin infusion nomogram for intensive glucose control in critically ill patients
    Clarence Chant
    Perioperative and Critical Care Services, Department of Pharmacy, St Michael s Hospital, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharmacotherapy 25:352-9. 2005
    ..To evaluate the effectiveness, safety, and associated patient outcomes of a simplified, nurse-directed insulin nomogram designed to achieve intensive blood glucose level control (target range 90-144 mg/dl)...
  24. ncbi High-frequency oscillation in adults: a utilization review
    Neill K J Adhikari
    Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Crit Care Med 39:2631-44. 2011
    ..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes...
  25. ncbi The use of wireless e-mail to improve healthcare team communication
    Chris O'Connor
    Department of Critical Care Medicine, Room D1 08, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N3M5
    J Am Med Inform Assoc 16:705-13. 2009
    ..To assess the impact of using wireless e-mail for clinical communication in an intensive care unit (ICU)...
  26. ncbi High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis
    Ryan Van Wert
    Department of Medicine, University of Toronto, Toronto, Canada
    Crit Care Med 38:1360-9. 2010
    ..To determine the effect of renal replacement therapy dose on mortality and dialysis dependence in patients with acute kidney injury...
  27. ncbi Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review
    Jason Phua
    F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
    Am J Respir Crit Care Med 179:220-7. 2009
    ..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing...
  28. ncbi Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis
    Sachin Sud
    Interdepartmental Division of Critical Care, University of Toronto, Faculty of Science, Toronto, Ont
    CMAJ 178:1153-61. 2008
    ..We sought to determine the effect of mechanical ventilation in the prone position on mortality, oxygenation, duration of ventilation and adverse events in patients with acute hypoxemic respiratory failure...
  29. ncbi Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study
    Ayodele Odutayo
    Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Can J Anaesth 59:934-42. 2012
    ..We undertook this study to characterize the epidemiology of acute kidney injury (AKI) in Canadian critical care units. We aimed to identify predictors of mortality for patients diagnosed with AKI...
  30. ncbi Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: secondary analysis from a randomized trial
    Kevin M Sanders
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    J Crit Care 23:58-63. 2008
    ..To examine the predictive validity of prior cultures at predicting the microorganism isolated at the time of suspicion of ventilator-associated pneumonia (VAP)...
  31. ncbi Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician survey
    Clarence Chant
    Pharmacy Department, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 36:1158-67. 2008
    ..To determine physician practice and perception about the management of intensive care unit (ICU)-acquired bacteriuria and funguria...
  32. ncbi Medical admission order sets to improve deep vein thrombosis prophylaxis rates and other outcomes
    Chris O'Connor
    Department of Medicine, Trillium Health Centre, Mississauga, Ontario, Canada
    J Hosp Med 4:81-9. 2009
    ..The value of order sets for clinical decision support has not been established...
  33. ncbi Drotrecogin alfa (activated) in severe sepsis
    Jan O Friedrich
    N Engl J Med 354:94-6; author reply 94-6. 2006
  34. ncbi Effect of prone positioning in patients with acute respiratory distress syndrome and high Simplified Acute Physiology Score II
    Sachin Sud
    Crit Care Med 36:2711-2; author reply 2712-3. 2008
  35. ncbi Recombinant activated factor VII for acute intracerebral hemorrhage
    Jan O Friedrich
    N Engl J Med 352:2133-4; author reply 2133-4. 2005