Research Topics
| P R FortinSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Timing of total joint replacement affects clinical outcomes among patients with osteoarthritis of the hip or kneePaul R Fortin
University of Toronto, Toronto, Ontario, Canada
Arthritis Rheum 46:3327-30. 2002..To determine the predictors of outcome in patients with osteoarthritis 2 years after receiving total hip or knee replacement...- Do lupus disease activity measures detect clinically important change?P R Fortin
McGill University Health Center, Department of Medicine, Montreal General Hospital Research Institute, Quebec, Canada
J Rheumatol 27:1421-8. 2000.... 
Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohortM B Urowitz
Toronto Western Hospital, Toronto, Ontario, Canada
Arthritis Care Res (Hoboken) 64:132-7. 2012..We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort...- An international perspective on the well being and health care costs for patients with systemic lupus erythematosus. Tri-Nation Study GroupA E Clarke
Department of Medicine, Montreal General Hospital, McGill University, Quebec, Canada
J Rheumatol 26:1500-11. 1999..To compare health care expenditure and health status for patients with systemic lupus erythematosus (SLE) between nations with distinct mechanisms for funding and delivering health care services... - Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosusJ G Hanly
Department of Medicine, Division of Rheumatology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Ann Rheum Dis 70:1726-32. 2011..This study examined a disease inception cohort of 1047 SLE patients to determine which autoantibodies at enrolment predicted subsequent neuropsychiatric events... - The relationship between health status, social support and satisfaction with medical care among patients with systemic lupus erythematosusD Da Costa
Division of Clinical Epidemiology, The Montreal General Hospital, McGill University, Quebec, Canada
Int J Qual Health Care 11:201-7. 1999..To examine the effect of physical and mental health status and social support on patient satisfaction with health care in patients with systemic lupus erythematosus (SLE)... - Determinants of health status in fibromyalgia: a comparative study with systemic lupus erythematosusD Da Costa
Division of Clinical Epidemiology, The Montreal General Hospital, Quebec, Canada
J Rheumatol 27:365-72. 2000.... - Mortality in systemic lupus erythematosusS Bernatsky
Montreal General Hospital, Montreal, Quebec, Canada
Arthritis Rheum 54:2550-7. 2006..The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished... 
Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosusM B Urowitz
Toronto Western Hospital, Toronto, Ontario, Canada
Arthritis Care Res (Hoboken) 62:881-7. 2010..To describe vascular events during an 8-year followup in a multicenter systemic lupus erythematosus (SLE) inception cohort and their attribution to atherosclerosis...- Living with lupus: a prospective pan-Canadian studyP L Dobkin
Division of Clinical Epidemiology, Montreal General Hospital Research Institute, Quebec, Canada
J Rheumatol 28:2442-8. 2001..To portray life with lupus for women affected by this disease and to identify predictors of fatigue, a common symptom that compromises patients' quality of life... - Lung cancer in systemic lupus erythematosusJ Bin
McGill University Health Center MUHC, Department of Medicine, Montreal, QC, Canada, and University Hospital, Lund, Sweden
Lung Cancer 56:303-6. 2007..Our objective was to provide a brief report of the lung cancer cases from an SLE cohort, with respect to demographics, histology, and exposures to smoking and immunosuppressive medications... - Underestimating the value of women: assessing the indirect costs of women with systemic lupus erythematosus. Tri-Nation Study GroupA E Clarke
Department of Medicine, Montreal General Hospital, Quebec, Canada
J Rheumatol 27:2597-604. 2000..We compared indirect costs incurred by women with systemic lupus erythematosus (SLE), a prototypical women's disease, calculated under varying assumptions for the value of diminished labor market and non-labor market activity... - Burden of autoantibodies and association with disease activity and damage in systemic lupus erythematosusZ Touma
University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Canada
Clin Exp Rheumatol 28:525-31. 2010..To determine whether immunological burden of autoantibodies as reflected by the number of cumulative antibodies present at inception and after 3 and 5 years is associated with or predicts subsequent disease activity and damage in lupus... - Inhibition of lupus anticoagulant activity by hexagonal phase phosphatidylethanolamine in the presence of prothrombinJ Rauch
Department of Medicine, The Montreal General Hospital Research Institute, McGill University, Quebec, Canada
Thromb Haemost 80:936-41. 1998..These data indicate that, for certain lupus anticoagulant antibodies, inhibition by hexagonal (II) phase PE is dependent on prothrombin, suggesting that these antibodies recognize a complex of PE and prothrombin... - Mortality related to cerebrovascular disease in systemic lupus erythematosusS Bernatsky
Division of Clinical Epidemiology, Montreal General Hospital, Montreal, Quebec, Canada
Lupus 15:835-9. 2006..In view of the paucity of large-scale studies of mortality attributed to neuropsychiatric outcomes in SLE, our findings highlight the need for additional research in large SLE cohorts... - Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory proteinM M Newkirk
Department of Medicine, The Montreal General Hospital Research Institute, McGill University, Quebec, Canada
J Rheumatol 26:597-603. 1999..To measure the serum levels of clusterin, an antiinflammatory protein, which binds and inactivates complement, in patients with systemic lupus erythematosus (SLE) to determine whether the levels correlate with disease... - The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosusC Wang
McGill University Health Centre, McGill University, Montreal, Quebec, Canada
J Rheumatol 28:525-32. 2001..EQ-5D is a valid instrument for the measure of health related quality of life in SLE... - An international cohort study of cancer in systemic lupus erythematosusS Bernatsky
Montreal General Hospital, Montreal, Quebec, Canada
Arthritis Rheum 52:1481-90. 2005..It is not yet known whether this association is mediated by genetic factors or exogenous exposures... - Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosusC Landolt-Marticorena
Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada
Ann Rheum Dis 68:1440-6. 2009..To study the longitudinal expression of interferon (IFN)-inducible genes in systemic lupus erythematosus (SLE) and determine their suitability as disease biomarkers... - Adaptation and validation of the rheumatoid arthritis quality of life scale for use in CanadaC Neville
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada
J Rheumatol 28:1505-10. 2001..The psychometric quality of the adapted questionnaires means they are suitable for inclusion in clinical trials involving patients with RA... - A targeted association study in systemic lupus erythematosus identifies multiple susceptibility allelesM L Budarf
Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
Genes Immun 12:51-8. 2011..This study confirms the existence of multiple genetic risk factors for SLE, and supports the notion that some risk factors for SLE are shared with other inflammatory disorders... - The systemic lupus erythematosus Tri-nation Study: absence of a link between health resource use and health outcomeA E Clarke
Division of Clinical Epidemiology, Department of Medicine McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Rheumatology (Oxford) 43:1016-24. 2004..Health consumption and health status in SLE in three countries with different health funding structures were compared... - The persistence of anticardiolipin antibodies is associated with an increased risk of the presence of lupus anticoagulant and anti-beta2-glycoprotein I antibodiesC Neville
Division of Clinical Epidemiology, Montreal General Hospital, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Rheumatology (Oxford) 45:1116-20. 2006..47], 1.36 (95% CI = 1.24-1.50) and 1.47 (95% CI = 1.31-1.65) respectively for each 10% increase in aCL-positive tests vs 0% positive tests. CONCLUSION: Persistence of aCL positivity is associated with an increased risk of LA/abeta2GPI... - Patients with systemic autoimmune diseases could not distinguish comorbidities from their index diseaseMarie Hudson
McGill University, Montreal, Quebec, Canada
J Clin Epidemiol 61:654-62. 2008..To assess the construct validity of the Self-Administered Comorbidity Questionnaire (SCQ) in patients with systemic sclerosis (SSc) and systemic lupus erythematosus (SLE)... - The importance of patient expectations in predicting functional outcomes after total joint arthroplastyNizar N Mahomed
Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, ON, Canada
J Rheumatol 29:1273-9. 2002..Greater understanding of the relationship between expectations and outcomes may improve the process of care and outcomes of TJA... - "What do you expect? You're just getting older": A comparison of perceived osteoarthritis-related and aging-related health experiences in middle- and older-age adultsMonique A M Gignac
Division of Outcomes and Health Care Research, Arthritis Community Research and Evaluation Unit, Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada
Arthritis Rheum 55:905-12. 2006..Similarities and differences in health changes, the meaning of these changes, and their impact were examined... - Thromboembolic risk in patients with high titre anticardiolipin and multiple antiphospholipid antibodiesCarolyn Neville
Division of Clinical Epidemiology, The Montreal General Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Thromb Haemost 90:108-15. 2003..5 [0.93-2.3] for ATE and 1.7 [1.1-2.5] for VTE. These results indicate that increased titres of aCL and multiple aPL were associated with an increased risk of a previous thrombotic event... - Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosisJeannine Kassis
Department of Hematology, , , Montreal, Quebec, Canada
Thromb Haemost 92:1312-9. 2004..37) for arterial thrombosis compared to those with neither risk factor. In conclusion, APCR phenotype and hyperhomocysteinemia are associated with a higher risk of venous and arterial thrombosis, respectively, in the presence of aPL... - Determinants of discordance between patients and physicians in their assessment of lupus disease activityJim C Yen
Division of Clinical Epidemiology, The McGill University Health Centre, Montreal, Quebec, Canada
J Rheumatol 30:1967-76. 2003.... - The presence of multiple prothrombotic risk factors is associated with a higher risk of thrombosis in individuals with anticardiolipin antibodiesMarie Hudson
Division of Rheumatology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
J Rheumatol 30:2385-91. 2003....