G H Fong

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
    J Peng
    Lawson Research Institute, St Joseph s Health Center, Departments of Pediatrics and Biochemistry, University of Western Ontario, London, ON, Canada N6A 4V2
    Proc Natl Acad Sci U S A 97:8386-91. 2000
  2. ncbi request reprint Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
    G H Fong
    Lawson Research Institute, St Joseph s Health Centre, Departments of Paediatrics and Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 4V2
    Development 126:3015-25. 1999
  3. ncbi request reprint Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:66-70. 1995
  4. ncbi request reprint Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 207:1-10. 1996
  5. ncbi request reprint Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 203:80-92. 1995
  6. ncbi request reprint Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 8:1897-909. 1994

Collaborators

  • L Zhang
  • Janet Rossant
  • J Peng
  • D J Dumont
  • L Drysdale
  • M C Puri
  • M L Breitman
  • G Gradwohl
  • K Alitalo
  • A Auerbach
  • M Gertsenstein

Detail Information

Publications6

  1. pmc The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
    J Peng
    Lawson Research Institute, St Joseph s Health Center, Departments of Pediatrics and Biochemistry, University of Western Ontario, London, ON, Canada N6A 4V2
    Proc Natl Acad Sci U S A 97:8386-91. 2000
    ..Our results suggest that EPAS-1 plays an important role at postvasculogenesis stages and is required for the remodeling of the primary vascular network into a mature hierarchy pattern...
  2. ncbi request reprint Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
    G H Fong
    Lawson Research Institute, St Joseph s Health Centre, Departments of Paediatrics and Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 4V2
    Development 126:3015-25. 1999
    ..These results define the primary defect in flt-1(-/-) embryos at the cellular level and demonstrate the importance of population density of progenitor cells in pattern formation...
  3. ncbi request reprint Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:66-70. 1995
    ..We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development...
  4. ncbi request reprint Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 207:1-10. 1996
    ..The flt-1 expression pattern also suggests that it may play important roles in both vasculogenesis and angiogenesis...
  5. ncbi request reprint Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 203:80-92. 1995
    ..These results suggest a possible dual role for VEGF which includes a chemotactic and/or a cellular maintenance role for VEGF during vascularization of the mouse embryo...
  6. ncbi request reprint Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 8:1897-909. 1994
    ....