Research Topics
| S B FlorescoSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedureStan B Floresco
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada
Behav Brain Res 190:85-96. 2008..Furthermore, they reveal that the relative difficulty of the type of shift rats are required to perform has a direct impact on whether or not the mPFC contributes to this form of behavioral flexibility...- Prefrontal NMDA receptors and cognition: working 2B rememberedStan B Floresco
Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
Neuron 77:603-5. 2013..In this issue of Neuron, Wang et al. (2013) report a previously uncharacterized role for NMDA NR2B receptors in driving mnemonic-related activity of prefrontal neurons... 
Pharmacological enhancement of memory and executive functioning in laboratory animalsStan B Floresco
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 36:227-50. 2011....
Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophreniaStan B Floresco
Department of Psychology, University of British Columbia, Vancouver, Canada
Schizophr Bull 31:888-94. 2005....- Amygdala-prefrontal cortical circuitry regulates effort-based decision makingStan B Floresco
Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, V6T 1Z4, Canada
Cereb Cortex 17:251-60. 2007..These data suggest that the serial transfer of information between the BLA and ACC guides response selection when evaluating the value of an expected outcome relative to the costs of performing a particular action... - Dissociable roles for the nucleus accumbens core and shell in regulating set shiftingStan B Floresco
Department of Psychology, Brain Research Center, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
J Neurosci 26:2449-57. 2006..The NAc core facilitates the acquisition and maintenance of novel behavioral strategies and elimination of inappropriate response options, whereas the shell may mediate learning about irrelevant stimuli... - Mesocortical dopamine modulation of executive functions: beyond working memoryStan B Floresco
Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada
Psychopharmacology (Berl) 188:567-85. 2006..Furthermore, the functional importance of other DA receptor subtypes that reside on PFC neurons (D2 and D4) is unclear... - Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathwayStan B Floresco
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Neurosci 27:2045-57. 2007..These findings may have important implications for understanding the pathophysiology underlying emotional and cognitive disturbances present in disorders such as depression and drug addiction... - Dopaminergic and glutamatergic regulation of effort- and delay-based decision makingStan B Floresco
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 33:1966-79. 2008..Furthermore, they suggest that dopamine and NMDA receptors make dissociable contributions to these different types of cost-benefit analyses... - Dopaminergic regulation of limbic-striatal interplayStan B Floresco
Department of Psychology and Brain Research Centre, University of British Columbia, Vancouver, BC
J Psychiatry Neurosci 32:400-11. 2007.... - Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behaviorS B Floresco
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Neuroscience 154:877-84. 2008.... - Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision makingStan B Floresco
University of British Columbia, Vancouver, British Columbia, Canada
Cogn Affect Behav Neurosci 8:375-89. 2008..The fact that similar neural circuits are recruited to solve these types of problems in both humans and animals suggests that animal models of decision making will prove useful in elucidating the mechanisms mediating these processes... - Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposureStan B Floresco
Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC V6T1Z4, Canada
Psychopharmacology (Berl) 205:189-201. 2009..Psychostimulant abuse has been linked to impairments in cost-benefit decision making... - Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shiftingStan B Floresco
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, Canada
Neuropsychopharmacology 31:297-309. 2006..These findings may have important implications for developing novel treatments for cognitive deficits observed in disorders such as attentional deficit and hyperactivity disorder and schizophrenia... - Neural circuits subserving behavioral flexibility and their relevance to schizophreniaStan B Floresco
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C V6T 1Z4, Canada
Behav Brain Res 204:396-409. 2009.... - Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmissionStan B Floresco
Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
Nat Neurosci 6:968-73. 2003.... - Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selectionS B Floresco
Department of Psychology, University of British Columbia Vancouver, British Columbia, Canada V6T 1Z4
J Neurosci 21:2851-60. 2001.... - Ventral striatal dopamine modulation of different forms of behavioral flexibilityDesirae M Haluk
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 34:2041-52. 2009..These findings suggest that deficits in these forms of executive functioning observed in disorders linked to dysfunction of the DA system may be attributable in part to aberrant increases or decreases in mesoaccumbens DA activity... - Dopamine D1 and NMDA receptors mediate potentiation of basolateral amygdala-evoked firing of nucleus accumbens neuronsS B Floresco
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Neurosci 21:6370-6. 2001..This may represent a cellular mechanism that facilitates approach behaviors directed toward reward-related stimuli that are mediated by BLA-NAc circuitries... - Dopaminergic modulation of risk-based decision makingJennifer R St Onge
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 34:681-97. 2009.... - Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortexJ K Seamans
Department of Psychology, University of British Columbia, Vancouver, Canada
Behav Neurosci 109:1063-73. 1995.... - A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foragingS B Floresco
Department of Psychology University of British Columbia, Vancouver, Canada
Behav Brain Res 80:161-8. 1996..The results are discussed with respect to of the underlying physiological interactions between limbic glutamate and mesoaccumbens DA transmission in the N.Acc... - The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking behaviorR J McLaughlin
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Neuroscience 146:1484-94. 2007.... - Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shellSarvin Ghods-Sharifi
Department of Psychology, University of British Columbia, Vancouver, BC V6T1Z4, Canada
Behav Neurosci 124:179-91. 2010..Furthermore, the contributions by the NAc core to this form of decision making can be dissociated from its role in delay discounting... - Thalamic-cortical-striatal circuitry subserves working memory during delayed responding on a radial arm mazeS B Floresco
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Neurosci 19:11061-71. 1999..The results are discussed with respect to a distributed neural network linking limbic, thalamic, cortical, and striatal regions, which mediates executive functions of working memory... - Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial informationS B Floresco
Department of Psychology, University of British Columbia, Vancouver, Canada
Behav Brain Res 81:163-71. 1996.... - Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neuronsS B Floresco
Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 21:4915-22. 2001..As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia... - Delay-dependent modulation of memory retrieval by infusion of a dopamine D1 agonist into the rat medial prefrontal cortexS B Floresco
Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
Behav Neurosci 115:934-9. 2001..When memory is decremented by an extended delay, activation of PFC DA D1 receptors by an agonist can improve cognitive function... - Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental areaStan B Floresco
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15206, USA
J Neurosci 23:3930-43. 2003..Thus, both the MD and VTA exert a complex gating action over PFC neural activity, either facilitating or inhibiting firing in the hippocampal-PFC pathway depending on the frequency and relative timing of the arrival of afferent input... - Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learningSarvin Ghods-Sharifi
Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Neurobiol Learn Mem 89:567-73. 2008..Furthermore, the lack of effect of OFC inactivations on the set-shift indicates that this type of behavioral flexibility does not require cognitive operations related to reversal learning... - High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memoryL A Galea
Department of Psychology, The University of British Columbia, 2136 West Mall, Vancouver B C, Canada V6T 1Z4
Behav Brain Res 126:115-26. 2001..Taken together these findings suggest that high levels of estradiol inhibit reference memory, stimulus response learning, and amygdala-dependent appetitive conditioning while having little effect on working memory... - Differential effects of dopaminergic manipulations on risky choiceJennifer R St Onge
Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
Psychopharmacology (Berl) 211:209-21. 2010..However, manipulations of DA activity may differentially alter risky choice when shifts in the relative value of probabilistic rewards are greater or lesser than those experienced previously... - Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shiftingAnnie E Block
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
Cereb Cortex 17:1625-36. 2007..These data indicate that set shifting is mediated by a distributed neural circuit, with separate neural pathways contributing dissociable components to this type of behavioral flexibility... - Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonistsMatthew N Hill
Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, V6T1Z4, BC, Canada
Psychopharmacology (Berl) 187:245-59. 2006.... - Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memoryKatia J Sinopoli
Department of Psychology, The Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neurobiol Learn Mem 86:293-304. 2006..These data provide further evidence for the notion that estradiol can dose-dependently alter memory processes and suggest that facilitation or disruptions of working memory by estradiol are site- and time-specific... - Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposureTakeshi Enomoto
Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver B C, Canada V6T 1Z4
Prog Neuropsychopharmacol Biol Psychiatry 33:668-75. 2009..The use of these procedures may prove useful in modeling impairments in this executive function observed in schizophrenia... - Regulation of firing of dopaminergic neurons and control of goal-directed behaviorsAnthony A Grace
Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Trends Neurosci 30:220-7. 2007.... - Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cuesFiona D Zeeb
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
Psychopharmacology (Berl) 211:87-98. 2010..However, lesions of the OFC in rats have both increased and decreased impulsivity in delay-discounting paradigms, where impulsive choice is defined as the selection of small immediate over larger delayed rewards... - Fundamental contribution by the basolateral amygdala to different forms of decision makingSarvin Ghods-Sharifi
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
J Neurosci 29:5251-9. 2009.... - Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response taskAnthony G Phillips
Department of Psychiatry and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, V6T 2A1
J Neurosci 24:547-53. 2004.... - Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fearGemma L Dalton
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 33:2416-26. 2008..Furthermore, these findings suggest that LTD may be a molecular mechanism that facilitates the selective modification of a learned association while leaving intact the ability to form a new memory... - Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotesJ Nasir
Department of Medical Genetics, University of British Columbia, Vancouver, Canada
Cell 81:811-23. 1995..These studies show that the HD gene is essential for postimplantation development and that it may play an important role in normal functioning of the basal ganglia... - Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 34:2733-45. 2009..Taken together, these findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB(1) receptor signaling contributes to the magnitude of the HPA response... - Electrophysiological interactions between striatal glutamatergic and dopaminergic systemsAnthony R West
Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
Ann N Y Acad Sci 1003:53-74. 2003....