S B Floresco

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada
    Behav Brain Res 190:85-96. 2008
  2. doi Prefrontal NMDA receptors and cognition: working 2B remembered
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    Neuron 77:603-5. 2013
  3. ncbi Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
    Stan B Floresco
    Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 6:968-73. 2003
  4. ncbi Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, Canada
    Neuropsychopharmacology 31:297-309. 2006
  5. doi Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior
    S B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neuroscience 154:877-84. 2008
  6. ncbi Amygdala-prefrontal cortical circuitry regulates effort-based decision making
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, V6T 1Z4, Canada
    Cereb Cortex 17:251-60. 2007
  7. ncbi Dissociable roles for the nucleus accumbens core and shell in regulating set shifting
    Stan B Floresco
    Department of Psychology, Brain Research Center, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    J Neurosci 26:2449-57. 2006
  8. doi Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making
    Stan B Floresco
    University of British Columbia, Vancouver, British Columbia, Canada
    Cogn Affect Behav Neurosci 8:375-89. 2008
  9. doi Neural circuits subserving behavioral flexibility and their relevance to schizophrenia
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C V6T 1Z4, Canada
    Behav Brain Res 204:396-409. 2009
  10. ncbi Mesocortical dopamine modulation of executive functions: beyond working memory
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada
    Psychopharmacology (Berl) 188:567-85. 2006

Collaborators

Detail Information

Publications45

  1. doi Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada
    Behav Brain Res 190:85-96. 2008
    ..Furthermore, they reveal that the relative difficulty of the type of shift rats are required to perform has a direct impact on whether or not the mPFC contributes to this form of behavioral flexibility...
  2. doi Prefrontal NMDA receptors and cognition: working 2B remembered
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    Neuron 77:603-5. 2013
    ..In this issue of Neuron, Wang et al. (2013) report a previously uncharacterized role for NMDA NR2B receptors in driving mnemonic-related activity of prefrontal neurons...
  3. ncbi Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
    Stan B Floresco
    Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 6:968-73. 2003
    ....
  4. ncbi Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, Canada
    Neuropsychopharmacology 31:297-309. 2006
    ..These findings may have important implications for developing novel treatments for cognitive deficits observed in disorders such as attentional deficit and hyperactivity disorder and schizophrenia...
  5. doi Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior
    S B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neuroscience 154:877-84. 2008
    ....
  6. ncbi Amygdala-prefrontal cortical circuitry regulates effort-based decision making
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, V6T 1Z4, Canada
    Cereb Cortex 17:251-60. 2007
    ..These data suggest that the serial transfer of information between the BLA and ACC guides response selection when evaluating the value of an expected outcome relative to the costs of performing a particular action...
  7. ncbi Dissociable roles for the nucleus accumbens core and shell in regulating set shifting
    Stan B Floresco
    Department of Psychology, Brain Research Center, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    J Neurosci 26:2449-57. 2006
    ..The NAc core facilitates the acquisition and maintenance of novel behavioral strategies and elimination of inappropriate response options, whereas the shell may mediate learning about irrelevant stimuli...
  8. doi Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making
    Stan B Floresco
    University of British Columbia, Vancouver, British Columbia, Canada
    Cogn Affect Behav Neurosci 8:375-89. 2008
    ..The fact that similar neural circuits are recruited to solve these types of problems in both humans and animals suggests that animal models of decision making will prove useful in elucidating the mechanisms mediating these processes...
  9. doi Neural circuits subserving behavioral flexibility and their relevance to schizophrenia
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, B C V6T 1Z4, Canada
    Behav Brain Res 204:396-409. 2009
    ....
  10. ncbi Mesocortical dopamine modulation of executive functions: beyond working memory
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada
    Psychopharmacology (Berl) 188:567-85. 2006
    ..Furthermore, the functional importance of other DA receptor subtypes that reside on PFC neurons (D2 and D4) is unclear...
  11. doi Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposure
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC V6T1Z4, Canada
    Psychopharmacology (Berl) 205:189-201. 2009
    ..Psychostimulant abuse has been linked to impairments in cost-benefit decision making...
  12. ncbi Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Neurosci 27:2045-57. 2007
    ..These findings may have important implications for understanding the pathophysiology underlying emotional and cognitive disturbances present in disorders such as depression and drug addiction...
  13. pmc Pharmacological enhancement of memory and executive functioning in laboratory animals
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 36:227-50. 2011
    ....
  14. pmc Dopaminergic regulation of limbic-striatal interplay
    Stan B Floresco
    Department of Psychology and Brain Research Centre, University of British Columbia, Vancouver, BC
    J Psychiatry Neurosci 32:400-11. 2007
    ....
  15. ncbi Dopaminergic and glutamatergic regulation of effort- and delay-based decision making
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 33:1966-79. 2008
    ..Furthermore, they suggest that dopamine and NMDA receptors make dissociable contributions to these different types of cost-benefit analyses...
  16. ncbi Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Schizophr Bull 31:888-94. 2005
    ....
  17. ncbi Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection
    S B Floresco
    Department of Psychology, University of British Columbia Vancouver, British Columbia, Canada V6T 1Z4
    J Neurosci 21:2851-60. 2001
    ....
  18. doi Ventral striatal dopamine modulation of different forms of behavioral flexibility
    Desirae M Haluk
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 34:2041-52. 2009
    ..These findings suggest that deficits in these forms of executive functioning observed in disorders linked to dysfunction of the DA system may be attributable in part to aberrant increases or decreases in mesoaccumbens DA activity...
  19. ncbi Dopamine D1 and NMDA receptors mediate potentiation of basolateral amygdala-evoked firing of nucleus accumbens neurons
    S B Floresco
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Neurosci 21:6370-6. 2001
    ..This may represent a cellular mechanism that facilitates approach behaviors directed toward reward-related stimuli that are mediated by BLA-NAc circuitries...
  20. doi Dopaminergic modulation of risk-based decision making
    Jennifer R St Onge
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 34:681-97. 2009
    ....
  21. ncbi Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex
    J K Seamans
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Neurosci 109:1063-73. 1995
    ....
  22. ncbi A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging
    S B Floresco
    Department of Psychology University of British Columbia, Vancouver, Canada
    Behav Brain Res 80:161-8. 1996
    ..The results are discussed with respect to of the underlying physiological interactions between limbic glutamate and mesoaccumbens DA transmission in the N.Acc...
  23. ncbi The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking behavior
    R J McLaughlin
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neuroscience 146:1484-94. 2007
    ....
  24. doi Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell
    Sarvin Ghods-Sharifi
    Department of Psychology, University of British Columbia, Vancouver, BC V6T1Z4, Canada
    Behav Neurosci 124:179-91. 2010
    ..Furthermore, the contributions by the NAc core to this form of decision making can be dissociated from its role in delay discounting...
  25. ncbi Delay-dependent modulation of memory retrieval by infusion of a dopamine D1 agonist into the rat medial prefrontal cortex
    S B Floresco
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    Behav Neurosci 115:934-9. 2001
    ..When memory is decremented by an extended delay, activation of PFC DA D1 receptors by an agonist can improve cognitive function...
  26. ncbi Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    S B Floresco
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4915-22. 2001
    ..As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia...
  27. ncbi Thalamic-cortical-striatal circuitry subserves working memory during delayed responding on a radial arm maze
    S B Floresco
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Neurosci 19:11061-71. 1999
    ..The results are discussed with respect to a distributed neural network linking limbic, thalamic, cortical, and striatal regions, which mediates executive functions of working memory...
  28. ncbi Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial information
    S B Floresco
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Brain Res 81:163-71. 1996
    ....
  29. ncbi Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning
    Sarvin Ghods-Sharifi
    Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neurobiol Learn Mem 89:567-73. 2008
    ..Furthermore, the lack of effect of OFC inactivations on the set-shift indicates that this type of behavioral flexibility does not require cognitive operations related to reversal learning...
  30. ncbi Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area
    Stan B Floresco
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15206, USA
    J Neurosci 23:3930-43. 2003
    ..Thus, both the MD and VTA exert a complex gating action over PFC neural activity, either facilitating or inhibiting firing in the hippocampal-PFC pathway depending on the frequency and relative timing of the arrival of afferent input...
  31. ncbi High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory
    L A Galea
    Department of Psychology, The University of British Columbia, 2136 West Mall, Vancouver B C, Canada V6T 1Z4
    Behav Brain Res 126:115-26. 2001
    ..Taken together these findings suggest that high levels of estradiol inhibit reference memory, stimulus response learning, and amygdala-dependent appetitive conditioning while having little effect on working memory...
  32. doi Differential effects of dopaminergic manipulations on risky choice
    Jennifer R St Onge
    Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
    Psychopharmacology (Berl) 211:209-21. 2010
    ..However, manipulations of DA activity may differentially alter risky choice when shifts in the relative value of probabilistic rewards are greater or lesser than those experienced previously...
  33. ncbi Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shifting
    Annie E Block
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Cereb Cortex 17:1625-36. 2007
    ..These data indicate that set shifting is mediated by a distributed neural circuit, with separate neural pathways contributing dissociable components to this type of behavioral flexibility...
  34. ncbi Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists
    Matthew N Hill
    Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, V6T1Z4, BC, Canada
    Psychopharmacology (Berl) 187:245-59. 2006
    ..Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear...
  35. doi Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure
    Takeshi Enomoto
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver B C, Canada V6T 1Z4
    Prog Neuropsychopharmacol Biol Psychiatry 33:668-75. 2009
    ..The use of these procedures may prove useful in modeling impairments in this executive function observed in schizophrenia...
  36. ncbi Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
    Anthony A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Trends Neurosci 30:220-7. 2007
    ....
  37. ncbi Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memory
    Katia J Sinopoli
    Department of Psychology, The Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neurobiol Learn Mem 86:293-304. 2006
    ..These data provide further evidence for the notion that estradiol can dose-dependently alter memory processes and suggest that facilitation or disruptions of working memory by estradiol are site- and time-specific...
  38. ncbi Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task
    Anthony G Phillips
    Department of Psychiatry and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, V6T 2A1
    J Neurosci 24:547-53. 2004
    ....
  39. doi Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues
    Fiona D Zeeb
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
    Psychopharmacology (Berl) 211:87-98. 2010
    ..However, lesions of the OFC in rats have both increased and decreased impulsivity in delay-discounting paradigms, where impulsive choice is defined as the selection of small immediate over larger delayed rewards...
  40. doi Fundamental contribution by the basolateral amygdala to different forms of decision making
    Sarvin Ghods-Sharifi
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    J Neurosci 29:5251-9. 2009
    ....
  41. ncbi Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear
    Gemma L Dalton
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 33:2416-26. 2008
    ..Furthermore, these findings suggest that LTD may be a molecular mechanism that facilitates the selective modification of a learned association while leaving intact the ability to form a new memory...
  42. ncbi Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
    J Nasir
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Cell 81:811-23. 1995
    ..These studies show that the HD gene is essential for postimplantation development and that it may play an important role in normal functioning of the basal ganglia...
  43. doi Acute stress impairs set-shifting but not reversal learning
    K A Butts
    Department of Psychiatry, University of British Columbia, Canada
    Behav Brain Res 252:222-9. 2013
    ..Thus, these data reveal that an immediate effect of acute stress is to impair mPFC-dependent cognition selectively by disrupting the ability to inhibit the use of a previously relevant cognitive strategy. ..
  44. pmc Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 34:2733-45. 2009
    ..Taken together, these findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB(1) receptor signaling contributes to the magnitude of the HPA response...
  45. ncbi Electrophysiological interactions between striatal glutamatergic and dopaminergic systems
    Anthony R West
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    Ann N Y Acad Sci 1003:53-74. 2003
    ....