Alastair Flint

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Effect of sertraline on risk of falling in older adults with psychotic depression on olanzapine: results of a randomized placebo-controlled trial
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Canada Department of Psychiatry, University Health Network, Toronto, Canada Toronto General and Toronto Rehab Research Institutes, Toronto, Canada Electronic address
    Am J Geriatr Psychiatry 22:332-6. 2014
  2. pmc Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD II
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Toronto, Canada
    BMC Psychiatry 13:38. 2013
  3. ncbi request reprint Effective use of electroconvulsive therapy in late-life depression
    Alastair J Flint
    University of Toronto, Geriatric Psychiatry Program, University Health Network, Toronto, Ontario
    Can J Psychiatry 47:734-41. 2002
  4. ncbi request reprint Generalised anxiety disorder in elderly patients : epidemiology, diagnosis and treatment options
    Alastair J Flint
    Department of Psychiatry, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Drugs Aging 22:101-14. 2005
  5. ncbi request reprint Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin system
    Alastair Flint
    Toronto General Hospital, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 27:663-71. 2002
  6. ncbi request reprint Relationship between clinical variables and symptomatic anxiety in late-life depression
    Alastair J Flint
    Toronto General Hospital, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 10:292-6. 2002
  7. pmc Effect of age on the frequency of anxiety disorders in major depression with psychotic features
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 18:404-12. 2010
  8. ncbi request reprint Factor structure of the hospital anxiety and depression scale in older patients with major depression
    Alastair J Flint
    Toronto General Hospital, Toronto, Canada
    Int J Geriatr Psychiatry 17:117-23. 2002
  9. ncbi request reprint Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression
    A J Flint
    Geriatric Psychiatry Program, The Toronto General Hospital, 8 Eaton North, Room 238, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
    Depress Anxiety 13:125-31. 2001
  10. ncbi request reprint Neurohormonal responses to cholecystokinin tetrapeptide: a comparison of younger and older healthy subjects
    A J Flint
    The Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychoneuroendocrinology 25:633-47. 2000

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc Effect of sertraline on risk of falling in older adults with psychotic depression on olanzapine: results of a randomized placebo-controlled trial
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Canada Department of Psychiatry, University Health Network, Toronto, Canada Toronto General and Toronto Rehab Research Institutes, Toronto, Canada Electronic address
    Am J Geriatr Psychiatry 22:332-6. 2014
    ..We therefore analyzed data from a RCT of the treatment of psychotic depression, to examine whether combined olanzapine and sertraline interacted with older age to increase the risk of falling compared with olanzapine plus placebo...
  2. pmc Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD II
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Toronto, Canada
    BMC Psychiatry 13:38. 2013
    ..On the other hand, premature discontinuation of antipsychotic medication has the potential risk of early relapse of a severe disorder...
  3. ncbi request reprint Effective use of electroconvulsive therapy in late-life depression
    Alastair J Flint
    University of Toronto, Geriatric Psychiatry Program, University Health Network, Toronto, Ontario
    Can J Psychiatry 47:734-41. 2002
    ..To review literature pertaining to the efficacy, safety, and tolerability of electroconvulsive therapy (ECT) in treating late-life depression...
  4. ncbi request reprint Generalised anxiety disorder in elderly patients : epidemiology, diagnosis and treatment options
    Alastair J Flint
    Department of Psychiatry, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Drugs Aging 22:101-14. 2005
    ..If a benzodiazepine is initiated, pharmacokinetic considerations favour the use of either lorazepam or oxazepam. Buspirone also has a more limited role than antidepressants in the treatment of late-life GAD...
  5. ncbi request reprint Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin system
    Alastair Flint
    Toronto General Hospital, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 27:663-71. 2002
    ..These findings are consistent with our hypothesis and suggest that age-related changes in the CCK system could contribute to the diminished panicogenic response to exogenous CCK-4 in older persons...
  6. ncbi request reprint Relationship between clinical variables and symptomatic anxiety in late-life depression
    Alastair J Flint
    Toronto General Hospital, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 10:292-6. 2002
    ..In this group of elderly depressed patients, medical burden, cognitive impairment, and negative psychosocial circumstances did not contribute in a clinically significant way to variance in severity of symptomatic anxiety...
  7. pmc Effect of age on the frequency of anxiety disorders in major depression with psychotic features
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 18:404-12. 2010
    ..To compare the frequency of anxiety disorders in older and younger persons with major depressive disorder with psychotic features...
  8. ncbi request reprint Factor structure of the hospital anxiety and depression scale in older patients with major depression
    Alastair J Flint
    Toronto General Hospital, Toronto, Canada
    Int J Geriatr Psychiatry 17:117-23. 2002
    ..The purpose of this exploratory study, therefore, was to examine the factor structure of the HADS in older patients with major depression...
  9. ncbi request reprint Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression
    A J Flint
    Geriatric Psychiatry Program, The Toronto General Hospital, 8 Eaton North, Room 238, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
    Depress Anxiety 13:125-31. 2001
    ..These findings suggest that pharmacotherapy resistance may constitute a risk factor for relapse or recurrence of remitted geriatric depression, even when patients are maintained on the medication that they eventually respond to...
  10. ncbi request reprint Neurohormonal responses to cholecystokinin tetrapeptide: a comparison of younger and older healthy subjects
    A J Flint
    The Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychoneuroendocrinology 25:633-47. 2000
    ..For the most part, maximum changes in hormonal levels were not correlated with symptom severity, suggesting that other factors may have contributed to the differential effect of panic on the HPA axis...
  11. ncbi request reprint Diagnosis and management of panic disorder in older patients
    Alastair J Flint
    Departments of Psychiatry, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Drugs Aging 20:881-91. 2003
    ..Given the delayed onset of action of antidepressant medication, the short-term use of adjunctive lorazepam in the first few weeks of treatment may be helpful in selected patients...
  12. pmc Anxiety disorders in late life
    A J Flint
    Department of Psychiatry, University of Toronto, Ont
    Can Fam Physician 45:2672-9. 1999
    ..To review the epidemiology, clinical characteristics, and treatment of anxiety disorders in late life...
  13. ncbi request reprint Two-year outcome of psychotic depression in late life
    A J Flint
    Geriatric Psychiatry Program, Toronto Hospital, Ont, Canada
    Am J Psychiatry 155:178-83. 1998
    ..The purpose of this study was to determine whether elderly patients with psychotic depression differed in long-term outcome from patients with nonpsychotic depression...
  14. ncbi request reprint Recurrence of first-episode geriatric depression after discontinuation of maintenance antidepressants
    A J Flint
    Geriatric Psychiatry Program, Toronto Hospital, Ont, Canada
    Am J Psychiatry 156:943-5. 1999
    ..Therefore, the authors examined the 2-year outcomes of elderly patients with first-episode major depression following discontinuation of their maintenance antidepressant medication...
  15. ncbi request reprint The treatment of psychotic depression in later life: a comparison of pharmacotherapy and ECT
    A J Flint
    Department of Psychiatry, University of Toronto, Canada
    Int J Geriatr Psychiatry 13:23-8. 1998
    ..Response to combination pharmacotherapy and to electroconvulsive therapy (ECT) was evaluated in elderly patients with psychotic depression...
  16. ncbi request reprint Maintenance treatment for recurrent depression in late life. A four-year outcome study
    A J Flint
    Geriatric Psychiatry Program, The Toronto Hospital and The Toronto Rehabilitation Institute, Ontario, Canada
    Am J Geriatr Psychiatry 8:112-6. 2000
    ..The cumulative probability of remaining well without recurrence was 70%. Longer time to respond to treatment and higher anxiety scores at the time of response predicted shorter time to recurrence...
  17. ncbi request reprint Effect of aging on cholecystokinin-induced panic
    A J Flint
    Department of Psychiatry, University of Toronto, Quebec, Canada
    Am J Psychiatry 155:283-5. 1998
    ..The goal of this study was to determine whether aging has an effect on healthy subjects' responses to the panicogenic agent cholecystokinin tetrapeptide (CCK-4)...
  18. pmc Pharmacologic treatment of depression in late life
    A J Flint
    Department of Psychiatry, University of Toronto, Ont
    CMAJ 157:1061-7. 1997
    ..The author emphasizes that, because of the high risk of relapse and recurrence, a long-term collaboration between the patient and the physician is required to successfully manage depression in late life...
  19. pmc Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder
    Tim V Salomons
    1 MRI Guided rTMS Clinic, Toronto Western Hospital, Toronto, ON, Canada 2 Department of Psychiatry, University Health Network, Toronto, ON, Canada 3 School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK
    Neuropsychopharmacology 39:488-98. 2014
    ....
  20. pmc Pharmacological treatment of post-stroke pathological laughing and crying
    Peter Giacobbe
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Psychiatry Neurosci 32:384. 2007
  21. ncbi request reprint The pharmacologic treatment of Alzheimer's disease: a guide for the general psychiatrist
    A J Flint
    Department of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 43:689-97. 1998
    ..To review the drug treatment of Alzheimer's disease (AD) and to provide guidelines for the physician on how to integrate these treatments into the overall management of this disorder...
  22. ncbi request reprint Choosing appropriate antidepressant therapy in the elderly. A risk-benefit assessment of available agents
    A J Flint
    Geriatric Psychiatry Program, Toronto Hospital, Ontario, Canada
    Drugs Aging 13:269-80. 1998
    ..There is no one 'first-line' antidepressant for elderly patients with depression. Selection of an antidepressant should be made on a case by case basis, taking into account each patient's characteristics...
  23. ncbi request reprint Anxiety and its disorders in late life: moving the field forward
    Alastair J Flint
    Am J Geriatr Psychiatry 13:3-6. 2005
  24. ncbi request reprint A delusion assessment scale for psychotic major depression: Reliability, validity, and utility
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital Westchester Division, West Chester, New York 10605, USA
    Biol Psychiatry 60:1336-42. 2006
    ..The development and assessment of the Delusional Assessment Scale (DAS) are described...
  25. ncbi request reprint Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:194-200. 2007
    ..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations...
  26. doi request reprint Weight gain during olanzapine treatment for psychotic depression: effects of dose and age
    Eric Smith
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Int Clin Psychopharmacol 23:130-7. 2008
    ..05 kg). Cumulative olanzapine dose was also significantly associated with weight gain (P<0.0001). Approximately 60% of completers of the 12-week trial experienced clinically significant weight gain (> or =7% of baseline weight)...
  27. ncbi request reprint Correlates of suicidality among patients with psychotic depression
    Ayal Schaffer
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Suicide Life Threat Behav 38:403-14. 2008
    ..These findings reinforce the evidence that patients with psychotic depression are at high risk for suicide and underscore the importance of examining correlates of suicidality specific to patients with psychotic depression...
  28. ncbi request reprint The complexity and challenge of non-major depression in late life
    Alastair J Flint
    Am J Geriatr Psychiatry 10:229-32. 2002
  29. ncbi request reprint Affective correlates of fear of falling in elderly persons
    Nadine Gagnon
    Department of Psychiatry, University of Toronto, Ontario, M5G 2C4, Canada
    Am J Geriatr Psychiatry 13:7-14. 2005
    ..Little is known about the psychological correlates of fear of falling. The purpose of this study was to determine whether clinically significant depression and anxiety were independently associated with fear of falling...
  30. ncbi request reprint Missed diagnosis of psychotic depression at 4 academic medical centers
    Anthony J Rothschild
    Department of Psychiatry, University of Massachusetts Medical School, and UMass Memorial Healthcare, Worcester, MA 01605, USA
    J Clin Psychiatry 69:1293-6. 2008
    ..Major depressive disorder with psychotic features (psychotic depression), though occurring relatively frequently in the general population, is a commonly missed psychiatric diagnosis...

Research Grants1

  1. Acute Pharmacotherapy of Unipolar Psychotic Depression
    Alastair Flint; Fiscal Year: 2006
    ..Remitted subjects are also followed during stabilization to determine the stability of remission and predictors of clinical and functional deterioration. ..