Affiliation: University of Toronto
- Effect of sertraline on risk of falling in older adults with psychotic depression on olanzapine: results of a randomized placebo-controlled trialAlastair J Flint
Department of Psychiatry, University of Toronto, Canada Department of Psychiatry, University Health Network, Toronto, Canada Toronto General and Toronto Rehab Research Institutes, Toronto, Canada Electronic address
Am J Geriatr Psychiatry 22:332-6. 2014..We therefore analyzed data from a RCT of the treatment of psychotic depression, to examine whether combined olanzapine and sertraline interacted with older age to increase the risk of falling compared with olanzapine plus placebo...
- Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD IIAlastair J Flint
Department of Psychiatry, University of Toronto, Toronto, Canada
BMC Psychiatry 13:38. 2013..On the other hand, premature discontinuation of antipsychotic medication has the potential risk of early relapse of a severe disorder...
- Effective use of electroconvulsive therapy in late-life depressionAlastair J Flint
University of Toronto, Geriatric Psychiatry Program, University Health Network, Toronto, Ontario
Can J Psychiatry 47:734-41. 2002..To review literature pertaining to the efficacy, safety, and tolerability of electroconvulsive therapy (ECT) in treating late-life depression...
- Generalised anxiety disorder in elderly patients : epidemiology, diagnosis and treatment optionsAlastair J Flint
Department of Psychiatry, University Health Network and University of Toronto, Toronto, Ontario, Canada
Drugs Aging 22:101-14. 2005..If a benzodiazepine is initiated, pharmacokinetic considerations favour the use of either lorazepam or oxazepam. Buspirone also has a more limited role than antidepressants in the treatment of late-life GAD...
- Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin systemAlastair Flint
Toronto General Hospital, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Neuropsychopharmacology 27:663-71. 2002..These findings are consistent with our hypothesis and suggest that age-related changes in the CCK system could contribute to the diminished panicogenic response to exogenous CCK-4 in older persons...
- Relationship between clinical variables and symptomatic anxiety in late-life depressionAlastair J Flint
Toronto General Hospital, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 10:292-6. 2002..In this group of elderly depressed patients, medical burden, cognitive impairment, and negative psychosocial circumstances did not contribute in a clinically significant way to variance in severity of symptomatic anxiety...
- Effect of age on the frequency of anxiety disorders in major depression with psychotic featuresAlastair J Flint
Department of Psychiatry, University of Toronto, Ontario, Canada
Am J Geriatr Psychiatry 18:404-12. 2010..To compare the frequency of anxiety disorders in older and younger persons with major depressive disorder with psychotic features...
- Factor structure of the hospital anxiety and depression scale in older patients with major depressionAlastair J Flint
Toronto General Hospital, Toronto, Canada
Int J Geriatr Psychiatry 17:117-23. 2002..The purpose of this exploratory study, therefore, was to examine the factor structure of the HADS in older patients with major depression...
- Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depressionA J Flint
Geriatric Psychiatry Program, The Toronto General Hospital, 8 Eaton North, Room 238, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
Depress Anxiety 13:125-31. 2001..These findings suggest that pharmacotherapy resistance may constitute a risk factor for relapse or recurrence of remitted geriatric depression, even when patients are maintained on the medication that they eventually respond to...
- Neurohormonal responses to cholecystokinin tetrapeptide: a comparison of younger and older healthy subjectsA J Flint
The Department of Psychiatry, University of Toronto, Ontario, Canada
Psychoneuroendocrinology 25:633-47. 2000..For the most part, maximum changes in hormonal levels were not correlated with symptom severity, suggesting that other factors may have contributed to the differential effect of panic on the HPA axis...
- Diagnosis and management of panic disorder in older patientsAlastair J Flint
Departments of Psychiatry, University Health Network and University of Toronto, Toronto, Ontario, Canada
Drugs Aging 20:881-91. 2003..Given the delayed onset of action of antidepressant medication, the short-term use of adjunctive lorazepam in the first few weeks of treatment may be helpful in selected patients...
- Anxiety disorders in late lifeA J Flint
Department of Psychiatry, University of Toronto, Ont
Can Fam Physician 45:2672-9. 1999..To review the epidemiology, clinical characteristics, and treatment of anxiety disorders in late life...
- Two-year outcome of psychotic depression in late lifeA J Flint
Geriatric Psychiatry Program, Toronto Hospital, Ont, Canada
Am J Psychiatry 155:178-83. 1998..The purpose of this study was to determine whether elderly patients with psychotic depression differed in long-term outcome from patients with nonpsychotic depression...
- Recurrence of first-episode geriatric depression after discontinuation of maintenance antidepressantsA J Flint
Geriatric Psychiatry Program, Toronto Hospital, Ont, Canada
Am J Psychiatry 156:943-5. 1999..Therefore, the authors examined the 2-year outcomes of elderly patients with first-episode major depression following discontinuation of their maintenance antidepressant medication...
- The treatment of psychotic depression in later life: a comparison of pharmacotherapy and ECTA J Flint
Department of Psychiatry, University of Toronto, Canada
Int J Geriatr Psychiatry 13:23-8. 1998..Response to combination pharmacotherapy and to electroconvulsive therapy (ECT) was evaluated in elderly patients with psychotic depression...
- Maintenance treatment for recurrent depression in late life. A four-year outcome studyA J Flint
Geriatric Psychiatry Program, The Toronto Hospital and The Toronto Rehabilitation Institute, Ontario, Canada
Am J Geriatr Psychiatry 8:112-6. 2000..The cumulative probability of remaining well without recurrence was 70%. Longer time to respond to treatment and higher anxiety scores at the time of response predicted shorter time to recurrence...
- Effect of aging on cholecystokinin-induced panicA J Flint
Department of Psychiatry, University of Toronto, Quebec, Canada
Am J Psychiatry 155:283-5. 1998..The goal of this study was to determine whether aging has an effect on healthy subjects' responses to the panicogenic agent cholecystokinin tetrapeptide (CCK-4)...
- Pharmacologic treatment of depression in late lifeA J Flint
Department of Psychiatry, University of Toronto, Ont
CMAJ 157:1061-7. 1997..The author emphasizes that, because of the high risk of relapse and recurrence, a long-term collaboration between the patient and the physician is required to successfully manage depression in late life...
- Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorderTim V Salomons
1 MRI Guided rTMS Clinic, Toronto Western Hospital, Toronto, ON, Canada 2 Department of Psychiatry, University Health Network, Toronto, ON, Canada 3 School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK
Neuropsychopharmacology 39:488-98. 2014....
- Pharmacological treatment of post-stroke pathological laughing and cryingPeter Giacobbe
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Psychiatry Neurosci 32:384. 2007
- The pharmacologic treatment of Alzheimer's disease: a guide for the general psychiatristA J Flint
Department of Psychiatry, University of Toronto, Ontario
Can J Psychiatry 43:689-97. 1998..To review the drug treatment of Alzheimer's disease (AD) and to provide guidelines for the physician on how to integrate these treatments into the overall management of this disorder...
- Choosing appropriate antidepressant therapy in the elderly. A risk-benefit assessment of available agentsA J Flint
Geriatric Psychiatry Program, Toronto Hospital, Ontario, Canada
Drugs Aging 13:269-80. 1998..There is no one 'first-line' antidepressant for elderly patients with depression. Selection of an antidepressant should be made on a case by case basis, taking into account each patient's characteristics...
- Anxiety and its disorders in late life: moving the field forwardAlastair J Flint
Am J Geriatr Psychiatry 13:3-6. 2005
- A delusion assessment scale for psychotic major depression: Reliability, validity, and utilityBarnett S Meyers
Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital Westchester Division, West Chester, New York 10605, USA
Biol Psychiatry 60:1336-42. 2006..The development and assessment of the Delusional Assessment Scale (DAS) are described...
- Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic featuresCarmen Andreescu
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 68:194-200. 2007..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations...
- Weight gain during olanzapine treatment for psychotic depression: effects of dose and ageEric Smith
Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
Int Clin Psychopharmacol 23:130-7. 2008..05 kg). Cumulative olanzapine dose was also significantly associated with weight gain (P<0.0001). Approximately 60% of completers of the 12-week trial experienced clinically significant weight gain (> or =7% of baseline weight)...
- Correlates of suicidality among patients with psychotic depressionAyal Schaffer
Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Suicide Life Threat Behav 38:403-14. 2008..These findings reinforce the evidence that patients with psychotic depression are at high risk for suicide and underscore the importance of examining correlates of suicidality specific to patients with psychotic depression...
- The complexity and challenge of non-major depression in late lifeAlastair J Flint
Am J Geriatr Psychiatry 10:229-32. 2002
- Affective correlates of fear of falling in elderly personsNadine Gagnon
Department of Psychiatry, University of Toronto, Ontario, M5G 2C4, Canada
Am J Geriatr Psychiatry 13:7-14. 2005..Little is known about the psychological correlates of fear of falling. The purpose of this study was to determine whether clinically significant depression and anxiety were independently associated with fear of falling...
- Missed diagnosis of psychotic depression at 4 academic medical centersAnthony J Rothschild
Department of Psychiatry, University of Massachusetts Medical School, and UMass Memorial Healthcare, Worcester, MA 01605, USA
J Clin Psychiatry 69:1293-6. 2008..Major depressive disorder with psychotic features (psychotic depression), though occurring relatively frequently in the general population, is a commonly missed psychiatric diagnosis...
- Acute Pharmacotherapy of Unipolar Psychotic DepressionAlastair Flint; Fiscal Year: 2006..Remitted subjects are also followed during stabilization to determine the stability of remission and predictors of clinical and functional deterioration. ..