Alison S Fleming

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Mothering begets mothering: the transmission of behavior and its neurobiology across generations
    Alison S Fleming
    Department of Psychology, Erindale College, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Pharmacol Biochem Behav 73:61-75. 2002
  2. ncbi request reprint Testosterone and prolactin are associated with emotional responses to infant cries in new fathers
    Alison S Fleming
    Department of Psychology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Horm Behav 42:399-413. 2002
  3. doi request reprint Accumbal dopamine function in postpartum rats that were raised without their mothers
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Mississauga, ON, Canada L5L 1C6
    Horm Behav 60:632-43. 2011
  4. doi request reprint Hormones that increase maternal responsiveness affect accumbal dopaminergic responses to pup- and food-stimuli in the female rat
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, ON, Canada
    Horm Behav 56:11-23. 2009
  5. ncbi request reprint Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, Canada
    Behav Neurosci 121:515-26. 2007
  6. ncbi request reprint The effects of adrenalectomy and corticosterone replacement on maternal memory in postpartum rats
    M Dean Graham
    Department of Psychology, University of Toronto at Mississauga, ON, Canada
    Horm Behav 49:353-61. 2006
  7. ncbi request reprint The effects of adrenalectomy and corticosterone replacement on induction of maternal behavior in the virgin female rat
    Stephanie L Rees
    Department of Psychology, University of Toronto at Mississauga, ON, Canada
    Horm Behav 49:337-45. 2006
  8. ncbi request reprint Effects of motherhood on physiological and subjective responses to infant cries in teenage mothers: a comparison with non-mothers and adult mothers
    Jennifer Giardino
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Mississauga, Ontario, Canada L5C 1C6
    Horm Behav 53:149-58. 2008
  9. doi request reprint Early postnatal experience and DRD2 genotype affect dopamine receptor expression in the rat ventral striatum
    Vedran Lovic
    Department of Psychology, University of Toronto Mississauga, Canada
    Behav Brain Res 237:278-82. 2013
  10. ncbi request reprint Previous maternal experience affects accumbal dopaminergic responses to pup-stimuli
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road N, Mississauga ON, Canada L5L 1C6
    Brain Res 1198:115-23. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Mothering begets mothering: the transmission of behavior and its neurobiology across generations
    Alison S Fleming
    Department of Psychology, Erindale College, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Pharmacol Biochem Behav 73:61-75. 2002
    ....
  2. ncbi request reprint Testosterone and prolactin are associated with emotional responses to infant cries in new fathers
    Alison S Fleming
    Department of Psychology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Horm Behav 42:399-413. 2002
    ....
  3. doi request reprint Accumbal dopamine function in postpartum rats that were raised without their mothers
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Mississauga, ON, Canada L5L 1C6
    Horm Behav 60:632-43. 2011
    ..Preweaning tactile stimulation could partially reverse these effects only in naturally cycling or parturient animals...
  4. doi request reprint Hormones that increase maternal responsiveness affect accumbal dopaminergic responses to pup- and food-stimuli in the female rat
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, ON, Canada
    Horm Behav 56:11-23. 2009
    ..However, the postpartum experience provides further modifications to this brain region to promote DA responses to pup stimuli...
  5. ncbi request reprint Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, Canada
    Behav Neurosci 121:515-26. 2007
    ..However, when PPI effects were partialled out, group differences were less strong, but persisted. This study demonstrated that mPFC manipulations affect actions rich in sequential structure in response to biologically relevant stimuli...
  6. ncbi request reprint The effects of adrenalectomy and corticosterone replacement on maternal memory in postpartum rats
    M Dean Graham
    Department of Psychology, University of Toronto at Mississauga, ON, Canada
    Horm Behav 49:353-61. 2006
    ..Corticosterone also increased maternal behavior upon initial exposure to foster pups. In conclusion, corticosterone enhanced maternal memory and initial maternal behavior in postpartum rats...
  7. ncbi request reprint The effects of adrenalectomy and corticosterone replacement on induction of maternal behavior in the virgin female rat
    Stephanie L Rees
    Department of Psychology, University of Toronto at Mississauga, ON, Canada
    Horm Behav 49:337-45. 2006
    ..In conclusion, exogenous corticosterone had an inhibitory effect on the expression of maternal behavior in the sensitized virgin rat, unlike the facilitatory effect previously found in the postpartum rat...
  8. ncbi request reprint Effects of motherhood on physiological and subjective responses to infant cries in teenage mothers: a comparison with non-mothers and adult mothers
    Jennifer Giardino
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Mississauga, Ontario, Canada L5C 1C6
    Horm Behav 53:149-58. 2008
    ....
  9. doi request reprint Early postnatal experience and DRD2 genotype affect dopamine receptor expression in the rat ventral striatum
    Vedran Lovic
    Department of Psychology, University of Toronto Mississauga, Canada
    Behav Brain Res 237:278-82. 2013
    ..These finding may explain why there are significant individual differences in the impact of early life adversity on dopamine-dependent processes and disorder vulnerabilities...
  10. ncbi request reprint Previous maternal experience affects accumbal dopaminergic responses to pup-stimuli
    Veronica M Afonso
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road N, Mississauga ON, Canada L5L 1C6
    Brain Res 1198:115-23. 2008
    ..The more experience a female had with pups, the greater was the DA response (p<.05). The results suggest that enhanced responding to pups following previous maternal experiences may be mediated through accumbal DA...
  11. ncbi request reprint Early deprivation, but not maternal separation, attenuates rise in corticosterone levels after exposure to a novel environment in both juvenile and adult female rats
    Stephanie L Rees
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ont L5L 1C6, Canada
    Behav Brain Res 175:383-91. 2006
    ..However, in adulthood, ED and MS rats tended to show a decreased proportion of inner grid crossings of the open field compared to AFR rats, suggesting a tendency for increased anxiety in these two separation groups...
  12. doi request reprint Dendritic morphology in the striatum and hypothalamus differentially exhibits experience-dependent changes in response to maternal care and early social isolation
    Soaleha Shams
    Department of Psychology, University of Toronto at Mississauga, 3559 Mississauga Road North, Mississauga, Ontario, L5L 1C6, Canada
    Behav Brain Res 233:79-89. 2012
    ....
  13. doi request reprint Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats
    Hiwote Belay
    Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Road N, Mississauga, Ontario, Canada
    Behav Neurosci 125:150-60. 2011
    ..These results are the first to indicate a role for genetic variation in the 5-HTT gene in physiology and behavior in the rat...
  14. ncbi request reprint Maternal isolation alters the expression of neural proteins during development: 'Stroking' stimulation reverses these effects
    Diptendu Chatterjee
    University of Toronto at Mississauga, 3359 Mississauga Rd N, Mississauga, Ontario, Canada L5L 1C6
    Brain Res 1158:11-27. 2007
    ....
  15. ncbi request reprint Prenatal restraint stress and motherless rearing disrupts expression of plasticity markers and stress-induced corticosterone release in adult female Sprague-Dawley rats
    Christie L Burton
    Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, Canada
    Brain Res 1158:28-38. 2007
    ..These results suggest that both prenatal and postnatal adversities have an influence on HPA axis responsivity and alter the expression of plasticity related neuronal proteins...
  16. doi request reprint Distal pup cues evoke dopamine responses in hormonally primed rats in the absence of pup experience or ongoing maternal behavior
    Veronica M Afonso
    Department of Psychology, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
    J Neurosci 33:2305-12. 2013
    ..The results suggest that NAC DA response reflects a state of responsiveness related to basal DA suppression in the hormonally primed female rat...
  17. ncbi request reprint Experience-dependent cell survival in the maternal rat brain
    Emis M Akbari
    Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, Canada
    Behav Neurosci 121:1001-11. 2007
    ..The results suggest that early preweaning maternal isolation alters the structural plasticity that occurs following a postpartum maternal experience...
  18. doi request reprint Artificial rearing of rat pups reveals the beneficial effects of mother care on neonatal inflammation and adult sensitivity to pain
    Cynthia B de Medeiros
    Department of Psychology, University of Toronto at Mississauga, Mississauga, Ontario L5L 1C6, Canada
    Pediatr Res 66:272-7. 2009
    ..In addition, this suggests that optimal level of maternal stimulation exists that determines adult pain sensitivity...
  19. ncbi request reprint Artificially-reared female rats show reduced prepulse inhibition and deficits in the attentional set shifting task--reversal of effects with maternal-like licking stimulation
    Vedran Lovic
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ont, Canada L5L 1C6
    Behav Brain Res 148:209-19. 2004
    ..In addition, there was a significant correlation between maternal behaviors and both PPI and the performance in the attentional set shifting task...
  20. ncbi request reprint The effects of vitamin D₃ during pregnancy and lactation on offspring physiology and behavior in sprague-dawley rats
    Pauline Pan
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada M1C1A4 Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Davis Building, Room 2037B, Mississauga, Ontario, Canada L5L1C6
    Dev Psychobiol 56:12-22. 2014
    ..For social behaviors, both juveniles and adults were affected by mothers' diets. In general, offspring of animals receiving abnormal concentrations of vitamin D showed the most deficits...
  21. pmc Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum mood
    Viara Mileva-Seitz
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e61443. 2013
    ..Finally, our findings highlight the importance of examining multiple dimensions of human maternal behavior in studies of genetic associations...
  22. doi request reprint The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women
    Andrea Gonzalez
    Department of Psychology, University of Toronto, 3359 Mississauga Road N, Mississauga, ON, Canada
    Psychoneuroendocrinology 34:76-86. 2009
    ..01). Our findings suggest that in a community sample of postpartum women, early adversity is associated with current HPA axis function. These findings may have implications for the nature of mother-infant interactions...
  23. doi request reprint Deconstructing early life experiences: distinguishing the contributions of prenatal and postnatal factors to adult male sexual behavior in the rat
    Cynthia B de Medeiros
    Department of Psychology, University of Toronto at Mississauga
    Psychol Sci 21:1494-501. 2010
    ..The reported differences in sexual behavior did not vary with the quality of maternal behavior or with sexual experience in adulthood...
  24. ncbi request reprint The nucleus accumbens shell is critical for normal expression of pup-retrieval in postpartum female rats
    Ming Li
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ont, Canada L5L 1C6
    Behav Brain Res 145:99-111. 2003
    ..These findings suggest that the shell, but not the core, is critical for the normal expression of pup-retrieval behavior possibly through its role in maintaining maternal motivation or attention...
  25. ncbi request reprint Experiential and hormonal correlates of maternal behavior in teen and adult mothers
    Katherine M Krpan
    Department of Psychology, Erindale College, University of Toronto, N Mississauga, Ontario, Canada L5L 1C6
    Horm Behav 47:112-22. 2005
    ..These results suggest that early life experiences are linked to mothering behavior and are consistent with the emerging human and animal literature on intergenerational effects of mothering style...
  26. doi request reprint Callosal oligodendrocyte number in postpartum Sprague-Dawley rats
    Marissa E Maheu
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Room 2037B SE, Mississauga, Ontario, Canada L5L 1C6
    Brain Res 1267:18-24. 2009
    ..Further investigation is required in order to confirm whether the effects observed are mediated by members of the PRL-family, experience, and/or other gestational/PP endocrine hormones...
  27. doi request reprint The roles of accumbal dopamine D1 and D2 receptors in maternal memory in rats
    Mayte Parada
    Department of Psychology, University of Toronto, Mississauga, Ontario, Canada
    Behav Neurosci 122:368-76. 2008
    ..These findings suggest that both the D1 and the D2 receptor subtypes play a role in the consolidation of maternal memory and they might do so by mediating the motivational salience of pup stimulation...
  28. ncbi request reprint Executive function and mothering: challenges faced by teenage mothers
    Elsie Chico
    Department of Psychology, University of Toronto, 3359 Mississauga Road N, Mississauga, ON, Canada, L5L1C6
    Dev Psychobiol 56:1027-35. 2014
    ..Among both groups there was a negative association between executive function and mothering; however, depending on the age of the mother different executive function tasks were relevant...
  29. ncbi request reprint Maternal affect and quality of parenting experiences are related to amygdala response to infant faces
    Jennifer Barrett
    a Department of Psychology, University of Toronto Mississauga, Mississauga, Canada
    Soc Neurosci 7:252-68. 2012
    ..This work was supported by an Ontario Mental Health Foundation operating grant awarded to Alison Fleming and a postdoctoral fellowship awarded to Jennifer Barrett. ..
  30. ncbi request reprint Effects of preweaning exposure to novel maternal odors on maternal responsiveness and selectivity in adulthood
    Akeel Shah
    Department of Psychology, University of Toronto, Mississauga, Ontario, L5L 1C6 Canada
    Dev Psychobiol 41:187-96. 2002
    ..Simple exposure to the lemon odorant out of context of the nest had no effect on adult maternal latencies or behavior...
  31. ncbi request reprint Artificial rearing causes changes in maternal behavior and c-fos expression in juvenile female rats
    Andrea Gonzalez
    Department of Psychology, University of Toronto at Mississauga, Ontario, Canada
    Behav Neurosci 116:999-1013. 2002
    ..The AR-min group showed the greatest difference in Fos-lir compared with the MR groups. Possible mechanisms that mediate the effects of rearing on the development of neural circuits underlying maternal behavior are discussed...
  32. ncbi request reprint The effects of adrenalectomy and corticosterone replacement on maternal behavior in the postpartum rat
    Stephanie L Rees
    Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, Canada L5L 1C6
    Horm Behav 46:411-9. 2004
    ..Corticosterone replacement reverses these effects. Corticosterone is not necessary for the initiation or maintenance of maternal behavior but plays a role in the modulation of ongoing maternal behavior...
  33. doi request reprint Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences
    Jennifer Barrett
    Department of Psychology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    J Child Psychol Psychiatry 52:368-97. 2011
    ....
  34. ncbi request reprint The effects of early rearing environment on the hormonal induction of maternal behavior in virgin rats
    Marko Novakov
    Psychology Department, University of Toronto at Mississauaga, Mississauga, Ontario, Canada L5L1C6
    Horm Behav 48:528-36. 2005
    ..AR) and hormonal treatment on the quality of maternal behavior exhibited. The highest level of licking and crouching was shown by the hormone-treated MR group. Mechanisms for these effects are discussed...
  35. ncbi request reprint The three faces of Jay S. Rosenblatt
    Alison S Fleming
    Department of Pyschology, University of Toronto at Mississauga, Ontario, Canada
    Dev Psychobiol 49:2-11. 2007
    ..Rosenblatt's approach and contributions to the study of maternal behavior and the mother-young relationship, focusing on the role in that development of his life as painter, analyst, and scientist. It is personal perspective...
  36. ncbi request reprint Early life tactile stimulation changes adult rat responsiveness to amphetamine
    Vedran Lovic
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Rd N, Mississauga, Canada ON L5C 1C6
    Pharmacol Biochem Behav 84:497-503. 2006
    ..The enhancement of the effect of amphetamine by artificial rearing was not apparent in artificially reared maximal stimulation rats...
  37. ncbi request reprint Effects of novel antipsychotics, amisulpiride and aripiprazole, on maternal behavior in rats
    Ming Li
    Centre for Addiction and Mental Health, Clarke Site 250 College Street, Toronto, Ontario, M5R 1T8, Canada
    Psychopharmacology (Berl) 181:600-10. 2005
    ..Amisulpiride and aripiprazole are new atypical antipsychotics with mechanisms of action distinct from the current typical and atypical antipsychotics. The effects of these drugs on maternal behavior have not been explored...
  38. ncbi request reprint Differential involvement of nucleus accumbens shell and core subregions in maternal memory in postpartum female rats
    Ming Li
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada
    Behav Neurosci 117:426-45. 2003
    ..It was concluded that the NA shell, but not the NA core, is involved in the consolidation of maternal memory...
  39. doi request reprint Effects of early deprivation and maternal separation on pup-directed behavior and HPA axis measures in the juvenile female rat
    Stephanie L Rees
    School of Psychology University of Ottawa Ottawa, ON K1N 6N5, Canada
    Dev Psychobiol 50:315-21. 2008
    ..Overall, the data suggest that although pup-exposure affects corticosterone levels, the HPA axis does not relate to juvenile maternal behavior in the present experiments...
  40. doi request reprint Parental behaviors in rats and mice
    Joseph S Lonstein
    University of Massachusetts, Amherst, Massachusetts, USA
    Curr Protoc Neurosci . 2002
    ....
  41. ncbi request reprint Maternal and littermate deprivation disrupts maternal behavior and social-learning of food preference in adulthood: tactile stimulation, nest odor, and social rearing prevent these effects
    Angel I Melo
    Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de Tlaxcala, CINVESTAV Laboratorio Tlaxcala Apdo Postal 62 Tlaxcala Tlax 90000, Mexico
    Dev Psychobiol 48:209-19. 2006
    ..These studies indicate that social stimulation from littermates during the preweaning period, in combination with odor from the nest and tactile stimulation, contributes to the development of affiliative behaviors...
  42. pmc Tactile stimulation during artificial rearing influences adult function and morphology in a sexually dimorphic neuromuscular system
    Kathryn M Lenz
    Program in Neuroscience, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA
    Dev Neurobiol 68:542-57. 2008
    ..These results suggest that tactile stimulation provided by maternal licking mediates some of the effects of maternal care on the development of male copulatory behavior...
  43. ncbi request reprint Effects of chronic typical and atypical antipsychotic drug treatment on maternal behavior in rats
    Ming Li
    Center for Addiction and Mental Health, Clarke Site, Toronto, Ontario, Canada M5R 1T8
    Schizophr Res 75:325-36. 2005
    ..It is concluded that chronic antipsychotic treatment disrupts active maternal behaviors and this disruption, most likely to lead to side effects in humans, should be avoided in future drug development...
  44. ncbi request reprint Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats
    Ming Li
    Centre for Addiction and Mental Health, The Clarke Division of CAMH, PET Centre, Clarke Site, 250 College Street, Toronto, Ontario M5T 1T8, Canada
    Schizophr Res 70:69-80. 2004
    ..This effect may be intrinsic to antipsychotic activity or may be reflective of a side-effect. Since the latter is more likely, this may be an effect to avoid in the design of future antipsychotics...