Research Topics
| David N FismanSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Effectiveness and cost-effectiveness of pediatric rotavirus vaccination in British Columbia: a model-based evaluationDavid N Fisman
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
Vaccine 30:7601-7. 2012..Two live rotavirus vaccines (RotaTeq(®) (Merck Frosst Canada Ltd.) and Rotarix™ (GlaxoSmithKline Inc.)), are now approved for use in Canada, but their economic attractiveness has not been evaluated in the Canadian context...- Seasonality of viral infections: mechanisms and unknownsD Fisman
The Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Clin Microbiol Infect 18:946-54. 2012..However, numerous areas of uncertainty exist, making this an exciting area for future research... 
Reactive strategies for containing developing outbreaks of pandemic influenzaSigrún Andradóttir
H Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
BMC Public Health 11:S1. 2011..This experience suggests the need to explore the epidemiological and economic effectiveness of additional, reactive strategies for combating pandemic influenza...- Vaccination against 2009 pandemic H1N1 in a population dynamical model of Vancouver, Canada: timing is everythingJessica M Conway
Division of Mathematical Modeling, University of British Columbia Centre for Disease Control, 655 West 12th Avenue, V5Z 4R4 Vancouver, British Columbia, Canada
BMC Public Health 11:932. 2011..We adapted a city-level contact network model to study different campaigns on influenza morbidity and mortality... - Estimation of the health impact and cost-effectiveness of influenza vaccination with enhanced effectiveness in CanadaDavid N Fisman
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 6:e27420. 2011..The health and economic impact of such vaccines in the Canadian population are uncertain... - Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modelingDavid N Fisman
Dalla Lana School of Public Health, University of Toronto, Canada
BMC Public Health 11:694. 2011..We evaluated pertussis trends in Toronto using all available specimen data, which allowed us to control for changing testing patterns and practices... - Prevalence of and risk factors for quinolone-resistant Neisseria gonorrhoeae infection in OntarioKaede V Ota
Division of Microbiology, Pediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario
CMAJ 180:287-90. 2009..We sought to determine its prevalence in the province of Ontario and to investigate risk factors for quinolone-resistant N. gonorrhoeae infection in a Canadian setting... - Epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in Ontario, Canada, 2000 to 2006Elizabeth M Brown
Ontario Agency for Health Protection and Promotion, Public Health Laboratories, 81 Resources Road, Toronto, Ontario, Canada M9P 3T1
Antimicrob Agents Chemother 54:1016-21. 2010..In contrast to trends of the 1990s, the incidence of IMD with DSP was stable in Ontario between 2000 and 2006. In Ontario, the serogroup rather than the penicillin MIC is the microbiological parameter most predictive of mortality... - Why "winter" vomiting disease? Seasonality, hydrology, and Norovirus epidemiology in Toronto, CanadaAmy L Greer
Child Health Evaluative Sciences, The Research Institute of the Hospital for Sick Children, Toronto, ON, Canada
Ecohealth 6:192-9. 2009..We hypothesize that the reservoir may be maintained through the discharge of wastewater containing virus particles; wintertime seasonality may be explained by enhanced viral persistence at low temperatures... - Environmental determinants of campylobacteriosis risk in Philadelphia from 1994 to 2007Alexander N J White
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Ecohealth 6:200-8. 2009.... - Environmental exposures and invasive meningococcal disease: an evaluation of effects on varying time scalesLaura M Kinlin
Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada
Am J Epidemiol 169:588-95. 2009..The latter effect may be due to decreased pathogen survival or virulence and may explain the wintertime seasonality of IMD in temperate regions of North America... - New endemic Legionella pneumophila serogroup I clones, Ontario, CanadaNathalie Tijet
Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
Emerg Infect Dis 16:447-54. 2010..These findings have general clinical implications for the study of Lp1 molecular evolution and for the identification of Lp1 circulating strains in North America... - Respiratory virus infection and risk of invasive meningococcal disease in central Ontario, CanadaAshleigh R Tuite
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
PLoS ONE 5:e15493. 2010.... - Laboratory-based evaluation of legionellosis epidemiology in Ontario, Canada, 1978 to 2006Victoria Ng
Child Health Evaluative Sciences, Research Institute of the Hospital for Sick Children, Toronto, Canada
BMC Infect Dis 9:68. 2009..We sought to provide a laboratory-based review of the epidemiology of legionellosis in Ontario over the past 3 decades, with a focus on changing rates of disease and species associated with legionellosis during that time period... - Optimal pandemic influenza vaccine allocation strategies for the Canadian populationAshleigh R Tuite
Department of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 5:e10520. 2010..We sought to determine optimal prioritization of vaccine distribution among different age and risk groups within the Canadian population, to minimize influenza-attributable morbidity and mortality... - Evaluation of coseasonality of influenza and invasive pneumococcal disease: results from prospective surveillanceStefan P Kuster
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
PLoS Med 8:e1001042. 2011..We aimed to investigate the relationship between influenza infection and IPD in Ontario, Canada, using several complementary methodological tools... - The role of cellular immunity in influenza H1N1 population dynamicsVenkata R Duvvuri
Centre for Disease Modelling, York University, Toronto, Ontario
BMC Infect Dis 12:329. 2012..Whether, and to what extent, the effect of this self-protective mechanism can be captured in the population dynamics of an influenza epidemic has not been addressed... - Rapid identification of herd effects with the introduction of serogroup C meningococcal conjugate vaccine in Ontario, Canada, 2000-2006Laura M Kinlin
The Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada The University of Toronto, Toronto, Ontario, Canada
Vaccine 27:1735-40. 2009..These apparent dramatic effects of conjugate C vaccine (both direct and indirect) may be important in the implementation and evaluation of vaccine policy in other jurisdictions... - The Philadelphia High-School STD Screening Program: key insights from dynamic transmission modelingDavid N Fisman
Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada
Sex Transm Dis 35:S61-5. 2008..We sought to assess program cost-effectiveness in a manner that allowed us to quantify the impact of including males students in the screened population... - The laboratory impact of changing syphilis screening from the rapid-plasma reagin to a treponemal enzyme immunoassay: a case-study from the Greater Toronto AreaSharmistha Mishra
Division of Infectious Diseases, University of Toronto, and Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
Sex Transm Dis 38:190-6. 2011..We sought to understand the consequences of this change on laboratory results and testing patterns with a population-based retrospective study of laboratory-based diagnoses of syphilis... - The impact of infection on population health: results of the Ontario burden of infectious diseases studyJeffrey C Kwong
Institute for Clinical Evaluative Sciences, Toronto, Canada
PLoS ONE 7:e44103. 2012..We sought to quantify the contribution of a wide range of infectious diseases to the overall infectious disease burden in a high-income setting... - Use of models to identify cost-effective interventions: pertussis vaccination for pediatric health care workersAmy L Greer
Public Health Agency of Canada, 180 Queen St W, 11th Floor, Toronto, Ontario, Canada M5V 3L7
Pediatrics 128:e591-9. 2011..We sought to evaluate the health-economic attractiveness of a diphtheria-tetanus-acellular pertussis booster vaccination program for health care workers in a pediatric intensive care setting... - Core groups, antimicrobial resistance and rebound in gonorrhoea in North AmericaChristina H Chan
Division of Epidemiology, Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, 155 College Street, Room 678, Toronto, Ontario, Canada M5T 3M7
Sex Transm Infect 88:200-4. 2012..Surveillance data suggest that incidence has increased in recent years after initially falling in the face of intensified control efforts... - Going with the flow: legionellosis risk in Toronto, Canada is strongly associated with local watershed hydrologyVictoria Ng
Research Institute of the Hospital for Sick Children, Toronto, Canada
Ecohealth 5:482-90. 2008..These observations suggest testable hypotheses for future empiric studies... - Cholera, canals, and contagion: Rediscovering Dr. Beck's reportAshleigh R Tuite
Dalla Lana School of Public Health, University of Toronto, Room 678, 155 College Street, Toronto, Ontario, Canada M5T 3M7
J Public Health Policy 32:320-33. 2011..We show that these themes continue to serve as obstacles to innovation in medical and public health practice today... - Estimation of the burden of disease and costs of genital Chlamydia trachomatis infection in CanadaAshleigh R Tuite
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
Sex Transm Dis 39:260-7. 2012..Rates of Chlamydia trachomatis (CT) infection in Canada have been increasing since the mid-1990s. We sought to estimate the burden of CT in this population... - Estimated epidemiologic parameters and morbidity associated with pandemic H1N1 influenzaAshleigh R Tuite
Research Institute of the Hospital for Sick Children, and the Dalla Lana School of Public Health, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario
CMAJ 182:131-6. 2010..We sought to estimate epidemiologic parameters for pandemic H1N1 influenza using data from initial reports of laboratory-confirmed cases... - Keeping vulnerable children safe from pertussis: preventing nosocomial pertussis transmission in the neonatal intensive care unitAmy L Greer
Child Health Evaluative Sciences, Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada
Infect Control Hosp Epidemiol 30:1084-9. 2009..To examine the impact of different acellular pertussis booster vaccination strategies on the probability of a nosocomial pertussis outbreak occurring and the distribution of outbreak sizes observed for each intervention strategy... - Of gastro and the gold standard: evaluation and policy implications of norovirus test performance for outbreak detectionDavid N Fisman
Division of Epidemiology and Surveillance, Ontario Agency for Health Protection and Promotion, Toronto, Canada
J Transl Med 7:23. 2009..Identification of NVG is complicated by the non-culturable nature of this virus, and the absence of a diagnostic gold standard makes traditional evaluation of test characteristics problematic... - Derivation and validation of a clinical prediction rule for nosocomial pneumonia after coronary artery bypass graft surgeryLaura M Kinlin
Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada
Clin Infect Dis 50:493-501. 2010..We sought to develop a prediction rule for pneumonia after coronary artery bypass grafting (CABG), a common surgical procedure... - Spectrum bias and loss of statistical power in discordant couple studies of sexually transmitted infectionsAshleigh R Tuite
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada
Sex Transm Dis 38:50-6. 2011..Discordant couple studies are frequently used to evaluate preventive interventions for sexually transmitted infections (STI). This study design may be vulnerable to spectrum bias when transmission risk is heterogeneous... - Use of gloves and reduction of risk of injury caused by needles or sharp medical devices in healthcare workers: results from a case-crossover studyLaura M Kinlin
Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Infect Control Hosp Epidemiol 31:908-17. 2010..We evaluated factors associated with gloving practices and identified associations between gloving practices and sharps-injury risk... - Optimal pandemic influenza vaccine allocation strategies for the canadian populationAshleigh Tuite
Dalla Lana School of Public Health, University of Toronto Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada and Public Health Agency of Canada
PLoS Curr 2:RRN1144. 2010..Vaccination may significantly reduce influenza-attributable morbidity and mortality, but the benefits are dependent on epidemic dynamics, time for program roll-out, and vaccine uptake... - The ABC of terms used in mathematical models of infectious diseasesSharmistha Mishra
Division of Infectious Diseases, St Michael s Hospital, University of Toronto, Toronto, Canada
J Epidemiol Community Health 65:87-94. 2011.... - Health-related quality of life in Parkinson disease: correlation between Health Utilities Index III and Unified Parkinson's Disease Rating Scale (UPDRS) in U.S. male veteransGalit Kleiner-Fisman
Department of Neurology, Baycrest Geriatric Hospital, Toronto, Ontario, Canada
Health Qual Life Outcomes 8:91. 2010.... - Cholera epidemic in Haiti, 2010: using a transmission model to explain spatial spread of disease and identify optimal control interventionsAshleigh R Tuite
Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada
Ann Intern Med 154:593-601. 2011..Haiti is in the midst of a cholera epidemic. Surveillance data for formulating models of the epidemic are limited, but such models can aid understanding of epidemic processes and help define control strategies... - Is a Mass Immunization Program for Pandemic (H1N1) 2009 Good Value for Money? Early Evidence from the Canadian ExperienceBeate Sander
Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada University of Guelph Dalla Lana School of Public Health, University of Toronto Sunnybrook Hospital, The University of Toronto Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto Toronto Health Economics and Technology Assessment Collaborative THETA and University of Toronto
PLoS Curr 1:RRN1137. 2009..Our analysis indicates this program will reduce influenza cases by 50%, preventing 35 deaths, and cutting treatment costs in half. A pandemic (H1N1) 2009 immunization program is likely to be highly cost-effective... - Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: a 13-year retrospective cohort studyKaede V Ota
The Hospital for Sick Children, Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
Clin Infect Dis 48:1237-43. 2009..This study investigated the incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis cases at a Canadian clinic that mainly serves men who have sex with men... - Meta-Analysis of Antibiotics and the Risk of Community-Associated Clostridium difficile InfectionKevin A Brown
Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
Antimicrob Agents Chemother 57:2326-32. 2013..Avoidance of high-risk antibiotics (such as clindamycin, CMCs, and fluoroquinolones) in favor of lower-risk antibiotics (such as penicillins, macrolides, and tetracyclines) may help reduce the incidence of CDI... 
Seasonality of infectious diseasesDavid N Fisman
Child Health Evaluative Sciences, Research Institute of the Hospital for Sick Children, and Ontario Provincial Public Health Laboratory, Toronto, Ontario, M5G 1E2, Canada
Annu Rev Public Health 28:127-43. 2007..Seasonality represents a rich area for future research...- Number-needed-to-vaccinate calculations: fallacies associated with exclusion of transmissionAshleigh R Tuite
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto and Decision Centre for Infectious Disease Epidemiology DeCIDE, 155 College Street, Toronto, Ontario, Canada
Vaccine 31:973-8. 2013..e., risk of infection in susceptible individuals). We postulated that such calculations could produce profoundly biased estimates of vaccine attractiveness... - Linking antimicrobial prescribing to antimicrobial resistance in the ICU: before and after an antimicrobial stewardship programAmy Hurford
The Fields Institute for Research in Mathematical Sciences, Toronto, ON, Canada
Epidemics 4:203-10. 2012.... - Projected cost-savings with herpes simplex virus screening in pregnancy: towards a new screening paradigmAshleigh R Tuite
Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada
Sex Transm Infect 87:141-8. 2011..The objective of this study was to assess the effectiveness and cost effectiveness of identifying pregnant women at risk of de novo HSV acquisition as a means of preventing vertical HSV transmission... - Highly conserved cross-reactive CD4+ T-cell HA-epitopes of seasonal and the 2009 pandemic influenza virusesVenkata R S K Duvvuri
MITACS Centre for Disease Modeling, York Institute of Health Research, Toronto, Ontario, Canada
Influenza Other Respi Viruses 4:249-58. 2010.... - The cost-effectiveness of directly observed highly-active antiretroviral therapy in the third trimester in HIV-infected pregnant womenCaitlin J McCabe
Child Health Evaluative Sciences, Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada
PLoS ONE 5:e10154. 2010..Our objective was to project the effectiveness and cost-effectiveness of directly observed administration of antiretroviral drugs in pregnancy... - Seasonal Influenza Vaccine Allocation in the Canadian Population during a PandemicAshleigh Tuite
Dalla Lana School of Public Health, University of Toronto Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada and Public Health Agency of Canada
PLoS Curr 1:RRN1143. 2009....