Jason E Fish

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
    Henry S Cheng
    Toronto General Research Institute, University Health Network, Toronto, Canada
    EMBO Mol Med 5:949-66. 2013
  2. pmc Taming endothelial activation with a microRNA
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    J Clin Invest 122:1967-70. 2012
  3. doi request reprint A primer on the role of microRNAs in endothelial biology and vascular disease
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Semin Nephrol 32:167-75. 2012
  4. pmc A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 138:1409-19. 2011
  5. pmc miR-126 regulates angiogenic signaling and vascular integrity
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 15:272-84. 2008
  6. pmc ETS factors regulate Vegf-dependent arterial specification
    Joshua D Wythe
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 26:45-58. 2013
  7. pmc MicroRNA control of vascular endothelial growth factor signaling output during vascular development
    Lan T H Dang
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 33:193-200. 2013
  8. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
  9. pmc MicroRNAs: opening a new vein in angiogenesis research
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Sci Signal 2:pe1. 2009
  10. pmc Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones
    Jason E Fish
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:810-26. 2010

Collaborators

Detail Information

Publications12

  1. pmc MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
    Henry S Cheng
    Toronto General Research Institute, University Health Network, Toronto, Canada
    EMBO Mol Med 5:949-66. 2013
    ..Thus, we uncover an important negative feedback regulatory loop that controls pro-inflammatory signalling in endothelial cells that may impact vascular inflammatory diseases. ..
  2. pmc Taming endothelial activation with a microRNA
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    J Clin Invest 122:1967-70. 2012
    ..These findings provide compelling evidence that modulation of microRNAs may be a useful therapeutic approach for inflammatory vascular diseases...
  3. doi request reprint A primer on the role of microRNAs in endothelial biology and vascular disease
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Semin Nephrol 32:167-75. 2012
    ....
  4. pmc A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 138:1409-19. 2011
    ..These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly...
  5. pmc miR-126 regulates angiogenic signaling and vascular integrity
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 15:272-84. 2008
    ..These findings illustrate that a single miRNA can regulate vascular integrity and angiogenesis, providing a new target for modulating vascular formation and function...
  6. pmc ETS factors regulate Vegf-dependent arterial specification
    Joshua D Wythe
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 26:45-58. 2013
    ....
  7. pmc MicroRNA control of vascular endothelial growth factor signaling output during vascular development
    Lan T H Dang
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 33:193-200. 2013
    ....
  8. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Collectively, these data implicate the CXCR4/CXCR7/SDF-1 pathway in Stx-mediated pathogenesis and suggest novel therapeutic strategies for prevention and/or treatment of complications associated with E. coli O157:H7 infection...
  9. pmc MicroRNAs: opening a new vein in angiogenesis research
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Sci Signal 2:pe1. 2009
    ..Additional microRNAs have been implicated in the regulation of various aspects of angiogenesis. Thus, targeting the expression of microRNAs may be a novel therapeutic approach for diseases involving excess or insufficient vasculature...
  10. pmc Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones
    Jason E Fish
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:810-26. 2010
    ....
  11. pmc Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction
    Ankur Saxena
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Circulation 117:2224-31. 2008
    ..One possible cell-independent alternative is the direct administration of small proteins to damaged myocardium...
  12. pmc MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
    Kathryn N Ivey
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell Stem Cell 2:219-29. 2008
    ..Our findings indicate that muscle-specific miRNAs reinforce the silencing of nonmuscle genes during cell lineage commitment and suggest that miRNAs may have general utility in regulating cell-fate decisions from pluripotent ES cells...