Jason E Fish

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Taming endothelial activation with a microRNA
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    J Clin Invest 122:1967-70. 2012
  2. doi request reprint A primer on the role of microRNAs in endothelial biology and vascular disease
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Semin Nephrol 32:167-75. 2012
  3. pmc A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 138:1409-19. 2011
  4. pmc miR-126 regulates angiogenic signaling and vascular integrity
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 15:272-84. 2008
  5. pmc ETS factors regulate Vegf-dependent arterial specification
    Joshua D Wythe
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 26:45-58. 2013
  6. pmc MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
    Henry S Cheng
    Toronto General Research Institute, University Health Network, Toronto, Canada
    EMBO Mol Med 5:949-66. 2013
  7. pmc MicroRNA control of vascular endothelial growth factor signaling output during vascular development
    Lan T H Dang
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 33:193-200. 2013
  8. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
  9. doi request reprint Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, and Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario M5G0A4, Canada Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada Heart and Stroke Richard Lewar Centre of Excellence, Toronto, Ontario M5G 1L7, Canada
    Development 141:4610-7. 2014
  10. pmc MicroRNAs: opening a new vein in angiogenesis research
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Sci Signal 2:pe1. 2009

Collaborators

Detail Information

Publications13

  1. pmc Taming endothelial activation with a microRNA
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    J Clin Invest 122:1967-70. 2012
    ..These findings provide compelling evidence that modulation of microRNAs may be a useful therapeutic approach for inflammatory vascular diseases...
  2. doi request reprint A primer on the role of microRNAs in endothelial biology and vascular disease
    Jason E Fish
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Semin Nephrol 32:167-75. 2012
    ....
  3. pmc A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 138:1409-19. 2011
    ..These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly...
  4. pmc miR-126 regulates angiogenic signaling and vascular integrity
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 15:272-84. 2008
    ..These findings illustrate that a single miRNA can regulate vascular integrity and angiogenesis, providing a new target for modulating vascular formation and function...
  5. pmc ETS factors regulate Vegf-dependent arterial specification
    Joshua D Wythe
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 26:45-58. 2013
    ....
  6. pmc MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
    Henry S Cheng
    Toronto General Research Institute, University Health Network, Toronto, Canada
    EMBO Mol Med 5:949-66. 2013
    ..Thus, we uncover an important negative feedback regulatory loop that controls pro-inflammatory signalling in endothelial cells that may impact vascular inflammatory diseases. ..
  7. pmc MicroRNA control of vascular endothelial growth factor signaling output during vascular development
    Lan T H Dang
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 33:193-200. 2013
    ....
  8. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Collectively, these data implicate the CXCR4/CXCR7/SDF-1 pathway in Stx-mediated pathogenesis and suggest novel therapeutic strategies for prevention and/or treatment of complications associated with E. coli O157:H7 infection...
  9. doi request reprint Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, and Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario M5G0A4, Canada Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada Heart and Stroke Richard Lewar Centre of Excellence, Toronto, Ontario M5G 1L7, Canada
    Development 141:4610-7. 2014
    ....
  10. pmc MicroRNAs: opening a new vein in angiogenesis research
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Sci Signal 2:pe1. 2009
    ..Additional microRNAs have been implicated in the regulation of various aspects of angiogenesis. Thus, targeting the expression of microRNAs may be a novel therapeutic approach for diseases involving excess or insufficient vasculature...
  11. pmc Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones
    Jason E Fish
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:810-26. 2010
    ....
  12. pmc Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction
    Ankur Saxena
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Circulation 117:2224-31. 2008
    ..One possible cell-independent alternative is the direct administration of small proteins to damaged myocardium...
  13. pmc MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
    Kathryn N Ivey
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell Stem Cell 2:219-29. 2008
    ..Our findings indicate that muscle-specific miRNAs reinforce the silencing of nonmuscle genes during cell lineage commitment and suggest that miRNAs may have general utility in regulating cell-fate decisions from pluripotent ES cells...