E N Fish
Affiliation: University of Toronto
Gao D, Fish E. Chemokines in breast cancer: Regulating metabolism. Cytokine. 2018;109:57-64 pubmed publisher
Galligan C, Keystone E, Fish E. Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis. J Autoimmun. 2016;69:38-50 pubmed publisher
..Specifically, we provide in vitro evidence that mouse-derived CD4+ T cells produce GM-CSF which induces fibrocyte proliferation. In turn, activated fibrocytes produce IL-6, promoting Th17 polarization. ..
Gao D, Rahbar R, Fish E. CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells. Open Biol. 2016;6: pubmed publisher
..The implications are that CCL5-CCR5 interactions in the tumour microenvironment regulate metabolic events, specifically glycolysis, to promote tumour proliferation and invasion. ..
Wang B, Wei L, Kotra L, Brown E, Fish E. A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection. Viruses. 2017;9: pubmed publisher
..Viewed altogether, these data suggest that the virulence associated with this conserved Y84 residue in NS1 is, in part, due to its role in regulating the host IFN response. ..
Wang B, Brown E, Fish E. Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation. Virology. 2017;508:170-179 pubmed publisher
Gao D, Cazares L, Fish E. CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis. BMC Cancer. 2017;17:834 pubmed publisher
..These findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis. ..