E N Fish

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity
    Jae Kwang Yoo
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada
    J Exp Med 207:1435-51. 2010
  2. pmc Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling
    Danlin Jia
    Department of Immunology, University of Toronto, Toronto, Canada
    PLoS ONE 5:e13927. 2010
  3. pmc Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: implications for diagnosis and monitoring drug therapy
    Carole L Galligan
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 4:e6703. 2009
  4. doi request reprint The role of circulating fibrocytes in inflammation and autoimmunity
    Carole L Galligan
    University Health Network, 67 College St, Toronto, Ontario, Canada
    J Leukoc Biol 93:45-50. 2013
  5. doi request reprint The X-files in immunity: sex-based differences predispose immune responses
    Eleanor N Fish
    Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Women s College Research Institute, Ontario, Canada
    Nat Rev Immunol 8:737-44. 2008
  6. doi request reprint Interferon-beta is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis
    C L Galligan
    Toronto General Research Institute, University Health Network, Toronto, Canada
    Mult Scler 16:1458-73. 2010
  7. ncbi request reprint Interferon-alpha/beta-receptor interactions: a complex story unfolding
    Raj Deonarain
    Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Curr Pharm Des 8:2131-7. 2002
  8. ncbi request reprint Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity
    C L Galligan
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Immun 8:480-91. 2007
  9. ncbi request reprint Poxvirus infection rapidly activates tyrosine kinase signal transduction
    J Masters
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Canadian Blood Services Building, Toronto, Ontario M5G 2M1, Canada
    J Biol Chem 276:48371-5. 2001
  10. pmc Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3
    J D Burke
    Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Canada
    J Virol 88:3485-95. 2014

Collaborators

  • Vivian Bykerk
  • Omar D Perez
  • Janet C Siebert
  • E C Keystone
  • Raj Deonarain
  • Bing Sun
  • Carole L Galligan
  • J D Burke
  • C L Galligan
  • Jae Kwang Yoo
  • Danlin Jia
  • Katherine A Siminovitch
  • E Baig
  • L C Platanias
  • Mona R Loutfy
  • Melissa M Brierley
  • J Masters
  • Renee W Y Chan
  • Ramtin Rahbar
  • J S Malik Peiris
  • John M Nicholls
  • Michael C W Chan
  • Darren P Baker
  • R Rahbar
  • T T Murooka
  • Suki M Y Lee
  • Ben Xuhao Wang
  • B Majchrzak-Kita
  • L M Pennell
  • Carl Virtanen
  • Dieu H Pham
  • Gabriella A Farcas
  • Mary Latchford
  • Elizabeth A LaMere
  • Patti Ferguson
  • Sarah Ward
  • Gary Levy
  • Margaret Chang
  • Hyoung Lho
  • Hassan Deif
  • Lawrence M Blatt
  • Kevin C Kain
  • Katharine A Siminovitch
  • Bryan Wolff
  • James W Dennis
  • Enoch K Y Lai
  • W Zeng
  • G McFadden
  • S Uddin
  • A A Hinek

Detail Information

Publications14

  1. pmc Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity
    Jae Kwang Yoo
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada
    J Exp Med 207:1435-51. 2010
    ..Collectively, our results identify and highlight the importance of LAPCs as immunomodulators of T2 immunity during influenza A virus infection...
  2. pmc Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling
    Danlin Jia
    Department of Immunology, University of Toronto, Toronto, Canada
    PLoS ONE 5:e13927. 2010
    ..The data suggest that NS1 can directly interfere with IFN signaling to enhance viral replication, but that treatment with IFN can nevertheless override these inhibitory effects to block H5N1 and H1N1 virus infections...
  3. pmc Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: implications for diagnosis and monitoring drug therapy
    Carole L Galligan
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 4:e6703. 2009
    ..Immune cell activation is a critical component therefore we examined the cellular activation of peripheral blood mononuclear cells (PBMCs) in the early stages of RA, in order to develop a novel diagnostic modality...
  4. doi request reprint The role of circulating fibrocytes in inflammation and autoimmunity
    Carole L Galligan
    University Health Network, 67 College St, Toronto, Ontario, Canada
    J Leukoc Biol 93:45-50. 2013
    ..Increased numbers of circulating fibrocytes are observed in RA, systemic scleroderma, and Graves' disease. Here, we review the current literature and potential involvement of fibrocytes in inflammation and autoimmunity...
  5. doi request reprint The X-files in immunity: sex-based differences predispose immune responses
    Eleanor N Fish
    Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Women s College Research Institute, Ontario, Canada
    Nat Rev Immunol 8:737-44. 2008
    ..It is crucial to address sex-based differences in disease pathogenesis and in the pharmacokinetics and pharmacodynamics of therapeutic medications to provide optimal disease management for both sexes...
  6. doi request reprint Interferon-beta is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis
    C L Galligan
    Toronto General Research Institute, University Health Network, Toronto, Canada
    Mult Scler 16:1458-73. 2010
    ..Interferon (IFN)-β is an effective therapy for relapsing-remitting multiple sclerosis, yet its mechanism of action remains ill-defined...
  7. ncbi request reprint Interferon-alpha/beta-receptor interactions: a complex story unfolding
    Raj Deonarain
    Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Curr Pharm Des 8:2131-7. 2002
    ..This review focuses on IFN-receptor interactions, the key residues involved in this interaction and the potential for targeted modifications of the ligand to enhance bioactivity...
  8. ncbi request reprint Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity
    C L Galligan
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Immun 8:480-91. 2007
    ..Signature RA FLS cell gene expression profiles may provide insights into disease pathogenesis and have utility in diagnosis, prognosis and drug responsiveness...
  9. ncbi request reprint Poxvirus infection rapidly activates tyrosine kinase signal transduction
    J Masters
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Canadian Blood Services Building, Toronto, Ontario M5G 2M1, Canada
    J Biol Chem 276:48371-5. 2001
    ..This provides a novel post-binding mechanism by which viruses can co-opt a cellular receptor to permit productive virus infection...
  10. pmc Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3
    J D Burke
    Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Canada
    J Virol 88:3485-95. 2014
    ....
  11. ncbi request reprint Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study
    Mona R Loutfy
    North York General Hospital, Toronto General Research Institute, Toronto, Ontario
    JAMA 290:3222-8. 2003
    ..Severe acute respiratory syndrome (SARS) is a new clinical entity for which no effective therapeutic strategy has been developed...
  12. ncbi request reprint Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry
    Melissa M Brierley
    Department of Immunology, University of Toronto, and Toronto General Research Institute, University Health Network, Toronto, Canada
    J Interferon Cytokine Res 22:835-45. 2002
    ..Although many of the literature findings are specific to defined cell systems or are tissue restricted, the intent of this review is to place these signaling cascades and their effectors in the context of distinct biologic outcomes...
  13. ncbi request reprint Antiviral strategies: the present and beyond
    J D Burke
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Canada
    Curr Mol Pharmacol 2:32-9. 2009
    ..Attention is focused on the potential use of interferons (IFN)-alpha/beta as broad spectrum antivirals in acute infections, to invoke both direct antiviral effects against viruses and activation of specific immune effector cells...
  14. pmc Fibrocyte activation in rheumatoid arthritis
    Carole L Galligan
    Toronto General Research Institute, University Health Network, 67 College Street, 4 424, Toronto, Ontario M5G 2M1, Canada
    Rheumatology (Oxford) 49:640-51. 2010
    ..Fibrocytes are multipotent circulating stem cells that may have a role in RA pathogenesis, perhaps as the precursors of the FLS cells, or by regulating FLS cell function...