E N Fish
Affiliation: University of Toronto
- The role of circulating fibrocytes in inflammation and autoimmunityCarole L Galligan
University Health Network, 67 College St, Toronto, Ontario, Canada
J Leukoc Biol 93:45-50. 2013..Increased numbers of circulating fibrocytes are observed in RA, systemic scleroderma, and Graves' disease. Here, we review the current literature and potential involvement of fibrocytes in inflammation and autoimmunity...
- The X-files in immunity: sex-based differences predispose immune responsesEleanor N Fish
Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Women s College Research Institute, Ontario, Canada
Nat Rev Immunol 8:737-44. 2008..It is crucial to address sex-based differences in disease pathogenesis and in the pharmacokinetics and pharmacodynamics of therapeutic medications to provide optimal disease management for both sexes...
- Interferon-alpha/beta-receptor interactions: a complex story unfoldingRaj Deonarain
Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Curr Pharm Des 8:2131-7. 2002..This review focuses on IFN-receptor interactions, the key residues involved in this interaction and the potential for targeted modifications of the ligand to enhance bioactivity...
- Interferon-beta is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitisC L Galligan
Toronto General Research Institute, University Health Network, Toronto, Canada
Mult Scler 16:1458-73. 2010..Interferon (IFN)-β is an effective therapy for relapsing-remitting multiple sclerosis, yet its mechanism of action remains ill-defined...
- Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitryMelissa M Brierley
Department of Immunology, University of Toronto, and Toronto General Research Institute, University Health Network, Toronto, Canada
J Interferon Cytokine Res 22:835-45. 2002..Although many of the literature findings are specific to defined cell systems or are tissue restricted, the intent of this review is to place these signaling cascades and their effectors in the context of distinct biologic outcomes...
- Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary studyMona R Loutfy
North York General Hospital, Toronto General Research Institute, Toronto, Ontario
JAMA 290:3222-8. 2003..These findings suggest that further investigation may be warranted to determine the role of interferon alfacon-1 as a therapeutic agent for the treatment of SARS...
- Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunityJae Kwang Yoo
Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada
J Exp Med 207:1435-51. 2010..Collectively, our results identify and highlight the importance of LAPCs as immunomodulators of T2 immunity during influenza A virus infection...
- Fibrocyte activation in rheumatoid arthritisCarole L Galligan
Toronto General Research Institute, University Health Network, 67 College Street, 4 424, Toronto, Ontario M5G 2M1, Canada
Rheumatology (Oxford) 49:640-51. 2010..Fibrocytes are multipotent circulating stem cells that may have a role in RA pathogenesis, perhaps as the precursors of the FLS cells, or by regulating FLS cell function...
- Antiviral strategies: the present and beyondJ D Burke
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Canada
Curr Mol Pharmacol 2:32-9. 2009..Attention is focused on the potential use of interferons (IFN)-alpha/beta as broad spectrum antivirals in acute infections, to invoke both direct antiviral effects against viruses and activation of specific immune effector cells...