Research Topics
Genomes and Genes | B B FinlaySummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Enteropathogenic E. coli exploitation of host epithelial cellsB B Finlay
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Ann N Y Acad Sci 797:26-31. 1996..Together these various bacterial molecules contribute to the intimate relationship that is formed by EPEC with host epithelial cells which results in A/E lesion formation and diarrhea...- Exploitation of mammalian host cell functions by bacterial pathogensB B Finlay
Biotechnology Laboratory, University of British Columbia, Vancouver, B C, Canada, V6T 1Z3
Science 276:718-25. 1997..Together these developments may lead to new therapeutic strategies... 
Common themes in microbial pathogenicity revisitedB B Finlay
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Microbiol Mol Biol Rev 61:136-69. 1997....- Enterohemorrhagic Escherichia coli O157:H7 produces Tir, which is translocated to the host cell membrane but is not tyrosine phosphorylatedR DeVinney
Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Infect Immun 67:2389-98. 1999..These findings highlight some of the differences and similarities between EHEC and EPEC virulence mechanisms, which can be exploited to further define the molecular basis of pedestal formation... - Enterohaemorrhagic and enteropathogenic Escherichia coli use a different Tir-based mechanism for pedestal formationR DeVinney
Biotechnology Laboratory, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Mol Microbiol 41:1445-58. 2001..These findings highlight differences in the mechanisms of pedestal formation by these closely related pathogens and indicate that EPEC and EHEC modulate different signalling pathways to affect the host actin cytoskeleton... - Locus of enterocyte effacement from Citrobacter rodentium: sequence analysis and evidence for horizontal transfer among attaching and effacing pathogensW Deng
Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
Infect Immun 69:6323-35. 2001..Our results indicate that the LEE has been acquired by C. rodentium and A/E E. coli strains independently during evolution... - Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathwaysJ Celli
Biotechnology Laboratory, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
EMBO J 20:1245-58. 2001..This constitutes a novel mechanism of phagocytosis avoidance by an extracellular pathogen... - Activation of Akt/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigDO Steele-Mortimer
Biotechnology Laboratory and Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 275:37718-24. 2000..SigD is also the first bacterial effector to be identified as an activator of Akt... - Characterization of Salmonella-induced filaments (Sifs) reveals a delayed interaction between Salmonella-containing vacuoles and late endocytic compartmentsJ H Brumell
Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T-1Z3, Canada
Traffic 2:643-53. 2001..Our findings demonstrate that Sif formation involves fusion of late endocytic compartments with the Salmonella-containing vacuole, and suggest that SifA modulates this event... - Pathogenic trickery: deception of host cell processesL A Knodler
Biotechnology Laboratory, Room 237-6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
Nat Rev Mol Cell Biol 2:578-88. 2001..These virulence factors often mimic host molecules, and mediate events as diverse as bacterial invasion, antiphagocytosis, and intracellular parastism... - Decreased apoptosis in the ileum and ileal Peyer's patches: a feature after infection with rabbit enteropathogenic Escherichia coli O103U Heczko
Biotechnology Laboratory and Departments of Microbiology and Immunology, Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
Infect Immun 69:4580-9. 2001..001). We concluded that REPEC O103 does not promote apoptosis. Furthermore, we cannot rule out the possibility that REPEC O103, in fact, decreases apoptotic levels in the rabbit ileum... - SifA permits survival and replication of Salmonella typhimurium in murine macrophagesJ H Brumell
Department of Biochemistry, University of British Columbia, Vancouver, Canada
Cell Microbiol 3:75-84. 2001..A family of SifA-related proteins and their importance to Salmonella pathogenesis is also discussed... - Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cellsS Gruenheid
Biotechnology Laboratory, University of British Columbia, 6174 University Boulevard, Vancouver V6T 1G3, Canada
Nat Cell Biol 3:856-9. 2001..Cells with null alleles of both mammalian Nck genes are resistant to the effects of EPEC on the actin cytoskeleton. These results implicate Nck adaptors as host-cell determinants of EPEC virulence... - Structural and biochemical characterization of the type III secretion chaperones CesT and SigEY Luo
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada
Nat Struct Biol 8:1031-6. 2001..Isothermal titration calorimetry studies of Tir-CesT and enzymatic activity profiles of SigD-SigE indicate that the effector proteins are not globally unfolded in the presence of their cognate chaperones... - Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C-gamma1B Kenny
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Infect Immun 65:2528-36. 1997..Inhibition of pedestal formation by tyrosine kinase inhibitors indicates an important role for tyrosine phosphorylation events during EPEC subversion of host processes... - Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestalsD L Goosney
Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Infect Immun 69:3315-22. 2001..These results demonstrate that although EPEC and EHEC recruit similar cytoskeletal proteins, there are also significant differences in pedestal composition... - Enteropathogenic Escherichia coli infection induces expression of the early growth response factor by activating mitogen-activated protein kinase cascades in epithelial cellsM de Grado
Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Infect Immun 69:6217-24. 2001..egr-1 is also induced during infection of mice by the A/E pathogen Citrobacter rodentium, suggesting that both Egr-1 and the activation of this mitogen-activated protein kinase signal transduction pathway may play a role in disease... - Salmonella interactions with host cells: in vitro to in vivoB B Finlay
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Philos Trans R Soc Lond B Biol Sci 355:623-31. 2000.... - Enteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitationD L Goosney
University of British Columbia, Vancouver, British Columbia, Canada
Emerg Infect Dis 5:216-23. 1999..We highlight recent advances in the pathogenesis of enteropathogenic Escherichia coli, Salmonella Typhimurium, and Shigella flexneri. Each illustrates how bacterial pathogens can exert dramatic effects on the host cytoskeleton... - Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretionA Abe
Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Mol Microbiol 33:1162-75. 1999..Collectively, these results indicate that CesT is a Tir chaperone that may act as an anti-degradation factor by specifically binding to its amino-terminus, forming a multimeric stabilized complex... - Bacterial pathogenesis: the answer to virulence is in the poreA Gauthier
Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Curr Biol 11:R264-7. 2001..Recent results suggest that Gram-positive pathogens may employ similar methods to deliver virulence factors into host cells... - Salmonella, the host and disease: a brief reviewBryan Coburn
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
Immunol Cell Biol 85:112-8. 2007..In this review, we explore some of the host and pathogenic mechanisms mobilized in the two predominant clinical syndromes associated with infection with Salmonella enterica species: enterocolitis and typhoid... - Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitisM Wlodarska
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
Infect Immun 79:1536-45. 2011..These results suggest that antibiotic perturbation of the microbiota can disrupt intestinal homeostasis and the integrity of intestinal defenses, which protect against invading pathogens and intestinal inflammation... 
Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal Paneth cell α-defensinsA Menendez
Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada
J Innate Immun 5:39-49. 2013....- Gene array technology to determine host responses to SalmonellaC M Rosenberger
Biotechnology Laboratory, Department of Microbiology and Immunology, 6174 University Boulevard, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Microbes Infect 3:1353-60. 2001..There is an exciting potential for the gene expression data generated in such studies to provide insights into host physiology, the pathophysiology of disease and novel therapeutics... - Microbial pathogenesis: new niches for salmonellaJ H Brumell
Biotechnology Laboratory and Department of Microbiology and Immunology, University of British Columbia, British Columbia, V6T-1Z3, Vancouver, Canada
Curr Biol 12:R15-7. 2002..Recent studies have shown that the fate of this vacuole is different in various cell types, and that the outcome of colonization is determined by both the infecting bacterium and defense mechanisms of the host cell... - Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cellsM A Stein
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Mol Microbiol 20:151-64. 1996..Collectively, these results suggest that sifA arose by horizontal gene transfer into Salmonella and its product is involved in a virulence-associated intracellular phenotype related to Salmonella-induced filament formation... - Salmonella invasion of nonphagocytic cells induces formation of macropinosomes in the host cellF Garcia-del Portillo
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Infect Immun 62:4641-5. 1994..These data suggest that massive uptake of extracellular fluid in S. typhimurium-infected epithelial cells is an event related to the invasion mechanisms used by this pathogen... - A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activationS L Marcus
Biotechnology Laboratory, University of British Columbia, Wesbrook Building 237, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
FEBS Lett 494:201-7. 2001..Thus, we have characterized a region near the carboxyl-terminus of SigD which is important for phosphatase activity. We discuss how dephosphorylation of inositol phospholipids by SigD in vivo might contribute to the activation of Akt... - Salmonella and apoptosis: to live or let die?L A Knodler
Biotechnology Laboratory and Department of Microbiology and Immunology, University of British Columbia, 237 6174 University Blvd, BC, Vancouver V6T 1Z3, Canada
Microbes Infect 3:1321-6. 2001..Here we describe the manipulation of apoptosis by Salmonella and discuss the advantages that such actions may confer to the bacteria, and its implications in resistance to disease... - Host immune response to antibiotic perturbation of the microbiotaM Wlodarska
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
Mucosal Immunol 3:100-3. 2010..Dysregulation of the homeostasis between mammals and their intestinal symbionts has been shown to predispose the host to enteric infection, and may lead to development of inflammatory bowel diseases... - Bacterial virulence strategies that utilize Rho GTPasesB B Finlay
Biotechnology Laboratory, University of British Columbia, Vancouver British Columbia, V6T 1Z3, Canada
Curr Top Microbiol Immunol 291:1-10. 2005..Collectively, these examples represent many key microbial virulence mechanisms that have led to a much deeper understanding of both microbial pathogens and GTPase functions... - Penetration of clinical isolates of Pseudomonas aeruginosa through MDCK epithelial cell monolayersY Hirakata
Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, Canada V5Z 4H4
J Infect Dis 181:765-9. 2000..This system is well suited for screening clinical isolates and their mutants for specific genes conferring the invasiveness phenotype... - Antigenic analysis of Bordetella pertussis filamentous hemagglutinin with phage display libraries and rabbit anti-filamentous hemagglutinin polyclonal antibodiesD R Wilson
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Infect Immun 66:4884-94. 1998..Leininger et al. (J. Infect. Dis. 175:1423-1431, 1997), peptides derived from residues of 1929 to 2019 of FHA are strong candidates for future protection studies... - The role of dynamin 3 in the testisK S Vaid
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
J Cell Physiol 210:644-54. 2007.... - Pathogens: bacterial needles ruled to length and specificityN A Thomas
The University of British Columbia, Biotechnology Laboratory, Vancouver, BC, Canada
Curr Biol 14:R192-4. 2004..The recent identification of a protein that functions as a 'molecular ruler' to determine the physical length of a bacterial extracellular needle advances our understanding of surface structure biogenesis... - Gut microbiology: fitting into the intestinal neighbourhoodB P Willing
Michael Smith Laboratories, University of British Columbia, 301 2185 East Mall, Michael Smith Building, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Curr Biol 19:R457-9. 2009..Microbes inhabiting the gut affect our health in profound and unexpected ways: new studies now show that these effects depend on synergistic and competitive interactions between the bacteria, which are influenced by diet... - Gut microbiota: metagenomics to study complex ecologyA Vacharaksa
The University of British Columbia, Michael Smith Laboratories, Vancouver, BC, Canada
Curr Biol 20:R569-71. 2010..The microbial community of the gastrointestinal tract is large and complex, making it difficult to study; the recent development of techniques for metagenomic analysis of gut microbiota should be a boon to the field... - Isolation and characterization of the aadA aminoglycoside-resistance gene from Salmonella choleraesuisK Y Leung
Department of Biochemistry, University of British Columbia, Vancouver, Canada
Mol Microbiol 6:2453-60. 1992..Southern hybridization analysis revealed that homologous aadA sequences were also present in other streptomycin-resistant Salmonella species...