B B Finlay

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Anti-immunology: evasion of the host immune system by bacterial and viral pathogens
    B Brett Finlay
    Michael Smith Laboratories, University of British Columbia, Vancouver, B C V6T 1Z4 Canada
    Cell 124:767-82. 2006
  2. ncbi request reprint Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection
    Mark E Wickham
    Michael Smith Laboratories, University of British Columbia, Vancouver BC, Canada
    J Infect Dis 194:819-27. 2006
  3. ncbi request reprint Host-microbe interactions: fulfilling a niche
    B Brett Finlay
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Cell Host Microbe 1:3-4. 2007
  4. pmc Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
    Ricarda Cortés-Vieyra
    Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico
    J Inflamm (Lond) 9:23. 2012
  5. doi request reprint Studying microbial pathogenesis and bacterial diseases. Interview by Hannah Branch
    B Brett Finlay
    Michael Smith Laboratories, Vancouver, BC, V6T 1Z4, Canada
    Future Microbiol 8:709-10. 2013
  6. pmc Repression of Salmonella enterica phoP expression by small molecules from physiological bile
    L Caetano M Antunes
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    J Bacteriol 194:2286-96. 2012
  7. pmc Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
    Kelly L Brown
    Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Transl Med 8:6. 2010
  8. pmc Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
    Mark E Wickham
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    BMC Infect Dis 7:65. 2007
  9. pmc Salmonella interactions with host cells: in vitro to in vivo
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Philos Trans R Soc Lond B Biol Sci 355:623-31. 2000
  10. pmc The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b
    Stephanie R Shames
    Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
    Infect Immun 79:4784-90. 2011

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint Anti-immunology: evasion of the host immune system by bacterial and viral pathogens
    B Brett Finlay
    Michael Smith Laboratories, University of British Columbia, Vancouver, B C V6T 1Z4 Canada
    Cell 124:767-82. 2006
    ..In this review, we highlight and compare some of the many molecular mechanisms that bacterial and viral pathogens use to evade host immune defenses...
  2. ncbi request reprint Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection
    Mark E Wickham
    Michael Smith Laboratories, University of British Columbia, Vancouver BC, Canada
    J Infect Dis 194:819-27. 2006
    ..The present study shows that virulence genes associated epidemiologically with outbreaks and HUS after non-O157 STEC infection are pivotal to the initiation, progression, and outcome of in vivo disease...
  3. ncbi request reprint Host-microbe interactions: fulfilling a niche
    B Brett Finlay
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Cell Host Microbe 1:3-4. 2007
    ....
  4. pmc Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
    Ricarda Cortés-Vieyra
    Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico
    J Inflamm (Lond) 9:23. 2012
    ..Also included is a brief overview on the importance of GSK3 in non-inflammatory processes during bacterial infection...
  5. doi request reprint Studying microbial pathogenesis and bacterial diseases. Interview by Hannah Branch
    B Brett Finlay
    Michael Smith Laboratories, Vancouver, BC, V6T 1Z4, Canada
    Future Microbiol 8:709-10. 2013
    ..BC, Canada), and is Director of the Severe Acute Respiratory Syndrome Accelerated Vaccine Initiative. He is also a valued member of several advisory and editorial boards, including that of Future Microbiology...
  6. pmc Repression of Salmonella enterica phoP expression by small molecules from physiological bile
    L Caetano M Antunes
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    J Bacteriol 194:2286-96. 2012
    ..Due to the critical role of phoP in Salmonella virulence, further studies in this area will likely reveal aspects of the interaction between Salmonella and bile that are relevant to disease...
  7. pmc Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
    Kelly L Brown
    Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Transl Med 8:6. 2010
    ..Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and the transcription factor NFkappaB for the rapid expression of immunity genes...
  8. pmc Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
    Mark E Wickham
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    BMC Infect Dis 7:65. 2007
    ..For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain...
  9. pmc Salmonella interactions with host cells: in vitro to in vivo
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Philos Trans R Soc Lond B Biol Sci 355:623-31. 2000
    ....
  10. pmc The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b
    Stephanie R Shames
    Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
    Infect Immun 79:4784-90. 2011
    ..The findings of this study together provide the first evidence that EspZ localizes to host mitochondria and that TIM17b contributes to protection against rapid cell death during EPEC infection...
  11. pmc Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG
    Philip R Hardwidge
    Michael Smith Laboratories, University of British Columbia, 301 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
    Infect Immun 73:2586-94. 2005
    ....
  12. pmc Type III secretion systems and disease
    Bryan Coburn
    Michael Smith Laboratories, UBC, 301 2185 East Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Clin Microbiol Rev 20:535-49. 2007
    ..Therefore, to facilitate patient care and improve outcomes, it is important to understand the T3SS-mediated virulence processes and to target T3SSs in therapeutic and prophylactic development efforts...
  13. ncbi request reprint Bacterial virulence strategies that utilize Rho GTPases
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver British Columbia, V6T 1Z3, Canada
    Curr Top Microbiol Immunol 291:1-10. 2005
    ..Collectively, these examples represent many key microbial virulence mechanisms that have led to a much deeper understanding of both microbial pathogens and GTPase functions...
  14. pmc Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium
    Bruce A Vallance
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada V6T 1Z3
    Infect Immun 71:3443-53. 2003
    ..rodentium infection of highly susceptible mouse strains. Determining the basis for these strains' susceptibility to intestinal colonization by an A/E pathogen will be the focus of future studies...
  15. ncbi request reprint Rapid response research to emerging infectious diseases: lessons from SARS
    B Brett Finlay
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Rev Microbiol 2:602-7. 2004
  16. ncbi request reprint Can innate immunity be enhanced to treat microbial infections?
    B Brett Finlay
    University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Rev Microbiol 2:497-504. 2004
  17. ncbi request reprint Bacterial avoidance of phagocytosis
    Jean Celli
    Biotechnology Laboratory, University of British Columbia, Room 237, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
    Trends Microbiol 10:232-7. 2002
    ..Recently, the molecular mechanisms of such antiphagocytic properties have been elucidated for some pathogens. Such mechanisms illustrate the diversity of mechanisms bacterial pathogens use to avoid phagocytic uptake...
  18. pmc Enterohemorrhagic Escherichia coli O157:H7 produces Tir, which is translocated to the host cell membrane but is not tyrosine phosphorylated
    R DeVinney
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Infect Immun 67:2389-98. 1999
    ..These findings highlight some of the differences and similarities between EHEC and EPEC virulence mechanisms, which can be exploited to further define the molecular basis of pedestal formation...
  19. ncbi request reprint Enteropathogenic E. coli exploitation of host epithelial cells
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Ann N Y Acad Sci 797:26-31. 1996
    ..Together these various bacterial molecules contribute to the intimate relationship that is formed by EPEC with host epithelial cells which results in A/E lesion formation and diarrhea...
  20. ncbi request reprint Enterohaemorrhagic and enteropathogenic Escherichia coli use a different Tir-based mechanism for pedestal formation
    R DeVinney
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Mol Microbiol 41:1445-58. 2001
    ..These findings highlight differences in the mechanisms of pedestal formation by these closely related pathogens and indicate that EPEC and EHEC modulate different signalling pathways to affect the host actin cytoskeleton...
  21. pmc Locus of enterocyte effacement from Citrobacter rodentium: sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens
    W Deng
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Infect Immun 69:6323-35. 2001
    ..Our results indicate that the LEE has been acquired by C. rodentium and A/E E. coli strains independently during evolution...
  22. pmc Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways
    J Celli
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    EMBO J 20:1245-58. 2001
    ..This constitutes a novel mechanism of phagocytosis avoidance by an extracellular pathogen...
  23. ncbi request reprint Characterization of Salmonella-induced filaments (Sifs) reveals a delayed interaction between Salmonella-containing vacuoles and late endocytic compartments
    J H Brumell
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T-1Z3, Canada
    Traffic 2:643-53. 2001
    ..Our findings demonstrate that Sif formation involves fusion of late endocytic compartments with the Salmonella-containing vacuole, and suggest that SifA modulates this event...
  24. ncbi request reprint Activation of Akt/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigD
    O Steele-Mortimer
    Biotechnology Laboratory and Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 275:37718-24. 2000
    ..SigD is also the first bacterial effector to be identified as an activator of Akt...
  25. ncbi request reprint Pathogenic trickery: deception of host cell processes
    L A Knodler
    Biotechnology Laboratory, Room 237-6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
    Nat Rev Mol Cell Biol 2:578-88. 2001
    ..These virulence factors often mimic host molecules, and mediate events as diverse as bacterial invasion, antiphagocytosis, and intracellular parastism...
  26. pmc Decreased apoptosis in the ileum and ileal Peyer's patches: a feature after infection with rabbit enteropathogenic Escherichia coli O103
    U Heczko
    Biotechnology Laboratory and Departments of Microbiology and Immunology, Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Infect Immun 69:4580-9. 2001
    ..001). We concluded that REPEC O103 does not promote apoptosis. Furthermore, we cannot rule out the possibility that REPEC O103, in fact, decreases apoptotic levels in the rabbit ileum...
  27. ncbi request reprint SifA permits survival and replication of Salmonella typhimurium in murine macrophages
    J H Brumell
    Department of Biochemistry, University of British Columbia, Vancouver, Canada
    Cell Microbiol 3:75-84. 2001
    ..A family of SifA-related proteins and their importance to Salmonella pathogenesis is also discussed...
  28. ncbi request reprint Structural and biochemical characterization of the type III secretion chaperones CesT and SigE
    Y Luo
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada
    Nat Struct Biol 8:1031-6. 2001
    ..Isothermal titration calorimetry studies of Tir-CesT and enzymatic activity profiles of SigD-SigE indicate that the effector proteins are not globally unfolded in the presence of their cognate chaperones...
  29. pmc Enteropathogenic Escherichia coli infection induces expression of the early growth response factor by activating mitogen-activated protein kinase cascades in epithelial cells
    M de Grado
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Infect Immun 69:6217-24. 2001
    ..egr-1 is also induced during infection of mice by the A/E pathogen Citrobacter rodentium, suggesting that both Egr-1 and the activation of this mitogen-activated protein kinase signal transduction pathway may play a role in disease...
  30. ncbi request reprint Exploitation of mammalian host cell functions by bacterial pathogens
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver, B C, Canada, V6T 1Z3
    Science 276:718-25. 1997
    ..Together these developments may lead to new therapeutic strategies...
  31. pmc Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C-gamma1
    B Kenny
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Infect Immun 65:2528-36. 1997
    ..Inhibition of pedestal formation by tyrosine kinase inhibitors indicates an important role for tyrosine phosphorylation events during EPEC subversion of host processes...
  32. pmc Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals
    D L Goosney
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Infect Immun 69:3315-22. 2001
    ..These results demonstrate that although EPEC and EHEC recruit similar cytoskeletal proteins, there are also significant differences in pedestal composition...
  33. ncbi request reprint Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells
    S Gruenheid
    Biotechnology Laboratory, University of British Columbia, 6174 University Boulevard, Vancouver V6T 1G3, Canada
    Nat Cell Biol 3:856-9. 2001
    ..Cells with null alleles of both mammalian Nck genes are resistant to the effects of EPEC on the actin cytoskeleton. These results implicate Nck adaptors as host-cell determinants of EPEC virulence...
  34. pmc Enteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitation
    D L Goosney
    University of British Columbia, Vancouver, British Columbia, Canada
    Emerg Infect Dis 5:216-23. 1999
    ..We highlight recent advances in the pathogenesis of enteropathogenic Escherichia coli, Salmonella Typhimurium, and Shigella flexneri. Each illustrates how bacterial pathogens can exert dramatic effects on the host cytoskeleton...
  35. ncbi request reprint Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion
    A Abe
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Mol Microbiol 33:1162-75. 1999
    ..Collectively, these results indicate that CesT is a Tir chaperone that may act as an anti-degradation factor by specifically binding to its amino-terminus, forming a multimeric stabilized complex...
  36. ncbi request reprint Salmonella, the host and disease: a brief review
    Bryan Coburn
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Immunol Cell Biol 85:112-8. 2007
    ..In this review, we explore some of the host and pathogenic mechanisms mobilized in the two predominant clinical syndromes associated with infection with Salmonella enterica species: enterocolitis and typhoid...
  37. pmc Dissecting virulence: systematic and functional analyses of a pathogenicity island
    Wanyin Deng
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 101:3597-602. 2004
    ..Our findings provide significant insights into bacterial virulence mechanisms and disease...
  38. pmc Common themes in microbial pathogenicity revisited
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Microbiol Mol Biol Rev 61:136-69. 1997
    ....
  39. ncbi request reprint Bacterial pathogenesis: the answer to virulence is in the pore
    A Gauthier
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Curr Biol 11:R264-7. 2001
    ..Recent results suggest that Gram-positive pathogens may employ similar methods to deliver virulence factors into host cells...
  40. pmc Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis
    M Wlodarska
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Infect Immun 79:1536-45. 2011
    ..These results suggest that antibiotic perturbation of the microbiota can disrupt intestinal homeostasis and the integrity of intestinal defenses, which protect against invading pathogens and intestinal inflammation...
  41. ncbi request reprint Microbial pathogenesis: new niches for salmonella
    J H Brumell
    Biotechnology Laboratory and Department of Microbiology and Immunology, University of British Columbia, British Columbia, V6T 1Z3, Vancouver, Canada
    Curr Biol 12:R15-7. 2002
    ..Recent studies have shown that the fate of this vacuole is different in various cell types, and that the outcome of colonization is determined by both the infecting bacterium and defense mechanisms of the host cell...
  42. ncbi request reprint Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE
    Mark E Wickham
    Michael Smith Laboratories, The University of British Columbia, 301 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
    Microbes Infect 9:400-7. 2007
    ..The induction of in vivo disease correlates strongly with the degree of colonisation, suggesting that the colonisation advantage type III secretion genes afford the bacteria, contribute to, and are required for, full virulence...
  43. ncbi request reprint Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses
    Brian K Coombes
    Michael Smith Laboratories, University of British Columbia, Vancouver, B C, V6T 1Z3, Canada
    Curr Biol 14:R856-67. 2004
    ..Here, we discuss how bacterial pathogens use an arsenal of secreted virulence proteins to modify the outcome of innate immune activation by altering how the immune system recognizes microbial invaders...
  44. doi request reprint Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal Paneth cell α-defensins
    A Menendez
    Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada
    J Innate Immun 5:39-49. 2013
    ....
  45. pmc Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice
    Mohammed A Khan
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia V6H 3V4, Canada
    Infect Immun 74:2522-36. 2006
    ....
  46. ncbi request reprint Gene array technology to determine host responses to Salmonella
    C M Rosenberger
    Biotechnology Laboratory, Department of Microbiology and Immunology, 6174 University Boulevard, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Microbes Infect 3:1353-60. 2001
    ..There is an exciting potential for the gene expression data generated in such studies to provide insights into host physiology, the pathophysiology of disease and novel therapeutics...
  47. ncbi request reprint Salmonella and apoptosis: to live or let die?
    L A Knodler
    Biotechnology Laboratory and Department of Microbiology and Immunology, University of British Columbia, 237 6174 University Blvd, BC, Vancouver V6T 1Z3, Canada
    Microbes Infect 3:1321-6. 2001
    ..Here we describe the manipulation of apoptosis by Salmonella and discuss the advantages that such actions may confer to the bacteria, and its implications in resistance to disease...
  48. ncbi request reprint Attaching and effacing pathogen-induced tight junction disruption in vivo
    Julian A Guttman
    The University of British Columbia, Michael Smith Laboratories, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Cell Microbiol 8:634-45. 2006
    ..These results suggest that the diarrhoea induced by A/E pathogens occurs as part of functional tight junction disruption...
  49. doi request reprint Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
    Guntram A Grassl
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 134:768-80. 2008
    ..Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis...
  50. ncbi request reprint Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map)
    Caixia Ma
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, BC, Canada
    Cell Microbiol 8:1669-86. 2006
    ..rodentium...
  51. pmc The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model
    Michelle L Zaharik
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3 Canada
    Infect Immun 72:5522-5. 2004
    ....
  52. ncbi request reprint Desmosomes are unaltered during infections by attaching and effacing pathogens
    Julian A Guttman
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Anat Rec (Hoboken) 290:199-205. 2007
    ..Our data suggest that, unlike tight junctions, the desmosome protein levels and localization, as well as desmosome morphology, are unaltered during A/E pathogenesis...
  53. ncbi request reprint Microbial pathogenesis and cytoskeletal function
    Samantha Gruenheid
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada V6T 1Z3
    Nature 422:775-81. 2003
    ..From the use of bacterial toxins to investigate Rho family GTPases to in vitro studies of actin polymerization using Listeria and Shigella, the study of pathogenesis has provided important tools to probe cytoskeletal function...
  54. ncbi request reprint Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice
    Wanyin Deng
    Biotechnology Laboratory, University of British Columbia, Room 237 Wesbrook Building, 6174 University Boulevard, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 48:95-115. 2003
    ..rodentium colonization of the mouse gut nor for inducing A/E lesions and colonic hyperplasia, thereby uncoupling colonization and disease from actin condensation for this A/E pathogen...
  55. pmc Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice
    Bruce A Vallance
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Infect Immun 70:6424-35. 2002
    ..rodentium infection. However, the selective expression of iNOS by uninfected but not infected cells suggests that this pathogen has developed mechanisms to locally limit its exposure to host-derived NO...
  56. ncbi request reprint Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens
    Carrie M Rosenberger
    Department of Microbiology and Immunology and Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
    Nat Rev Mol Cell Biol 4:385-96. 2003
    ..This review highlights recent advances in our understanding of the many interference strategies that are used by bacterial pathogens to undermine macrophage signalling...
  57. pmc Secretin of the enteropathogenic Escherichia coli type III secretion system requires components of the type III apparatus for assembly and localization
    Annick Gauthier
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada V6T 1Z3
    Infect Immun 71:3310-9. 2003
    ..These data indicate that, contrary to previous indications, correct insertion and function of EscC secretin in the outer membrane depends not only on the sec-dependent secretion pathway but also on other type III apparatus components...
  58. pmc Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target
    Roya Zoraghi
    Department of Medicine, Centre for High Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Antimicrob Agents Chemother 55:2042-53. 2011
    ....
  59. ncbi request reprint Current progress in enteropathogenic and enterohemorrhagic Escherichia coli vaccines
    Cathy Horne
    Biochemistry Labouratory, University of British Columbia, Vancouver, BC, Canada
    Expert Rev Vaccines 1:483-93. 2002
    ..Several lines of investigation indicate the feasibility of such strategies and justify further development of a vaccine targeting these significant intestinal pathogens...
  60. ncbi request reprint Bacterial pathogenesis: exploiting cellular adherence
    Erin C Boyle
    Department of Microbiology and Immunology, Biotechnology Laboratory, Wesbrook Building, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Curr Opin Cell Biol 15:633-9. 2003
    ..Recent studies have contributed to our understanding of bacterial adherence mechanisms and the consequences of receptor engagement; they have also highlighted alternative functions of cell adhesion molecules...
  61. pmc Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
    Kirk S B Bergstrom
    Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada
    PLoS Pathog 6:e1000902. 2010
    ..Such actions limit tissue damage and translocation of pathogenic and commensal bacteria across the epithelium...
  62. doi request reprint Proteomics as a probe of microbial pathogenesis and its molecular boundaries
    Amit P Bhavsar
    The University of British Columbia, Michael Smith Laboratories, 301 2185 East Mall Road, Vancouver, BC, V6T 1Z4, Canada
    Future Microbiol 5:253-65. 2010
    ..In addition, we will discuss areas where proteomics may help shape further investigation and discovery in this field...
  63. ncbi request reprint Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7
    Samantha Gruenheid
    Biotechnology Laboratory, University of British Columbia, Room 237, Wesbrook Building, 6174 University Boulevard, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 51:1233-49. 2004
    ..coli and Citrobacter rodentium, and was absent from non-pathogenic strains of E. coli and non-LEE-containing pathogens. NleA was determined to play a key role in virulence of C. rodentium in a mouse infection model...
  64. ncbi request reprint Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli
    Philip R Hardwidge
    Biotechnology Laboratory, University of British Columbia, Wesbrook Building, 6174 University Boulevard, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:20127-36. 2004
    ..These data provide a framework for future biochemical analyses of host-pathogen interactions...
  65. pmc Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes
    Michelle L Zaharik
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 99:15705-10. 2002
    ..This study demonstrates the presence of a previously undescribed direct influence of a mammalian innate host resistance locus on a pathogen at the genetic level...
  66. doi request reprint Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus
    Artem Cherkasov
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Proteome Res 10:1139-50. 2011
    ..Thus, this empirical MRSA-252 PIN provides a rich source for identifying critical proteins essential for network stability, many of which can be considered as prospective antimicrobial drug targets...
  67. pmc Salmonella invasion of nonphagocytic cells induces formation of macropinosomes in the host cell
    F Garcia-del Portillo
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Infect Immun 62:4641-5. 1994
    ..These data suggest that massive uptake of extracellular fluid in S. typhimurium-infected epithelial cells is an event related to the invasion mechanisms used by this pathogen...
  68. ncbi request reprint A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation
    S L Marcus
    Biotechnology Laboratory, University of British Columbia, Wesbrook Building 237, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
    FEBS Lett 494:201-7. 2001
    ..Thus, we have characterized a region near the carboxyl-terminus of SigD which is important for phosphatase activity. We discuss how dephosphorylation of inositol phospholipids by SigD in vivo might contribute to the activation of Akt...
  69. ncbi request reprint Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells
    M A Stein
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Mol Microbiol 20:151-64. 1996
    ..Collectively, these results suggest that sifA arose by horizontal gene transfer into Salmonella and its product is involved in a virulence-associated intracellular phenotype related to Salmonella-induced filament formation...
  70. doi request reprint Host immune response to antibiotic perturbation of the microbiota
    M Wlodarska
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    Mucosal Immunol 3:100-3. 2010
    ..Dysregulation of the homeostasis between mammals and their intestinal symbionts has been shown to predispose the host to enteric infection, and may lead to development of inflammatory bowel diseases...
  71. ncbi request reprint Virulence is positively selected by transmission success between mammalian hosts
    Mark E Wickham
    Michael Smith Laboratories, University of British Columbia, 301 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada
    Curr Biol 17:783-8. 2007
    ..These results directly demonstrate that virulence is selected via the fitness advantage it provides to the host-to-host cycle of pathogenic species...
  72. pmc Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo
    Julian A Guttman
    The University of British Columbia, Michael Smith Laboratories, and Department of Cellular and Physiological Sciences, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Infect Immun 74:6075-84. 2006
    ....
  73. doi request reprint Molecular mechanisms of Escherichia coli pathogenicity
    Matthew A Croxen
    Michael Smith Laboratories, The University of British Columbia, 301 2185 East Mall, Vancouver, British Columbia, V6T 1Z4, Canada
    Nat Rev Microbiol 8:26-38. 2010
    ..In this Review, we focus on the recent advances in our understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans...
  74. doi request reprint Quorum sensing in bacterial virulence
    L Caetano M Antunes
    Michael Smith Laboratories, The University of British Columbia, Vancouver, Canada
    Microbiology 156:2271-82. 2010
    ..We discuss some of the new strategies to combat bacterial virulence based on the inhibition of bacterial quorum sensing systems...
  75. ncbi request reprint Hierarchical delivery of an essential host colonization factor in enteropathogenic Escherichia coli
    Nikhil A Thomas
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Biol Chem 282:29634-45. 2007
    ..Collectively, the results suggest a coordinated mechanism involving both Tir and CesT for type III effector injection into host cells...
  76. pmc Role for CD2AP and other endocytosis-associated proteins in enteropathogenic Escherichia coli pedestal formation
    Julian A Guttman
    Michael Smith Laboratories, The University of British Columbia, Vancouver, Canada
    Infect Immun 78:3316-22. 2010
    ..This study further demonstrates that endocytic proteins are key components of EPEC pedestals and suggests a novel endocytosis subversion strategy employed by these extracellular bacteria...
  77. ncbi request reprint An anti-infective peptide that selectively modulates the innate immune response
    Monisha G Scott
    Inimex Pharmaceuticals Inc, 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2
    Nat Biotechnol 25:465-72. 2007
    ..To our knowledge, an innate defense regulator that counters infection by selective modulation of innate immunity without obvious toxicities has not been reported previously...
  78. pmc A comprehensive proteomic analysis of the type III secretome of Citrobacter rodentium
    Wanyin Deng
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    J Biol Chem 285:6790-800. 2010
    ....
  79. ncbi request reprint Insertion of the bacterial type III translocon: not your average needle stick
    Brian K Coombes
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Trends Microbiol 13:92-5. 2005
    ..New evidence suggests that membrane insertion of the bacterial type III apparatus might turn on a calcium-dependent signaling pathway resulting in phagolysosomal fusion...
  80. ncbi request reprint Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems
    Leigh A Knodler
    Biotechnology Laboratory, Room 237, 6174 University Blvd, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 43:1089-103. 2002
    ..Thus, we demonstrate a functional and regulatory cross-talk between three chromosomal PAIs, SPI-1, SPI-2 and SPI-5, which has significant implications for the evolution and role of PAIs in bacterial pathogenesis...
  81. ncbi request reprint Delivery of dangerous goods: type III secretion in enteric pathogens
    Michelle L Zaharik
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Int J Med Microbiol 291:593-603. 2002
    ..The following is a brief review of the way in which TTSSs and their effectors contribute to the pathogenic nature of the prototypic diarrheal pathogens Salmonella, Shigella, Yersinia and enteropathogenic Escherichia coli (EPEC)...
  82. ncbi request reprint SifA, a type III secreted effector of Salmonella typhimurium, directs Salmonella-induced filament (Sif) formation along microtubules
    John H Brumell
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Traffic 3:407-15. 2002
    ..Our findings demonstrate the essential role of microtubule dynamics in the formation of Sifs and the utility of this epitope tagging strategy for the study of bacterial type III secreted proteins...
  83. pmc Disruption of the Salmonella-containing vacuole leads to increased replication of Salmonella enterica serovar typhimurium in the cytosol of epithelial cells
    John H Brumell
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Infect Immun 70:3264-70. 2002
    ..Our findings demonstrate the requirement of the host cell endosomal system for maintenance of the SCV and that loss of this compartment allows increased replication of serovar Typhimurium in the cytosol of epithelial cells...
  84. ncbi request reprint Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes
    Leigh A Knodler
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada
    Mol Microbiol 49:685-704. 2003
    ..The enrichment of Salmonella effectors in DRMs on these intracellular membranes probably permits specific interactions with host cell molecules that are concentrated in these signalling platforms...
  85. pmc Helicobacter pylori infection targets adherens junction regulatory proteins and results in increased rates of migration in human gastric epithelial cells
    Victoria S Conlin
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B C V6T 1Z3, Canada
    Infect Immun 72:5181-92. 2004
    ..These data indicate that destabilizing epithelial cell adherence is one of the factors increasing the risk of H. pylori-infected individuals developing gastric cancer...
  86. pmc Translocated intimin receptor and its chaperone interact with ATPase of the type III secretion apparatus of enteropathogenic Escherichia coli
    Annick Gauthier
    Biotechnology Laboratory and Department of Biochemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Bacteriol 185:6747-55. 2003
    ....
  87. pmc SseK1 and SseK2 are novel translocated proteins of Salmonella enterica serovar typhimurium
    Sonya L Kujat Choy
    Biotechnology Laboratory, University of British Columbia, Room 237, Wesbrook Building, 6174 University Blvd, Vancouver, BC, Canada V6T 1Z3
    Infect Immun 72:5115-25. 2004
    ..In summary, this work demonstrates that SseK1 and SseK2 are novel translocated proteins of serovar Typhimurium...
  88. pmc Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens
    Wanyin Deng
    Michael Smith Laboratories, University of British Columbia, 301 2185, East Mall, Vancouver, British Columbia V6T 1Z4, Canada
    Infect Immun 73:2135-46. 2005
    ....
  89. ncbi request reprint CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli
    Nikhil A Thomas
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Mol Microbiol 57:1762-79. 2005
    ..These findings indicate that CesT is centrally involved in recruiting multiple type III effectors to the T3SS via EscN for efficient secretion, and functionally redefine the role of CesT in multiple type III effector interactions...
  90. ncbi request reprint Interpreting the host-pathogen dialogue through microarrays
    Brian K Coombes
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Adv Appl Microbiol 54:291-331. 2004
  91. pmc Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli
    Annick Gauthier
    Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
    Antimicrob Agents Chemother 49:4101-9. 2005
    ..Overall, we have identified a class of compounds that can be used as a tool to probe the mechanism(s) that regulates virulence gene expression in EPEC...
  92. pmc Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid
    Brian K Coombes
    Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Proc Natl Acad Sci U S A 102:17460-5. 2005
    ..These data suggest that overexpression of virulence-associated type III secretion genes can have an adverse effect on bacterial pathogenesis in vivo...
  93. pmc Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine
    Nat F Brown
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Pathog 1:e32. 2005
    ..This induction of expression precedes any documented SPI-2-dependent phases of typhoid and may be involved in preparing Salmonella to successfully resist the antimicrobial environment encountered within macrophages...
  94. ncbi request reprint Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens
    Julian A Guttman
    The University of British Columbia, Michael Smith Laboratories, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Cell Microbiol 9:131-41. 2007
    ..The altered localization of AQPs is partially dependent on the bacterial type III effector proteins EspF and EspG. We conclude that altered AQP localization may be a contributing factor to diarrhoea during bacterial infection...
  95. ncbi request reprint Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 87:641-50. 2006
    ..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection...
  96. ncbi request reprint The temperature-sensing protein TlpA is repressed by PhoP and dispensable for virulence of Salmonella enterica serovar Typhimurium in mice
    Ohad Gal-Mor
    Michael Smith Laboratories, University of British Columbia, Room 301, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
    Microbes Infect 8:2154-62. 2006
    ..Cumulatively, our data do not support the previous hypothesis that TlpA plays a role in the pathogenicity of Salmonella per se, but may suggest an alternative function for TlpA unrelated to host infection...
  97. doi request reprint Gut microbiology: fitting into the intestinal neighbourhood
    B P Willing
    Michael Smith Laboratories, University of British Columbia, 301 2185 East Mall, Michael Smith Building, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Curr Biol 19:R457-9. 2009
    ..Microbes inhabiting the gut affect our health in profound and unexpected ways: new studies now show that these effects depend on synergistic and competitive interactions between the bacteria, which are influenced by diet...
  98. pmc Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein
    S D Mills
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3 Canada
    Proc Natl Acad Sci U S A 94:12638-43. 1997
    ..This indicates possible similarities between the strategies used by pathogenic bacteria to elicit programmed cell death in both plant and animal hosts...
  99. ncbi request reprint Penetration of clinical isolates of Pseudomonas aeruginosa through MDCK epithelial cell monolayers
    Y Hirakata
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, Canada V5Z 4H4
    J Infect Dis 181:765-9. 2000
    ..This system is well suited for screening clinical isolates and their mutants for specific genes conferring the invasiveness phenotype...
  100. doi request reprint Lack of functional P-selectin ligand exacerbates Salmonella serovar typhimurium infection
    Winnie W S Kum
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 182:6550-61. 2009
    ....
  101. ncbi request reprint Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL
    Brian K Coombes
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:49804-15. 2004
    ..These data also suggest the existence of a previously unrecognized regulatory element within SPI-2 for the "effector operon" region downstream of sseD that might demarcate the expression of translocators and effectors...