Carlos Fernandez-Patron

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. doi request reprint Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 54:575-82. 2009
  2. doi request reprint MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE
    Jeffrey Odenbach
    Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 57:123-30. 2011
  3. ncbi request reprint Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway
    Li Hao
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circ Res 94:68-76. 2004
  4. doi request reprint Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis
    Prabhakara Reddy Nagareddy
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada T6G 2H7
    Cardiovasc Res 84:368-77. 2009
  5. doi request reprint Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circulation 119:2480-9. 2009
  6. doi request reprint Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart
    Xiang Wang
    From the Departments of Biochemistry X W, E B, S H A, C F P and Physiology A T, Z K, Mazankowski Alberta Heart Institute Z K, C F P, Cardiovascular Research Group Z K, C F P, and Faculty of Medicine and Dentistry X W, E B, S H A, C F P, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 65:882-8. 2015
  7. doi request reprint Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease
    Evan Berry
    Department of Biochemistry, School of Translational Medicine, University of Alberta, Edmonton, Alta, Canada
    J Vasc Res 50:52-68. 2013
  8. doi request reprint Mitochondrial dysfunction in the hypertensive rat brain: respiratory complexes exhibit assembly defects in hypertension
    Ana Lopez-Campistrous
    Department of Biochemistry, Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 51:412-9. 2008
  9. doi request reprint MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    FEBS Lett 589:490-6. 2015
  10. ncbi request reprint Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: a convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?
    Carlos Fernandez-Patron
    Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada
    Can J Physiol Pharmacol 85:97-104. 2007

Collaborators

  • Zamaneh Kassiri
  • Wang Zheng
  • Liang Li
  • Richard Schulz
  • John H McNeill
  • Fan Zhang
  • Dawei Zhang
  • Xiang Wang
  • Li Hao
  • Ana Lopez-Campistrous
  • Evan Berry
  • Jeffrey Odenbach
  • Tatsujiro Oka
  • Fung Lan Chow
  • Samuel Hernandez-Anzaldo
  • Stephan Cooper
  • Prabhakara Reddy Nagareddy
  • Gary D Lopaschuk
  • Tamiko Nishimura
  • Difei Sun
  • Abhijit Takawale
  • Ayinuer Adijiang
  • Ana Maria Bosonea
  • Gary Lopaschuk
  • Kathleen M Macleod
  • Barry A Finegan
  • Fung L Chow
  • Stephan B Cooper
  • Jeff Odenbach
  • Sandra Kelly
  • Paul Semchuk
  • Dong Ton
  • Michael J Ellison
  • Wang Xiang
  • Joerg Sander
  • Hua Wo
  • Min Du

Detail Information

Publications13

  1. doi request reprint Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 54:575-82. 2009
    ..Targeting TACE has potential therapeutic importance for modulating agonist-induced cardiac remodeling...
  2. doi request reprint MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE
    Jeffrey Odenbach
    Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 57:123-30. 2011
    ..This suggests a functional specialization of MMP-2 in agonist-induced cardiovascular disease development that has potential implications for the design of metalloproteinase-based therapeutic strategies...
  3. ncbi request reprint Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway
    Li Hao
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circ Res 94:68-76. 2004
    ..Because this mechanism is triggered by agonists typically overexpressed in hypertension, its blockade may have therapeutic potential for simultaneously inhibiting pathological vasoconstriction and growth in hypertensive disorders...
  4. doi request reprint Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis
    Prabhakara Reddy Nagareddy
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada T6G 2H7
    Cardiovasc Res 84:368-77. 2009
    ..In the present study, we examined whether MMP modulation of vascular tone involves phosphoinositide 3-kinase (PI3K) and mitochondrial ATP synthesis...
  5. doi request reprint Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circulation 119:2480-9. 2009
    ..Here, we report that matrix metalloproteinase-7 (MMP-7) and a disintegrin and metalloproteinase-12 (ADAM-12) form a novel signaling axis in these processes...
  6. doi request reprint Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart
    Xiang Wang
    From the Departments of Biochemistry X W, E B, S H A, C F P and Physiology A T, Z K, Mazankowski Alberta Heart Institute Z K, C F P, Cardiovascular Research Group Z K, C F P, and Faculty of Medicine and Dentistry X W, E B, S H A, C F P, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 65:882-8. 2015
    ..This complex phenotype is, at least in part, because of the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway being upregulated in MMP-2 deficiency. ..
  7. doi request reprint Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease
    Evan Berry
    Department of Biochemistry, School of Translational Medicine, University of Alberta, Edmonton, Alta, Canada
    J Vasc Res 50:52-68. 2013
    ..The emerging links between metalloproteinases and lipids are intriguing and suggest new therapeutic targets in hypertensive cardiac disease...
  8. doi request reprint Mitochondrial dysfunction in the hypertensive rat brain: respiratory complexes exhibit assembly defects in hypertension
    Ana Lopez-Campistrous
    Department of Biochemistry, Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 51:412-9. 2008
    ..This mitochondrial dysfunction localizes to the brain stem and is, therefore, likely to contribute to the development, as well as to pathophysiological complications, of hypertension...
  9. doi request reprint MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    FEBS Lett 589:490-6. 2015
    ..Furthermore, MMP-2 overexpression renders Hepa1-c1c7 cells resistant to PCSK9-induced LDLR degradation. The data suggest that pathological MMP-2 overexpression may protect the LDLR from PCSK-9-induced degradation. ..
  10. ncbi request reprint Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: a convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?
    Carlos Fernandez-Patron
    Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada
    Can J Physiol Pharmacol 85:97-104. 2007
    ..If this hypothesis is proven generally correct, then transactivation blockers have general therapeutic potential in hypertension regardless of the causative agonist...
  11. ncbi request reprint Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species
    Li Hao
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Arterioscler Thromb Vasc Biol 26:819-25. 2006
    ..Focusing on adrenoceptors, we examined whether the MMP-dependent signaling pathway depends on reactive oxygen species (ROS)...
  12. doi request reprint Proteomic analysis of brain mitochondrial proteome and mitochondrial complexes
    Ana Lopez-Campistrous
    Department of Biochemistry, Institute for Biomolecular Design, University of Alberta, Edmonton, AB, Canada
    Methods Mol Biol 1005:129-41. 2013
    ..This approach allows for a comprehensive identification of mitochondrial proteomic differences between health and disease conditions...
  13. pmc A novel PKD2L1 C-terminal domain critical for trimerization and channel function
    Wang Zheng
    Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, T6G 2H7, Edmonton, AB, Canada
    Sci Rep 5:9460. 2015
    ..Thus, our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. ..