Niall D Ferguson

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Acute respiratory distress syndrome 40 years later: time to revisit its definition
    Jason Phua
    University of Toronto, Interdepartmental Division of Critical Care Medicine, Toronto, Ontario, Canada
    Crit Care Med 36:2912-21. 2008
  2. ncbi request reprint Optimizing sedative use in the intensive care unit
    Niall D Ferguson
    Department of Medicine, Division of Respirology, Critical Care Medicine Program, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, M5G 1X5, Canada
    Intensive Care Med 28:44-7. 2002
  3. ncbi request reprint Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial
    Niall D Ferguson
    Division of Respirology, Department of Medicine, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Intensive Care Med 30:1111-6. 2004
  4. ncbi request reprint Development of a clinical definition for acute respiratory distress syndrome using the Delphi technique
    Niall D Ferguson
    Interdepartmental Division of Critical Care, University of Toronto, ON, Canada
    J Crit Care 20:147-54. 2005
  5. ncbi request reprint A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion
    Henry E Fessler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, USA
    Crit Care Med 35:1649-54. 2007
  6. ncbi request reprint The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, 600 University Avenue, Suite 18 206, Toronto, ON M5G 1X5, Canada
    Intensive Care Med 38:1573-82. 2012
  7. pmc Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, 399 Bathurst Street, F2 150, Toronto, Ontario M5T 2S8, Canada
    Crit Care 11:R96. 2007
  8. ncbi request reprint Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
  9. doi request reprint High-frequency oscillation in early acute respiratory distress syndrome
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    N Engl J Med 368:795-805. 2013
  10. doi request reprint Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, The University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:256-61. 2013

Detail Information

Publications56

  1. doi request reprint Acute respiratory distress syndrome 40 years later: time to revisit its definition
    Jason Phua
    University of Toronto, Interdepartmental Division of Critical Care Medicine, Toronto, Ontario, Canada
    Crit Care Med 36:2912-21. 2008
    ..The aim of this article is to critically evaluate the definition of acute respiratory distress syndrome and examine the impact the definition has on clinical practice and research...
  2. ncbi request reprint Optimizing sedative use in the intensive care unit
    Niall D Ferguson
    Department of Medicine, Division of Respirology, Critical Care Medicine Program, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, M5G 1X5, Canada
    Intensive Care Med 28:44-7. 2002
  3. ncbi request reprint Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial
    Niall D Ferguson
    Division of Respirology, Department of Medicine, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Intensive Care Med 30:1111-6. 2004
    ....
  4. ncbi request reprint Development of a clinical definition for acute respiratory distress syndrome using the Delphi technique
    Niall D Ferguson
    Interdepartmental Division of Critical Care, University of Toronto, ON, Canada
    J Crit Care 20:147-54. 2005
    ..The objective of this study is to describe the implementation of formal consensus techniques in the development of a clinical definition for acute respiratory distress syndrome...
  5. ncbi request reprint A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion
    Henry E Fessler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, USA
    Crit Care Med 35:1649-54. 2007
    ..We provide guidelines for HFO in adults with acute respiratory distress syndrome that should optimize the lung-protective characteristics of this ventilation mode...
  6. ncbi request reprint The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, 600 University Avenue, Suite 18 206, Toronto, ON M5G 1X5, Canada
    Intensive Care Med 38:1573-82. 2012
    ..Our objective was to revise the definition of acute respiratory distress syndrome (ARDS) using a conceptual model incorporating reliability and validity, and a novel iterative approach with formal evaluation of the definition...
  7. pmc Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, 399 Bathurst Street, F2 150, Toronto, Ontario M5T 2S8, Canada
    Crit Care 11:R96. 2007
    ....
  8. ncbi request reprint Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
    ..To examine the attitudes and preferences of surrogate decision makers (SDMs) regarding their involvement in the consent to research process for ICU patients...
  9. doi request reprint High-frequency oscillation in early acute respiratory distress syndrome
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    N Engl J Med 368:795-805. 2013
    ....
  10. doi request reprint Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, The University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:256-61. 2013
    ..Outcome measures that integrate mortality and morbidity, like quality-adjusted life years (QALYs), have been proposed for critical care clinical trials...
  11. ncbi request reprint Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: the Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study
    Niall D Ferguson
    Department of Medicine, Division of Respirology, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Crit Care Med 33:479-86. 2005
    ..To determine the safety, feasibility, and lung-recruitment efficacy of an explicit ventilation protocol combining high-frequency oscillatory ventilation and recruitment maneuvers...
  12. doi request reprint Recruitment maneuvers for acute lung injury: a systematic review
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 178:1156-63. 2008
    ..There are conflicting data regarding the safety and efficacy of recruitment maneuvers (RMs) in patients with acute lung injury (ALI)...
  13. doi request reprint High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome
    Sachin Sud
    Division of Critical Care, Department of Medicine, Trillium Health Center, University of Toronto, Mississauga, Canada
    Cochrane Database Syst Rev 2:CD004085. 2013
    ..This review was originally published in 2004 and was updated in 2011...
  14. doi request reprint Complications from recruitment maneuvers in patients with acute lung injury: secondary analysis from the lung open ventilation study
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Respir Care 57:1842-9. 2012
    ..There are limited data on the safety and efficacy of recruitment maneuvers (RMs) in acute lung injury (ALI) patients...
  15. doi request reprint High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
    Sachin Sud
    Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
    BMJ 340:c2327. 2010
    ..To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS)...
  16. ncbi request reprint Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine and the Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 33:2228-34. 2005
    ..A second objective was to determine the accuracy of clinical diagnoses of ARDS made in daily practice...
  17. doi request reprint High-frequency oscillation in adults: a utilization review
    Neill K J Adhikari
    Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Crit Care Med 39:2631-44. 2011
    ..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes...
  18. doi request reprint Ventilation practices and critical events during transport of ventilated patients outside of hospital: a retrospective cohort study
    Jeffrey M Singh
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Prehosp Emerg Care 13:316-23. 2009
    ..We set out to describe ventilation practice, the use of lung-protective ventilation strategies, administration of sedation and neuromuscular blockade, and related critical events during out-of-hospital transport of ventilated patients...
  19. doi request reprint Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review
    Jason Phua
    F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
    Am J Respir Crit Care Med 179:220-7. 2009
    ..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing...
  20. pmc Is it time to increase the frequency of use of high-frequency oscillatory ventilation?
    Jeffrey M Singh
    Interdepartmental Division of Critical Care Medicine, and Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Crit Care 9:339-40. 2005
    ..This editorial attempts to put these results in context with previous work and highlights challenges to be addressed in future studies...
  21. doi request reprint Utility of draining pleural effusions in mechanically ventilated patients
    Ewan C Goligher
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    Curr Opin Pulm Med 18:359-65. 2012
    ..It is controversial whether patients benefit from pleural drainage in terms of either physiological or clinical outcomes...
  22. doi request reprint Patients' preferences for enrolment into critical-care trials
    Damon C Scales
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 35:1703-12. 2009
    ..Most critically ill patients are incapable of providing informed consent for research...
  23. ncbi request reprint Point: High-frequency ventilation is the optimal physiological approach to ventilate ARDS patients
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    J Appl Physiol 104:1230-1. 2008
  24. ncbi request reprint High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome
    Niall D Ferguson
    Department of Medicine, Division of Respirology, Critical Care Medicine Program, Mount Sinai Hospital, 600 University Avenue, University of Toronto, Toronto, Ontario, Canada
    Intensive Care Med 28:1073-7. 2002
    ..In addition, to examine the effects of clinical variables on the presence of a high PAWP (>18 mmHg) and the effect of an elevated PAWP on mortality...
  25. pmc Outcomes of interfacility critical care adult patient transport: a systematic review
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, University of Toronto, 399 Bathurst Street, F2 150, Toronto, Ontario, M5T 2S8, Canada
    Crit Care 10:R6. 2006
    ..We aimed to determine the adverse events and important prognostic factors associated with interfacility transport of intubated and mechanically ventilated adult patients...
  26. doi request reprint Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial
    Orla M Smith
    Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Crit Care 28:28-39. 2013
    ..Successful completion of randomized trials depends upon efficiently and ethically screening patients and obtaining informed consent. Awareness of modifiable barriers to obtaining consent may inform ongoing and future trials...
  27. pmc Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis
    Ewan C Goligher
    Interdepartmental Division of Critical Care, Mount Sinai Hospital and the University Health Network, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Crit Care 15:R46. 2011
    ..Pleural effusions are frequently drained in mechanically ventilated patients but the benefits and risks of this procedure are not well established...
  28. pmc Year in review 2006: Critical Care--Respirology
    Daniela Vasquez
    Interdepartmental Division of Critical Care Medicine, University of Toronto, and University Health Network, Toronto, Ontario, Canada
    Crit Care 11:224. 2007
    ....
  29. ncbi request reprint Mechanical ventilation: epidemiological insights into current practices
    Ewan Goligher
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 15:44-51. 2009
    ..To describe the trends in the results of epidemiological studies of mechanical ventilation...
  30. ncbi request reprint Lung-protective ventilation in neurosurgical patients
    Gregory J Lowe
    Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, Toronto, Canada
    Curr Opin Crit Care 12:3-7. 2006
    ..The extension of these principles to patients with brain injuries is challenging, as many of them are out of keeping with usual brain-protective management...
  31. ncbi request reprint Nursing and infection-control issues during high-frequency oscillatory ventilation
    Anne Marie Sweeney
    Toronto Western Hospital, University Health Network, Canada
    Crit Care Med 33:S204-8. 2005
    ..To review the specific nursing and infection-control issues that arise during the care of patients receiving high-frequency oscillatory ventilation (HFOV)...
  32. doi request reprint Corticosteroid use in the intensive care unit: a survey of intensivists
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Can J Anaesth 60:652-9. 2013
    ..The efficacy of systemic corticosteroids in many critical illnesses remains uncertain. Our primary objective was to survey intensivists in North America about their perceived use of corticosteroids in clinical practice...
  33. doi request reprint Prophylactic magnesium for improving neurologic outcome after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis
    Eyal Golan
    Department of Medicine, University Health Network, Toronto, Ontario, Canada M5T 2S8
    J Crit Care 28:173-81. 2013
    ..Neurologic disability is common after aneurysmal subarachnoid hemorrhage (aSAH). Our objective was to systematically review the prophylactic use of magnesium to improve neurologic outcomes in these patients...
  34. ncbi request reprint Core competency in mechanical ventilation: development of educational objectives using the Delphi technique
    Ewan C Goligher
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Crit Care Med 40:2828-32. 2012
    ..We sought to identify and standardize the core clinical knowledge and skills required to care for patients receiving mechanical ventilation...
  35. ncbi request reprint New therapies for adults with acute lung injury. High-frequency oscillatory ventilation
    Niall D Ferguson
    Department of Medicine, Division of Respirology, Critical Care Medicine Programme, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Clin 18:91-106. 2002
    ..Future research may define the role of HFOV as a more routine strategy for preventing VALI in this patient population...
  36. doi request reprint Prolonged time to alarm in infusion devices operated at low flow rates
    Roy Ilan
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Crit Care Med 36:2763-5. 2008
    ..To evaluate the time to occlusion alarm for peristaltic infusion devices used in Toronto adult critical care units...
  37. doi request reprint Better infrastructure for critical care trials: nomenclature, etymology, and informatics
    Jeffrey M Singh
    Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, Toronto, ON, Canada
    Crit Care Med 37:S173-7. 2009
    ....
  38. doi request reprint Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute respiratory distress syndrome
    Imelda M Galvin
    Queen s University, Kingston
    Cochrane Database Syst Rev 7:CD003707. 2013
    ..Although PLV has been shown to improve gas exchange and to reduce inflammation in experimental models of ALI, a previous systematic review did not find any evidence to support or refute its use in humans with ALI and ARDS...
  39. ncbi request reprint Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Madrid, Spain
    Crit Care Med 35:1284-9. 2007
    ..To describe the outcome of patients with sepsis according to location on a ward or in an intensive care unit...
  40. ncbi request reprint Evolution of mechanical ventilation in response to clinical research
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
    Am J Respir Crit Care Med 177:170-7. 2008
    ..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...
  41. ncbi request reprint One for all, and all for one? The globalization of critical care
    Eddy Fan
    Crit Care Med 36:2942-3. 2008
  42. ncbi request reprint Epidemiology of acute lung injury and acute respiratory distress syndrome
    Fernando Frutos-Vivar
    Intensive Care Unit, Hospital Universitario de Getafe, Madrid, Spain
    Semin Respir Crit Care Med 27:327-36. 2006
    ..Also discussed are the myriad causes of ARDS, incidence, epidemiology, mortality, and factors that influence outcome...
  43. ncbi request reprint SOAP and sepsis--analyzing what comes out in the wash
    Warren L Lee
    Crit Care Med 34:552-4. 2006
  44. ncbi request reprint Tracheostomy for ventilated patients--not when, but in whom?
    Niall D Ferguson
    Crit Care Med 33:2695-6. 2005
  45. ncbi request reprint "Stop right there...I gotta know right now!" Do steroids really help for CAP?
    Damon C Scales
    Am J Respir Crit Care Med 172:643-4; author reply 644-5. 2005
  46. pmc Pro/con clinical debate: tracheostomy is ideal for withdrawal of mechanical ventilation in severe neurological impairment
    Luciana Mascia
    Crit Care 8:327-30. 2004
    ..In this issue of Critical Care two groups debate the merits of tracheostomy before extubation in a patient with neurological impairment. What becomes very clear is the need for more high quality data for this common clinical problem...
  47. ncbi request reprint Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings
    Andres Esteban
    Hospital Universitario de Getafe, Madrid, Spain
    Ann Intern Med 141:440-5. 2004
    ..The American-European Consensus Conference definition for the acute respiratory distress syndrome (ARDS) has never been validated...
  48. ncbi request reprint Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome
    Niall D Ferguson
    Hospital Universitario de Getafe, Madrid, Spain
    Crit Care Med 33:21-30. 2005
    ....
  49. ncbi request reprint Tracheostomy: it's time to move from art to science
    Damon C Scales
    Crit Care Med 34:3039-40. 2006
  50. ncbi request reprint Risk factors for extubation failure in patients following a successful spontaneous breathing trial
    Fernando Frutos-Vivar
    Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
    Chest 130:1664-71. 2006
    ..To assess the factors associated with reintubation in patients who had successfully passed a spontaneous breathing trial...
  51. pmc Inhaled nitric oxide for acute respiratory distress syndrome
    Niall D Ferguson
    BMJ 334:757-8. 2007
  52. ncbi request reprint High-frequency oscillation: how high should we go?
    Lorenzo Del Sorbo
    Crit Care Med 35:1623-4. 2007
  53. ncbi request reprint Understanding high-frequency oscillation: lessons from the animal kingdom
    Niall D Ferguson
    Intensive Care Med 33:1316-8. 2007
  54. ncbi request reprint Ventilator-induced lung injury: another sign of aging?
    Joan R Badia
    Intensive Care Med 34:796-9. 2008
  55. doi request reprint Effect of a nursing-implemented sedation protocol on weaning outcome
    Susana Arias-Rivera
    Intensive Care Unit and Burn Unit, Hospital Universitario de Getafe, Madrid, Spain
    Crit Care Med 36:2054-60. 2008
    ..To evaluate the effect of the implementation of a nursing-driven protocol of sedation on duration of intubation...
  56. ncbi request reprint Noninvasive positive-pressure ventilation for respiratory failure after extubation
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Madrid, Spain
    N Engl J Med 350:2452-60. 2004
    ..We conducted a multicenter, randomized trial to evaluate the effect of noninvasive positive-pressure ventilation on mortality in this clinical setting...