Michael G Fehlings

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Current status of clinical trials for acute spinal cord injury
    Michael G Fehlings
    Division of Neurosurgery and Cell and Molecular Biology, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Injury 36:B113-22. 2005
  2. ncbi request reprint The role and timing of early decompression for cervical spinal cord injury: update with a review of recent clinical evidence
    Michael G Fehlings
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Injury 36:B13-26. 2005
  3. doi request reprint The evidence for intraoperative neurophysiological monitoring in spine surgery: does it make a difference?
    Michael G Fehlings
    Neural Repair and Regeneration, University of Toronto Spine Program, University of Toronto Neuroscience Program, Toronto, ON, Canada
    Spine (Phila Pa 1976) 35:S37-46. 2010
  4. pmc The role of neural precursor cells and self assembling peptides in nerve regeneration
    Xiao Zhao
    Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
    J Otolaryngol Head Neck Surg 42:60. 2013
  5. pmc Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model
    Mahmood Chamankhah
    Krembil Neuroscience Center, Division of Cell and Molecular Biology, Toronto Western Hospital, Toronto, ON, Canada
    BMC Genomics 14:583. 2013
  6. doi request reprint A clinical prediction model to determine outcomes in patients with cervical spondylotic myelopathy undergoing surgical treatment: data from the prospective, multi-center AOSpine North America study
    Lindsay A Tetreault
    Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada E mail address for M G Fehlings
    J Bone Joint Surg Am 95:1659-66. 2013
  7. doi request reprint Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study
    Michael G Fehlings
    Division of Neurosurgery, University of Toronto, Toronto Western Hospital, West Wing, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada E mail address for M G Fehlings
    J Bone Joint Surg Am 95:1651-8. 2013
  8. pmc Predictors of treatment outcomes in geriatric patients with odontoid fractures: AOSpine North America multi-centre prospective GOF study
    Michael G Fehlings
    Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario
    Spine (Phila Pa 1976) 38:881-6. 2013
  9. doi request reprint The diagnosis of spinal tumors: established and emerging methods
    George M Ibrahim
    University of Toronto, Toronto Western Hospital, Krembil Neuroscience Center, Division of Neurosurgery and Spinal Program, 399 Bathurst St, Toronto ON, M5G, Canada 416 603 5627 416 603 5298
    Expert Opin Med Diagn 6:95-108. 2012
  10. pmc Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS)
    Michael G Fehlings
    Divisions of Neurosurgery and Orthopedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e32037. 2012

Collaborators

Detail Information

Publications148 found, 100 shown here

  1. ncbi request reprint Current status of clinical trials for acute spinal cord injury
    Michael G Fehlings
    Division of Neurosurgery and Cell and Molecular Biology, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Injury 36:B113-22. 2005
    ..Clearly trials of improved neuroprotective agents are required. Promising potential therapies for ASCI include riluzole, minocycline, erythropoietin, and the fusogen polyethylene glycol, as well as mild hypothermia...
  2. ncbi request reprint The role and timing of early decompression for cervical spinal cord injury: update with a review of recent clinical evidence
    Michael G Fehlings
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Injury 36:B13-26. 2005
    ..Urgent decompression in acute cervical spinal cord injury remains a reasonable practice option and can be performed safely...
  3. doi request reprint The evidence for intraoperative neurophysiological monitoring in spine surgery: does it make a difference?
    Michael G Fehlings
    Neural Repair and Regeneration, University of Toronto Spine Program, University of Toronto Neuroscience Program, Toronto, ON, Canada
    Spine (Phila Pa 1976) 35:S37-46. 2010
    ....
  4. pmc The role of neural precursor cells and self assembling peptides in nerve regeneration
    Xiao Zhao
    Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
    J Otolaryngol Head Neck Surg 42:60. 2013
    ..We examined the combinatorial effect of neural precursor cells (NPC) and self assembling peptide (SAP) administration on nerve regeneration...
  5. pmc Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model
    Mahmood Chamankhah
    Krembil Neuroscience Center, Division of Cell and Molecular Biology, Toronto Western Hospital, Toronto, ON, Canada
    BMC Genomics 14:583. 2013
    ..To understand the distinct molecular events underlying this injury model we analyzed global mRNA abundance changes during the acute, subacute and chronic stages of a moderate to severe injury to the rat spinal cord...
  6. doi request reprint A clinical prediction model to determine outcomes in patients with cervical spondylotic myelopathy undergoing surgical treatment: data from the prospective, multi-center AOSpine North America study
    Lindsay A Tetreault
    Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada E mail address for M G Fehlings
    J Bone Joint Surg Am 95:1659-66. 2013
    ....
  7. doi request reprint Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study
    Michael G Fehlings
    Division of Neurosurgery, University of Toronto, Toronto Western Hospital, West Wing, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada E mail address for M G Fehlings
    J Bone Joint Surg Am 95:1651-8. 2013
    ..The objective of this study was to evaluate the impact of surgical decompression on functional, quality-of-life, and disability outcomes at one year after surgery in a large cohort of patients with this condition...
  8. pmc Predictors of treatment outcomes in geriatric patients with odontoid fractures: AOSpine North America multi-centre prospective GOF study
    Michael G Fehlings
    Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario
    Spine (Phila Pa 1976) 38:881-6. 2013
    ..Multicenter prospective cohort study...
  9. doi request reprint The diagnosis of spinal tumors: established and emerging methods
    George M Ibrahim
    University of Toronto, Toronto Western Hospital, Krembil Neuroscience Center, Division of Neurosurgery and Spinal Program, 399 Bathurst St, Toronto ON, M5G, Canada 416 603 5627 416 603 5298
    Expert Opin Med Diagn 6:95-108. 2012
    ..Increasing knowledge of tumor biology and better discrimination of tumor subtypes will continue to play a significant role in guiding patient-specific treatment decisions...
  10. pmc Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS)
    Michael G Fehlings
    Divisions of Neurosurgery and Orthopedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e32037. 2012
    ..Our objective was to evaluate the relative effectiveness of early (<24 hours after injury) versus late (≥ 24 hours after injury) decompressive surgery after traumatic cervical SCI...
  11. doi request reprint Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial
    Michael G Fehlings
    Department of Surgery, Division of Neurosurgery and Spinal Program, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    J Neurosurg Spine 17:151-6. 2012
    ..Clinical trial registration no.: NCT00876889...
  12. doi request reprint Is surgery for cervical spondylotic myelopathy cost-effective? A cost-utility analysis based on data from the AOSpine North America prospective CSM study
    Michael G Fehlings
    Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg Spine 17:89-93. 2012
    ..This study evaluates the cost-effectiveness of this type of surgery in terms of cost per quality-adjusted life year (QALY) gained...
  13. pmc Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury
    Newton Cho
    Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Center, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    J Neuroinflammation 9:134. 2012
    ..Since members of the gp130 family all share a common signal transduction pathway via the JAK/STAT system, we performed the first study of a relatively new member of the gp130 family, IL-11, in SCI...
  14. pmc Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration
    W Mark Erwin
    University of Toronto and Toronto Western Hospital, Mc13 310, 399 Bathurst Street, Toronto M5T 2S8
    Arthritis Res Ther 13:R215. 2011
    ..Therefore we evaluated the ability of notochordal cell conditioned medium (NCCM) to protect NP cells from IL-1ß and IL-1ß +FasL-mediated cell death and degeneration...
  15. ncbi request reprint Management strategies to optimize clinical outcomes after acute traumatic spinal cord injury: integration of medical and surgical approaches
    J R Wilson
    Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
    J Neurosurg Sci 56:1-11. 2012
    ..In this article we review the current evidence surrounding the medical and surgical management of SCI, as well as identify areas where future research is needed...
  16. pmc Transmembrane potential induced on the internal organelle by a time-varying magnetic field: a model study
    Hui Ye
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    J Neuroeng Rehabil 7:12. 2010
    ..These potential changes in the organelles could have a significant impact on their functionality. However, a quantitative analysis on the magnetically-induced membrane potential on the internal organelles has not been performed...
  17. doi request reprint The challenges of managing spine and spinal cord injuries: an evolving consensus and opportunities for change
    Michael G Fehlings
    Division of Neurosurgery and Spinal Program, University of Toronto, Toronto, ON, Canada
    Spine (Phila Pa 1976) 35:S161-5. 2010
    ..The current Spine issue serves as an update to clinicians on these topics as well as a framework for stimulating new discussion and research in the field as a whole...
  18. pmc Cellular treatments for spinal cord injury: the time is right for clinical trials
    Michael G Fehlings
    University Health Network, Toronto Western Hospital, Toronto, ON M5T2S8, Canada
    Neurotherapeutics 8:704-20. 2011
    ..The field of regenerative neuroscience should not be stalled at the animal model stage, but instead the clinical trials need to be focused, safe, and ethical, backed up by a robust, translationally relevant preclinical research strategy...
  19. doi request reprint Decision making in the surgical treatment of cervical spine metastases
    Michael G Fehlings
    Department of Surgery, Toronto Western Hospital Spinal Program, University of Toronto, Toronto, ON, Canada
    Spine (Phila Pa 1976) 34:S108-17. 2009
    ..Qualitative systematic review of the literature...
  20. doi request reprint Synopsis of the 10th International Neurotrauma Symposium: from bench to bedside in neurotrauma translational research
    Michael G Fehlings
    Division of Neurosurgery, University of Toronto, 399 Bathurst Street, Suite 4WW449, Toronto, Ontario, M5T 2S8, Canada
    Expert Rev Neurother 11:1115-20. 2011
    ....
  21. pmc A series of systematic reviews on the treatment of acute spinal cord injury: a foundation for best medical practice
    Michael G Fehlings
    Department of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 28:1329-33. 2011
    ....
  22. ncbi request reprint Interobserver and intraobserver reliability of maximum canal compromise and spinal cord compression for evaluation of acute traumatic cervical spinal cord injury
    Michael G Fehlings
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Canada
    Spine (Phila Pa 1976) 31:1719-25. 2006
    ..Prospective, blinded validation study of an objective, quantitative measure to assess maximum canal compromise (MCC) and maximum spinal cord compression (MSCC) in individuals with acute cervical spinal cord injury (SCI)...
  23. doi request reprint A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury
    Michael G Fehlings
    Department of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 28:787-96. 2011
    ..Further clinical trials with Cethrin in SCI patients are planned, to establish evidence of efficacy...
  24. doi request reprint Current practice in the timing of surgical intervention in spinal cord injury
    Michael G Fehlings
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada
    Spine (Phila Pa 1976) 35:S166-73. 2010
    ..Systematic review of the literature and prospective survey study...
  25. pmc Immunoglobulin G: a potential treatment to attenuate neuroinflammation following spinal cord injury
    Michael G Fehlings
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    J Clin Immunol 30:S109-12. 2010
    ....
  26. doi request reprint Timing of surgical intervention in spinal trauma: what does the evidence indicate?
    Michael G Fehlings
    Division of Neurosurgery and Spine Program, University of Toronto, Toronto, ON, Canada
    Spine (Phila Pa 1976) 35:S159-60. 2010
    ..Based on the emerging evidence, it is recommended that patients with major spine trauma or spinal cord injury should undergo surgical treatment, when deemed appropriate, within 24 hours of their injury...
  27. doi request reprint The impact of facet dislocation on clinical outcomes after cervical spinal cord injury: results of a multicenter North American prospective cohort study
    Jefferson R Wilson
    Department of Surgery, Divisions of Neurosurgery and Orthopedic Surgery, Spinal Program, University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 38:97-103. 2013
    ..A multicenter prospective cohort study...
  28. pmc Immunoglobulin G (IgG) attenuates neuroinflammation and improves neurobehavioral recovery after cervical spinal cord injury
    Dung Hoang Nguyen
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Neuroinflammation 9:224. 2012
    ..Due to its putative, though poorly characterized immuno-modulatory effects, IgG has been used clinically to treat neuroinflammatory disorders such as Guillain-Barré syndrome, but its effects in neurotrauma remain largely unexplored...
  29. doi request reprint Predictors of surgical outcome in cervical spondylotic myelopathy
    Alina Karpova
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 38:392-400. 2013
    ..Prospective study...
  30. ncbi request reprint Multimodality intraoperative neurophysiologic monitoring findings during surgery for adult tethered cord syndrome: analysis of a series of 44 patients with long-term follow-up
    Guillermo Paradiso
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 31:2095-102. 2006
    ..The results of multimodality intraoperative neurophysiologic monitoring were compared with the "gold standard" (neurologic outcomes)...
  31. doi request reprint Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord
    Soheila Karimi-Abdolrezaee
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Center, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 30:1657-76. 2010
    ..These findings could potentially bring us closer to the application of NPCs for patients suffering from chronic SCI or other conditions characterized by the formation of a glial scar...
  32. ncbi request reprint Myelination of congenitally dysmyelinated spinal cord axons by adult neural precursor cells results in formation of nodes of Ranvier and improved axonal conduction
    Eftekhar Eftekharpour
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, Canada M5T 2S8
    J Neurosci 27:3416-28. 2007
    ..These data suggest the therapeutic potential of aNPCs to promote functionally significant myelination in CNS disorders characterized by longstanding myelin deficiency...
  33. pmc An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury
    Gregory W J Hawryluk
    Division of Genetics and Development, Krembil Neuroscience Center, Toronto Western Research Institute, University Health Network, Toronto, Canada
    Stem Cells Dev 21:2222-38. 2012
    ..Trophins may contribute to the benefits associated with cell-based repair strategies for spinal cord injury...
  34. ncbi request reprint Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  35. ncbi request reprint Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites
    Baosong Liu
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:5309-19. 2006
    ..Thus, ischemic insults promote targeting of GluR2-lacking AMPARs to synapses of hippocampal neurons, mechanisms that may be relevant to ischemia-induced synaptic remodeling and/or neuronal death...
  36. doi request reprint Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair
    W Mark Erwin
    Division of Orthopaedic Surgery, University of Toronto, Toronto, Canada
    Spine (Phila Pa 1976) 38:211-6. 2013
    ..An in vitro and in vivo evaluation of intervertebral disc (IVD)-derived stem/progenitor cells...
  37. doi request reprint Reliability of quantitative magnetic resonance imaging methods in the assessment of spinal canal stenosis and cord compression in cervical myelopathy
    Alina Karpova
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Spine (Phila Pa 1976) 38:245-52. 2013
    ..Prospective, blinded reliability study of quantitative magnetic resonance imaging (MRI) measures in patients with cervical myelopathy...
  38. doi request reprint Intraoperative multimodality monitoring in adult spinal deformity: analysis of a prospective series of one hundred two cases with independent evaluation
    Nasir A Quraishi
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 34:1504-12. 2009
    ..A retrospective analysis of prospectively collected data of 102 consecutive adult patients who underwent intraoperative neurophysiological monitoring (IOM) during spinal deformity corrective surgery...
  39. doi request reprint A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury
    Yang Liu
    Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
    Acta Biomater 9:8075-88. 2013
    ..As the first detailed examination of the pathophysiological properties of QL6 in SCI, this work reveals the therapeutic potential of SAPs, and may suggest an approach for the reconstruction of the injured spinal cord...
  40. doi request reprint Systemic polyethylene glycol promotes neurological recovery and tissue sparing in rats after cervical spinal cord injury
    Darryl C Baptiste
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Neuropathol Exp Neurol 68:661-76. 2009
    ..The modest extent of locomotor recovery after treatment with PEG suggests, however, that this compound may notconfer sufficient neuroprotection to be used clinically as a single treatment...
  41. ncbi request reprint A quantitative and reproducible method to assess cord compression and canal stenosis after cervical spine trauma: a study of interrater and intrarater reliability
    Julio C Furlan
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 32:2083-91. 2007
    ..Reliability study...
  42. pmc A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors
    Jefferson R Wilson
    Department of Surgery, Division of Neurosurgery and Spinal Program, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    J Neurotrauma 29:2263-71. 2012
    ..93 in the original dataset, and 0.92 (95% CI 0.92,0.93) across the bootstraps, indicating excellent predictive discrimination. These models will have important clinical impact to guide decision making and to counsel patients and families...
  43. doi request reprint Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy
    Wen Ru Yu
    Department of Pathology, Toronto Western Research Institute, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, and University of Toronto, Room 4W 449, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Brain 134:1277-92. 2011
    ..Our findings highlight the possibility of medical treatments for cervical spondylotic myelopathy that are complementary to surgical decompression...
  44. ncbi request reprint Use of osteogenic protein-1 in patients at high risk for spinal pseudarthrosis: a prospective cohort study assessing safety, health-related quality of life, and radiographic fusion. Invited submission from the Joint Section on Disorders of the Spine and P
    Julio C Furlan
    Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario, Canada
    J Neurosurg Spine 7:486-95. 2007
    ..This prospective study examines the safety and efficacy of OP-1 use in patients considered to be at a high risk for developing pseudarthrosis following reconstructive spinal surgery...
  45. ncbi request reprint Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery
    Mital Joshi
    Department of Surgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
    J Neurotrauma 19:191-203. 2002
    ..In addition, we provide a detailed neuroanatomical study of clip compression injury in mice that can be used to study the molecular mechanisms of SCI in knockout and transgenic mice...
  46. ncbi request reprint Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats
    Eftekhar Eftekharpour
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, McMaster University, Hamilton, Canada
    Exp Neurol 193:334-49. 2005
    ..Further understanding of these issues in this model could provide critical insights for neurological disorders characterized by demyelination...
  47. doi request reprint Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases
    Arjun Sahgal
    Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
    Lancet Oncol 14:e310-20. 2013
    ....
  48. doi request reprint Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A
    Ishita Siddiq
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 29:2647-59. 2012
    ..Collectively, the results provide supportive evidence for the concept of acute and delayed treatment following TBI using VEGF-ZFP to induce angiogenesis, reduce cell death, and enhance functional recovery...
  49. doi request reprint Sensorimotor cortical activation in patients with cervical spinal cord injury with persisting paralysis
    Michael T Jurkiewicz
    Toronto Rehabilitation Institute, Toronto, Canada
    Neurorehabil Neural Repair 24:136-40. 2010
    ..It is well documented that cortical sensorimotor representations are altered following nervous system pathology. However, little is known about these representations over time and, more specifically, in paralyzed individuals...
  50. pmc The impact of age on mortality, impairment, and disability among adults with acute traumatic spinal cord injury
    Julio C Furlan
    Department of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Neurotrauma 26:1707-17. 2009
    ..Given this fact, rehabilitation protocols that are more focused on functional recovery may reduce disability among older people with acute traumatic SCI...
  51. doi request reprint The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis
    James W Austin
    Institute of Medical Science, University of Toronto, Canada
    Biomaterials 33:4555-64. 2012
    ..Our data suggest that HAMC is capable of modulating inflammation and scarring events, leading to improved functional recovery following severe SCI associated with arachnoiditis...
  52. doi request reprint Predictive value of intraoperative neurophysiological monitoring during cervical spine surgery: a prospective analysis of 1055 consecutive patients
    Michael O Kelleher
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Neurosurg Spine 8:215-21. 2008
    ..The authors sought to define the incidence of significant intraoperative electrophysiological changes and new postoperative neurological deficits in a cohort of patients undergoing cervical surgery...
  53. doi request reprint Anterior versus posterior surgical approaches to treat cervical spondylotic myelopathy: outcomes of the prospective multicenter AOSpine North America CSM study in 264 patients
    Michael G Fehlings
    University of Toronto, Toronto, Ontario, Canada University of Washington, Seattle, WA Emory University, Atlanta, GA University of Kansas, Kansas City, KS Thomas Jefferson University, Philadelphia, PA University of Utah, Salt Lake City, UT University of Virginia, Charlottesville, VA New England Baptist Hospital, Boston, MA Boston Spine Group, Newton, MA Spine Education and Research Institute, Denver, CO Brigham and Woman s Hospital, Boston, MA Indiana Spine Group, Indianapolis, IN The CORE Institute, Phoenix, AZ and John Hopkins University, Baltimore, MD
    Spine (Phila Pa 1976) 38:2247-52. 2013
    ..A prospective observational multicenter study...
  54. pmc Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance
    Crystal A Ruff
    Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 33:11899-915. 2013
    ..This study describes, for the first time mechanistically, the functional characteristics and anatomical integration of nonimmortalized donor SVZ-derived murine aNPCs in the dysmyelinated brain at key developmental time points. ..
  55. doi request reprint Perioperative and delayed complications associated with the surgical treatment of cervical spondylotic myelopathy based on 302 patients from the AOSpine North America Cervical Spondylotic Myelopathy Study
    Michael G Fehlings
    Department of Neurosurgery, University of Toronto, Ontario, Canada
    J Neurosurg Spine 16:425-32. 2012
    ..The authors sought to assess the rates of and risk factors associated with perioperative and delayed complications associated with the surgical treatment of CSM...
  56. ncbi request reprint Surgical treatment of cervical myeloradiculopathy associated with movement disorders: indications, technique, and clinical outcome
    Albert S Wong
    Division of Neurosurgery, University of Toronto, and Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Spinal Disord Tech 18:S107-14. 2005
    ..We report on eight patients with movement disorders causing progressive cervical myeloradiculopathy who were treated successfully by cervical decompression and reconstruction...
  57. ncbi request reprint Functional changes in genetically dysmyelinated spinal cord axons of shiverer mice: role of juxtaparanodal Kv1 family K+ channels
    Kusum Sinha
    Div of Cell and Molecular Biology, Univ of Toronto, Toronto Western Hospital, Univ Health Network, Rm 4W 449, 399 Bathurst St, Toronto, Ontario M5T 2S8, Canada
    J Neurophysiol 95:1683-95. 2006
    ..l and Kv1.2 along the internodes of spinal cord axons associated with the biophysical consequences caused by alterations in the myelin sheaths...
  58. doi request reprint An economic evaluation of perioperative adverse events associated with spinal surgery
    Erik K Hellsten
    Institute of Health Policy, Management, and Evaluation, University of Toronto, Health Sciences Building, 155 College St, Suite 425, Toronto, ON M5T 3M6, Canada
    Spine J 13:44-53. 2013
    ..Although a number of studies have attempted to estimate the economic impact of AEs, few have directly linked costs to clinician-reported event severity...
  59. doi request reprint Expression and functional role of BK channels in chronically injured spinal cord white matter
    Hui Ye
    Department of Genetics and Development, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, Canada
    Neurobiol Dis 47:225-36. 2012
    ..Thus, pharmacological targeting of axonal BK channels may provide a therapeutic strategy for the treatment of chronic SCI, by restoring conduction to the remaining functional axons...
  60. doi request reprint Clinical prediction model for acute inpatient complications after traumatic cervical spinal cord injury: a subanalysis from the Surgical Timing in Acute Spinal Cord Injury Study
    Jefferson R Wilson
    Department of Surgery, Division of Neurosurgery, University of Toronto, Ontario, Canada
    J Neurosurg Spine 17:46-51. 2012
    ..In addition, the authors sought to create a prediction model using clinical variables documented at hospital admission to predict acute complication development...
  61. doi request reprint Vertebral compression fracture (VCF) after spine stereotactic body radiation therapy (SBRT): analysis of predictive factors
    Marcelo V R Cunha
    Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 84:e343-9. 2012
    ..The analysis incorporated the recently described Spinal Instability Neoplastic Score (SINS) criteria...
  62. doi request reprint Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization
    James W Rowland
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Center, University Health Network, Toronto, Ontario, Canada
    Stem Cells Dev 20:1829-45. 2011
    ....
  63. doi request reprint Survey of neurosurgical management of central nervous system hemorrhage in patients receiving anticoagulation therapy: current practice is highly variable and may be suboptimal
    Gregory W J Hawryluk
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    World Neurosurg 76:299-303. 2011
    ..The authors conducted a survey at the 2010 American Association of Neurological Surgeons (AANS) annual meeting to determine how these patients are currently being managed by neurosurgeons...
  64. doi request reprint The impact of co-morbidities on age-related differences in mortality after acute traumatic spinal cord injury
    Julio C Furlan
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Neurotrauma 26:1361-7. 2009
    ..Our findings have implications for future clinical trials of therapies for adult patients with acute SCI and for management strategies of elderly individuals with SCI...
  65. doi request reprint Gene therapy for traumatic central nervous system injury and stroke using an engineered zinc finger protein that upregulates VEGF-A
    Philippe M D'Onofrio
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 28:1863-79. 2011
    ..Our results indicate that VEGF ZFP therapy is neuroprotective following traumatic injury or stroke in the adult mammalian CNS...
  66. ncbi request reprint Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury
    Alun Ackery
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 23:604-16. 2006
    ..These results strongly suggest that inhibiting Fas receptor activation is neuroprotective after acute SCI and that this strategy may have important translational significance...
  67. ncbi request reprint The use of C1 lateral mass screws in complex cervical spine surgery: indications, techniques, and outcome in a prospective consecutive series of 25 cases
    Thorsteinn Gunnarsson
    Division of Neurosurgery, Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital, University of Toronto, Toronto, Canada
    J Spinal Disord Tech 20:308-16. 2007
    ..The objectives of this study were to assess the safety and the clinical/radiographic outcomes in patients undergoing cervical spine surgery using C1 lateral mass screws (C1-LMS)...
  68. doi request reprint Current status of experimental cell replacement approaches to spinal cord injury
    Eftekhar Eftekharpour
    Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital and Division of Genetics and Development, Toronto Western Research Institute, Canada
    Neurosurg Focus 24:E19. 2008
    ..Nonetheless, the future for stem cell-based reparative strategies for treating SCI appears bright...
  69. doi request reprint Molecular mechanisms of Fas-mediated cell death in oligodendrocytes
    James W Austin
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto, Ontario, Canada
    J Neurotrauma 25:411-26. 2008
    ..These data also add to an emerging body of evidence, which strongly implicates Fas-mediated apoptosis of oligodendrocytes as a potential mediator in the pathobiology of a variety of neurological disorders, including SCI...
  70. doi request reprint Radiation-induced vertebral compression fracture following spine stereotactic radiosurgery: clinicopathological correlation
    Ameen Al-Omair
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Canada
    J Neurosurg Spine 18:430-5. 2013
    ..In those scenarios in which it is unclear based on imaging if true tumor progression has occurred, the authors recommend biopsy to rule out radiation-induced effects within the bone prior to initiating salvage therapies...
  71. doi request reprint Development of the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP): reviewing measurement specific to the upper limb in tetraplegia
    Sukhvinder Kalsi-Ryan
    Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg Spine 17:65-76. 2012
    ..Primary outcome measures for the upper limb in trials concerning human spinal cord injury (SCI) need to distinguish between functional and neurological changes and require satisfying psychometric properties for clinical application...
  72. doi request reprint Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury
    Wen Ru Yu
    Divisions of Genetics and Development and Neurosurgery, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada
    Eur J Neurosci 29:114-31. 2009
    ..However, in lpr spinal cord cultures, FasL neutralization had no protective effects. In summary, these data provide direct evidence for the induction of intrinsic mitochondrial signaling pathways following Fas activation after SCI...
  73. doi request reprint Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy
    Wen Ru Yu
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Neurobiol Dis 33:149-63. 2009
    ....
  74. ncbi request reprint Admission and acute complication rate for outpatient lumbar microdiscectomy
    Aria Fallah
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Can J Neurol Sci 37:49-53. 2010
    ..This is the first study comparing the immediate success of outpatient lumbar microdiscectomy with respect to acute complication and conversion to inpatient rate. Long-term pain relief is not examined in this study...
  75. pmc Pre-hospital care management of a potential spinal cord injured patient: a systematic review of the literature and evidence-based guidelines
    Henry Ahn
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 28:1341-61. 2011
    ....
  76. ncbi request reprint Acute cervical traumatic spinal cord injury: MR imaging findings correlated with neurologic outcome--prospective study with 100 consecutive patients
    Firoz Miyanji
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, 399 Bathurst St, West Wing, 4th Floor, Room 449, Toronto, Ontario, Canada
    Radiology 243:820-7. 2007
    ..To prospectively evaluate whether quantitative and qualitative magnetic resonance (MR) imaging assessments after spinal cord injury (SCI) correlate with patient neurologic status and are predictive of outcome at long-term follow-up...
  77. doi request reprint Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury
    Charles H Tator
    Division of Neurosurgery and Spinal Program, Toronto Western Hospital and University of Toronto, Ontario, Canada
    J Neurosurg Spine 17:157-229. 2012
    ..A recommendation is made for the development and validation of a preclinical scoring system involving worldwide experts in preclinical and clinical SCI...
  78. ncbi request reprint Surgical management of tethered cord syndrome in adults: indications, techniques, and long-term outcomes in 60 patients
    Gabriel Y F Lee
    Department of Surgery, University of Toronto, Ontario, Canada
    J Neurosurg Spine 4:123-31. 2006
    ..The authors performed a retrospective study of clinical outcomes after neurosurgical intervention in 60 adults with TCS...
  79. doi request reprint Functional and clinical outcomes following surgical treatment in patients with cervical spondylotic myelopathy: a prospective study of 81 cases
    Julio C Furlan
    Division of Genetics and Development, Toronto Western Research Institute, Ontario, Canada
    J Neurosurg Spine 14:348-55. 2011
    ..This study examines the potential confounding effects of age, sex, duration of symptoms, and comorbidities on the functional outcomes and postoperative complications in patients who underwent cervical decompressive surgery...
  80. ncbi request reprint Hematologic abnormalities within the first week after acute isolated traumatic cervical spinal cord injury: a case-control cohort study
    Julio C Furlan
    Department of Surgery, Division of Neurosurgery, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 31:2674-83. 2006
    ..Case-control cohort study...
  81. ncbi request reprint Emerging drugs for spinal cord injury
    Darryl C Baptiste
    Toronto Western Hospital, Division of Cellular and Molecular Biology, Toronto Western Research Institute and Krembil Neuroscience Centre, 12th Floor Room 407 McLaughlin Pavilion, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    Expert Opin Emerg Drugs 13:63-80. 2008
    ..This review summarizes several promising pharmacological approaches for the therapeutic management of traumatic spinal cord injury (SCI), which are either in early-phase clinical trials or nearing clinical translation...
  82. doi request reprint Modular double sucrose gap apparatus for improved recording of compound action potentials from rat and mouse spinal cord white matter preparations
    Alexander A Velumian
    Division of Neurosurgery, Toronto Western Hospital, University Health Network, Canada
    J Neurosci Methods 187:33-40. 2010
    ....
  83. pmc Fas/FasL-mediated apoptosis and inflammation are key features of acute human spinal cord injury: implications for translational, clinical application
    Wen Ru Yu
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON M5T 2S8, Canada
    Acta Neuropathol 122:747-61. 2011
    ....
  84. ncbi request reprint Agreement between orthopedic surgeons and neurosurgeons regarding a new algorithm for the treatment of thoracolumbar injuries: a multicenter reliability study
    Y Raja Rampersaud
    Division of Orthopaedic and Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    J Spinal Disord Tech 19:477-82. 2006
    ..This information could be important in establishing consensus-based protocols for managing these challenging injuries...
  85. doi request reprint Is age a key determinant of mortality and neurological outcome after acute traumatic spinal cord injury?
    Julio C Furlan
    Department of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8
    Neurobiol Aging 31:434-46. 2010
    ..Treatment protocols for SCI need to identify preventable predictors of mortality in the elderly post-SCI, recognizing that the potential for neurological recovery among elderly survivors of SCI is similar to that of younger individuals...
  86. ncbi request reprint Confocal imaging of changes in glial calcium dynamics and homeostasis after mechanical injury in rat spinal cord white matter
    Linda R Mills
    Division of Cellular and Molecular Biology, The Toronto Western Hospital Research Institute, University Health Network, Toronto, Canada
    Neuroimage 21:1069-82. 2004
    ..The results further show that trauma can enhance calcium regulation in surviving glial cells in the acute post-injury period...
  87. ncbi request reprint Descending vasomotor pathways in humans: correlation between axonal preservation and cardiovascular dysfunction after spinal cord injury
    Julio C Furlan
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Canada
    J Neurotrauma 20:1351-63. 2003
    ..This information adds to our knowledge of pathobiology of cardiovascular dysfunction after human SCI and may ultimately suggest novel therapeutic strategies as regenerative and reparative approaches become translated to the clinic...
  88. ncbi request reprint Multimodality intraoperative monitoring during complex lumbosacral procedures: indications, techniques, and long-term follow-up review of 61 consecutive cases
    Andrei V Krassioukov
    Department of Surgery, University of Toronto, Ontario, Canada
    J Neurosurg Spine 1:243-53. 2004
    ..The purpose of this study was to examine the neurological outcomes after complex lumbosacral surgery in patients undergoing multimodality neurophysiological monitoring...
  89. doi request reprint A novel approach to quantitatively assess posttraumatic cervical spinal canal compromise and spinal cord compression: a multicenter responsiveness study
    Julio C Furlan
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Canada
    Spine (Phila Pa 1976) 36:784-93. 2011
    ..Multicenter retrospective study...
  90. ncbi request reprint The effects of gender on clinical and neurological outcomes after acute cervical spinal cord injury
    Julio C Furlan
    Department of Surgery, Division of Neurosurgery, University of Toronto, Ontario, Canada
    J Neurotrauma 22:368-81. 2005
    ..These issues may be of key clinical importance in developing improved management protocols for SCI so as to maximize functional recovery and quality-of-life...
  91. doi request reprint Os odontoideum: etiology and surgical management
    Babak Arvin
    Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Neurosurgery 66:22-31. 2010
    ..The etiology of os odontoideum remains controversial, but there is now emerging consensus on the traumatic etiology of os odontoideum rather than a congenital source...
  92. ncbi request reprint Anterior cervical screw extrusion leading to acute upper airway obstruction: case report
    David T Wong
    Division of Neurosurgery, Department of Anesthesiology, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 30:E683-6. 2005
    ..Case report of late postoperative complication...
  93. ncbi request reprint Intraoperative adverse events and related postoperative complications in spine surgery: implications for enhancing patient safety founded on evidence-based protocols
    Y Raja Rampersaud
    Division of Orthopaedic and Neurosurgery, Krembil Neuroscience Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 31:1503-10. 2006
    ..Prospective observational study...
  94. doi request reprint Molecular and electrophysiological evidence for the expression of BK channels in oligodendroglial precursor cells
    Josef Buttigieg
    Krembil Neuroscience Center, Division of Cell and Molecular Biology, Toronto, ON, Canada
    Eur J Neurosci 34:538-47. 2011
    ..We conclude that the BK channel is involved in regulating Ca(2+) influx in OPCs, and may potentially play a role during differentiation of oligodendroglial lineage cells...
  95. ncbi request reprint The timing of surgical intervention in the treatment of spinal cord injury: a systematic review of recent clinical evidence
    Michael G Fehlings
    Division of Neurosurgery and Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 31:S28-35; discussion S36. 2006
    ..Evidence-based literature review...
  96. pmc Assessment of impairment in patients with acute traumatic spinal cord injury: a systematic review of the literature
    Julio C Furlan
    Department of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Neurotrauma 28:1445-77. 2011
    ..Our results also suggest that there is no instrument with appropriate psychometric properties for this particular population...
  97. doi request reprint Are induced pluripotent stem cells the future of cell-based regenerative therapies for spinal cord injury?
    Ryan P F Salewski
    Division of Genetics and Development, Toronto Western Research Institute, Toronto, Ontario M5T 2S8, Canada
    J Cell Physiol 222:515-21. 2010
    ..In this review, we will evaluate the recent advancements in the field of iPS cells including their capacity for differentiation toward neural lineages that may allow iPS cells transplantation in cell-based therapy for spinal cord repair...
  98. doi request reprint Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model
    Hui Ye
    Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Med Biol Eng Comput 49:107-19. 2011
    ..The mathematical basis of this conclusion was discussed. The analytic solution can potentially be used to modify the activation function in current cable equations describing magnetic stimulation...
  99. pmc Spinal cord injury: a systematic review of current treatment options
    David W Cadotte
    Division of Neurosurgery, University of Toronto, and Neural Repair and Regeneration, Spinal Program, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
    Clin Orthop Relat Res 469:732-41. 2011
    ..Research has revealed an understanding of mechanisms that occur after the primary injury and contribute to functional loss. By targeting these secondary mechanisms of injury, clinicians may be able to offer improved recovery after SCI...
  100. doi request reprint Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury
    Gregory W J Hawryluk
    Division of Genetics and Development, Toronto Western Research Institute, Toronto, Ontario, Canada
    Neurosurg Focus 25:E14. 2008
    ..Taken together, recent advances suggest that optimism for patients and clinicians alike is justified, as there is real hope that several safe and effective therapies for SCI may become available over the next decade...
  101. ncbi request reprint Pharmacological approaches to repair the injured spinal cord
    Darryl C Baptiste
    Division of Cell and Molecular Biology, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Neurotrauma 23:318-34. 2006
    ..We anticipate that these studies will harken an era of renewed interest in translational clinical trials. Ultimately, due to the multi-factorial pathophysiology of traumatic SCI, effective therapies will require combined approaches...