Research Topics
| Justin A EzekowitzSummaryAffiliation: University of Alberta Country: Canada Publications
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Detail Information
Publications
The interaction among sex, hemoglobin and outcomes in a specialty heart failure clinicJustin A Ezekowitz
Division of Cardiology, University of Alberta, Edmonton, Alberta T6G 2H7
Can J Cardiol 21:165-71. 2005..Accordingly, the relationship among sex, anemia and outcomes in CHF was analyzed...
Novel pharmacologic therapies in development for acute decompensated heart failureJustin A Ezekowitz
Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
Curr Cardiol Rep 15:329. 2013..This review will explore current and future novel pharmacologic therapies for the treatment of acute heart failure...
Standardizing care for acute decompensated heart failure in a large megatrial: the approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)Justin A Ezekowitz
University of Alberta, Edmonton, Canada
Am Heart J 157:219-28. 2009..This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning...
Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarctionJustin A Ezekowitz
Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
J Am Coll Cardiol 53:13-20. 2009..The purpose of this study was to examine the long-term incidence of heart failure (HF) in elderly patients with myocardial infarction (MI)...
Aldosterone blockade and left ventricular dysfunction: a systematic review of randomized clinical trialsJustin A Ezekowitz
Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
Eur Heart J 30:469-77. 2009..Aldosterone blockade has been used to treat acute myocardial infarction (MI) and chronic heart failure...
Comparison of one-year outcome (death and rehospitalization) in hospitalized heart failure patients with left ventricular ejection fraction >50% versus those with ejection fraction <50%Justin A Ezekowitz
Division of Cardiology, University of Alberta, Alberta, Edmonton, Canada
Am J Cardiol 102:79-83. 2008....
Acute heart failure in the emergency department: short and long-term outcomes of elderly patients with heart failureJustin A Ezekowitz
Division of Cardiology, Department of Medicine University of Alberta, Canada
Eur J Heart Fail 10:308-14. 2008..We examined discharge rates, and whether outcomes, including mortality, differed based on admission status in AHF...
Trends in heart failure care: has the incident diagnosis of heart failure shifted from the hospital to the emergency department and outpatient clinics?Justin A Ezekowitz
Division of Cardiology 2C2 WMC, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada
Eur J Heart Fail 13:142-7. 2011..Our objective was to describe the incidence, prevalence, or outcomes for HF patients diagnosed in the outpatient or emergency department (ED) setting...
Insights into the change in brain natriuretic peptide after ST-elevation myocardial infarction (STEMI): why should it be better than baseline?Justin A Ezekowitz
2C2 Cardiology UAH, University of Alberta, 8440 112 Street, Edmonton, AB T6G 2B7, Canada
Can J Physiol Pharmacol 85:173-8. 2007..This likely reflects the variability in NT-proBNP at presentation and the ability to integrate subsequent important physiologic sequelae of STEMI such as reperfusion and infarct size...
The epidemiology and management of elderly patients with myocardial infarction or heart failureJustin A Ezekowitz
Division of Cardiology, University of Alberta, 2C2 WMC, 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada
Heart Fail Rev 15:407-13. 2010..Attention to this issue is important when selecting treatment strategies and a focus on the goals of care is critical when decisions for care must be undertaken...
The correlation of standard heart failure assessment and palliative care questionnaires in a multidisciplinary heart failure clinicJustin A Ezekowitz
Division of Cardiology and Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta
J Pain Symptom Manage 42:379-87. 2011....
Predicting chronic left ventricular dysfunction 90 days after ST-segment elevation myocardial infarction: An Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) SubstudyJustin A Ezekowitz
University of Alberta and the Canadian VIGOUR Center, Edmonton, Alberta, Canada
Am Heart J 160:272-8. 2010....
Association between direct measures of body composition and prognostic factors in chronic heart failureAntigone Oreopoulos
School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Mayo Clin Proc 85:609-17. 2010....
Incidence of heart failure and mortality after acute coronary syndromesPadma Kaul
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Am Heart J 165:379-85.e2. 2013..We examined the 1-year incidence of HF and its association with mortality among patients surviving their first acute coronary syndrome (ACS) hospitalization...
Do anthropometric indices accurately reflect directly measured body composition in men and women with chronic heart failure?Antigone Oreopoulos
School of Public Health, University of Alberta, 8440 112th Street, Edmonton, AB, Canada
Congest Heart Fail 17:90-2. 2011..Anthropometric indices do not accurately reflect body composition in patients with CHF, especially in women. When accurate assessment of body composition is required, direct measurements should be obtained...
Acute heart failure: perspectives from a randomized trial and a simultaneous registryJustin A Ezekowitz
Mazankowski Alberta Heart Institute and the University of Alberta, Edmonton, AB, Canada
Circ Heart Fail 5:735-41. 2012....
Impact of specialist follow-up in outpatients with congestive heart failureJustin A Ezekowitz
Division of Cardiology, University of Alberta, Edmonton, Alta
CMAJ 172:189-94. 2005..Methods to improve timely and appropriate access to specialists and to improve collaborative care structures are needed...
Resource use in the last 6 months of life among patients with heart failure in CanadaPadma Kaul
Department of Medicine, Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
Arch Intern Med 171:211-7. 2011..Heart failure (HF) is a debilitating and chronic condition associated with significant morbidity and mortality. However, much less is known about end-of-life (EOL) costs among patients with HF...
N-terminal pro-brain natriuretic peptide and the timing, extent and mortality in ST elevation myocardial infarctionJustin A Ezekowitz
University of Alberta, Edmonton, Canada
Can J Cardiol 22:393-7. 2006..NT-proBNP at baseline, 24 h and 72 h after presentation with acute STEMI, is an independent predictor of a poor outcome and adds clinically useful prognostic information...
Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failureJustin A Ezekowitz
Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
Circulation 107:223-5. 2003..Further research into the mechanisms of anemia in CHF and randomized controlled trials to test whether correction of anemia improves prognosis in CHF are needed...
Risk stratification schemes, anticoagulation use and outcomes: the risk--treatment paradox in patients with newly diagnosed non-valvular atrial fibrillationRoopinder K Sandhu
Department of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
Heart 97:2046-50. 2011..To examine whether warfarin use and outcomes differ across CHADS(2) and CHA(2)DS(2)-VASc risk strata for non-valvular atrial fibrillation (NVAF)...
Heart failure is a risk factor for orthopedic fracture: a population-based analysis of 16,294 patientsSean van Diepen
Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
Circulation 118:1946-52. 2008..Heart failure (HF) is associated with factors that may contribute to accelerated bone loss and subsequent fractures. Whether it leads to an increased fracture risk is unknown...
Mortality and readmission of patients with heart failure, atrial fibrillation, or coronary artery disease undergoing noncardiac surgery: an analysis of 38 047 patientsSean van Diepen
Mazankowski Alberta Heart Institute, Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada
Circulation 124:289-96. 2011..The purpose of this study is to compare the postoperative mortality of patients with HF, AF, or CAD undergoing major and minor noncardiac surgery...
Ethnic differences in 1-year mortality among patients hospitalised with heart failurePadma Kaul
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Heart 97:1048-53. 2011..The objective of this study was to examine the impact of ethnicity on 1-year mortality among patients with heart failure in a single payer healthcare system with universal access...
Does silent myocardial infarction add prognostic value in ST-elevation myocardial infarction patients without a history of prior myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) TrialMustafa Toma
University of Alberta, Edmonton, Alberta, Canada
Am Heart J 160:671-7. 2010..ST-elevation myocardial infarction (STEMI) patients with a prior MI history have worse outcomes. The prognostic significance of silent MI (pathologic Q waves outside the ST-elevation territory) in STEMI is unclear...
Assessment of dyspnea in acute decompensated heart failure: insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flowJustin A Ezekowitz
University of Alberta, Edmonton, Canada
J Am Coll Cardiol 59:1441-8. 2012..This study hypothesized that peak expiratory flow rate (PEFR) would increase with acute heart failure (AHF) treatment over the first 24 h, related to a Dyspnea Index (DI) change and treatment effect...
Patterns of care and outcomes differ for urban versus rural patients with newly diagnosed heart failure, even in a universal healthcare systemJohn Michael Gamble
Department of Public Health Sciences, University of Alberta, Edmonton, Canada
Circ Heart Fail 4:317-23. 2011..We aimed to determine whether outcomes differ for patients with incident heart failure (HF) by urban-rural status...
Meta-analysis: cardiac resynchronization therapy for patients with less symptomatic heart failureNawaf S Al-Majed
Mazankowski Alberta Heart Institute, University of Alberta, Canada
Ann Intern Med 154:401-12. 2011..Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with advanced symptoms of heart failure...
Comparison of direct body composition assessment methods in patients with chronic heart failureAntigone Oreopoulos
School of Public Health, University of Alberta, Edmonton, Alberta, Canada
J Card Fail 16:867-72. 2010..We examined the validity of leg-to-leg bioelectrical impedance analysis (BIA) and near-infrared interactance (NIR) to assess body composition in chronic heart failure (CHF) patients...
Systematic review: implantable cardioverter defibrillators for adults with left ventricular systolic dysfunctionJustin A Ezekowitz
University of Alberta Evidence Based Practice Center, Edmonton, Alberta, Canada
Ann Intern Med 147:251-62. 2007..Patients with left ventricular (LV) systolic dysfunction have an increased risk for ventricular arrhythmias...
Heart failure is a clinically and densitometrically independent risk factor for osteoporotic fractures: population-based cohort study of 45,509 subjectsSumit R Majumdar
Department of Medicine, University of Alberta, 2F1 24 Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440 112th Street, Edmonton, Alberta, Canada T6G 2B7
J Clin Endocrinol Metab 97:1179-86. 2012..The aim of the study was to determine whether heart failure is associated with an increased risk of major osteoporotic fractures that is independent of bone mineral density (BMD)...
Use of oral proton pump inhibitors is not associated with harm in patients with chronic heart failure in an ambulatory settingGavin Y Oudit
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, 8440 112 Street, Edmonton, Alberta, Canada
Eur J Heart Fail 13:1211-5. 2011..We conducted this study to determine whether PPI use was associated with excess mortality in patients with both ischaemic and non-ischaemic heart failure (HF)...
Systematic review: cardiac resynchronization in patients with symptomatic heart failureFinlay A McAlister
The University of Alberta and Capital Health Evidence based Practice Center, Edmonton, Alberta, Canada
Ann Intern Med 141:381-90. 2004..Even with optimal pharmacotherapy, symptomatic heart failure is associated with substantial morbidity and mortality...
Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failureFinlay A McAlister
University of Alberta Hospital, 2F1 21 Walter Mackenzie Health Sciences Centre, 8440 112 Street, Edmonton, Alberta, Canada
Ann Intern Med 150:784-94. 2009..Guidelines recommend that patients with heart failure receive beta-blockers in doses used in the trials that have proven their efficacy. Although the adverse effects of beta-blockade are dose-related, it is unclear whether the benefits are...
The unrecognized burden of osteoporosis-related vertebral fractures in patients with heart failureKristin J Lyons
Department of Medicine, University of Alberta, Edmonton, Canada
Circ Heart Fail 4:419-24. 2011..Our objectives were to describe the prevalence and predictors of the most common osteoporotic fracture, vertebral compression fractures (VCF), in patients with HF...
The epidemiology of atrial fibrillation in adults depends on locale of diagnosisRoopinder K Sandhu
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
Am Heart J 161:986-992.e1. 2011..Previous studies on atrial fibrillation (AF) epidemiology have used various case definitions for AF, but the effect of location of diagnosis on the apparent epidemiology of AF is unknown...
The prevalence of natural health product use in patients with acute cardiovascular diseaseAws Alherbish
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 6:e19623. 2011....
Association of global weather changes with acute coronary syndromes: gaining insights from clinical trials dataJeffrey A Bakal
Faculty of Medicine and Dentistry, Canadian VIGOUR Centre, University of Alberta, Research Innovation, 2 132 Li Ka Shing Centre for Heath, Edmonton, Alberta, Canada, T6G 2E1
Int J Biometeorol 57:401-8. 2013..Additionally there appeared to be an association with gender, region and a history of stroke. This methodology may provide a useful global insight into assessing the biometeorologic component of diseases from international data...
Neither diabetes nor glucose-lowering drugs are associated with mortality after noncardiac surgery in patients with coronary artery disease or heart failureMikael Hanninen
Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
Can J Cardiol 29:423-8. 2013..It is unclear whether diabetes mellitus or use of particular glucose-lowering agents is associated with increased risk of mortality after noncardiac surgery in patients with known cardiac disease...
The 2010 Canadian Cardiovascular Society guidelines for the diagnosis and management of heart failure update: Heart failure in ethnic minority populations, heart failure and pregnancy, disease management, and quality improvement/assurance programsJonathan G Howlett
University of Calgary, Alberta, Canada
Can J Cardiol 26:185-202. 2010..Both of these topics were written from a clinical perspective. It is hoped that the present update will become a useful tool for health care providers and planners in the ongoing evolution of care for HF patients in Canada...
The timing of implantable cardioverter-defibrillator implantation in patients with heart failureNawaf S Al-Majed
Mazankowski Alberta Heart Institute, University of Alberta, 8440 112 Street, Edmonton, Alberta, Canada
Curr Cardiol Rep 14:299-307. 2012....
Angiotensin receptor blockers and risk of myocardial infarction: systematic reviewMichael A McDonald
Division of Cardiology, University of Alberta, 2C2 WMC, University of Alberta Hospital, 8440-112 Street, Edmonton, AB, Canada T6G 2B7
BMJ 331:873. 2005..Until further information specifically dealing with this issue is available from large prospective trials, our findings may alleviate recent concerns over the safety of this class of medications...
Implantable cardioverter defibrillators in primary and secondary prevention: a systematic review of randomized, controlled trialsJustin A Ezekowitz
University of Alberta, Edmonton, Alberta T6G 2H7, Canada
Ann Intern Med 138:445-52. 2003..However, their impact on total mortality is sensitive to baseline risk for arrhythmic death. Decisions about resource allocation for ICDs depend on accurate stratification of patients according to risk...
The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACHAntigone Oreopoulos
Department of Clinical Epidemiology, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Eur Heart J 30:2584-92. 2009..Patients with obesity may be presenting earlier and receiving more aggressive treatment compared with those with normal BMI...
Carotid chemoreceptor modulation of blood flow during exercise in healthy humansMichael K Stickland
Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Physiol 589:6219-30. 2011..These findings indicate that the carotid chemoreceptor contributes to skeletal muscle blood flow regulation during normoxic exercise in healthy humans, but that the influence of the CC on blood flow regulation in hypoxia is limited...
Stroke: strategies for primary preventionJustin A Ezekowitz
University of Alberta, Faculty of Medicine and Dentistry, Edmonton, Alberta
Am Fam Physician 68:2379-86. 2003..Controversy exists about the roles of angiotensin-converting enzyme inhibitors and aspirin in the primary prevention of stroke...
Stretching for prediction: the case for brain natriuretic peptideJustin A Ezekowitz
Can J Cardiol 20:684-5. 2004
Anemia in patients with advanced heart failureJustin A Ezekowitz
J Am Coll Cardiol 49:2301; author reply 2302. 2007
Canadian Cardiovascular Society Consensus Conference guidelines on heart failure--2008 update: best practices for the transition of care of heart failure patients, and the recognition, investigation and treatment of cardiomyopathiesJ Malcom
University of Western Ontario, London, Canada
Can J Cardiol 24:21-40. 2008....
