Research Topics
| A J EvansSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasiasMaisa Yoshimoto
Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, 610 University Ave, Room 9 721, Toronto, Ontario, M5G 2M9 Canada
Cancer Genet Cytogenet 169:128-37. 2006..These findings draw attention to the usefulness of this relatively simple FISH assay for future applications in clinical laboratories...- Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experienceAndrew J Evans
Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Semin Diagn Pathol 26:165-76. 2009..In addition to its superior speed and image quality, the VS approach readily facilitates consultation with colleagues on difficult cases. As a result, there has been greater overall pathologist satisfaction with VS TP... 
The use of whole genome amplification to study chromosomal changes in prostate cancer: insights into genome-wide signature of preneoplasia associated with cancer progressionSimon Hughes
Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario M5G 2M9, Canada
BMC Genomics 7:65. 2006..This admixture with benign tissue can complicate genomic analyses in CaP. Specifically, when DNA is bulk-extracted the genetic information obtained represents an average for all of the cells within the sample...- Primary large cell neuroendocrine carcinoma of the urinary bladderAndrew J Evans
Department of Pathology, University Health Network, University of Toronto, Ontario, Canada
Arch Pathol Lab Med 126:1229-32. 2002..Currently, the patient has no evidence of local or metastatic disease 2 years after initial diagnosis... - Frequently asked questions concerning the use of whole-slide imaging telepathology for neuropathology frozen sectionsAndrew J Evans
Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
Semin Diagn Pathol 27:160-6. 2010..The reader is directed to the recent literature for more detailed information on WSI as well as a complete description of our TP program... 
Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experienceAndrew J Evans
Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Hum Pathol 40:1070-81. 2009..In addition to its superior speed and image quality, the VS approach readily facilitates consultation with colleagues on difficult cases. As a result, there has been greater overall pathologist satisfaction with VS TP...- Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimensAndrew J Evans
Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada
Am J Surg Pathol 32:1503-12. 2008..Interobserver variability for EPE and SM interpretation was principally related to the lack of a clearly definable prostatic capsule and crush/thermal artifact along the edge of the gland, respectively... - Treatment effects in the prostate including those associated with traditional and emerging therapiesAndrew J Evans
Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, ON, Canada
Adv Anat Pathol 18:281-93. 2011..An emphasis is placed on these specific modalities as they are currently in use as primary, salvage, or investigational therapy in the treatment of prostate cancer... - Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancerAndrew J Evans
Department of Pathology and Laboratory Medicine, University Health Network, Mt Sinai Hospital, Toronto, Ontario, Canada
Am J Surg Pathol 30:684-93. 2006..LCNEC of prostate is a distinct clinicopathologic entity that typically manifests after long-term hormonal therapy for prostatic adenocarcinoma and likely arises through clonal progression under the selection pressure of therapy... - Alpha-methylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsiesA J Evans
Department of Laboratory Medicine and Pathology, University of Toronto, University Health Network, Ontario, Canada
J Clin Pathol 56:892-7. 2003.... - Defining a 0.5-mb region of genomic gain on chromosome 6p22 in bladder cancer by quantitative-multiplex polymerase chain reactionAndrew J Evans
Department of Pathology, University Health Network Princess Margaret Hospital, Toronto Ontario, Canada
Am J Pathol 164:285-93. 2004..This also represents the first study identifying DNA copy number increases for DEK in bladder cancer... - Topographical analysis of telomere length and correlation with genomic instability in whole mount prostatectomiesA M Joshua
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Prostate 71:778-90. 2011..Evidence suggests that telomere dysfunction is a plausible mechanism for some of these abnormalities on the basis of the break-fusion-bridge cycle that can lead to manifestations of genomic instability... - Intraductal carcinoma of the prostate: a distinct histopathological entity with important prognostic implicationsP C Henry
Department of Pathology, University Health Network, Ontario, Canada
J Clin Pathol 62:579-83. 2009..In this review, a historical overview of the description of IDCP will be presented followed by a summary of the current histological diagnostic criteria and the recommendations for management and reporting of IDCP... - Mucin-producing urothelial-type adenocarcinoma of prostate: report of two cases of a rare and diagnostically challenging entityMichael W Curtis
Department of Pathology and Laboratory Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
Mod Pathol 18:585-90. 2005..The mucinous conventional prostatic adenocarcinoma was positive for PSA and prostatic acid phosphatase and negative for cytokeratin 7, cytokeratin 20 and 34betaE12. All tumors were positive for carcinoembryonic antigen... - Correlation of the primary Gleason pattern on prostate needle biopsy with clinico-pathological factors in Gleason 7 tumorsEthan D Grober
Division of Urology, Department of Surgery and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can J Urol 11:2157-62. 2004..The utility of distinguishing a primary Gleason pattern on needle biopsy among patients with Gleason 7 tumors remains unclear given the limited and conflicting literature addressing this issue... - Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangementMaisa Yoshimoto
Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
Neoplasia 8:465-9. 2006..Analysis of genomic architecture in the region of genomic rearrangement suggests that tracts of microhomology could facilitate TMPRSS2/ERG fusion events... - Breast carcinoma with basal phenotype: mammographic findingsAngela A Luck
Nottingham International Breast Education Centre, Nottingham City Hospital, Hucknall Rd, Nottingham NG5 1PB, United Kingdom
AJR Am J Roentgenol 191:346-51. 2008..Basal phenotype has been found to be an independent poor prognostic factor for breast cancer. The aim of this study was to assess the mammographic appearance of screening-detected breast carcinoma with the basal phenotype... - Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinomaMichelle L Gervais
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Lab Invest 87:1252-64. 2007..These findings provide the first evidence of aberrant nuclear localization of E-cadherin in CC-RCC harboring VHL mutations, and suggest potential prognostic value of VHL and E-cadherin in CC-RCC... - Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancerMasoom A Haider
Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, University of Toronto, 610 University Ave, Toronto, ON M5G 2M9, Canada
AJR Am J Roentgenol 189:323-8. 2007..The objective of our study was to compare T2-weighted MRI alone and T2 combined with diffusion-weighted imaging (DWI) for the localization of prostate cancer... - Prostate gland: MR imaging appearance after vascular targeted photodynamic therapy with palladium-bacteriopheophorbideMasoom A Haider
Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada
Radiology 244:196-204. 2007.... - Techniques, safety and accuracy of sampling of renal tumors by fine needle aspiration and core biopsyAlessandro Volpe
Department of Surgical Oncology Division of Urology, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
J Urol 178:379-86. 2007..There have been concerns about safety and accuracy. This review provides an update on the current techniques, indications and accuracy of needle biopsy of renal tumors...