Christopher G Ellis

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?
    Christopher G Ellis
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Microcirculation 19:440-50. 2012
  2. ncbi request reprint Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis
    Christopher G Ellis
    Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8, Canada
    Am J Physiol Heart Circ Physiol 282:H156-64. 2002
  3. pmc Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats
    Christopher G Ellis
    Dept of Medical Biophysics, Univ of Western Ontario, London, ON, N6A 5C1, Canada
    Am J Physiol Heart Circ Physiol 298:H1661-70. 2010
  4. pmc The microcirculation as a functional system
    Christopher G Ellis
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Crit Care 9:S3-8. 2005
  5. ncbi request reprint Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle
    Ryon M Bateman
    University of Western Ontario and the London Health Sciences Centre, Department of Medical Biophysics, London, ON, Canada
    Crit Care Med 36:225-31. 2008
  6. ncbi request reprint In vivo videomicroscopy reveals differential effects of the vascular-targeting agent ZD6126 and the anti-angiogenic agent ZD6474 on vascular function in a liver metastasis model
    Hemanth J Varghese
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Angiogenesis 7:157-64. 2004
  7. pmc A micro-delivery approach for studying microvascular responses to localized oxygen delivery
    Nour W Ghonaim
    Biomedical Engineering Graduate Program, The University of Western Ontario, London, ON, Canada
    Microcirculation 18:646-54. 2011
  8. pmc Microvascular flow modeling using in vivo hemodynamic measurements in reconstructed 3D capillary networks
    Graham M Fraser
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Microcirculation 19:510-20. 2012
  9. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003
  10. doi request reprint Ascorbate reduces mouse platelet aggregation and surface P-selectin expression in an ex vivo model of sepsis
    Dan Secor
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    Microcirculation 20:502-10. 2013

Research Grants

Collaborators

Detail Information

Publications26

  1. pmc What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?
    Christopher G Ellis
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Microcirculation 19:440-50. 2012
    ....
  2. ncbi request reprint Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis
    Christopher G Ellis
    Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8, Canada
    Am J Physiol Heart Circ Physiol 282:H156-64. 2002
    ..Capillary O(2) extraction increased threefold (P < 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O(2) transport in early stage sepsis is likely the result of a microcirculatory dysfunction...
  3. pmc Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats
    Christopher G Ellis
    Dept of Medical Biophysics, Univ of Western Ontario, London, ON, N6A 5C1, Canada
    Am J Physiol Heart Circ Physiol 298:H1661-70. 2010
    ....
  4. pmc The microcirculation as a functional system
    Christopher G Ellis
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Crit Care 9:S3-8. 2005
    ..The mechanism(s) responsible for this dysfunctional microvasculature must be understood in order to develop appropriate management strategies for sepsis...
  5. ncbi request reprint Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle
    Ryon M Bateman
    University of Western Ontario and the London Health Sciences Centre, Department of Medical Biophysics, London, ON, Canada
    Crit Care Med 36:225-31. 2008
    ..The objectives of this study were to determine whether sepsis-induced NO overproduction increased capillary stopped-flow and modulated tissue oxygen consumption in skeletal muscle...
  6. ncbi request reprint In vivo videomicroscopy reveals differential effects of the vascular-targeting agent ZD6126 and the anti-angiogenic agent ZD6474 on vascular function in a liver metastasis model
    Hemanth J Varghese
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Angiogenesis 7:157-64. 2004
    ..Understanding differences in the modes of action of VTAs and anti-angiogenic agents will be important in optimizing their clinical application and in developing appropriate combination strategies...
  7. pmc A micro-delivery approach for studying microvascular responses to localized oxygen delivery
    Nour W Ghonaim
    Biomedical Engineering Graduate Program, The University of Western Ontario, London, ON, Canada
    Microcirculation 18:646-54. 2011
    ..However, previous studies have measured the collective response of stimulating large areas of the microvascular network at the tissue surface...
  8. pmc Microvascular flow modeling using in vivo hemodynamic measurements in reconstructed 3D capillary networks
    Graham M Fraser
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Microcirculation 19:510-20. 2012
    ..We describe a systematic approach to modeling blood flow using reconstructed capillary networks and in vivo hemodynamic measurements. Our goal was to produce flow solutions that represent convective O(2) delivery in vivo...
  9. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003
    ..NO also regulates mitochondrial respiration. During sepsis, NO over-production mediates systemic hypotension and microvascular reactivity, and is seemingly protective of microvascular blood flow...
  10. doi request reprint Ascorbate reduces mouse platelet aggregation and surface P-selectin expression in an ex vivo model of sepsis
    Dan Secor
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    Microcirculation 20:502-10. 2013
    ..In this study, we hypothesized that ascorbate reduces aggregation of platelets and their surface expression of P-selectin (a key adhesion molecule) in mice...
  11. pmc Toward a multiscale description of microvascular flow regulation: o(2)-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks
    Daniel Goldman
    Department of Medical Biophysics, University of Western Ontario London, ON, Canada
    Front Physiol 3:246. 2012
    ..Taken together, these models lay the groundwork for investigating the systems biology of the regulation of microvascular perfusion distribution by erythrocyte-derived ATP...
  12. pmc Mapping 3-D functional capillary geometry in rat skeletal muscle in vivo
    Graham M Fraser
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Heart Circ Physiol 302:H654-64. 2012
    ..The described mapping software is a valuable tool for the quantification of in vivo microvascular geometry, hemodynamics, and oxygenation, thus providing rich data sets for experiment-based computational models...
  13. doi request reprint Transfusion of stored red blood cells adhere in the rat microvasculature
    Ian H Chin-Yee
    Department of Medical Biophysics, University of Western Ontario, Ontario, Canada
    Transfusion 49:2304-10. 2009
    ..The objective of this study was to determine whether duration of RBC storage and LR influence RBC adhesion in vivo in capillaries...
  14. ncbi request reprint A finite difference model of O2 transport in aortic valve cusps: importance of intrinsic microcirculation
    Renee J Filion
    Department of Medical Biophysics, Medical Sciences Building, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Heart Circ Physiol 285:H2099-104. 2003
    ..Overall, the in vivo model developed in this study confirmed the need for an intrinsic microcirculation in the thicker basal regions of aortic cusps...
  15. ncbi request reprint Mapping of the functional microcirculation in vital organs using contrast-enhanced in vivo video microscopy
    Hemanth J Varghese
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Heart Circ Physiol 288:H185-93. 2005
    ..This study demonstrates that postprocessing of fluorescence contrast video sequences of the microcirculation can provide quantitative images useful for studies in a wide range of model systems...
  16. pmc Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries
    Dan Secor
    Critical Illness Research, Victoria Research Laboratories, Lawson Health Research Institute, London, ON, N6C 2V5, Canada
    Intensive Care Med 36:1928-34. 2010
    ..Since inflammatory and coagulation pathways cross-activate, we tested if stoppage of blood flow in septic capillaries is due to oxidant-dependent adhesion of platelets in these microvessels...
  17. pmc Comparison of generated parallel capillary arrays to three-dimensional reconstructed capillary networks in modeling oxygen transport in discrete microvascular volumes
    Graham M Fraser
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Microcirculation 20:748-63. 2013
    ..We compare RMN to PCA under several simulated physiological conditions to determine how the use of different vascular geometry affects oxygen transport solutions...
  18. doi request reprint Estrogen modulates the contribution of neuropeptide Y to baseline hindlimb blood flow control in female Sprague-Dawley rats
    Dwayne N Jackson
    Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1351-7. 2010
    ..There was no change in Y(2)R expression or peptidase activity among the groups. These data support the hypothesis that estrogen blunts Y(1)R activation in the rat hindlimb through an effect on Y(1)R expression and NPY concentration...
  19. doi request reprint Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells
    Matthew J Frontini
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Nat Biotechnol 29:421-7. 2011
    ..This mature physiological competency was attained by targeting mesenchymal cells rather than endothelial cells, a finding that could inform strategies for therapeutic angiogenesis and tissue engineering...
  20. ncbi request reprint Optimization of nitric oxide chemiluminescence operating conditions for measurement of plasma nitrite and nitrate
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, N6B 1B8, Canada
    Clin Chem 48:570-3. 2002
  21. ncbi request reprint Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model
    Daniel Goldman
    Dept of Mathematical Sciences, New Jersey Institute of Technology, Univ Heights, Newark, NJ 07102, USA
    Am J Physiol Heart Circ Physiol 287:H2535-44. 2004
    ..The model predicts that decreased FCD, increased fast flow, and increased Vo2 in sepsis expose skeletal muscle to significant regions of hypoxia, which could affect local cellular and organ function...
  22. ncbi request reprint A new video image analysis system to study red blood cell dynamics and oxygenation in capillary networks
    Shruti A Japee
    Department of Biomedical Engineering, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, 23298, USA
    Microcirculation 12:489-506. 2005
    ....
  23. ncbi request reprint Automated method for tracking individual red blood cells within capillaries to compute velocity and oxygen saturation
    Shruti A Japee
    Department of Biomedical Engineering, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, 23298, USA
    Microcirculation 12:507-15. 2005
    ..This method uses a recently developed Measurement and Analysis System for Capillary Oxygen Transport (MASCOT) and the concept of space-time images to track RBCs between consecutive frames of video recordings of the microcirculation...
  24. ncbi request reprint Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow
    Daniel Goldman
    Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
    Am J Physiol Heart Circ Physiol 290:H2277-85. 2006
    ..Thus heterogeneous stoppage of individual capillaries is a likely factor in pathological supply dependency...
  25. ncbi request reprint Flow visualization tools for image analysis of capillary networks
    Shruti A Japee
    Department of Biomedical Engineering, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Microcirculation 11:39-54. 2004
    ..We have developed several image processing tools to aid in the selection of such capillaries for analysis and to obtain quick overviews of RBC flow through the microcirculation...
  26. ncbi request reprint Effect of nitric oxide on capillary hemodynamics and cell injury in the pancreas during Pseudomonas pneumonia-induced sepsis
    Barbara Tribl
    Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Am J Physiol Heart Circ Physiol 286:H340-5. 2004
    ..We conclude that, in this normotensive pneumonia model of sepsis, NO overproduction was protective of microvascular perfusion in the pancreas...

Research Grants2

  1. Microvascular O2 Delivery: Impact of Erythrocyte-Released ATP
    Christopher Ellis; Fiscal Year: 2007
    ..e., ATP release from RBCs of type 2 diabetics is compromised. ..