Marc Ekker

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer
    Luc Poitras
    Center for Advanced Research in Environmental Genomics CAREG Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Development 134:1755-65. 2007
  2. pmc Modeling neurodegeneration in zebrafish
    Yanwei Xi
    Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N6N5, Canada
    Curr Neurol Neurosci Rep 11:274-82. 2011
  3. pmc Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, K1N 6N5, Canada
    BMC Evol Biol 10:157. 2010
  4. doi request reprint Functional resolution of duplicated hoxb5 genes in teleosts
    Olga Jarinova
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Development 135:3543-53. 2008
  5. doi request reprint In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio)
    Shelby L Steele
    Department of Biology, University of Ottawa, Ottawa, ON, Canada, K1N 6N5
    J Exp Biol 214:1445-57. 2011
  6. pmc An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
    Luc Poitras
    Center for Advanced Research in Environmental Genomics CAREG, Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada
    Development 137:3089-97. 2010
  7. pmc The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Dev Dyn 239:2298-306. 2010
  8. doi request reprint Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer
    Noel Ghanem
    Center for Advanced Research in Environmental Genomics CAREG, Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Dev Biol 322:415-24. 2008
  9. ncbi request reprint Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons
    Noel Ghanem
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 27:5012-22. 2007
  10. doi request reprint Interactive effects of development and hypoxia on catecholamine synthesis and cardiac function in zebrafish (Danio rerio)
    Shelby L Steele
    Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie Street, Ottawa, ON, K1N 6N5, Canada
    J Comp Physiol B 181:527-38. 2011

Collaborators

  • Man Yu
  • Steven M Sperber
  • Vishal Saxena
  • Shuk Han Cheng
  • Byrappa Venkatesh
  • Qiaoming Long
  • Christopher J Martyniuk
  • Jared Coffin Talbot
  • Lucie Jeannotte
  • Luc Poitras
  • Noel Ghanem
  • Yanwei Xi
  • Shelby L Steele
  • Gary Hatch
  • Ryan B MacDonald
  • John L R Rubenstein
  • Steve F Perry
  • Mélanie Debiais-Thibaud
  • Olga Jarinova
  • Sandra Noble
  • Bhaja Krushna Padhi
  • Byung K Park
  • Bernd Pelster
  • Mario Tiberi
  • Rafael Godoy
  • Xiaodi Yang
  • Thorsten Schwerte
  • Jean Philippe Gagné
  • Cindy Lesage-Pelletier
  • Steven P Hamilton
  • Joel Ryan
  • Guy G Poirier
  • Isabelle Kelly
  • Ayse E Yilbas
  • Boon Hui Tay
  • Kyle Martin
  • Vincent Wai Tsun Li
  • Kwok Hong Andy Lo
  • Christelle Prudhomme
  • Félix Antoine Bérubé-Simard
  • Josée Aubin
  • Magdalena Grzyb
  • Jason Long
  • Marie Andrée Akimenko
  • Bethan L Thomas
  • Anuradha Choudhury
  • Paul T Sharpe
  • Gary T Hatch
  • Angel Amores
  • Byung Keon Park

Detail Information

Publications19

  1. ncbi request reprint The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer
    Luc Poitras
    Center for Advanced Research in Environmental Genomics CAREG Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Development 134:1755-65. 2007
    ....
  2. pmc Modeling neurodegeneration in zebrafish
    Yanwei Xi
    Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N6N5, Canada
    Curr Neurol Neurosci Rep 11:274-82. 2011
    ....
  3. pmc Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, K1N 6N5, Canada
    BMC Evol Biol 10:157. 2010
    ..We then conducted a comparative study of the sequence and enhancer activity of CmURE2 with that of orthologous regulatory sequences from zebrafish and mouse...
  4. doi request reprint Functional resolution of duplicated hoxb5 genes in teleosts
    Olga Jarinova
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Development 135:3543-53. 2008
    ..Our results highlight the importance of interactions between CNEs in the execution of complementary subfunctions of duplicated genes...
  5. doi request reprint In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio)
    Shelby L Steele
    Department of Biology, University of Ottawa, Ottawa, ON, Canada, K1N 6N5
    J Exp Biol 214:1445-57. 2011
    ..Overall, this study provides insight into the function and evolution of both fish and mammalian β-adrenergic receptors...
  6. pmc An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
    Luc Poitras
    Center for Advanced Research in Environmental Genomics CAREG, Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada
    Development 137:3089-97. 2010
    ..This study illustrates the clear functional consequences of a single nucleotide variation in an ultraconserved non-coding sequence in the context of developmental abnormalities associated with disease...
  7. pmc The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Dev Dyn 239:2298-306. 2010
    ..Our results indicate the dlx genes are regulated by an evolutionarily conserved genetic pathway and may play a role in GABAergic interneuron differentiation in the zebrafish forebrain...
  8. doi request reprint Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer
    Noel Ghanem
    Center for Advanced Research in Environmental Genomics CAREG, Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Dev Biol 322:415-24. 2008
    ....
  9. ncbi request reprint Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons
    Noel Ghanem
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 27:5012-22. 2007
    ..These data suggest that interneuron subtypes use distinct combinations of Dlx1/Dlx2 enhancers from the time they are specified through adulthood...
  10. doi request reprint Interactive effects of development and hypoxia on catecholamine synthesis and cardiac function in zebrafish (Danio rerio)
    Shelby L Steele
    Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie Street, Ottawa, ON, K1N 6N5, Canada
    J Comp Physiol B 181:527-38. 2011
    ....
  11. ncbi request reprint Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements
    Steven M Sperber
    Department of Cellular and Molecular Medicine, University of Ottawa, and Ottawa Health Research Institute, Canada
    Dev Biol 314:59-70. 2008
    ..Defects in the differentiation of ectomesenchymal derivatives, including sensory ganglia and cartilage elements, indicate a role for dlx2a in specification and maintenance of cranial neural crest...
  12. doi request reprint Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function
    Yanwei Xi
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada K1N6N5
    Eur J Neurosci 31:623-33. 2010
    ..These results indicate that normal PINK1 function during development is necessary for the proper positioning of populations of dopaminergic neurons and for the establishment of neuronal circuits in which they are implicated...
  13. doi request reprint Activity of dlx5a/dlx6a regulatory elements during zebrafish GABAergic neuron development
    Man Yu
    Centre for Advanced Research in Environmental Genomics CAREG, Department of Biology, University of Ottawa, ON, Canada
    Int J Dev Neurosci 29:681-91. 2011
    ..Together, our data suggest that zebrafish dlx5a/dlx6a intergenic CREs may be involved in a conserved genetic pathway necessary for proper dlx expression during zebrafish GABAergic neuron development...
  14. doi request reprint Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon
    Yanwei Xi
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Dev Dyn 240:2539-47. 2011
    ..This transgenic line will be useful for the study of DA neuron development and in models of DA neuron loss...
  15. pmc Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters
    Noel Ghanem
    Ottawa Health Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Genome Res 13:533-43. 2003
    ....
  16. ncbi request reprint Microarray analysis in the zebrafish (Danio rerio) liver and telencephalon after exposure to low concentration of 17alpha-ethinylestradiol
    Christopher J Martyniuk
    Centre for Advanced Research in Environmental Genomics, 30 Marie Curie, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Aquat Toxicol 84:38-49. 2007
    ....
  17. ncbi request reprint Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish
    Bhaja Krushna Padhi
    Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, ON, Canada K1Y 4E9
    Gene 368:37-45. 2006
    ..This contrasts with other members of the keratin gene family, which diverged independently between fish and mammals...
  18. ncbi request reprint Intergenic enhancers with distinct activities regulate Dlx gene expression in the mesenchyme of the branchial arches
    Byung K Park
    Ottawa Health Research Institute at the Ottawa Hospital, Ottawa, ON, Canada K1Y 4E9
    Dev Biol 268:532-45. 2004
    ....
  19. doi request reprint Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio)
    Shelby L Steele
    Univ of Ottawa, Dept of Biology, Ottawa, ON, Canada K1N 6N5
    Am J Physiol Regul Integr Comp Physiol 297:R412-20. 2009
    ..This is the first study to demonstrate a specific role of the M(2) muscarinic receptor in the initiation of hypoxic bradycardia in fish...