Thomas R Einarson

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Cost impact of switching histamine(2)-receptor antagonists to nonprescription status
    Michelle D Furler
    Graduate Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 36:1135-41. 2002
  2. ncbi request reprint Treatments for metastatic melanoma: synthesis of evidence from randomized trials
    Philip Lui
    Leslie Dan Faculty of Pharmacy, 144 College Street, Toronto, ON, Canada M5S 3M2
    Cancer Treat Rev 33:665-80. 2007
  3. pmc Effect of iron content on the tolerability of prenatal multivitamins in pregnancy
    Patricia Nguyen
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    BMC Pregnancy Childbirth 8:17. 2008
  4. ncbi request reprint Evidence based review of escitalopram in treating major depressive disorder in primary care
    Thomas R Einarson
    Faculty of Pharmacy, Department of Clinical Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Int Clin Psychopharmacol 19:305-10. 2004
  5. pmc Relationship between blood glucose and carotid intima media thickness: A meta-analysis
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:37. 2010
  6. ncbi request reprint The Authority/Pharmacotherapy Care model: an explanatory model of the drug use process in primary care
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, Department of Health Policy, Management, and Evaluation, Faculty of Medicine, University of Toronto, Toronto, ON M5S 2S2, Canada
    Res Social Adm Pharm 1:101-17. 2005
  7. ncbi request reprint An examination of the effect of cytochrome P450 drug interactions of hydroxymethylglutaryl-coenzyme A reductase inhibitors on health care utilization: a Canadian population-based study
    Thomas R Einarson
    University of Toronto, Toronto, Ontario, Canada
    Clin Ther 24:2126-36. 2002
  8. doi request reprint Cost-effectiveness analysis of atypical long-acting antipsychotics for treating chronic schizophrenia in Finland
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    J Med Econ 16:1096-105. 2013
  9. ncbi request reprint Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes
    Josephine Djulus
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 67:1280-4. 2006
  10. doi request reprint Systematic review and quality assessment of economic evaluations and quality-of-life studies related to generalized anxiety disorder
    Basil G Bereza
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada basil berezawutoronto
    Clin Ther 31:1279-308. 2009

Detail Information

Publications84

  1. ncbi request reprint Cost impact of switching histamine(2)-receptor antagonists to nonprescription status
    Michelle D Furler
    Graduate Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 36:1135-41. 2002
    ..The histamine(2)-receptor antagonists (H(2)RAs) underwent such status change in the UK in 1994, the US in 1995, and Canada in 1996...
  2. ncbi request reprint Treatments for metastatic melanoma: synthesis of evidence from randomized trials
    Philip Lui
    Leslie Dan Faculty of Pharmacy, 144 College Street, Toronto, ON, Canada M5S 3M2
    Cancer Treat Rev 33:665-80. 2007
    ..Advanced melanomas (non-resectable Stage-III/IV) are fatal, with few effective treatments. It remains unclear if other drugs offer improvements over the standard, dacarbazine...
  3. pmc Effect of iron content on the tolerability of prenatal multivitamins in pregnancy
    Patricia Nguyen
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    BMC Pregnancy Childbirth 8:17. 2008
    ....
  4. ncbi request reprint Evidence based review of escitalopram in treating major depressive disorder in primary care
    Thomas R Einarson
    Faculty of Pharmacy, Department of Clinical Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Int Clin Psychopharmacol 19:305-10. 2004
    ..A pharmacoeconomic analysis is also required to determine whether these clinical advantages for the patients translate into economic advantages for the health care system...
  5. pmc Relationship between blood glucose and carotid intima media thickness: A meta-analysis
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:37. 2010
    ..The link has not been established between glucose and CIMT; therefore, we sought to assess the relationship between glucose and CIMT...
  6. ncbi request reprint The Authority/Pharmacotherapy Care model: an explanatory model of the drug use process in primary care
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, Department of Health Policy, Management, and Evaluation, Faculty of Medicine, University of Toronto, Toronto, ON M5S 2S2, Canada
    Res Social Adm Pharm 1:101-17. 2005
    ..Drug utilization studies have proliferated and many variants exist. Few models have been presented that account for all of the different types of studies and approaches...
  7. ncbi request reprint An examination of the effect of cytochrome P450 drug interactions of hydroxymethylglutaryl-coenzyme A reductase inhibitors on health care utilization: a Canadian population-based study
    Thomas R Einarson
    University of Toronto, Toronto, Ontario, Canada
    Clin Ther 24:2126-36. 2002
    ..Cytochrome P450-related drug interactions can lead to adverse effects that may affect health care resource utilization...
  8. doi request reprint Cost-effectiveness analysis of atypical long-acting antipsychotics for treating chronic schizophrenia in Finland
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    J Med Econ 16:1096-105. 2013
    ..This study determined the cost-effectiveness of long-acting antipsychotic (LAI) drugs paliperidone palmitate (PP-LAI), olanzapine pamoate (OLZ-LAI), and risperidone (RIS-LAI) for chronic schizophrenia...
  9. ncbi request reprint Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes
    Josephine Djulus
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 67:1280-4. 2006
    ..Currently, apart from a few case reports and case series in the literature, there are no studies evaluating the safety of this drug during pregnancy...
  10. doi request reprint Systematic review and quality assessment of economic evaluations and quality-of-life studies related to generalized anxiety disorder
    Basil G Bereza
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada basil berezawutoronto
    Clin Ther 31:1279-308. 2009
    ..The objectives of this article were to systematically review, summarize the results of, and assess the quality of economic evaluations and humanistic studies related to patients with generalized anxiety disorder (GAD)...
  11. pmc Pain due to multiple sclerosis: analysis of the prevalence and economic burden in Canada
    Charles Piwko
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    Pain Res Manag 12:259-65. 2007
    ..Multiple sclerosis (MS) is a neurological disease affecting approximately 50,000 Canadians. Although studies have described overall MS costs, none have focused specifically on MS-related pain...
  12. doi request reprint Advanced cutaneous malignant melanoma: a systematic review of economic and quality-of-life studies
    Richard P Cashin
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Value Health 11:259-71. 2008
    ..We systematically reviewed published articles describing the impact of interventions (drugs and screening) on quality of life (QoL) in patients with MM, and articles that measured QoL in MM...
  13. doi request reprint Economic and clinical comparison of atypical depot antipsychotic drugs for treatment of chronic schizophrenia in the Czech Republic
    Thomas R Einarson
    University of Toronto, Toronto, Canada
    J Med Econ 16:1089-95. 2013
    ..The Czech Republic is faced with making choices between pharmaceutical products, including depot injectable antipsychotics. A pharmacoeconomic analysis was conducted to determine the cost-effectiveness of atypical depots...
  14. ncbi request reprint Polypharmacy in HIV: impact of data source and gender on reported drug utilization
    Michelle D Furler
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    AIDS Patient Care STDS 18:568-86. 2004
    ..Our findings emphasize the complexity of pharmacotherapy in HIV and the need for comprehensive drug assessment, particularly because of the risks of drug-drug interactions and decreased adherence secondary to therapeutic complexity...
  15. ncbi request reprint Willingness to pay for a treatment for pain in multiple sclerosis
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    Pharmacoeconomics 27:149-58. 2009
    ..Multiple sclerosis (MS) is a chronic neurological disease that affects 240 per 100 000 Canadians. Of these patients, 10-80% (average 70%) experience pain. Sativex is a cannabis-based drug recently approved for neuropathic pain...
  16. ncbi request reprint Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study
    Adrienne Einarson
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Psychiatry 54:242-6. 2009
    ..To ascertain if antidepressants, as a group, increase the risk for major malformations, as well as assessing each individual antidepressant...
  17. ncbi request reprint Validation of an economic model of paliperidone palmitate for chronic schizophrenia
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    J Med Econ 16:1267-74. 2013
    ..The primary purpose was to cross-validate a recent pharmacoeconomic model comparing long-acting injectable (LAI) antipsychotics for treating chronic schizophrenia in Sweden. The secondary purpose was to provide external validation...
  18. pmc Health state utilities and quality of life in patients with hepatitis B
    Gloria Woo
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Can J Gastroenterol 26:445-51. 2012
    ..The effect of chronic hepatitis B (CHB) infection on health-related quality of life (HRQoL) and health state utilities has not been well characterized...
  19. doi request reprint Evaluation of the risk of congenital cardiovascular defects associated with use of paroxetine during pregnancy
    Adrienne Einarson
    Motherisk Program, Hospital for Sick Children, Division of Clinical Pharmacology, University of Toronto, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Am J Psychiatry 165:749-52. 2008
    ..In this study, the authors sought to determine whether paroxetine was associated with an increased risk of cardiovascular defects in infants of women exposed to the drug during the first trimester of pregnancy...
  20. ncbi request reprint Longitudinal trends in antiretroviral use in a cohort of men and women in Ontario, Canada
    Michelle D Furler
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    AIDS Patient Care STDS 20:245-57. 2006
    ....
  21. ncbi request reprint Quantifying the global rates of nausea and vomiting of pregnancy: a meta analysis
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    J Popul Ther Clin Pharmacol 20:e171-83. 2013
    ..Nausea and vomiting of pregnancy (NVP) is the most common medical condition in pregnancy, affecting women worldwide. It is unclear whether its prevalence and severity NVP are variable across different nations and races...
  22. ncbi request reprint Prevalence of nausea and vomiting of pregnancy in the USA: a meta analysis
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    J Popul Ther Clin Pharmacol 20:e163-70. 2013
    ..The rates of NVP in the USA have not been systematically calculated...
  23. ncbi request reprint Evidence-based review of clinical outcomes of guideline-recommended pharmacotherapies for generalized anxiety disorder
    Basil G Bereza
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario
    Can J Psychiatry 57:470-8. 2012
    ..To quantify the rates of clinical outcomes of Canadian Psychiatric Association (CPA) guideline-recommended pharmacotherapies for generalized anxiety disorder (GAD) by drug classification within each treatment line...
  24. ncbi request reprint Antidepressant use during pregnancy and the rates of spontaneous abortions: a meta-analysis
    Michiel E H Hemels
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 39:803-9. 2005
    ....
  25. ncbi request reprint Sensitivity of patient outcomes to pharmacist interventions. Part III: systematic review and meta-analysis in hyperlipidemia management
    Marcio Machado
    Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 42:1195-207. 2008
    ..Multidisciplinary interventions, including those performed by pharmacists, are important for improving patients' outcomes...
  26. ncbi request reprint Quality and content of abstracts in papers reporting about drug exposures during pregnancy
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Birth Defects Res A Clin Mol Teratol 76:621-8. 2006
    ..Our objectives were to evaluate the quality of information in abstracts reporting human fetal outcomes following drug exposure during pregnancy...
  27. ncbi request reprint Economic evaluation of Avonex (interferon beta-Ia) in patients following a single demyelinating event
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, 1175 North Service Road West, Suite 211, Oakville, Ontario, Canada
    Mult Scler 11:542-51. 2005
    ..This study determined the cost effectiveness of Avonex compared to current treatment in delaying the onset of CDMS...
  28. ncbi request reprint Newer antidepressants in pregnancy and rates of major malformations: a meta-analysis of prospective comparative studies
    Thomas R Einarson
    Faculty of Pharmacy, Department of Clinical Pharmacology, Faculty of Medicine, University of Toronto, Ont, Canada
    Pharmacoepidemiol Drug Saf 14:823-7. 2005
    ..A substantial number of women of childbearing age suffer from depression. Despite this, relatively little is known about the safety of antidepressant use during pregnancy...
  29. doi request reprint Patterns of paediatric analgesic use in Africa: a systematic review
    Parvaz Madadi
    Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Arch Dis Child 97:1086-91. 2012
    ..2%). There were 455 suspected adverse drug reactions which included 17 deaths. Analgesic use reported in African children appears to fall short of WHO standards...
  30. ncbi request reprint Do findings differ across research design? The case of antidepressant use in pregnancy and malformations
    Thomas R Einarson
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Popul Ther Clin Pharmacol 19:e334-48. 2012
    ..Many studies examining the teratogenic potential of antidepressants have been published. A variety of observational designs have been used with apparent conflicting results, although odds ratios were rarely >2...
  31. ncbi request reprint Nausea and vomiting of pregnancy (NVP) and depression: cause or effect?
    Pina Bozzo
    The Motherisk Program, The Hospital forSick Children, Toronto, Canada
    Clin Invest Med 34:E245. 2011
    ..Several studies have linked depression with nausea and vomiting of pregnancy (NVP); however, researchers were unable to determine whether depression was caused by NVP or by a pre-existing condition...
  32. ncbi request reprint Prevalence of depression during pregnancy: systematic review
    Heather A Bennett
    Faculty of Pharmacy and Department of Medicine, University of Toronto, Ontario, Canada
    Obstet Gynecol 103:698-709. 2004
    ....
  33. ncbi request reprint Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis
    Y Ingrid Goh
    Department of Pharmaceutical Sciences, University of Toronto, and The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
    J Obstet Gynaecol Can 28:680-9. 2006
    ..Several studies have also proposed the effectiveness of these supplements in preventing other birth defects; however, such effects have never been systematically examined...
  34. ncbi request reprint The weekly cost of nausea and vomiting of pregnancy for women calling the Toronto Motherisk Program
    Charles Piwko
    The Hospital for Sick Children, Toronto, Canada
    Curr Med Res Opin 23:833-40. 2007
    ..Nausea with or without vomiting of pregnancy (NVP) is the most common medical condition in pregnancy. NVP, even with mild symptoms, is associated with costs to society, patients, and the health care system...
  35. doi request reprint Management and prevention of diabetic foot ulcers and infections: a health economic review
    Ivy Chow
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharmacoeconomics 26:1019-35. 2008
    ..Other innovations (becaplermin, bioengineered living-skin equivalents, filgrastim, cadexomer iodine ointment, hyperbaric oxygen, Promogran may be cost effective in this population but more studies are needed to confirm these findings...
  36. doi request reprint Blood glucose and subsequent cardiovascular disease: update of a meta-analysis
    Thomas R Einarson
    University of Toronto, ON, Canada
    Curr Med Res Opin 27:2155-63. 2011
    ..No restrictions were placed on language or publication date...
  37. ncbi request reprint Probiotic safety in pregnancy: a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp
    Jean Jaques Dugoua
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, and Motherisk Program, Hospital for Sick Children, Toronto ON
    J Obstet Gynaecol Can 31:542-52. 2009
    ..No RCTs were available for Saccharomyces during pregnancy. Lactobacillus and Bifidobacterium had no effect on the incidence of Caesarean section, birth weight, or gestational age. The safety of Saccharomyces during pregnancy is unknown...
  38. doi request reprint Assessing the reporting and scientific quality of meta-analyses of randomized controlled trials of treatments for anxiety disorders
    Basil G Bereza
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 42:1402-9. 2008
    ..Meta-analyses of randomized controlled trials (RCTs) constitute the highest level of evidence, but their usefulness depends on their quality...
  39. ncbi request reprint Medicinal and recreational marijuana use by patients infected with HIV
    Michelle D Furler
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    AIDS Patient Care STDS 18:215-28. 2004
    ..The role of poverty in patient choice of medicinal marijuana despite access to care and the large proportion of women using marijuana for pain constitute areas for further study...
  40. ncbi request reprint Quality assessment of meta-analyses of RCTs of pharmacotherapy in major depressive disorder
    Michiel E H Hemels
    Faculty of Pharmacology, University of Toronto, Canada
    Curr Med Res Opin 20:477-84. 2004
    ..89; p < 0.05). the quality of reporting in MAs of RCTs of pharmacotherapy for major depressive disorder (MDD) in adults (18-65 years) without comorbidities and examine trends over time...
  41. doi request reprint The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis
    Simerpal K Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1541-5; quiz 1540, 1546. 2009
    ..The aim of this study is to determine the fetal safety of PPIs during early pregnancy through systematic literature review...
  42. ncbi request reprint The effectiveness of Proctofoam-HC for treatment of hemorrhoids in late pregnancy
    Sabina Vohra
    The Motherisk Program, Hospital for Sick Children, Toronto, ON, Canada
    J Obstet Gynaecol Can 31:654-9. 2009
    ..Currently no topical anti-hemorrhoidal agents have been studied for effectiveness in pregnancy. This study evaluated the effectiveness of Proctofoam-HC used during the last trimester of pregnancy...
  43. doi request reprint Systematic review and meta-analysis of the effect of warming local anesthetics on injection pain
    Mary Ellen Hogan
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Ann Emerg Med 58:86-98.e1. 2011
    ..We determine the effectiveness of warming local anesthetics to reduce pain in adults and children undergoing local anesthetic infiltration into intradermal or subcutaneous tissue...
  44. ncbi request reprint HOPE study impact on ACE inhibitors use
    Michiel E H Hemels
    Graduate Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 37:640-5. 2003
    ..The HOPE (Heart Outcomes Prevention Evaluation) study showed that ramipril benefits patients at high risk for cardiovascular disease. We analyzed ACE inhibitor use and costs in Canada before and after publication of HOPE...
  45. ncbi request reprint Cost analysis of ropinirole versus levodopa in the treatment of Parkinson's disease
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    Pharmacoeconomics 21:115-27. 2003
    ..Not all patients with Parkinson's disease (PD) respond to levodopa and others develop dyskinesias. Ropinirole, a dopamine agonist, is associated with fewer dyskinesias than levodopa...
  46. ncbi request reprint Increased use of antidepressants in Canada: 1981-2000
    Michiel E H Hemels
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 36:1375-9. 2002
    ..To provide a descriptive analysis of Canadian utilization (prescriptions, cost, cost per prescription) of antidepressants (ATC-code: N06A)...
  47. ncbi request reprint Intratympanic gentamicin for Menière's disease: a meta-analysis
    Raanan Cohen-Kerem
    Department of Otolaryngology Head and Neck Surgery and the Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Laryngoscope 114:2085-91. 2004
    ..To systematically review the published experience on intratympanic gentamicin treatment for intractable Menière's disease...
  48. ncbi request reprint Topical calcineurin inhibitors in the treatment of atopic dermatitis: a meta-analysis of current evidence
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    Am J Clin Dermatol 5:267-79. 2004
    ..To summarize success rates of the topical calcineurin inhibitors tacrolimus and pimecrolimus in treating atopic dermatitis...
  49. ncbi request reprint Willingness to pay for inhaled insulin: a contingent valuation approach
    Hamid Sadri
    Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Pharmacoeconomics 23:1215-27. 2005
    ..To determine the willingness to pay (WTP) of patients with diabetes mellitus for inhaled insulin...
  50. ncbi request reprint Reference values for hair cotinine as a biomarker of active and passive smoking in women of reproductive age, pregnant women, children, and neonates: systematic review and meta-analysis
    Ana Florescu
    Public Health Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Ther Drug Monit 29:437-46. 2007
    ..These new values should facilitate clinical diagnosis of active and passive exposure to tobacco smoke. Such diagnosis is critical in pregnancy and in a large number of tobacco-induced medical conditions...
  51. ncbi request reprint To accept or reject? A guide to peer reviewing of medical journal papers
    Thomas R Einarson
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada
    J Popul Ther Clin Pharmacol 19:e328-33. 2012
    ..Scientists and clinicians are often called upon to review papers and may need guidance to optimize their performance as reviewers...
  52. ncbi request reprint International drug price comparisons: quality assessment
    Marcio Machado
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Rev Panam Salud Publica 29:46-51. 2011
    ..To quantitatively summarize results (i.e., prices and affordability) reported from international drug price comparison studies and assess their methodological quality...
  53. ncbi request reprint Collaborative medication management in a team-based primary care practice: an explanatory conceptual framework
    Jana M Bajcar
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Res Social Adm Pharm 1:408-29. 2005
    ..The roles and functions of these individuals can be difficult to define, because of a lack of a common ground for discussion. Deliberating the topic is important for developing a team approach to medication management...
  54. ncbi request reprint Efficacy of botulinum toxin type A for the prophylaxis of episodic migraine headaches: a meta-analysis of randomized, double-blind, placebo-controlled trials
    Adam J Shuhendler
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Pharmacotherapy 29:784-91. 2009
    ..To assess the efficacy of botulinum toxin type A in lowering the frequency of migraine headaches in patients with episodic migraines...
  55. ncbi request reprint Sensitivity of patient outcomes to pharmacist interventions. Part II: Systematic review and meta-analysis in hypertension management
    Marcio Machado
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 41:1770-81. 2007
    ..Hypertension is a major health concern worldwide due to its deleterious impact. Few studies have quantitatively assessed pharmacists' interventions in hypertensive patients...
  56. ncbi request reprint Clinical and cost implications of target joints in Canadian boys with severe hemophilia A
    Melissa Kern
    Division of Hematology Oncology, The Hospital for Sick Children, Ontario, Canada
    J Pediatr 145:628-34. 2004
    ..To compare target joint-associated costs incurred by boys with severe hemophilia A 1 year before and 1 year after development of a target joint (pre-TJ, post-TJ)...
  57. pmc Pharmacoeconomic analysis of paliperidone palmitate for treating schizophrenia in Greece
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5V 3M8, Canada
    Ann Gen Psychiatry 11:18. 2012
    ..abstract:..
  58. doi request reprint An analysis of potentially prolactin-related adverse events and abnormal prolactin values in randomized clinical trials with paliperidone palmitate
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Ann Pharmacother 46:1322-30. 2012
    ..However, few individuals with elevated prolactin levels (hyperprolactinemia) have symptomatic potentially prolactin-related adverse events (PPR-AEs)...
  59. pmc Seroprevalence of Toxoplasma gondii infection among veterinary staff in Ontario, Canada (2002): implications for teratogenic risk
    Samar Shuhaiber
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    BMC Infect Dis 3:8. 2003
    ..gondii antibody among veterinary staff, to ascertain whether they have an increased risk through occupational exposure. Our secondary objective was to examine their practices regarding cats, toxoplasma infection, and pregnancy...
  60. ncbi request reprint Quality of structured abstracts of original research articles in the British Medical Journal, the Canadian Medical Association Journal and the Journal of the American Medical Association: a 10-year follow-up study
    Ho Lun Wong
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, ON, Canada
    Curr Med Res Opin 21:467-73. 2005
    ....
  61. ncbi request reprint Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses
    Gloria Woo
    Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 139:1218-29. 2010
    ..We evaluated the relative efficacies of the first 12 months of CHB treatments...
  62. ncbi request reprint Clinical pharmacy services in the home: Canadian case studies
    Linda D MacKeigan
    Faculty of Pharmacy and Home Care Evaluation and Research Centre, University of Toronto, Ontario, Canada
    J Am Pharm Assoc (Wash) 42:735-42. 2002
    ..Design: Home care practices in Canada were identified using key informant and snowball sampling methods. Case descriptions of each pharmacy were composed using data obtained via a faxed questionnaire and a follow-up telephone interview...
  63. ncbi request reprint Malformation rates in children of women with untreated epilepsy: a meta-analysis
    Shawn Fried
    University of Toronto, Toronto, Ontario, Canada
    Drug Saf 27:197-202. 2004
    ..It is widely quoted that women with epilepsy have a higher than baseline risk for giving birth to a child with malformations, independent of the effects of antiepileptic drugs...
  64. ncbi request reprint Economic evaluation of an extended acellular pertussis vaccine program for adolescents in Québec, Canada
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    Paediatr Drugs 7:123-36. 2005
    ..The purpose of this analysis was to estimate the health and economic impact of an additional booster dose of the acellular vaccine in adolescents in Québec...
  65. ncbi request reprint Statistics in the pharmacy literature
    Charlene M Lee
    Master of Science Student, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada University Health Network, Toronto
    Ann Pharmacother 38:1412-8. 2004
    ..Research in statistical methods is essential for maintenance of high quality of the published literature...
  66. ncbi request reprint Use of complementary and alternative medicine by HIV-infected outpatients in Ontario, Canada
    Michelle D Furler
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    AIDS Patient Care STDS 17:155-68. 2003
    ..CAM use in Canadian patients with HIV is extremely common, with higher use among women. The definition of CAM has a substantial impact both on reported prevalence rates and on predictors of CAM use...
  67. ncbi request reprint Cost analysis of secondary prophylaxis with oral clodronate versus pamidronate in metastatic breast cancer patients
    Dorothy Romanus
    Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Support Care Cancer 12:844-51. 2004
    ..We compared the direct medical costs of secondary prophylaxis with bisphosphonates (BPs) in bone metastases (BMs) of breast cancer (BCa) from a payer perspective...
  68. ncbi request reprint Duloxetine and venlafaxine-XR in the treatment of major depressive disorder: a meta-analysis of randomized clinical trials
    Peter Mj Vis
    Faculty of Pharmacy, University of Utrecht, Utrecht, Netherlands
    Ann Pharmacother 39:1798-807. 2005
    ..Duloxetine has joined venlafaxine on the antidepressant market as a second serotonin-norepinephrine reuptake inhibitor. No previous studies have directly compared these drugs...
  69. ncbi request reprint Cost-effectiveness of escitalopram for generalized anxiety disorder in Canada
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc Oakville, ON, Canada
    Curr Med Res Opin 24:1539-48. 2008
    ..Generalized Anxiety Disorder (GAD) is a common chronic disease with a lifetime prevalence estimated to range from 4.2% to 12.7%. GAD places a substantial burden upon patients and healthcare resources...
  70. ncbi request reprint Problems with maternal antidepressant treatment and neonatal outcomes study
    Thomas R Einarson
    Arch Gen Psychiatry 64:866; author reply 867-8. 2007
  71. ncbi request reprint Cost-effectiveness analysis of escitalopram: a new SSRI in the first-line treatment of major depressive disorder in Austria
    Michiel E H Hemels
    International Department of Health Economics and Epidemiology, H Lundbeck A S, Paris, France
    Curr Med Res Opin 20:869-78. 2004
    ..To compare the cost-effectiveness of escitalopram, a new selective serotonin reuptake inhibitor (SSRI), with (generic) citalopram in the first-line treatment of major depressive disorder (MDD) in Austria...
  72. ncbi request reprint Cost-effectiveness of escitalopram versus citalopram in the treatment of severe depression
    Michiel E H Hemels
    International Department of Health Economics and Epidemiology, H Lundbeck A S, 37 Avenue Pierre 1er de Serbie, 75008 Paris, France
    Ann Pharmacother 38:954-60. 2004
    ..Severe depression is associated with an extensive economic burden on both the patient and society...
  73. ncbi request reprint Sensitivity of patient outcomes to pharmacist interventions. Part I: systematic review and meta-analysis in diabetes management
    Marcio Machado
    Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Ann Pharmacother 41:1569-82. 2007
    ..Pharmacists participate in managing diabetes therapy. Despite many reviews, few have quantified the impact of pharmacists' interventions...
  74. ncbi request reprint Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, ON, Canada
    Curr Med Res Opin 23:17-24. 2007
    ..Debilitating pain, occurring in 50-70% of multiple sclerosis (MS) patients, is poorly understood and infrequently studied. We summarized efficacy and safety data of cannabinoid-based drugs for neuropathic pain...
  75. ncbi request reprint The economic impact of introducing serotonin-noradrenaline reuptake inhibitors into the Brazilian national drug formulary: cost-effectiveness and budget-impact analyses
    Marcio Machado
    Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Pharmacoeconomics 25:979-90. 2007
    ....
  76. ncbi request reprint Direct health care costs of 4 common skin ulcers in New Mexico Medicaid fee-for-service patients
    Ritesh N Kumar
    College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Adv Skin Wound Care 17:143-9. 2004
    ..To determine health care costs associated with pressure ulcers, ulcers of the lower limbs, other chronic ulcers, and venous leg ulcers from the New Mexico Medicaid fee-for-service program perspective...
  77. ncbi request reprint Association between corneal thickness, mean intraocular pressure, disease stability and severity, and cost of treatment in glaucoma: a Canadian analysis
    John H Walker
    PharmIdeas Research and Consulting Inc, Oakville, ON, Canada
    Curr Med Res Opin 21:489-94. 2005
    ..We determined the association between the mean corneal thickness (CT) and visual field mean defect (VF) severity as well as with mean intraocular pressure (IOP), disease stability, and cost of glaucoma therapy in a Canadian setting...
  78. ncbi request reprint Screening for glaucoma in Canada: a systematic review of the literature
    Thomas R Einarson
    PharmIdeas Research and Consulting Inc, ON, Canada
    Can J Ophthalmol 41:709-21. 2006
    ..To provide a recommendation on screening for glaucoma in Canada based on a review of recent evidence available in the literature...
  79. ncbi request reprint Contribution of Latin America to pharmacovigilance
    Juan Camilo González
    Head of Pharmacovigilance, Merck Sharp and Dohme, Bogota, Colombia
    Ann Pharmacother 40:1394-99. 2006
    ..Pharmacovigilance activities have been ongoing for 4 decades. However, little is known (especially outside of the area) about the contribution of Latin America to this field...
  80. ncbi request reprint Remission, dropouts, and adverse drug reaction rates in major depressive disorder: a meta-analysis of head-to-head trials
    Marcio Machado
    Universidad de Chile, Santiago, Chile
    Curr Med Res Opin 22:1825-37. 2006
    ....
  81. ncbi request reprint Depressive symptoms among women screened in obstetrics settings
    Heather A Bennett
    J Womens Health (Larchmt) 13:119; author reply 120. 2004
  82. ncbi request reprint Cost of glaucoma in Canada: analyses based on visual field and physician's assessment
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc Canada
    J Glaucoma 12:456-62. 2003
    ..A longitudinal, retrospective study investigated the cost of primary open angle glaucoma (POAG)...
  83. ncbi request reprint Association between mean intraocular pressure, disease stability and cost of treating glaucoma in Canada
    Colin Vicente
    PharmIdeas Research and Consulting Inc, Oakville, ON, Canada
    Curr Med Res Opin 20:1245-51. 2004
    ....
  84. ncbi request reprint Meta-analysis of placebo rates in major depressive disorder trials
    Pieter Stolk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands
    Ann Pharmacother 37:1891-9. 2003
    ..Placebo effects in major depressive disorder (MDD) have received much interest in the medical literature. However, few quantitative analyses have been done in homogeneous populations...