Research Topics
| J J EggermontSummaryAffiliation: University of Calgary Country: Canada Publications
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Detail Information
Publications
Context dependence of spectro-temporal receptive fields with implications for neural codingJos J Eggermont
Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
Hear Res 271:123-32. 2011..Effects on STRF shape of task and attention are also briefly reviewed. Models to account for these changes, potential improvements to STRF analysis, and implications for neural coding are discussed...
Comparison of LFP-based and spike-based spectro-temporal receptive fields and cross-correlation in cat primary auditory cortexJos J Eggermont
Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
PLoS ONE 6:e20046. 2011..This larger correlation distance combined with the reduced CF gradient and much broader frequency selectivity suggests that LFPs are not a substitute for spike activity in primary auditory cortex...- Spectro-temporal sound density-dependent long-term adaptation in cat primary auditory cortexBoris Gourévitch
Department of Physiology and Biophysics, Department of Psychology, University of Calgary, Calgary, Alberta, Canada
Eur J Neurosci 27:3310-21. 2008..Our findings suggest that low stimulus rates may produce a specific acoustic environment that shapes the primary auditory cortex through very different processing than for spectro-temporally more dense and complex sounds... - Spectrotemporal receptive fields during spindling and non-spindling epochs in cat primary auditory cortexT Britvina
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Neuroscience 154:1576-88. 2008..Overall, our results suggests that thalamic cells during spindling respond to incoming stimuli-related inputs and, moreover, cause more powerful stimulus-related or spontaneous activation of the cortex... - Multi-frequency auditory stimulation disrupts spindling activity in anesthetized animalsT Britvina
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Neuroscience 151:888-900. 2008..The possible mechanism of suppression of spindle waves is discussed and it is suggested that suppression likely occurs through activity of the specific auditory pathway... - Hearing loss, hyperacusis, or tinnitus: What is modeled in animal research?Jos J Eggermont
Department of Physiology and Pharmacology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 Electronic address
Hear Res 295:140-9. 2013..Furthermore, the synaptic mechanisms underlying spontaneous firing rate changes may be different from those involved in driven neural activity... 
The neuroscience of tinnitusJos J Eggermont
Department of Physiology and Biophysics, and Department of Psychology, University of Calgary, Alberta, Canada T2N 1N4
Trends Neurosci 27:676-82. 2004..Downregulation of intracortical inhibition induced by damage to the cochlea or to auditory projection pathways highlights neural processes that underlie the sensation of phantom sound...- Tinnitus: neurobiological substratesJos J Eggermont
Departments of Physiology, Biophysics and Psychology, University of Calgary, 2500 University Drive N W, Alberta, Calgary T2N 1N4, Canada
Drug Discov Today 10:1283-90. 2005..Although changes in transmitter-receptor systems have become better documented, there are currently no proven drug treatments for humans. Methods for preventing tinnitus have been demonstrated in animal studies... - Auditory-evoked potential studies of cortical maturation in normal hearing and implanted children: correlations with changes in structure and speech perceptionJos J Eggermont
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Acta Otolaryngol 123:249-52. 2003.... - Properties of correlated neural activity clusters in cat auditory cortex resemble those of neural assembliesJos J Eggermont
Dept of Psychology, University of Calgary, Calgary, Alberta, Canada
J Neurophysiol 96:746-64. 2006..The coincident and noncoincident output of the clusters could potentially act in parallel and may serve different modes of stimulus coding... - Pathophysiology of tinnitusJos J Eggermont
Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada
Prog Brain Res 166:19-35. 2007..These include changes in ion channels, receptor systems, single unit firing rate, and population responses. Most findings in humans can be interpreted as resulting from increased neural synchrony... - The neurophysiology of auditory perception: from single units to evoked potentialsJos J Eggermont
Department of Physiology, University of Calgary, Canada
Audiol Neurootol 7:71-99. 2002..As such, they are signs of perceptual activity, but not comprehensive representations thereof... - The role of sound in adult and developmental auditory cortical plasticityJos J Eggermont
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Ear Hear 29:819-29. 2008..However, in children, the long lasting absence of auditory stimulation arrests cortical development... - Temporal modulation transfer functions in cat primary auditory cortex: separating stimulus effects from neural mechanismsJos J Eggermont
Neuroscience Research Group, Department of Physiology and Biophysics and Department of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Neurophysiol 87:305-21. 2002..For nonclick stimuli, there was a systematic difference between the vector strength for LFPs and MU activity that can likely be attributed to postactivation suppression mechanisms... - Between sound and perception: reviewing the search for a neural codeJ J Eggermont
Neuroscience Research Group, Department of Physiology, University of Calgary, 2500 University Drive N W, Calgary, AB, Canada T2N 1N4
Hear Res 157:1-42. 2001..A multiplexed coding of complex sound is proposed whereby the contours set up widespread synchrony across those neurons in all auditory cortical areas that are activated by the texture of sound... - Role of auditory cortex in noise- and drug-induced tinnitusJos J Eggermont
Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada
Am J Audiol 17:S162-9. 2008..To elucidate the role of auditory cortex in tinnitus... - Neural responses in primary auditory cortex mimic psychophysical, across-frequency-channel, gap-detection thresholdsJ J Eggermont
Department of Physiology and Biophysics and Department of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Neurophysiol 84:1453-63. 2000.... - Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthoodJ J Eggermont
Department of Physiology, University of Calgary, 2500 University Drive N W, Calgary, Alta, Canada
Hear Res 142:89-101. 2000..Because most other neural response properties are normal in the reorganized part of cortex, sub-cortical topographic map changes are likely involved in producing the altered cortical topographic maps... - Correlated neural activity as the driving force for functional changes in auditory cortexJos J Eggermont
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Hear Res 229:69-80. 2007..This links cortical reorganization with hypersynchrony that can be considered as an important driving force underlying tinnitus... - Salicylate and quinine selectively increase spontaneous firing rates in secondary auditory cortexJ J Eggermont
Department of Physiology and Biophysics, The University of Calgary, Alta, Canada
Hear Res 117:149-60. 1998..This suggests that tinnitus inducing agents selectively increase spontaneous firing rates in the extralemniscal pathway... - Cross-correlation and joint spectro-temporal receptive field properties in auditory cortexMasahiko Tomita
Department of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Neurophysiol 93:378-92. 2005..Thus the ongoing network activity is significantly different from that during stimulation and changes afterng arousal during stimulation... - Long-term, partially-reversible reorganization of frequency tuning in mature cat primary auditory cortex can be induced by passive exposure to moderate-level soundsMartin Pienkowski
Department of Physiology and Pharmacology, University of Calgary, Calgary, Alta, Canada T2N 1N4
Hear Res 257:24-40. 2009..This could have implications for persistently noisy work/recreation/living environments, even at levels considerably below those presently considered unacceptable... - Nonlinear cross-frequency interactions in primary auditory cortex spectrotemporal receptive fields: a Wiener-Volterra analysisMartin Pienkowski
Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
J Comput Neurosci 28:285-303. 2010..Our results indicate that the strong combination sensitivity and cross-frequency facilitation suggested by previous two-tone-paradigm studies are much less pronounced when using more temporally-dense stimuli... - Kindling limits the interictal neuronal temporal response properties in cat primary auditory cortexPamela A Valentine
Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada
Epilepsia 46:171-8. 2005..CONCLUSIONS: Repeated epileptiform activity interferes with temporal processing in cat auditory cortex in the interictal state. This may have implications for people with epileptic foci in auditory-related areas... - Wiener-Volterra characterization of neurons in primary auditory cortex using poisson-distributed impulse train inputsMartin Pienkowski
Department of Physiology, University of Calgary, Calgary, Alberta, Canada, T2N 1N4
J Neurophysiol 101:3031-41. 2009..It appears that modulation-tuning in AI arises in part from an interplay of two nonlinear processes with distinct time courses... - A nonparametric approach for detection of bursts in spike trainsBoris Gourévitch
Department of Physiology and Biophysics, Department of Psychology, University of Calgary, 2500 University Drive N W, Calgary, Alberta, Canada
J Neurosci Methods 160:349-58. 2007..It presents an alternative to the PS method for non-Poisson spike trains and is simple to implement... - Spatial representation of neural responses to natural and altered conspecific vocalizations in cat auditory cortexBoris Gourévitch
Department of Physiology and Biophysics, 2500 University Drive NW, University of Calgary, Calgary, Alberta, Canada T2N 1N4
J Neurophysiol 97:144-58. 2007.... - Passive exposure of adult cats to moderate-level tone pip ensembles differentially decreases AI and AII responsiveness in the exposure frequency rangeMartin Pienkowski
Department of Physiology and Pharmacology, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada
Hear Res 268:151-62. 2010..On the other hand, responses in secondary auditory cortex (AII) were suppressed predominantly around 4 and 16 kHz, with little or no suppression in between... - Changes in spontaneous firing rate and neural synchrony in cat primary auditory cortex after localized tone-induced hearing lossSatoshi Seki
Departments of Physiology and Biophysics, and Psychology, University of Calgary, 2500 University Drive N.W, Calgary, AB, Canada T2N 1N4
Hear Res 180:28-38. 2003..A third finding was that exposed animals showed higher spontaneous activity compared to controls regardless of the presence of cortical reorganization. This may be a correlate of tinnitus in the presence of only minor hearing losses... - Neural correlates of an auditory afterimage in primary auditory cortexA J Noreña
Department of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, Calgary, Alberta, Canada T2N IN4
J Assoc Res Otolaryngol 4:312-28. 2003..We also found that the ps of "Out" neurons were dependent on the type of NN. Potentially, a combination of increased p and increased FR might be a neurophysiological correlate of the ZT... - Changes in cat primary auditory cortex after minor-to-moderate pure-tone induced hearing lossSatoshi Seki
Department of Physiology and Biophysics, University of Calgary, 2500 University Drive N.W, AB, Canada T2N 1N4
Hear Res 173:172-86. 2002..3 octave, P<0.05) than for cats with normal tonotopic maps. This is not what one would expect in cases of pseudo-plasticity characterized by concurrent shifts in BW(20dB) and CF as a result of residual sensitivity to lower frequencies... - Changes in spontaneous neural activity immediately after an acoustic trauma: implications for neural correlates of tinnitusA J Noreña
Department of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4
Hear Res 183:137-53. 2003..Moreover, rho was elevated in the Be-Ab2, Ab1-Ab2 and Ab2-Ab2 groups; this increase was significantly correlated to the changes in SFR. The results are discussed in the context of a neural correlate of tinnitus... - Neural connectivity only accounts for a small part of neural correlation in auditory cortexJ J Eggermont
Department of Psychology, University of Calgary, Alberta, Canada
Exp Brain Res 110:379-91. 1996..Cross-interval analysis suggests that the correlations in auditory cortex are dynamic and may show random switching between states of stronger and weaker synchronization... - Kindling changes burst firing, neural synchrony and tonotopic organization of cat primary auditory cortexPamela A Valentine
Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Alberta, Canada
Cereb Cortex 14:827-39. 2004..Thus, electrical kindling resulted in substantial alterations in unit firing characteristics and reorganization of cat auditory cortex... - Stimulus dependence of spectro-temporal receptive fields in cat primary auditory cortexPamela A Valentine
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Hear Res 196:119-33. 2004..Comparison of the 20/s and 120/s stimuli showed that the resulting increase in inhibition was strongest in the center of the STRF... - Spontaneous burst-firing in three auditory cortical fields: its relation to local field potentials and its effect on inter-area cross-correlationsP A Valentine
Department of Psychology, University of Calgary, Alta, Canada
Hear Res 154:146-57. 2001..Burst-onset times in different auditory fields were not correlated. Thus, the major cause of the observed correlation of spontaneous firing in different cortical areas is not synchronous burst-firing... - Comparison between local field potentials and unit cluster activity in primary auditory cortex and anterior auditory field in the catArnaud Norena
Department of Physiology, Neuroscience Research Group, University of Calgary, 2500 University Drive N W, Calgary, AB, Canada
Hear Res 166:202-13. 2002..The sharper tuning curves for MU activity compared to those of LFP events are likely the result of intracortical inhibitory processes... - Effects of adaptation on spectrotemporal receptive fields in primary auditory cortexMartin Pienkowski
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Neuroreport 20:1198-203. 2009..It also needs to be taken into account when comparing spectrotemporal receptive fields measured under adapted and nonadapted conditions... - Ringing ears: the neuroscience of tinnitusLarry E Roberts
Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada
J Neurosci 30:14972-9. 2010..A brain network involving limbic and other nonauditory regions is active in tinnitus and may be driven when spectrotemporal information conveyed by the damaged ear does not match that predicted by central auditory processing... - Intracortical microstimulation induced changes in spectral and temporal response properties in cat auditory cortexPamela A Valentine
Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4
Hear Res 183:109-25. 2003..This suggests a lasting reduction in inhibition in a small region surrounding the ICMS site that allows expansion of the frequency range normally represented in the vicinity of the stimulation electrode... - Maturational delays in cortical evoked potentials in cochlear implant usersJ J Eggermont
Department of Psychology, University of Calgary, Alberta, Canada
Acta Otolaryngol 117:161-3. 1997..It appears that maturation of P1 latency in normal and implanted children occurs at the same rate, but the time to maturity in implanted subjects is delayed by an amount approximately equal to the duration of deafness... - Power spectrum auditory brainstem response: novel approach to the evaluation of patients with unilateral auditory symptomsJoseph C Dort
Department of Surgery and Community Health Sciences, University of Calgary, Calgary, AB, Canada
J Otolaryngol Head Neck Surg 38:59-66. 2009..This study presents our initial results using the power spectrum ABR (PSABR) as another tool in detecting patients at higher risk for AN... - Spectrotemporal receptive fields in anesthetized cat primary auditory cortex are context dependentBoris Gourévitch
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Cereb Cortex 19:1448-61. 2009..We thus emphasize some aspects of context dependency of STRFs, that is, how the balance of inhibitory and excitatory inputs is able to shape the neural response from the spectral content of stimuli... - Intermittent exposure with moderate-level sound impairs central auditory function of mature animals without concomitant hearing lossMartin Pienkowski
Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
Hear Res 261:30-5. 2010..e., absolute threshold shifts). Our results have implications for occupational noise exposure standards, which presently may not prevent changes in central auditory function that cannot be detected on the standard behavioral audiogram... - Effects of noise-induced hearing loss at young age on voice onset time and gap-in-noise representations in adult cat primary auditory cortexNaotaka Aizawa
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
J Assoc Res Otolaryngol 7:71-81. 2006..This suggests that mild hearing loss acquired in early age may affect cortical temporal processing in adulthood... - Neural changes in cat auditory cortex after a transient pure-tone traumaArnaud J Noreña
Department of Physiology, Neuroscience Research Group, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Neurophysiol 90:2387-401. 2003..The results suggest the involvement of both a decrease and an increase in inhibition. They are discussed in terms of changes in central inhibition and its implications for tonotopic map plasticity... - The effect of MR scanner noise on auditory cortex activity using fMRICarrie J Scarff
Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada
Hum Brain Mapp 22:341-9. 2004..These results demonstrate the direct effect of scanner noise and high-intensity tonal stimuli on measurements of auditory cortex tonotopy... - Central tinnitusJos J Eggermont
Department of Physiology and Biophysics and Department of Psychology, University of Calgary, 2500 University Drive N W, Alta, T2N1N4, Calgary, Canada
Auris Nasus Larynx 30:S7-12. 2003..All long-standing tinnitus may thus be called central tinnitus, despite the fact that it is initiated by cochlear hearing loss or is localized to the hearing loss ear... - A Markov model for interspike interval distributions of auditory cortical neurons that do not show periodic firingsTatiana Britvina
Departments of Physiology and Biophysics, and Psychology, University of Calgary, 2500 University Drive N W, Calgary, Alberta, Canada
Biol Cybern 96:245-64. 2007..This procedure can identify and track the influence of changing brain states on the single-unit firing patterns in experimental animals... - Evaluating information transfer between auditory cortical neuronsBoris Gourévitch
Department of Physiology and Biophysics and Department of Psychology, University of Calgary, Calgary, Alberta, Canada
J Neurophysiol 97:2533-43. 2007..The normalized transfer entropy shows similarities and differences with the strength of cross-correlation; these form the basis for revisiting the neural assembly concept... - Coupling of mesoscopic brain oscillations: recent advances in analytical and theoretical perspectivesCalvin K Young
Behavioural Neuroscience Group, Department of Psychology, University of Calgary, Calgary, AB, Canada
Prog Neurobiol 89:61-78. 2009..To achieve this, only the correct application of analytical tools may shed light on the intricacies of information representation, generation, binding, encoding, storage and retrieval in the brain... - Mild noise-induced hearing loss at young age affects temporal modulation transfer functions in adult cat primary auditory cortexNaotaka Aizawa
Department of Physiology and Biophysics, University of Calgary, Calgary, Alta, Canada Department of Psychology, University of Calgary, Calgary, Alta, Canada
Hear Res 223:71-82. 2007..Effects of reduced central inhibition are visible in the broadening of frequency-tuning curves, and in the increased limiting rates for AMnoise... - Effects of an acute acoustic trauma on the representation of a voice onset time continuum in cat primary auditory cortexMasahiko Tomita
Departments of Physiology and Biophysics, and Psychology, Neuroscience Research Group, University of Calgary, 2500 University Drive N.W, Calgary, Alta, Canada T2N 1N4
Hear Res 193:39-50. 2004..The present study is the first one in showing an impairment of the temporal resolution of neurons in AI caused by an acute acoustic trauma... - A simple indicator of nonstationarity of firing rate in spike trainsBoris Gourévitch
Department of Physiology, University of Calgary, Calgary, Alta, Canada
J Neurosci Methods 163:181-7. 2007..This method is compared to the Mann-Kendall test of trend detection and the Runs test on simulated and real spike trains... - Simultaneous 3-T fMRI and high-density recording of human auditory evoked potentialsCarrie J Scarff
Department of Psychology, University of Calgary, Calgary, Alberta, Canada, T2N 1N4
Neuroimage 23:1129-42. 2004..This suggests that 64 electrodes may be optimal for use in simultaneous recording of EEG and fMRI... - Sound frequency representation in primary auditory cortex is level tolerant for moderately loud, complex soundsMartin Pienkowski
Department of Psychology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
J Neurophysiol 106:1016-27. 2011.... - Differential ear effects of profound unilateral deafness on the adult human central auditory systemDeepak Khosla
HRL Laboratories, LLC, Malibu, CA 90265, USA
J Assoc Res Otolaryngol 4:235-49. 2003..Specifically, these changes were found only in those subjects affected by profound left ear unilateral deafness... - Maturation of human central auditory system activity: separating auditory evoked potentials by dipole source modelingCurtis Ponton
Electrophysiology Laboratory, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
Clin Neurophysiol 113:407-20. 2002..Thus, the purpose of this study was to evaluate central auditory system maturation based dipole modeling of multi-electrode long-latency AEPs recordings... - Enriched acoustic environment after noise trauma reduces hearing loss and prevents cortical map reorganizationArnaud J Noreña
Neurosciences and Sensory Systems Laboratory, Unité Mixte de Recherche Centre National de la Recherche Scientifique 5020, Universite Claude Bernard, 69366 Lyon, Cedex 7, France
J Neurosci 25:699-705. 2005..This finding has implications for the treatment of hearing disorders, such as tinnitus, that have been linked to cortical tonotopic map reorganization... - What's to lose and what's to learn: development under auditory deprivation, cochlear implants and limits of cortical plasticityAndrej Kral
Laboratory of Auditory Neuroscience, Department of Neurophysiology and Pathophysiology, University of Hamburg School of Medicine, Germany
Brain Res Rev 56:259-69. 2007..In consequence, the ability to learn is compromised in sensory deprivation, resulting in a sensitive period for recovery... - Maturation of human central auditory system activity: the T-complexInger Tonnquist-Uhlen
Department of Audiology, Karolinska Hospital, Stockholm, Sweden
Clin Neurophysiol 114:685-701. 2003..Its robust presence in 5-8 year olds supports its potential usefulness in assessing language impairment... - Spectrally enhanced acoustic environment disrupts frequency representation in cat auditory cortexArnaud J Noreña
Neurosciences and Sensory Systems Laboratory, UMR Centre National de la Recherche Scientifique 5020, Universite Claude Bernard, Lyon, France
Nat Neurosci 9:932-9. 2006..We observed fewer than normal appropriately tuned short-latency responses to EAE frequencies, together with more common long-latency responses tuned to EAE-neighboring frequencies... - Enriched acoustic environment after noise trauma abolishes neural signs of tinnitusArnaud J Noreña
Neurosciences and Sensory Systems Laboratory, UMR CNRS 5020, Universite Claude Bernard, Lyon, France
Neuroreport 17:559-63. 2006..This is interpreted as an absence of putative neural signs of tinnitus... - Increasing spectrotemporal sound density reveals an octave-based organization in cat primary auditory cortexArnaud J Noreña
Integrative and Adaptive Neurobiology Laboratory, Unité Mixte de Recherche 6149, Université de Provence Centre National de la Recherche Scientifique, Centre St Charles, 13331 Marseille Cedex 03, France
J Neurosci 28:8885-96. 2008..Plausibly, the over-representation may be a functional correlate of the periodic pattern of corticocortical connections observed along the tonotopic axis of cat auditory cortex...