Vladimir Dzavik

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Long-term survival in 11,661 patients with multivessel coronary artery disease in the era of stenting: a report from the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators
    V Dzavik
    University of Alberta Hospital, and the Royal Alexandra Hospital, Edmonton, Alberta, Canada
    Am Heart J 142:119-26. 2001
  2. pmc Stent fracture after everolimus-eluting stent implantation
    Ali S Almasood
    Interventional Cardiology Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, 6 246 EN, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4
    Cardiol Res Pract 2011:320983. 2011
  3. ncbi request reprint Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study
    Vladimir Dzavik
    University Health Network, Toronto General Hospital, 6 246, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
    Eur Heart J 28:1109-16. 2007
  4. ncbi request reprint Predictors of long-term outcome after crush stenting of coronary bifurcation lesions: importance of the bifurcation angle
    Vladimir Dzavik
    Interventional Cardiology Program, Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:762-9. 2006
  5. ncbi request reprint Progress in percutaneous management of coronary bifurcation lesions
    V Dzavik
    Interventional Cardiology Program, Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Minerva Cardioangiol 53:379-401. 2005
  6. doi request reprint The sPLA2 Inhibition to Decrease Enzyme Release after Percutaneous Coronary Intervention (SPIDER-PCI) trial
    Vladimir Dzavik
    Interventional Cardiology Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Circulation 122:2411-8. 2010
  7. ncbi request reprint Outcome of patients aged >or=75 years in the SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK (SHOCK) trial: do elderly patients with acute myocardial infarction complicated by cardiogenic shock respond differently to emergen
    Vladimir Dzavik
    Interventional Cardiology Program, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Am Heart J 149:1128-34. 2005
  8. pmc Randomized trial of percutaneous coronary intervention for subacute infarct-related coronary artery occlusion to achieve long-term patency and improve ventricular function: the Total Occlusion Study of Canada (TOSCA)-2 trial
    Vladimir Dzavik
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Circulation 114:2449-57. 2006
  9. ncbi request reprint Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry
    V Dzavik
    University of Toronto, Toronto, Ontario, Canada
    Eur Heart J 24:828-37. 2003
  10. ncbi request reprint New frontiers and unresolved controversies in percutaneous coronary intervention
    Vladimir Dzavik
    Interventional Cardiology Program, Division of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada
    Am J Cardiol 91:27A-33A. 2003

Research Grants

Detail Information

Publications90

  1. ncbi request reprint Long-term survival in 11,661 patients with multivessel coronary artery disease in the era of stenting: a report from the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators
    V Dzavik
    University of Alberta Hospital, and the Royal Alexandra Hospital, Edmonton, Alberta, Canada
    Am Heart J 142:119-26. 2001
    ....
  2. pmc Stent fracture after everolimus-eluting stent implantation
    Ali S Almasood
    Interventional Cardiology Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, 6 246 EN, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4
    Cardiol Res Pract 2011:320983. 2011
    ..Everolimus eluting stents (EESs) represent a new generation of DES with promising results. The occurrence of SF with EES has not been well established. The present paper describes two cases of EES fracture associated with ISR...
  3. ncbi request reprint Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study
    Vladimir Dzavik
    University Health Network, Toronto General Hospital, 6 246, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
    Eur Heart J 28:1109-16. 2007
    ..We assessed preliminary efficacy and safety of four doses of l-n-monomethyl-arginine (l-NMMA), a non-selective NOS inhibitor, in patients with AMI complicated by CS despite an open infarct-related artery...
  4. ncbi request reprint Predictors of long-term outcome after crush stenting of coronary bifurcation lesions: importance of the bifurcation angle
    Vladimir Dzavik
    Interventional Cardiology Program, Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:762-9. 2006
    ..We hypothesized that the bifurcation angle (BA) may affect the outcome of crush stenting (CS) of bifurcation lesions and thus set out to determine the effect of the BA on outcome of patients undergoing coronary bifurcation CS...
  5. ncbi request reprint Progress in percutaneous management of coronary bifurcation lesions
    V Dzavik
    Interventional Cardiology Program, Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Minerva Cardioangiol 53:379-401. 2005
    ..Nonetheless, well-designed randomized trials evaluating the various bifurcation techniques especially in complex bifurcation lesions are needed...
  6. doi request reprint The sPLA2 Inhibition to Decrease Enzyme Release after Percutaneous Coronary Intervention (SPIDER-PCI) trial
    Vladimir Dzavik
    Interventional Cardiology Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Circulation 122:2411-8. 2010
    ..The central hypothesis of this study was that treatment with varespladib, a small-molecule inhibitor of sPLA(2) would reduce postprocedural release of cardiac biomarkers after elective percutaneous coronary intervention...
  7. ncbi request reprint Outcome of patients aged >or=75 years in the SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK (SHOCK) trial: do elderly patients with acute myocardial infarction complicated by cardiogenic shock respond differently to emergen
    Vladimir Dzavik
    Interventional Cardiology Program, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Am Heart J 149:1128-34. 2005
    ..We sought to determine the reason for this finding by examining the baseline characteristics and outcomes of the 2 treatment groups by age...
  8. pmc Randomized trial of percutaneous coronary intervention for subacute infarct-related coronary artery occlusion to achieve long-term patency and improve ventricular function: the Total Occlusion Study of Canada (TOSCA)-2 trial
    Vladimir Dzavik
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Circulation 114:2449-57. 2006
    ....
  9. ncbi request reprint Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry
    V Dzavik
    University of Toronto, Toronto, Ontario, Canada
    Eur Heart J 24:828-37. 2003
    ..We examined the effect of age on treatment and outcomes of patients with cardiogenic shock in the SHOCK Trial Registry...
  10. ncbi request reprint New frontiers and unresolved controversies in percutaneous coronary intervention
    Vladimir Dzavik
    Interventional Cardiology Program, Division of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada
    Am J Cardiol 91:27A-33A. 2003
    ....
  11. ncbi request reprint Predictors of improvement in left ventricular function after percutaneous revascularization of occluded coronary arteries: a report from the Total Occlusion Study of Canada (TOSCA)
    V Dzavik
    University Health Network, Toronto, Ontario, Canada
    Am Heart J 142:301-8. 2001
    ....
  12. doi request reprint Choice of stent and outcomes after treatment of drug-eluting stent restenosis in highly complex lesions
    Xavier Freixa
    Peter Munk Cardiac Centre, University Health Network, Interventional Cardiology Program, Division of Cardiology, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 81:E16-22. 2013
    ..Our aim was to compare the outcomes of a same versus different drug-eluting stent (DES) implantation strategy for the treatment of DES instent restenosis (ISR)...
  13. doi request reprint The adverse long-term impact of renal impairment in patients undergoing percutaneous coronary intervention in the drug-eluting stent era
    Clare E Appleby
    Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Circ Cardiovasc Interv 2:309-16. 2009
    ..CKD is associated with poor in-hospital outcomes after percutaneous coronary intervention, but its effect beyond 1 year, particularly in the drug-eluting stent (DES) era, has not been reported...
  14. pmc Angiographic and clinical outcomes of drug-eluting versus bare metal stent deployment in the Occluded Artery Trial
    Vladimir Dzavik
    Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 73:771-9. 2009
    ..We aimed to determine if stenting of the target occlusion in OAT with drug-eluting stents (DES) was associated with more favorable angiographic results and clinical outcome when compared with treatment with BMS...
  15. ncbi request reprint Routine early angioplasty after fibrinolysis for acute myocardial infarction
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, ON, Canada
    N Engl J Med 360:2705-18. 2009
    ..The role and optimal timing of routine PCI after fibrinolysis have not been established...
  16. doi request reprint Thrombocytopenia at baseline is a predictor of inhospital mortality in patients undergoing percutaneous coronary intervention
    Christopher B Overgaard
    Interventional Cardiology Program, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:120-4. 2008
    ..Whether TP has any influence on the outcome of PCI patients is unknown. Our aim was to determine if TP at baseline impacts on inhospital mortality in patients undergoing PCI at our institution...
  17. ncbi request reprint Selective use of embolic protection devices during saphenous vein grafts interventions: a single-center experience
    Shahar Lavi
    Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 75:1037-44. 2010
    ..To report on outcomes with selective use of embolic protection devices (EPD) during percutaneous coronary intervention (PCI) to saphenous vein grafts (SVG)...
  18. ncbi request reprint Efficacy and safety of a routine early invasive strategy after fibrinolysis stratified by glycoprotein IIb/IIIa inhibitor use during percutaneous coronary intervention: a pre-specified subgroup analysis of the TRANSFER-AMI randomised controlled trial
    Juan J Russo
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Heart 100:873-80. 2014
    ..We evaluated the efficacy and safety of an early invasive strategy post-fibrinolysis in relation to glycoprotein (GP) IIb/IIIa inhibitor use...
  19. ncbi request reprint Rationale and design of the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI)
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, Ontario, Canada
    Am Heart J 155:19-25. 2008
    ..The role of routine early PCI after fibrinolysis, using stents and contemporary pharmacotherapy, has not been studied in a large adequately powered randomized trial...
  20. doi request reprint Effect of radial versus femoral access on radiation dose and the importance of procedural volume: a substudy of the multicenter randomized RIVAL trial
    Sanjit S Jolly
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    JACC Cardiovasc Interv 6:258-66. 2013
    ..The authors sought to compare the radiation dose between radial and femoral access...
  21. doi request reprint Efficacy and safety of enoxaparin compared with unfractionated heparin in the pharmacoinvasive management of acute ST-segment elevation myocardial infarction: Insights from the TRANSFER-AMI trial
    Shahar Lavi
    London Health Sciences Centre, Ontario, Canada
    Am Heart J 163:176-81.e2. 2012
    ....
  22. doi request reprint In-hospital outcomes of very elderly patients (85 years and older) undergoing percutaneous coronary intervention
    Clare E Appleby
    Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 77:634-41. 2011
    ..To compare in-hospital outcomes of a large cohort of very elderly patients (age ≥ 85 years) with younger patients (age < 85 years) undergoing percutaneous coronary intervention (PCI) for all indications at our institution...
  23. doi request reprint Long-term safety and effectiveness of drug-eluting stents for the treatment of saphenous vein grafts disease: a population-based study
    Dennis T Ko
    Division of Cardiology, Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    JACC Cardiovasc Interv 4:965-73. 2011
    ..The purpose of this study was to evaluate the long-term safety and effectiveness of drug-eluting stents (DES) for the treatment of saphenous vein graft (SVG) disease...
  24. doi request reprint Impact of renal insufficiency on angiographic, procedural, and in-hospital outcomes following percutaneous coronary intervention
    Mark D Osten
    Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada
    Am J Cardiol 101:780-5. 2008
    ....
  25. doi request reprint Efficacy of early invasive management post-fibrinolysis in men versus women with ST-elevation myocardial infarction: a subgroup analysis from Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarctio
    Vineet Bhan
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 164:343-50. 2012
    ..However, it is not clear whether treatment efficacy differs between men and women...
  26. ncbi request reprint Long-term outcomes after percutaneous coronary intervention of bifurcation narrowings
    Nicholas Collins
    Interventional Cardiology Program, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Am J Cardiol 102:404-10. 2008
    ....
  27. pmc First Canadian experience with high-risk percutaneous coronary intervention with assistance of a percutaneously deployed left ventricular assist device
    Jonas Eichhofer
    Division of Cardiology, University Health Network, University of Toronto, Ontario
    Can J Cardiol 24:e82-5. 2008
    ..Larger studies will be required to identify whether a survival benefit or improvement in left ventricular function can be achieved when using the Impella device to support patients undergoing high-risk PCI or those in cardiogenic shock...
  28. doi request reprint Antithrombotic therapy after coronary stenting in patients with nonvalvular atrial fibrillation
    Kay W Ho
    Interventional Cardiology Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Can J Cardiol 29:213-8. 2013
    ..We aimed to determine whether TT is associated with a decreased stroke rate and an acceptable bleeding rate in this population...
  29. doi request reprint Inhibition of sPLA2 and endothelial function: a substudy of the SPIDER-PCI trial
    Shahar Lavi
    London Health Sciences Centre, Toronto, Ontario, Canada University of Western Ontario, London, Ontario, Canada
    Can J Cardiol 28:215-21. 2012
    ..We evaluated whether endothelial function is attenuated after PCI and if inhibition of secretory phospholipase A2 (sPLA2) activity augments endothelial function and coronary flow reserve (CFR) in these patients...
  30. doi request reprint Decreased risk of stent fracture-related restenosis between paclitaxel-eluting stents and sirolimus eluting stents: results of long-term follow-up
    Xavier Freixa
    Peter Munk Cardiac Centre, Interventional Cardiology Program, Division of Cardiology, University Health Network, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 79:559-65. 2012
    ..To compare the outcomes between paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) for the treatment of drug-eluting stent (DES) fracture...
  31. ncbi request reprint Decreased complication rates using the transradial compared to the transfemoral approach in percutaneous coronary intervention in the era of routine stenting and glycoprotein platelet IIb/IIIa inhibitor use: a large single-center experience
    Jonas Eichhofer
    Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Am Heart J 156:864-70. 2008
    ..We sought to determine the association between the choice of the vascular access site and procedural complications after PCI performed with routine stenting and GP IIb/IIIa inhibition...
  32. ncbi request reprint Routine use of glycoprotein IIb/IIIa inhibitor therapy is associated with an improved in-hospital outcome after percutaneous coronary intervention: Insights from a large, prospective, single-centre registry
    Cynthia A Jackevicius
    University Health Network, Toronto, Ontario
    Can J Cardiol 21:27-32. 2005
    ..Clinical trials have demonstrated the benefit of glycoprotein IIb/IIIa inhibitors (GPIs) with stenting in the setting of percutaneous coronary intervention (PCI) in reducing adverse cardiac outcomes...
  33. doi request reprint Sex differences in the management and outcomes of Ontario patients with cardiogenic shock complicating acute myocardial infarction
    Husam M Abdel-Qadir
    Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Can J Cardiol 29:691-6. 2013
    ..Sex differences in the management of acute myocardial infarction (AMI) patients with cardiogenic shock (CS) have not been well studied...
  34. doi request reprint Clinical outcomes and cost implications of routine early PCI after fibrinolysis: one-year follow-up of the Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI) study
    Akshay Bagai
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 165:630-637.e2. 2013
    ....
  35. ncbi request reprint Relationship between risk stratification at admission and treatment effects of early invasive management following fibrinolysis: insights from the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infa
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, and University of Toronto, Toronto, Ontario, Canada, M5B 1W8
    Eur Heart J 32:1994-2002. 2011
    ..We sought to determine the effectiveness of early routine percutaneous coronary intervention (PCI) post-fibrinolysis for ST-elevation myocardial infarction (STEMI) in relation to baseline risk status...
  36. pmc Late outcomes following percutaneous coronary interventions: results from a large, observational registry
    Clare E Appleby
    University Health Network, University of Toronto, Ontario
    Can J Cardiol 26:e218-24. 2010
    ..Data regarding the long-term clinical outcomes of patients undergoing PCI are lacking...
  37. ncbi request reprint Long-term outcomes using a two-stent technique for the treatment of coronary bifurcations
    Xavier Freixa
    Peter Munk Cardiac Centre, University Health Network, Interventional Cardiology Program, Division of Cardiology, Toronto, Ontario, Canada
    Int J Cardiol 168:446-51. 2013
    ..Long-term outcome associated with the utilization of these techniques is unknown. Our objective was to evaluate the long-term outcomes after bifurcation PCI utilizing these 2 techniques with a prospective PCI registry...
  38. doi request reprint Predictors of radial artery size in patients undergoing cardiac catheterization: insights from the Good Radial Artery Size Prediction (GRASP) study
    Mark A Kotowycz
    Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Can J Cardiol 30:211-6. 2014
    ..Although use of a sheath larger than the artery is a risk factor for radial artery occlusion, radial artery size is not routinely measured. We aimed to identify bedside predictors of radial artery diameter...
  39. doi request reprint Long-term outcomes after percutaneous intervention of the internal thoracic artery anastomosis: the use of drug-eluting stents is associated with a higher need of repeat revascularization
    Xavier Freixa
    Peter Munk Cardiac Centre, University Health Network, Interventional Cardiology Program, Division of Cardiology, Toronto, Ontario, Canada
    Can J Cardiol 28:458-63. 2012
    ....
  40. pmc Long-term outcomes after a strategy of percutaneous coronary intervention of the infarct-related artery with drug-eluting stents or bare metal stents vs medical therapy alone in the Occluded Artery Trial (OAT)
    Xavier Freixa
    Peter Munk Cardiac Centre, University Health Network, Toronto, Newmarket, Canada
    Am Heart J 163:1011-8. 2012
    ..The aim of the study was to conduct an exploratory analysis of long-term outcomes for DES vs. BMS deployment vs. MED in the OAT...
  41. ncbi request reprint Impact of renal insufficiency on outcome after contemporary percutaneous coronary intervention
    Daniel J Blackman
    Interventional Cardiology Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Am Heart J 151:146-52. 2006
    ..The effect of milder degrees of renal insufficiency (RI) is less clear, especially with routine stenting and glycoprotein IIb/IIIa inhibitor therapy, which may be of particular benefit in patients with RI...
  42. doi request reprint Temporal trends in cardiogenic shock treatment and outcomes among ontario patients with myocardial infarction between 1992 and 2008
    Husam M Abdel-Qadir
    Interventional Cardiology Program, Peter Munk Cardiac Centre, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada
    Circ Cardiovasc Qual Outcomes 4:440-7. 2011
    ..Clinical trials have demonstrated that emergent revascularization improves survival of patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). However, rates of uptake and impact on outcomes remain uncertain...
  43. doi request reprint The Toronto score for in-hospital mortality after percutaneous coronary interventions
    Saqib Chowdhary
    Interventional Cardiology Program, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    Am Heart J 157:156-63. 2009
    ..Most existing prediction models of in-hospital mortality after PCI were derived from 1990s data, and their current relevance is uncertain...
  44. ncbi request reprint N-acetylcysteine reduces contrast-associated nephropathy but not clinical events during long-term follow-up
    Steven E S Miner
    University of Toronto and the Department of Medicine at the University Health Network, Toronto, Ontario, Canada
    Am Heart J 148:690-5. 2004
    ..N-acetylcysteine (NAC) has been shown to reduce the risk of nephropathy; however, the impact of NAC on long-term clinical outcomes has not been assessed...
  45. ncbi request reprint Health-related quality of life outcomes of patients with coronary artery disease treated with cardiac surgery, percutaneous coronary intervention or medical management
    Colleen M Norris
    Faculty of Nursing, University of Alberta, Edmonton, Canada
    Can J Cardiol 20:1259-66. 2004
    ....
  46. ncbi request reprint Effect of percutaneous coronary intervention of nonacute total coronary artery occlusions on QT dispersion
    David M Goodhart
    Department of Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
    Am Heart J 151:529.e1-529.e6. 2006
    ..We sought to assess the effect of percutaneous revascularization (PCI) of TCO on QTd and the relationship between QTd and long-term vessel patency...
  47. doi request reprint Two-year outcomes after deployment of XIENCE V everolimus-eluting stents in patients undergoing percutaneous coronary intervention of bifurcation lesions: a report from the SPIRIT V single arm study
    Vladimir Dzavik
    Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada
    Catheter Cardiovasc Interv 82:E163-72. 2013
    ..2013 Wiley Periodicals, Inc. ..
  48. ncbi request reprint Balloon crush: treatment of bifurcation lesions using the crush stenting technique as adapted for transradial approach of percutaneous coronary intervention
    Pitt O Lim
    Interventional Cardiology Program, Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario M5G 2C4, Canada
    Catheter Cardiovasc Interv 63:412-6. 2004
    ..We have demonstrated that the modified crush stenting technique is feasible and can be safely adapted for use in a 6 Fr transradial percutaneous coronary intervention approach...
  49. doi request reprint Effects of radial versus femoral artery access in patients with acute coronary syndromes with or without ST-segment elevation
    Shamir R Mehta
    McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 60:2490-9. 2012
    ....
  50. ncbi request reprint A calcified neointima--"stent" within a stent
    Clare E Appleby
    Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Canada
    J Invasive Cardiol 21:141-3. 2009
    ..We describe a case of restenosis in a patient presenting with angina 8 years after original stent deployment. Intravascular ultrasound greyscale imaging and virtual histology demonstrated that this "neointima" was calcified...
  51. ncbi request reprint Percutaneous treatment of dissection of the ascending aorta occurring as a complication during coronary angioplasty of a saphenous vein bypass graft
    Prasad Shah
    Toronto General Hospital, University Health Network, University of Toronto, Canada
    J Interv Cardiol 18:45-8. 2005
    ..The aortic dissection that had progressed retrogradely into the ascending aorta was treated percutaneously by stenting in the saphenous vein graft with a membrane-covered stent...
  52. ncbi request reprint Impact of delays to cardiac surgery after failed angioplasty and stenting
    Mat Lotfi
    Division of Cardiology, Department of Medicine, University Health Network, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, EN 12 238, Toronto, Ontario M5G 2C4, Canada
    J Am Coll Cardiol 43:337-42. 2004
    ..This study was designed to determine the likelihood of harm in patients having additional delays before urgent coronary artery bypass graft (UCABG) surgery after percutaneous coronary intervention (PCI)...
  53. ncbi request reprint Triple wire technique for removal of fractured angioplasty guidewire
    Nicholas Collins
    University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    J Invasive Cardiol 19:E230-4. 2007
    ..Various methods of management available in cases of device dislodgement or fracture are discussed, as is the potential mechanism of guidewire fracture...
  54. ncbi request reprint Medical therapy v. PCI in stable coronary artery disease: a cost-effectiveness analysis
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada HCW, DTK
    Med Decis Making 33:891-905. 2013
    ..It remains unclear if these benefits are sufficient to offset their increased costs and small increase in adverse events...
  55. doi request reprint Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock
    Sean van Diepen
    1Divisions of Critical Care and Cardiology, University of Alberta, Edmonton, Alberta, Canada 2Cardiovascular Clinical Research Center, New York University School of Medicine, New York, NY 3Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 4Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada 5Institute of Cardiology, Warsaw, Poland 6Wilhelminen Hospital, Vienna, Austria 7Third Faculty of Medicine, Charles University Prague, Czech Republic 8Robert Wood Johnson Medical School and Cooper University Hospital, Camden, NJ 9University of Vermont, Burlington, VT 10Newark Beth Israel Medical Center, Newark, NJ
    Crit Care Med 42:281-8. 2014
    ..The prevalence and outcomes associated with β and renin-angiotensin-aldosterone system blocker therapy in patients with ongoing cardiogenic shock is unknown...
  56. ncbi request reprint An international survey of clinical practice during primary percutaneous coronary intervention for ST-elevation myocardial infarction with a focus on aspiration thrombectomy
    Juan J Russo
    University of Toronto, Toronto, Ontario, Canada
    EuroIntervention 8:1143-8. 2013
    ..We sought to evaluate practices during PPCI for ST-elevation myocardial infarction (STEMI), including the use of aspiration thrombectomy, and to determine the feasibility of conducting a definitive aspiration thrombectomy trial...
  57. doi request reprint Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease
    Christopher B Overgaard
    Division of Cardiology, University of Toronto, Toronto, Ontario, Canada M5G 2C4
    Circulation 118:1047-56. 2008
  58. ncbi request reprint Effect of bare metal stenting on angiographic and clinical outcomes in diabetic and nondiabetic patients undergoing percutaneous coronary intervention of nonacute occluded coronary arteries: a report from the Total Occlusion Study of Canada (TOSCA)
    Kok Meng Yee
    Division of Cardiology, University Health Network, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 66:178-84. 2005
    ..This analysis forms an important background for future studies that are needed to examine the effect of stenting with drug-eluting stents in diabetics as well as nondiabetics with nonacute coronary occlusions...
  59. doi request reprint Severe hemolysis associated with use of the Impella LP 2.5 mechanical assist device
    Matthew Sibbald
    Interventional Cardiology Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 80:840-4. 2012
    ..We advise routine measurement of biochemical markers of hemolysis and serial hemoglobin values during Impella device support to allow timely detection and treatment of this important complication...
  60. pmc Canadian quality indicators for percutaneous coronary interventions
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Can J Cardiol 24:899-903. 2008
    ..However, quality indicators for percutaneous coronary intervention (PCI) have not been developed in Canada...
  61. doi request reprint Percutaneous revascularization and long term clinical outcomes of diabetic patients randomized in the Occluded Artery Trial (OAT)
    Christopher B Overgaard
    Peter Munk Cardiac Centre, University Heath Network, Toronto, Ontario, Canada
    Int J Cardiol 168:2416-22. 2013
    ..Diabetic patients are at higher risk for cardiovascular events; we examined their outcomes overall with PCI and optimal medical therapy alone (MED)...
  62. ncbi request reprint Spontaneous dissection of the left main coronary artery
    Prasad Shah
    Interventional Cardiology Program, Toronto General Hospital, University Health Network, Ontario
    Can J Cardiol 20:815-8. 2004
    ..The authors describe a 33-year-old pregnant woman who presented with a non-ST segment elevation myocardial infarction secondary to a spontaneous dissection of the left main coronary artery...
  63. ncbi request reprint Effect of vasopressin on hemodynamics in patients with refractory cardiogenic shock complicating acute myocardial infarction
    Sanjit Jolly
    The Interventional Cardiology Program, Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:1617-20. 2005
    ..In a cohort of patients who developed refractory cardiogenic shock after myocardial infarction, vasopressin was associated with increased mean arterial pressure and no adverse effect on other hemodynamic parameters...
  64. ncbi request reprint A modified balloon crush approach improves side branch access and side branch stent apposition during crush stenting of coronary bifurcation lesions
    Nicholas Collins
    Interventional Cardiology Program, Division of Cardiology, University Health Network, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 68:365-71. 2006
    ..We aimed to assess the feasibility of a modified balloon crush technique for percutaneous treatment of coronary bifurcation stenoses...
  65. doi request reprint Quantitative coronary angiography findings of patients who received previous breast radiotherapy
    Wei Wang
    Department of Radiation Oncology, University Health Network, University of Toronto, Canada
    Radiother Oncol 100:184-8. 2011
    ..To compare the coronary angiographic findings between patients who had previous left sided versus right sided breast cancer radiotherapy (RT)...
  66. ncbi request reprint Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Marek Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 107:251-7. 2003
    ....
  67. ncbi request reprint Acute profound thrombocytopenia associated with eptifibatide therapy
    Jeff Nagge
    Interventional Cardiology and Thrombosis Treatment Program, University Health Network Toronto General Hospital, Toronto, Ontario, Canada
    Pharmacotherapy 23:374-9. 2003
    ..Thus, clinicians should routinely monitor platelet counts in patients receiving glycoprotein IIb-IIIa inhibitors within 2-4 hours of the start of the infusion...
  68. ncbi request reprint A randomized trial of the effect of community pharmacist intervention on cholesterol risk management: the Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP)
    Ross T Tsuyuki
    Epidemiology Coordinating and Research EPICORE Centre, Division of Cardiology, University of Alberta, 213 Heritage Medical Research Centre, Edmonton, Alberta, Canada T6G 2S2
    Arch Intern Med 162:1149-55. 2002
    ..This study aimed to determine the effect of a program of community pharmacist intervention on the process of cholesterol risk management in patients at high risk for cardiovascular events...
  69. pmc Coronary intervention for persistent occlusion after myocardial infarction
    Judith S Hochman
    Cardiovascular Clinical Research Center, Leon Charney Division of Cardiology, New York University School of Medicine, New York 10016, USA
    N Engl J Med 355:2395-407. 2006
    ....
  70. ncbi request reprint Hemodynamic parameters are prognostically important in cardiogenic shock but similar following early revascularization or initial medical stabilization: a report from the SHOCK Trial
    Raban V Jeger
    Cardiovascular Clinical Research Center, New York University School of Medicine, New York, NY, USA
    Chest 132:1794-803. 2007
    ..In cardiogenic shock (CS), conclusive data on serial hemodynamic measurements for treatment guidance and prognosis are lacking...
  71. ncbi request reprint Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial
    John H Alexander
    Duke University, Durham, NC, USA
    JAMA 297:1657-66. 2007
    ..Preliminary, single-center studies suggested a beneficial effect of NOS inhibition on hemodynamics, renal function, and survival in patients with cardiogenic shock...
  72. ncbi request reprint First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation
    Christopher K Dyke
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 105:2385-91. 2002
    ....
  73. pmc Transfer for urgent percutaneous coronary intervention early after thrombolysis for ST-elevation myocardial infarction: the TRANSFER-AMI pilot feasibility study
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, Canada
    Can J Cardiol 22:1121-6. 2006
    ..Urgent PCI after thrombolysis may optimize reperfusion and prevent reinfarction and recurrent ischemia...
  74. ncbi request reprint Echocardiographic predictors of survival and response to early revascularization in cardiogenic shock
    Michael H Picard
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 107:279-84. 2003
    ....
  75. pmc Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction
    Judith S Hochman
    Cardiovascular Clinical Research Center, New York University School of Medicine, New York 10016, USA
    JAMA 295:2511-5. 2006
    ....
  76. ncbi request reprint Inadvertent detachment of an entrapped Cutting Balloon from the balloon catheter during treatment of in-stent restenosis
    Daniel Blackman
    Department of Cardiology, Toronto General Hospital
    J Invasive Cardiol 17:E27-9. 2005
    ..Using intravascular ultrasound guidance, a drug-eluting stent was placed at the ostium of the anomalous artery, correcting both the baseline narrowing and the phasic, systolic arterial compression...
  77. ncbi request reprint Functional status and quality of life after emergency revascularization for cardiogenic shock complicating acute myocardial infarction
    Lynn A Sleeper
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Am Coll Cardiol 46:266-73. 2005
    ....
  78. ncbi request reprint Effects of long term cholesterol lowering on coronary atherosclerosis in patient risk factor subgroups: the Simvastatin/enalapril Coronary Atherosclerosis Trial (SCAT)
    Jeffrey R Burton
    University of Alberta Hospitals and Department of Medicine, University of Alberta, Edmonton
    Can J Cardiol 19:487-91. 2003
    ..Also, this treatment effect occurs in the presence or absence of the traditional coronary risk factors...
  79. ncbi request reprint Design and methodology of the Occluded Artery Trial (OAT)
    Judith S Hochman
    Am Heart J 150:627-42. 2005
    ..If not, this strategy should be avoided in this large subgroup of post-MI patients...
  80. ncbi request reprint Systemic inflammatory response syndrome after acute myocardial infarction complicated by cardiogenic shock
    Shun Kohsaka
    Department of Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital and Baylor College of Medicine, Houston, USA
    Arch Intern Med 165:1643-50. 2005
    ....
  81. ncbi request reprint A 16-week fenofibrate treatment increases LDL particle size in type IIA dyslipidemic patients
    Isabelle Lemieux
    Lipid Research Center, CHUL Research Center, Quebec, Sainte Foy, Canada
    Atherosclerosis 162:363-71. 2002
    ....
  82. ncbi request reprint Bifurcating saphenous vein and left internal thoracic graft anatomy: treatment of a left main equivalent saphenous interposition vein graft lesion and virtual histology/grey scale IVUS characterization post-intervention
    Farrukh Hussain
    Int J Cardiol 122:179-81. 2007
    ..Virtual histology (VH) and grey scale intravascular ultrasound (IVUS) were utilized to visualize plaque characteristics in this novel lesion...
  83. ncbi request reprint Prediction of distal embolization during percutaneous coronary intervention in saphenous vein grafts
    William Joseph van Gaal
    Department of Cardiology, John Radcliffe Hospital, Oxford, UK
    Am J Cardiol 99:603-6. 2007
    ..In conclusion, distal embolization during SVG PCI is universal. Embolic burden cannot be predicted by clinical or angiographic variables, and embolic protection should be used in all patients...
  84. ncbi request reprint Sex differences in access to coronary revascularization after cardiac catheterization: importance of detailed clinical data
    William A Ghali
    University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada
    Ann Intern Med 136:723-32. 2002
    ..Although some studies suggest that access to cardiac procedures may differ by sex, others have found no evidence of gender bias in cardiac care...
  85. ncbi request reprint Restrictive physiology in cardiogenic shock: observations from echocardiography
    Harmony R Reynolds
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    Am Heart J 151:890.e9-15. 2006
    ..We hypothesized that restrictive physiology plays a role in cardiogenic shock (CS)...
  86. ncbi request reprint Late potentials in female triathletes before and after prolonged strenuous exercise
    Darren E R Warburton
    Faculty of Physical Education and Recreation, Div of Cardiology, Faculty of Medicine, Univ of Alberta, Edmonton, AB, T6G 2M7
    Can J Appl Physiol 28:153-64. 2003
    ..In conclusion, a small portion of female triathletes display LP before and after PSE, which are not worsened by PSE nor related to increased LV dimensions and/or mass...
  87. ncbi request reprint Drug-eluting stents in total coronary occlusions: another piece of the puzzle solved?
    Vladimir Dzavik
    Am Heart J 152:807-9. 2006
  88. ncbi request reprint Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction
    Stephen J Nicholls
    Department of Cardiovascular Medicine and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, 9500 Euclid Ave, NE 10, Cleveland, OH 44195, USA
    Circulation 116:2315-24. 2007
    ..It is unclear whether abnormalities of arginine and nitric oxide metabolism are related to hemodynamic dysfunction and mortality in patients with cardiogenic shock (CS) after acute myocardial infarction...
  89. pmc The use of lipid-lowering therapy for secondary prevention in patients undergoing percutaneous coronary intervention
    Jessica M Ma
    Pharmacy Department, Toronto East General Hospital, Canada
    Can J Cardiol 22:419-23. 2006
    ....
  90. ncbi request reprint Classification of coronary artery bifurcation lesions and treatments: time for a consensus!
    Yves Louvard
    Institut Cardiovasculaire Paris Sud, Massy, France
    Catheter Cardiovasc Interv 71:175-83. 2008
    ..They are often small scale and display methodological flaws and other shortcomings such as inaccurate designation of lesions, heterogeneity, and inadequate description of techniques implemented...

Research Grants4

  1. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2004
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
  2. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2002
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
  3. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2003
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
  4. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2001
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..