S M Dunn

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Mutagenesis of the rat alpha1 subunit of the gamma-aminobutyric acid(A) receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands
    S M Dunn
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Mol Pharmacol 56:768-74. 1999
  2. ncbi request reprint Agonist binding to the Torpedo acetylcholine receptor. 1. Complexities revealed by dissociation kinetics
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Biochemistry 36:3846-53. 1997
  3. ncbi request reprint Agonist binding to the Torpedo acetylcholine receptor. 2. Complexities revealed by association kinetics
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Biochemistry 36:3854-63. 1997
  4. ncbi request reprint Roles of agonist-binding sites in nicotinic acetylcholine receptor function
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Biochem Biophys Res Commun 279:358-62. 2000
  5. doi request reprint Feeding barley grain steeped in lactic acid modulates rumen fermentation patterns and increases milk fat content in dairy cows
    S Iqbal
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    J Dairy Sci 92:6023-32. 2009
  6. doi request reprint Barley grain-based diet treated with lactic acid and heat modulated plasma metabolites and acute phase response in dairy cows
    S Iqbal
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, Canada
    J Anim Sci 90:3143-52. 2012
  7. ncbi request reprint Characterization of the interaction of zopiclone with gamma-aminobutyric acid type A receptors
    M Davies
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Mol Pharmacol 58:756-62. 2000
  8. doi request reprint Perturbations of plasma metabolites correlated with the rise of rumen endotoxin in dairy cows fed diets rich in easily degradable carbohydrates
    Q Zebeli
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada T6G 2P5
    J Dairy Sci 94:2374-82. 2011
  9. doi request reprint Strong associations among rumen endotoxin and acute phase proteins with plasma minerals in lactating cows fed graded amounts of concentrate
    Q Zebeli
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Anim Sci 88:1545-53. 2010
  10. ncbi request reprint Cholinergic binding sites on the pentameric acetylcholine receptor of Torpedo californica
    S M Dunn
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Biochemistry 32:8608-15. 1993

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Mutagenesis of the rat alpha1 subunit of the gamma-aminobutyric acid(A) receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands
    S M Dunn
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Mol Pharmacol 56:768-74. 1999
    ..These results indicate that the characteristics of the residue at position 101 of the alpha1 subunit play a crucial role in determining the efficacy of benzodiazepine-site ligands...
  2. ncbi request reprint Agonist binding to the Torpedo acetylcholine receptor. 1. Complexities revealed by dissociation kinetics
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Biochemistry 36:3846-53. 1997
    ..These results, in addition to those presented in the accompanying manuscript, lead to the proposal that [3H]suberyldicholine is able to cross-link the two subsites or at least sterically occlude the second site...
  3. ncbi request reprint Agonist binding to the Torpedo acetylcholine receptor. 2. Complexities revealed by association kinetics
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Biochemistry 36:3854-63. 1997
    ..Analogues in which n < 5 behave like acetylcholine, i.e., a second ligand binding pathway is observed, but longer ligands (n = 5-10) act like suberyldicholine and may be long enough to cross-link the sites...
  4. ncbi request reprint Roles of agonist-binding sites in nicotinic acetylcholine receptor function
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Biochem Biophys Res Commun 279:358-62. 2000
    ..It is thus necessary to invoke the presence of additional binding sites in channel opening...
  5. doi request reprint Feeding barley grain steeped in lactic acid modulates rumen fermentation patterns and increases milk fat content in dairy cows
    S Iqbal
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    J Dairy Sci 92:6023-32. 2009
    ..In conclusion, results demonstrated that treatment of barley grain with LA lowered the risk of subacute rumen acidosis and maintained high milk fat content in late-lactating Holstein cows fed diets based on barley grain...
  6. doi request reprint Barley grain-based diet treated with lactic acid and heat modulated plasma metabolites and acute phase response in dairy cows
    S Iqbal
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, Canada
    J Anim Sci 90:3143-52. 2012
    ..In conclusion, results indicated that feeding dairy cows barley grain steeped in 1.0% LA and treated with heat modulated the profile of plasma metabolites and acute phase response...
  7. ncbi request reprint Characterization of the interaction of zopiclone with gamma-aminobutyric acid type A receptors
    M Davies
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Mol Pharmacol 58:756-62. 2000
    ..In summary, these data suggest that histidine 101 of the alpha1-subunit plays a similar role in ligand recognition for zopiclone, diazepam, and flunitrazepam...
  8. doi request reprint Perturbations of plasma metabolites correlated with the rise of rumen endotoxin in dairy cows fed diets rich in easily degradable carbohydrates
    Q Zebeli
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada T6G 2P5
    J Dairy Sci 94:2374-82. 2011
    ....
  9. doi request reprint Strong associations among rumen endotoxin and acute phase proteins with plasma minerals in lactating cows fed graded amounts of concentrate
    Q Zebeli
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Anim Sci 88:1545-53. 2010
    ..Results suggest that new feeding strategies should be developed to curb the release of endotoxin in the rumen fluid to prevent perturbing minerals in the plasma...
  10. ncbi request reprint Cholinergic binding sites on the pentameric acetylcholine receptor of Torpedo californica
    S M Dunn
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Biochemistry 32:8608-15. 1993
    ..abstract truncated at 250 words)..
  11. doi request reprint Feeding rolled barley grain steeped in lactic acid modulated energy status and innate immunity in dairy cows
    S Iqbal
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
    J Dairy Sci 93:5147-56. 2010
    ..Taken together, our results demonstrated that feeding barley grain steeped in 0.5% LA modulated both energy status and innate immunity of dairy cows fed relatively high levels (45% of dry matter) of dietary concentrate...
  12. doi request reprint Backgrounding and finishing diets are associated with inflammatory responses in feedlot steers
    B N Ametaj
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Anim Sci 87:1314-20. 2009
    ..More research is warranted to elucidate the mechanisms behind the inflammatory responses observed in feedlot steers and their implications for health issues and the production efficiency of feedlot operations...
  13. doi request reprint Intermittent parenteral administration of endotoxin triggers metabolic and immunological alterations typically associated with displaced abomasum and retained placenta in periparturient dairy cows
    Q Zebeli
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada T6G 2P5
    J Dairy Sci 94:4968-83. 2011
    ..In conclusion, our results indicate a role of endotoxemia, during the periparturient period, in development of metabolic and immune disturbances, as well as in the etiopathology of displaced abomasum and retained placenta in dairy cows...
  14. ncbi request reprint Feeding high proportions of barley grain in a total mixed ration perturbs diurnal patterns of plasma metabolites in lactating dairy cows
    B N Ametaj
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    J Dairy Sci 92:1084-91. 2009
    ..However, further research is warranted to understand involvement of these metabolic changes on the long-term health and productivity of dairy cows...
  15. ncbi request reprint Effects of propofol and pentobarbital on ligand binding to GABAA receptors suggest a similar mechanism of action
    M Davies
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Can J Physiol Pharmacol 76:46-52. 1998
    ..The results of these studies demonstrate that propofol and pentobarbital modulate the binding of ligands to the GABAA receptor in a similar manner, suggesting that these drugs may have a common mechanism of action...
  16. doi request reprint A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows
    F Saleem
    Department of Biological and Computing Sciences, University of Alberta, Edmonton, AB, Canada TG6 2P5
    J Dairy Sci 95:6606-23. 2012
    ..These results may improve our understanding of diet-related rumen metabolism and the influence of grain on the overall health of dairy cattle...
  17. doi request reprint Feeding high proportions of barley grain stimulates an inflammatory response in dairy cows
    D G V Emmanuel
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
    J Dairy Sci 91:606-14. 2008
    ..In conclusion, feeding dairy cows high proportions (30 and 45% DM basis) of barley grain was associated with lower feed intake and rumen pH, increased endotoxin in the rumen fluid, and stimulation of an inflammatory response...
  18. ncbi request reprint Identification of a unique domain in bovine brain GABAA receptors that is photoaffinity labelled by [3H]Ro15-4513
    M Davies
    Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Biochem Biophys Res Commun 246:650-3. 1998
    ..This region of the GABAA receptor has not previously been implicated in the formation of the benzodiazepine binding site and may be part of a unique recognition domain for inverse agonists...
  19. ncbi request reprint Mutagenesis of the GABA(A) receptor alpha1 subunit reveals a domain that affects sensitivity to GABA and benzodiazepine-site ligands
    M Davies
    Department of Pharmacology and Centre for Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 79:55-62. 2001
    ..These results suggest that a domain within this small extracellular loop between TMII-TMIII plays a role in determining the sensitivity of GABA(A) receptors to both GABA and benzodiazepine-site ligands...
  20. doi request reprint Identification of predictive biomarkers of disease state in transition dairy cows
    D Hailemariam
    Department of Agricultural, Food and Nutritional Science, Edmonton, Alberta, Canada T6G 2P5
    J Dairy Sci 97:2680-93. 2014
    ..Further research is warranted to validate these potential predictive biomarkers. ..
  21. ncbi request reprint Intravaginal administration of lactic acid bacteria modulated the incidence of purulent vaginal discharges, plasma haptoglobin concentrations, and milk production in dairy cows
    B N Ametaj
    Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada Electronic address
    Res Vet Sci 96:365-70. 2014
    ..Further research is warranted to evaluate the effects of LAB on reproductive performance in a larger cohort of cows. ..
  22. doi request reprint Intermittently-induced endotoxaemia has no effect on post-challenge plasma metabolites, but increases body temperature and cortisol concentrations in periparturient dairy cows
    Q Zebeli
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, Vetmeduni Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
    Res Vet Sci 95:1155-62. 2013
    ..In conclusion, LPS administrations did not notably affect post-challenge metabolic responses in periparturient dairy cows but increased the level of plasma cortisol and the body temperature after the highest LPS challenge...
  23. ncbi request reprint Acidosis and lipopolysaccharide from Escherichia coli B:055 cause hyperpermeability of rumen and colon tissues
    D G V Emmanuel
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
    J Dairy Sci 90:5552-7. 2007
    ..Further research is warranted to understand the mechanism(s) by which acidic pH of the rumen digesta and presence of LPS make rumen and colon tissues "leaky"...
  24. ncbi request reprint Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH
    S M Dunn
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Biochemistry 29:8569-76. 1990
    ..5). In addition, the pH profile suggests the involvement of a second ionizable group having a pK of about 8 since, above pH 7, the proportion of the NADPH-binding form decreases.(ABSTRACT TRUNCATED AT 250 WORDS)..