Research Topics
| Bernard P DunckerSummaryAffiliation: University of Waterloo Country: Canada Publications
| Collaborators
|
Detail Information
Publications
A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agentsAngela E Varrin
Department of Biology, University of Waterloo, Ontario, Canada
Mol Cell Biol 25:7494-504. 2005..Thus, the alteration of the M motif may facilitate the role of Dbf4 as a checkpoint target...- An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexesJeffrey W Semple
Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
EMBO J 25:5150-8. 2006.... - The origin recognition complex protein familyBernard P Duncker
Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
Genome Biol 10:214. 2009..Current avenues of research have identified roles for ORC proteins in the development of neuronal and muscle tissue, and are probing their relationship to genome integrity... 
Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeastsBernard P Duncker
Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
Mutat Res 532:21-7. 2003..The present review is a comparative survey of data obtained from studies conducted with S. pombe and S. cerevisae, and a consideration of models for the role played by Dbf4/Cdc7 in checkpoint responses...- The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stressDarryl R Jones
Department of Biology, University of Waterloo, Waterloo, ON, Canada
Cell Cycle 9:2018-26. 2010..These results support a model whereby DDK interaction with Mcm2 is important to stabilize and/or restart replication forks during conditions where a prolonged S-phase checkpoint is triggered... 
Characterization of p53 expression in rainbow troutMichelle Liu
Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
Comp Biochem Physiol C Toxicol Pharmacol 154:326-32. 2011..In contrast to mammals, these checkpoint-inducing agents provoked no apparent increase in rainbow trout p53 levels. These results infer the presence of alternate DNA damage checkpoint mechanisms in rainbow trout cells...- ORC function in late G1: maintaining the license for DNA replicationLance F Da Silva
Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
Cell Cycle 6:128-30. 2007..Loss of MCM association at origins may be mediated by the displacement of Mcm10 and/or Orc2 as a consequence of late G(1) Orc6 depletion... - A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbationsRohan D Gidvani
Department of Biology, University of Waterloo, Waterloo, ON, Canada
BMC Syst Biol 6:78. 2012..We have developed an ordinary differential equation-based model of the protein-protein interaction network describing replication initiation... - The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoformsJohny Bozdarov
Department of Biology, University of Waterloo, Ontario, Canada
Comp Biochem Physiol C Toxicol Pharmacol 157:16-23. 2013..Based on the genomic rtrad1 sequence the splice variants contain only partial exons which are consistent with the splicing of rad1 variants in mammals. This is the first time that rad1 has been fully characterized in a fish species... - Proteomic profiles of white sucker (Catostomus commersonii) sampled from within the Thunder Bay Area of Concern reveal up-regulation of proteins associated with tumor formation and exposure to environmental estrogensDenina B D Simmons
Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada
Environ Sci Technol 46:1886-94. 2012..The protein expression profiles indicate that white sucker health has benefited from the remediation of the Thunder Bay Harbour site, whereas white sucker from the Kaministiquia River site are impacted by ongoing contaminant discharges... - Transcriptional regulation of ACC deaminase gene expression in Pseudomonas putida UW4Zhenyu Cheng
Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L3G1, Canada
Can J Microbiol 54:128-36. 2008..The data are interpreted in terms of a model in which AcdR and AcdB co-regulate the expression of the acdS gene... - Characterization of rainbow trout CHK2 and its potential as a genotoxicity biomarkerJessica D Steinmoeller
Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
Comp Biochem Physiol C Toxicol Pharmacol 149:491-9. 2009..The tissue specific expression of CHK2 and its ability to respond to bleomycin treatment suggests that some checkpoint proteins may serve as suitable biomarkers for DNA damage in rainbow trout and other fish species... - ORC-associated replication factors as biomarkers for cancerJeffrey W Semple
Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada
Biotechnol Adv 22:621-31. 2004..Similarly encouraging results have been obtained in preliminary studies examining Cdc6 protein and Cdc7 kinase transcript levels in normal and cancerous cells... - Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targetsPhilippe Pasero
Institute of Molecular Genetics, , 34293 Montpellier Cedex 5, France
Cell Cycle 2:568-72. 2003.... - An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firingBernard P Duncker
Department of Molecular Biology, University of Geneva, Quai Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
Proc Natl Acad Sci U S A 99:16087-92. 2002..Moreover, its overexpression perturbs the regulation of late, but not early, origin firing in wild-type cells after treatment with hydroxyurea...