Bernard P Duncker

Summary

Affiliation: University of Waterloo
Country: Canada

Publications

  1. pmc An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes
    Jeffrey W Semple
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    EMBO J 25:5150-8. 2006
  2. pmc A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents
    Angela E Varrin
    Department of Biology, University of Waterloo, Ontario, Canada
    Mol Cell Biol 25:7494-504. 2005
  3. ncbi request reprint Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts
    Bernard P Duncker
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
    Mutat Res 532:21-7. 2003
  4. pmc The origin recognition complex protein family
    Bernard P Duncker
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Genome Biol 10:214. 2009
  5. ncbi request reprint The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress
    Darryl R Jones
    Department of Biology, University of Waterloo, Waterloo, ON, Canada
    Cell Cycle 9:2018-26. 2010
  6. pmc Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits
    Matthew D Ramer
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L3G1, Canada
    J Biol Chem 288:14926-35. 2013
  7. doi request reprint The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoforms
    Johny Bozdarov
    Department of Biology, University of Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 157:16-23. 2013
  8. doi request reprint The p53/HSP70 inhibitor, 2-phenylethynesulfonamide, causes oxidative stress, unfolded protein response and apoptosis in rainbow trout cells
    Fanxing Zeng
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Aquat Toxicol 146:45-51. 2014
  9. doi request reprint Characterization of p53 expression in rainbow trout
    Michelle Liu
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 154:326-32. 2011
  10. ncbi request reprint ORC function in late G1: maintaining the license for DNA replication
    Lance F Da-Silva
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Cell Cycle 6:128-30. 2007

Collaborators

  • Brendan J McConkey
  • Denina B D Simmons
  • Zhenyu Cheng
  • J J Heikkila
  • Brian Dixon
  • Niels C Bols
  • Fanxing Zeng
  • James P Sherry
  • Michelle Liu
  • Matthew D Ramer
  • Jeffrey W Semple
  • Lance F Da-Silva
  • Johny Bozdarov
  • Catherine Tee
  • Rohan D Gidvani
  • Philippe Pasero
  • Darryl R Jones
  • Jessica D Steinmoeller
  • Ajai A Prasad
  • Angela E Varrin
  • Hagen Richter
  • Evelyin S Suman
  • Karen Stanger
  • Martina Spranger
  • Nicole Bieberstein
  • Peter Sudmant
  • Lance F Dasilva
  • Grace Li
  • Brian P Ingalls
  • Philip K Chan
  • Kazuhiro Fujiki
  • Kirsten M Müller
  • Aman Arya
  • Eric J Jervis
  • Jennifer Ah-Kee
  • Lutz Kummer
  • Hyder Al-Attar
  • Rolf Peter Scholz
  • Kenji Shimada

Detail Information

Publications17

  1. pmc An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes
    Jeffrey W Semple
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    EMBO J 25:5150-8. 2006
    ....
  2. pmc A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents
    Angela E Varrin
    Department of Biology, University of Waterloo, Ontario, Canada
    Mol Cell Biol 25:7494-504. 2005
    ..Thus, the alteration of the M motif may facilitate the role of Dbf4 as a checkpoint target...
  3. ncbi request reprint Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts
    Bernard P Duncker
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
    Mutat Res 532:21-7. 2003
    ..The present review is a comparative survey of data obtained from studies conducted with S. pombe and S. cerevisae, and a consideration of models for the role played by Dbf4/Cdc7 in checkpoint responses...
  4. pmc The origin recognition complex protein family
    Bernard P Duncker
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Genome Biol 10:214. 2009
    ..Current avenues of research have identified roles for ORC proteins in the development of neuronal and muscle tissue, and are probing their relationship to genome integrity...
  5. ncbi request reprint The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress
    Darryl R Jones
    Department of Biology, University of Waterloo, Waterloo, ON, Canada
    Cell Cycle 9:2018-26. 2010
    ..These results support a model whereby DDK interaction with Mcm2 is important to stabilize and/or restart replication forks during conditions where a prolonged S-phase checkpoint is triggered...
  6. pmc Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits
    Matthew D Ramer
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L3G1, Canada
    J Biol Chem 288:14926-35. 2013
    ..Finally, constitutive overexpression of each individual MCM subunit was examined, and genotoxic sensitivity was found to be specific to Mcm2 or Mcm4 overexpression, further pointing to the importance of the DDK-MCM ring interaction...
  7. doi request reprint The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoforms
    Johny Bozdarov
    Department of Biology, University of Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 157:16-23. 2013
    ..Based on the genomic rtrad1 sequence the splice variants contain only partial exons which are consistent with the splicing of rad1 variants in mammals. This is the first time that rad1 has been fully characterized in a fish species...
  8. doi request reprint The p53/HSP70 inhibitor, 2-phenylethynesulfonamide, causes oxidative stress, unfolded protein response and apoptosis in rainbow trout cells
    Fanxing Zeng
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Aquat Toxicol 146:45-51. 2014
    ..Despite these multiple actions, PES should be useful for studying fish cellular survival pathways. ..
  9. doi request reprint Characterization of p53 expression in rainbow trout
    Michelle Liu
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 154:326-32. 2011
    ..In contrast to mammals, these checkpoint-inducing agents provoked no apparent increase in rainbow trout p53 levels. These results infer the presence of alternate DNA damage checkpoint mechanisms in rainbow trout cells...
  10. ncbi request reprint ORC function in late G1: maintaining the license for DNA replication
    Lance F Da-Silva
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Cell Cycle 6:128-30. 2007
    ..Loss of MCM association at origins may be mediated by the displacement of Mcm10 and/or Orc2 as a consequence of late G(1) Orc6 depletion...
  11. pmc A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations
    Rohan D Gidvani
    Department of Biology, University of Waterloo, Waterloo, ON, Canada
    BMC Syst Biol 6:78. 2012
    ..We have developed an ordinary differential equation-based model of the protein-protein interaction network describing replication initiation...
  12. doi request reprint Proteomic profiles of white sucker (Catostomus commersonii) sampled from within the Thunder Bay Area of Concern reveal up-regulation of proteins associated with tumor formation and exposure to environmental estrogens
    Denina B D Simmons
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada
    Environ Sci Technol 46:1886-94. 2012
    ..The protein expression profiles indicate that white sucker health has benefited from the remediation of the Thunder Bay Harbour site, whereas white sucker from the Kaministiquia River site are impacted by ongoing contaminant discharges...
  13. doi request reprint Transcriptional regulation of ACC deaminase gene expression in Pseudomonas putida UW4
    Zhenyu Cheng
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L3G1, Canada
    Can J Microbiol 54:128-36. 2008
    ..The data are interpreted in terms of a model in which AcdR and AcdB co-regulate the expression of the acdS gene...
  14. doi request reprint Characterization of rainbow trout CHK2 and its potential as a genotoxicity biomarker
    Jessica D Steinmoeller
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 149:491-9. 2009
    ..The tissue specific expression of CHK2 and its ability to respond to bleomycin treatment suggests that some checkpoint proteins may serve as suitable biomarkers for DNA damage in rainbow trout and other fish species...
  15. ncbi request reprint ORC-associated replication factors as biomarkers for cancer
    Jeffrey W Semple
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada
    Biotechnol Adv 22:621-31. 2004
    ..Similarly encouraging results have been obtained in preliminary studies examining Cdc6 protein and Cdc7 kinase transcript levels in normal and cancerous cells...
  16. ncbi request reprint Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targets
    Philippe Pasero
    Institute of Molecular Genetics, CNRS UMR 5535 and Université Montpellier II, 34293 Montpellier Cedex 5, France
    Cell Cycle 2:568-72. 2003
    ....
  17. pmc An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing
    Bernard P Duncker
    Department of Molecular Biology, University of Geneva, Quai Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 99:16087-92. 2002
    ..Moreover, its overexpression perturbs the regulation of late, but not early, origin firing in wild-type cells after treatment with hydroxyurea...