Daniel J Dumont

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
    Elena Bogdanovic
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s Research Institute, Research Building, S 218, Toronto, Ontario M4N 3M5, Canada
    J Cell Sci 119:3551-60. 2006
  2. pmc Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development
    Harold Kim
    Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e52197. 2013
  3. pmc The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
    Philipp Kümpers
    Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Munster, Albert Schweitzer Strasse 33, Münster 48149 Germany
    Crit Care 15:R261. 2011
  4. pmc Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy
    Amy Baker
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Breast Cancer Res 12:R70. 2010
  5. pmc Tyrosine phosphorylation of Grb14 by Tie2
    Celina Sturk
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Cell Commun Signal 8:30. 2010
  6. pmc Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature
    Harold Kim
    Sunnybrook Research Institute University of Toronto 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada
    BMC Dev Biol 10:72. 2010
  7. pmc 25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner
    Vicky Pkh Nguyen
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, M4N 3M5, Canada
    J Angiogenes Res 2:24. 2010
  8. pmc A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice
    Daniel Voskas
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Am J Pathol 166:843-55. 2005
  9. pmc An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice
    Daniel Voskas
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Leukoc Biol 84:59-67. 2008
  10. doi request reprint Differential proteomic analysis of lymphatic, venous, and arterial endothelial cells extracted from bovine mesenteric vessels
    Vicky P K H Nguyen
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Proteomics 10:1658-72. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
    Elena Bogdanovic
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s Research Institute, Research Building, S 218, Toronto, Ontario M4N 3M5, Canada
    J Cell Sci 119:3551-60. 2006
    ..Altogether, these data begin our understanding of the regulation of Tie2 and the activity of the angiopoietins after engaging the endothelial cell surface...
  2. pmc Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development
    Harold Kim
    Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e52197. 2013
    ..These conclusions have far reaching implications on how we understand the vascular specificity of lymphangiogenesis...
  3. pmc The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
    Philipp Kümpers
    Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Munster, Albert Schweitzer Strasse 33, Münster 48149 Germany
    Crit Care 15:R261. 2011
    ..Here we evaluate the efficacy of a novel polyethylene glycol (PEG)-clustered Tie2 agonist peptide, Vasculotide (VT), to protect against vascular leakage and mortality in a murine model of polymicrobial abdominal sepsis...
  4. pmc Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy
    Amy Baker
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Breast Cancer Res 12:R70. 2010
    ..In this report, we examine the potential of lymphangiogenic therapy to restore lymphatic function and reduce post-surgical lymphedema...
  5. pmc Tyrosine phosphorylation of Grb14 by Tie2
    Celina Sturk
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Cell Commun Signal 8:30. 2010
    ..Furthermore, Grb14 has also been shown to interact with Tie2, however tyrosine phosphorylation of this Grb family member has yet to be reported...
  6. pmc Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature
    Harold Kim
    Sunnybrook Research Institute University of Toronto 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada
    BMC Dev Biol 10:72. 2010
    ..While the in vitro data suggest that gene reprogramming occurs upon Prox1 expression, it is not clear if this is a direct result of Prox1 in vascular endothelial cells in vivo...
  7. pmc 25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner
    Vicky Pkh Nguyen
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, M4N 3M5, Canada
    J Angiogenes Res 2:24. 2010
    ..25-OHC and other oxidized forms of cholesterol are implicated in modulating inflammatory responses involved in development of atherosclerosis and colon carcinogenesis...
  8. pmc A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice
    Daniel Voskas
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Am J Pathol 166:843-55. 2005
    ..Furthermore, the skin lesions in double-transgenic mice markedly improved after administration of the immunosuppressive anti-psoriatic agent cyclosporine, thus demonstrating the clinical significance of this new model...
  9. pmc An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice
    Daniel Voskas
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Leukoc Biol 84:59-67. 2008
    ....
  10. doi request reprint Differential proteomic analysis of lymphatic, venous, and arterial endothelial cells extracted from bovine mesenteric vessels
    Vicky P K H Nguyen
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Proteomics 10:1658-72. 2010
    ..The lack of substantial overlap between our results and those of other groups' comparative studies are discussed. Functional implications of differences in levels of various proteins identified in the three cell types are also discussed...
  11. pmc Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2
    Vicky P K H Nguyen
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    BMC Cell Biol 8:10. 2007
    ..In this study, we examined the effects of the angiopoietins on lymphatic, venous and arterial primary endothelial cells (bmLEC, bmVEC and bmAEC, respectively), which were isolated and cultured from bovine mesenteric vessels...
  12. ncbi request reprint Functional inhibition of secreted angiopoietin: a novel role for angiopoietin 1 in coronary vessel patterning
    Nicole L Ward
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s Research Institute, Toronto, Ontario, Canada M4N 3M5
    Biochem Biophys Res Commun 323:937-46. 2004
    ..Ang1cc contains the coiled-coiled domain, which can heterodimerize with other angiopoietins produced in the same cell. We show that Ang1cc can inhibit Tie2 activation and can inhibit Ang1 activity in vitro and in vivo...
  13. doi request reprint Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
    John M L Ebos
    Sunnybrook Health Sciences Centre, Molecular and Cellular Biology Research, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 68:521-9. 2008
    ....
  14. pmc Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide
    Saeid Babaei
    Terrence Donnelly Heart Center and Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Pathol 162:1927-36. 2003
    ..In summary, our results demonstrate for the first time that endothelial-derived NO is required for Ang1-induced angiogenesis, and that the PI3-kinase signaling mediates the activation of eNOS and NO release in response to Ang1...
  15. pmc Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk
    Paul Van Slyke
    Sunnybrook and Women s Research Institute, 2075 Bayview Avenue, Research Building S 218, Toronto, Ontario, Canada M4N 3M5
    Mol Cell Biol 25:3831-41. 2005
    ..Collectively these results demonstrate that Dok-R acts as an EGFR-recruited scaffolding molecule that processively assembles c-Src and Csk to attenuate signaling from the EGFR...
  16. ncbi request reprint Gene expression analysis of Tek/Tie2 signaling
    Stephen H Chen
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s Research Institute, Toronto, Ontario, Canada
    Physiol Genomics 22:257-67. 2005
    ..The results of this study provide valuable insight into the potential association between Tie2 signaling and other known angiogenic pathways as well as genes that might have novel functions in vascular remodeling...
  17. ncbi request reprint Lymphangiogenesis following obstruction of large postnodal lymphatics in sheep
    Azadeh Jila
    Neuroscience Research Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Microvasc Res 73:214-23. 2007
    ..The lymph node appeared to have some role in limiting the impact of post-nodal lymph obstruction, a function that appeared to be compromised by lymph stasis...
  18. pmc The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice
    Lakshmi Kugathasan
    Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    J Exp Med 206:2221-34. 2009
    ..Thus, these findings firmly establish that endothelial survival signaling via the Ang1-Tie2 pathway is protective in PAH...
  19. pmc Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis
    Kazunobu Tachibana
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Rm 982, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Mol Cell Biol 25:4693-702. 2005
    ....
  20. ncbi request reprint Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis
    Yuval Shaked
    Department of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario M3N 4M5, Canada
    Cancer Cell 7:101-11. 2005
    ..Finally, treatment with a targeted VEGFR-2 antibody caused a dose-dependent reduction in viable CEPs that precisely paralleled its previously and empirically determined antitumor activity...
  21. doi request reprint Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1
    Elena Bogdanovic
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Research Building, S 218, Toronto, ON, M4N 3M5, Canada
    Histochem Cell Biol 132:225-37. 2009
    ..Our results suggest that one pathway mediating the internalization of Tie2 in response to Ang1 is through clathrin-coated pits...
  22. ncbi request reprint Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and blood vessel architecture
    Alexandra L Haninec
    Divisions of Molecular and Cellular Biology Research, Sunnybrook and Women s Research Institute, Toronto, Ont, Canada
    Biochem Biophys Res Commun 345:1299-307. 2006
    ....
  23. doi request reprint Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes
    Sébastien Trop
    Clinician Investigator Program, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada Platform of Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Surg Res 187:43-52. 2014
    ..South Asian ethnicity is an independent risk factor for mortality after coronary artery bypass. We tested the hypothesis that this risk results from a greater inflammatory response to cardiopulmonary bypass (CPB)...
  24. pmc Inhibition of T cell protein tyrosine phosphatase enhances interleukin-18-dependent hematopoietic stem cell expansion
    Annie Bourdeau
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stem Cells 31:293-304. 2013
    ....
  25. doi request reprint The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis
    Gurpreet K Lakhanpal
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Blood 116:428-36. 2010
    ....
  26. pmc Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease
    Nicole L Ward
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s College Research Institute, Toronto, Canada
    Am J Pathol 165:889-99. 2004
    ..Our findings suggest that controlling excessive angiogenesis during liver disease may promote the restoration of the portal vein circuit and aid in the resolution of disease-associated portal hypertension...
  27. ncbi request reprint Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes
    Nicole L Ward
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s College Research Institute, Toronto, Ontario M4N 3M5, Canada
    J Comp Neurol 482:244-56. 2005
    ..Understanding interactions between the developing nervous and vascular systems will lead to novel insight into how the two systems interact throughout development, during senescence, and in disease...
  28. doi request reprint Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation
    Christina Wehrle
    Division of Molecular and Cellular Biology Research, Sunnybrook Research Institute, Toronto, Ontario, Canada, M4N 3M5
    Biochem J 423:375-80. 2009
    ..In summary, our results illustrate that c-Cbl interacts with the Tie2 signalling complex in a stimulation-dependent manner, and that this interaction is required for Tie2 ubiquitylation, internalization and degradation...
  29. pmc Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
    Shahrzad Jalali
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    BMC Neurol 10:114. 2010
    ..Therefore, the aim of this study was to investigate the activation of cell survival signaling molecules in response to ultrasound-mediated BBB opening;..
  30. ncbi request reprint Cell-based angiopoietin-1 gene therapy for acute lung injury
    Sarah D McCarter
    St Michael s Hospital, Toronto, ON, M5B 1W8, Canada
    Am J Respir Crit Care Med 175:1014-26. 2007
    ..Angiopoietin-1 (Ang-1), a ligand for the endothelial Tie2 receptor, is an endothelial survival and vascular stabilization factor that reduces endothelial permeability and inhibits leukocyte-endothelium interactions...
  31. ncbi request reprint Angiopoietin 1 expression levels in the myocardium direct coronary vessel development
    Nicole L Ward
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s College Research Institute, Toronto, Ontario, Canada
    Dev Dyn 229:500-9. 2004
    ..These results suggest a pivotal role for Angiopoietin 1 in cardiovascular development, specifically the development of the epicardium and coronary vasculature...
  32. doi request reprint Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections
    Adam Tuer
    University of Toronto, Department of Physics, Institute for Optical Sciences, Department of Chemical and Physical Sciences, 3359 Mississauga Road North, Mississauga, Ontario, L5L 1C6 Canada
    J Biomed Opt 15:026018. 2010
    ..Multicontrast nonlinear microscopy has the potential to differentiate between cancerous and healthy tissue at a single cell level...
  33. pmc A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function
    Nina Jones
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s College Research Institute, Toronto, Ontario M4N 3M5, Canada
    Mol Cell Biol 23:2658-68. 2003
    ..Together, these findings demonstrate that tyrosine residue 1106 on Tie2 is critical for coupling downstream cell migration signal transduction pathways with Ang1 stimulation in endothelial cells...