Anne Duffy

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint Childhood anxiety: an early predictor of mood disorders in offspring of bipolar parents
    Anne Duffy
    Hotchkiss Brain Institute and Department of Psychiatry, University of Calgary, Calgary, AB, Canada T2N 4Z6
    J Affect Disord 150:363-9. 2013
  2. doi request reprint The nature of the association between childhood ADHD and the development of bipolar disorder: a review of prospective high-risk studies
    Anne Duffy
    Department of Psychiatry, University of Calgary, Alberta, Canada
    Am J Psychiatry 169:1247-55. 2012
  3. doi request reprint Adolescent substance use disorder during the early stages of bipolar disorder: a prospective high-risk study
    Anne Duffy
    Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
    J Affect Disord 142:57-64. 2012
  4. doi request reprint Pituitary volumes in relatives of bipolar patients: high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Room 3089, QEII HSC, A J Lane Bldg 5909 Veteran s Memorial Lane, B3H 2E2, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 258:357-62. 2008
  5. doi request reprint Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjects
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 259:263-9. 2009
  6. doi request reprint Striatal volumes in affected and unaffected relatives of bipolar patients--high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, 5909 Veteran s Memorial Lane, Halifax, Canada
    J Psychiatr Res 43:724-9. 2009
  7. ncbi request reprint The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents
    Anne Duffy
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Bipolar Disord 9:828-38. 2007
  8. doi request reprint Early stages in the development of bipolar disorder
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 121:127-35. 2010
  9. doi request reprint Early course of bipolar disorder in high-risk offspring: prospective study
    Anne Duffy
    MD, Department of Psychiatry, Dalhousie University IWK Health Centre, 5850 5980 University Avenue, P O Box 9700, Halifax, Nova Scotia, Canada B3K 6R8
    Br J Psychiatry 195:457-8. 2009
  10. ncbi request reprint Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study
    Julie Garnham
    Department of Psychiatry, Capital District Health Authority, Halifax, Canada
    J Affect Disord 104:185-90. 2007

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Childhood anxiety: an early predictor of mood disorders in offspring of bipolar parents
    Anne Duffy
    Hotchkiss Brain Institute and Department of Psychiatry, University of Calgary, Calgary, AB, Canada T2N 4Z6
    J Affect Disord 150:363-9. 2013
    ..Anxiety disorders are common among the offspring of parents with bipolar disorder (BD). This study investigated the nature of the association between anxiety disorders and mood disorders in a prospectively studied high-risk cohort...
  2. doi request reprint The nature of the association between childhood ADHD and the development of bipolar disorder: a review of prospective high-risk studies
    Anne Duffy
    Department of Psychiatry, University of Calgary, Alberta, Canada
    Am J Psychiatry 169:1247-55. 2012
    ....
  3. doi request reprint Adolescent substance use disorder during the early stages of bipolar disorder: a prospective high-risk study
    Anne Duffy
    Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
    J Affect Disord 142:57-64. 2012
    ..We studied this relationship in a prospectively assessed cohort of high-risk offspring...
  4. doi request reprint Pituitary volumes in relatives of bipolar patients: high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Room 3089, QEII HSC, A J Lane Bldg 5909 Veteran s Memorial Lane, B3H 2E2, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 258:357-62. 2008
    ..To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipolar subjects...
  5. doi request reprint Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjects
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 259:263-9. 2009
    ..The current study investigated whether or not deficits in early information processing were present before the onset and/or during the early stages of bipolar disorder...
  6. doi request reprint Striatal volumes in affected and unaffected relatives of bipolar patients--high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, 5909 Veteran s Memorial Lane, Halifax, Canada
    J Psychiatr Res 43:724-9. 2009
    ..We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders...
  7. ncbi request reprint The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents
    Anne Duffy
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Bipolar Disord 9:828-38. 2007
    ..A major aim of this longitudinal high-risk study is to identify reliable early indicators of emerging bipolar disorder (BD) among offspring from well-characterized parents...
  8. doi request reprint Early stages in the development of bipolar disorder
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 121:127-35. 2010
    ..We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology...
  9. doi request reprint Early course of bipolar disorder in high-risk offspring: prospective study
    Anne Duffy
    MD, Department of Psychiatry, Dalhousie University IWK Health Centre, 5850 5980 University Avenue, P O Box 9700, Halifax, Nova Scotia, Canada B3K 6R8
    Br J Psychiatry 195:457-8. 2009
    ..We did not find evidence of pre-pubertal mania. In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder...
  10. ncbi request reprint Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study
    Julie Garnham
    Department of Psychiatry, Capital District Health Authority, Halifax, Canada
    J Affect Disord 104:185-90. 2007
    ..The objective of this study was to evaluate effectiveness of commonly used prophylactic treatments for bipolar disorder in a naturalistic setting and to explore factors associated with treatment response...
  11. ncbi request reprint Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia
    Can J Psychiatry 54:726-33. 2009
    ..To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design)...
  12. doi request reprint Findings from bipolar offspring studies: methodology matters
    Anne Duffy
    Department of Psychiatry, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada
    Early Interv Psychiatry 5:181-91. 2011
    ..In this review, we compare different methods of ascertainment and assessment, and their impact on study findings...
  13. pmc A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopy
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 33:531-40. 2008
    ..We searched for biological vulnerability markers using proton magnetic resonance spectroscopy (MRS) in both affected and unaffected participants at high genetic risk for bipolar disorder...
  14. ncbi request reprint MMPI as a measure of subthreshold and residual psychopathology among the offspring of lithium responsive and non-responsive bipolar parents
    Natasha Demidenko
    Bipolar Disorders Research Unit, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Bipolar Disord 6:323-8. 2004
    ..The present study compares MMPI profiles completed by the well or remitted offspring of two groups of bipolar parents divided on the basis of parental response to long-term lithium...
  15. ncbi request reprint Temperament, life events, and psychopathology among the offspring of bipolar parents
    Anne Duffy
    Department of Psychiatry, Montreal Children s Hospital, 4018 St Catherine St West, Montreal, Quebec, Canada
    Eur Child Adolesc Psychiatry 16:222-8. 2007
    ..The present study examines the relationship between temperament, recent and remote life events, and psychopathology among the offspring of parents with bipolar disorder and well comparisons...
  16. doi request reprint White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: a two-center high-risk study
    Eva Gunde
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Psychiatr Res 45:76-82. 2011
    ..It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, or even represent biological risk factor for BD...
  17. ncbi request reprint A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment
    Anne Duffy
    Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Psychiatry 63:1171-8. 2002
    ..The aim of this study was to prospectively characterize the clinical course, including antecedent and comorbid conditions, among the offspring of 2 groups of bipolar parents divided on the basis of response to lithium...
  18. pmc Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Psychiatry 9:4. 2009
    ..The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder...
  19. doi request reprint Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrus
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    Biol Psychiatry 73:144-52. 2013
    ..Thus, we examined the associations among genetic risk, illness burden, lithium treatment, and brain structure in BD...
  20. ncbi request reprint Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigine
    Michael J Passmore
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Bipolar Disord 5:110-4. 2003
    ..We conducted a study of clinical presentation and family history in patients responsive to either of two commonly used mood stabilizers, lithium and lamotrigine...
  21. doi request reprint Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune system
    Anne Duffy
    Departments of Psychiatry, Dalhousie University, Halifax, Nova Scotia
    Early Interv Psychiatry 6:128-37. 2012
    ..The study aims to provide a selective review of the literature pertaining to the hypothalamic-pituitary-adrenal (HPA) axis and immune abnormalities as informative biological indicators of vulnerability in bipolar disorder (BD)...
  22. pmc Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 108:263-9. 2008
    ..This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders...
  23. doi request reprint The developmental trajectory of bipolar disorder
    Anne Duffy
    Anne Duffy, MSc, MD, FRCPC Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia and Mood Disorders Centre of Ottawa, Ontario Julie Horrocks, PhD, Department of Mathematics and Statistics, University of Guelph, Ontario Sarah Doucette, MSc, Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia Charles Keown Stoneman, MSc, Department of Mathematics and Statistics, University of Guelph, Ontario Shannon McCloskey, Med, Mood Disorders Centre of Ottawa, Ontario Paul Grof, MD, PhD, FRCPC, Mood Disorders Centre of Ottawa, Ontario, and Department of Psychiatry, University of Toronto, Ontario, Canada
    Br J Psychiatry 204:122-8. 2014
    ..Bipolar disorder is highly heritable and therefore longitudinal observation of children of affected parents is important to mapping the early natural history...
  24. ncbi request reprint The cortisol awakening response in bipolar illness: a pilot study
    Dorian Deshauer
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario
    Can J Psychiatry 48:462-6. 2003
    ..We hypothesized that the free cortisol response to waking, believed to be genetically influenced, would be elevated in a significant percentage of cases, regardless of the afternoon Dexamethasone Suppression Test (DST) value...
  25. ncbi request reprint The early natural history of bipolar disorder: what we have learned from longitudinal high-risk research
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia
    Can J Psychiatry 55:477-85. 2010
    ..In this regard, the development of specialty psychiatric programs aiming to identify youth in the early stages of evolving psychosis are substantially ahead of services for youth in the early stages of evolving major mood disorders...
  26. ncbi request reprint Salivary cortisol secretion in remitted bipolar patients and offspring of bipolar parents
    Dorian Deshauer
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
    Bipolar Disord 8:345-9. 2006
    ..The purpose of this study is to replicate findings of increased cortisol secretion during clinical remission in bipolar patients and in the offspring of bipolar parents, rigorously controlling for known confounders...
  27. ncbi request reprint Is response to prophylactic lithium a familial trait?
    Paul Grof
    Department of Psychiatry, University of Ottawa, Ontario, Canada
    J Clin Psychiatry 63:942-7. 2002
    ..However, this recommendation has not been adequately substantiated in the literature. We tested the hypothesis that response to long-term lithium treatment is a familial trait...
  28. ncbi request reprint Does bipolar disorder exist in children? A selected review
    Anne Duffy
    Department of Psychiatry, McGill University, Montreal Children s Hospital, Quebec, Canada
    Can J Psychiatry 52:409-17. 2007
    ..Some children manifest antecedent nonspecific psychopathology in early childhood. Therefore, as currently diagnosed, BD does not manifest as such typically until at least adolescence...