Lisheng Du

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada
    Am J Med Genet 96:56-60. 2000
  2. ncbi request reprint Gender differences in association between serotonin transporter gene polymorphism and personality traits
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ontario, Canada
    Psychiatr Genet 10:159-64. 2000
  3. ncbi request reprint Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ontario, Canada
    J Affect Disord 65:37-44. 2001
  4. ncbi request reprint Serotonergic genes and suicidality
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ontario, Canada
    Crisis 22:54-60. 2001
  5. ncbi request reprint Does fluoxetine influence major depression by modifying five-factor personality traits?
    Lisheng Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, 1145 Carling Ave, Ottawa, Ontario K1Z 7K4, Canada
    J Affect Disord 71:235-41. 2002
  6. doi request reprint GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes
    Michael O Poulter
    Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:645-52. 2008
  7. ncbi request reprint Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects
    Zul Merali
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Biol Psychiatry 59:594-602. 2006
  8. ncbi request reprint MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males
    Lisheng Du
    Institute of Mental Health Research, University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 15:2097-101. 2004
  9. ncbi request reprint Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    Int J Neuropsychopharmacol 7:501-6. 2004
  10. ncbi request reprint Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    J Neurosci 23:8788-99. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada
    Am J Med Genet 96:56-60. 2000
    ..Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:56-60, 2000...
  2. ncbi request reprint Gender differences in association between serotonin transporter gene polymorphism and personality traits
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ontario, Canada
    Psychiatr Genet 10:159-64. 2000
    ..They may also explain the inconsistencies in previous reports on association of Neuroticism with 5-HTTLPR from studies using different proportions of male and female subjects...
  3. ncbi request reprint Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ontario, Canada
    J Affect Disord 65:37-44. 2001
    ..The aim of the present investigation was to determine whether there is an association between TPH gene polymorphism and major depression. particularly in patients with suicidal ideation...
  4. ncbi request reprint Serotonergic genes and suicidality
    L Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ontario, Canada
    Crisis 22:54-60. 2001
    ..1 (95% CI 1.2-3.7). The association between polymorphism in serotonergic genes and suicidality supports the hypothesis that genetic factors can modulate suicide risk by influencing serotonergic activity...
  5. ncbi request reprint Does fluoxetine influence major depression by modifying five-factor personality traits?
    Lisheng Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, 1145 Carling Ave, Ottawa, Ontario K1Z 7K4, Canada
    J Affect Disord 71:235-41. 2002
    ....
  6. doi request reprint GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes
    Michael O Poulter
    Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:645-52. 2008
    ..Epigenetic mechanisms may be involved in the reprogramming of gene expression in response to stressful stimuli. This investigation determined whether epigenetic phenomena might similarly be associated with suicide/depression...
  7. ncbi request reprint Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects
    Zul Merali
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Biol Psychiatry 59:594-602. 2006
    ..Postmortem levels of several stress- and depression-relevant neuropeptides were assessed in brain regions of depressed suicides relative to control subjects that had died of other causes...
  8. ncbi request reprint MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males
    Lisheng Du
    Institute of Mental Health Research, University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 15:2097-101. 2004
    ..These data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients...
  9. ncbi request reprint Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    Int J Neuropsychopharmacol 7:501-6. 2004
    ..These results implicate the C(-1019)G 5-HT1A gene polymorphism as a potential marker for antidepressant response, suggesting a role for repression of the 5-HT1A gene...
  10. ncbi request reprint Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    J Neurosci 23:8788-99. 2003
    ..We suggest a novel transcriptional model in which the G(-1019) allele derepresses 5-HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide...
  11. pmc Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, ON, Canada
    J Psychiatry Neurosci 33:131-41. 2008
    ..Our objective was to investigate which 5-HT receptor subtypes might be associated with depression and suicide, whether receptor differences vary across brain regions and whether they are moderated by sex...
  12. ncbi request reprint High activity-related allele of MAO-A gene associated with depressed suicide in males
    Lisheng Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 13:1195-8. 2002
    ..The results thus provide further evidence that genetic factors can modulate risk for depression, suicide or both by influencing monoaminergic activity in sexually dimorphic manner...
  13. ncbi request reprint Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region
    Zul Merali
    University of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Neurosci 24:1478-85. 2004
    ....
  14. pmc Altered Organization of GABA(A) Receptor mRNA Expression in the Depressed Suicide Brain
    Michael O Poulter
    Molecular Brain Research Group, Department of Physiology and Pharmacology, Robarts Research Institute, University of Western Ontario London, Ontario, Canada
    Front Mol Neurosci 3:3. 2010
    ....