Research Topics
| A DonnerSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Detail Information
Publications
Imputation strategies for missing continuous outcomes in cluster randomized trialsMonica Taljaard
Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada
Biom J 50:329-45. 2008..Within-cluster multiple imputation is shown to be the least powerful among the procedures considered...- Pitfalls of and controversies in cluster randomization trialsAllan Donner
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
Am J Public Health 94:416-22. 2004..We discuss several topics related to these issues, with emphasis on the choices that must be made in the planning stages of a trial and on some potential pitfalls to be avoided... - A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trialJin Yang
Division of Bacterial Diseases, Guangxi Center for Disease Control, 80 Taoyuan Road, Nanning 530021, Guangxi, China
BMC Public Health 5:49. 2005.... - Sample size requirements for the comparison of two or more coefficients of inter-observer agreementA Donner
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
Stat Med 17:1157-68. 1998..I consider cases of both a continuous and a dichotomous outcome measure. Three examples illustrate the results... - Interval estimation for a difference between intraclass kappa statisticsAllan Donner
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
Biometrics 58:209-15. 2002..Sample size requirements that achieve a prespecified expected width for a confidence interval about a difference of kappa statistic are also presented... - Methods for the statistical analysis of binary data in split-cluster designsAllan Donner
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario N6A 5C1, Canada
Biometrics 60:919-25. 2004.... - Statistical methods for the meta-analysis of cluster randomization trialsA Donner
Department of Epidemiology and Biostatistics, Kresge Building, The University of Western Ontario, London, Ontario N6A 5C1, Canada
Stat Methods Med Res 10:325-38. 2001..The advantages and disadvantages of each method are discussed in the context of an example... - Issues in the meta-analysis of cluster randomized trialsAllan Donner
Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
Stat Med 21:2971-80. 2002..In this paper we review and comment on a selected number of these issues, including problems of study heterogeneity, difficulties in estimating design effects from individual trials and the choice of statistical methods... - The merits of breaking the matches: a cautionary taleAllan Donner
Department of Epidemiology and Biostatistics, Schulich School of Medicine, University of Western Ontario, London, Canada
Stat Med 26:2036-51. 2007.... - Construction of confidence limits about effect measures: a general approachG Y Zou
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont, Canada N6A 5C1
Stat Med 27:1693-702. 2008..Numerical evaluation shows that this closed-form procedure outperforms existing methods, including the bootstrap... - Statistical inferences for a twin correlation with multinomial outcomesE Bartfay
Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, Canada
Stat Med 20:249-62. 2001..Other inference problems are also discussed, including point estimation, hypothesis testing and sample size estimation. An example is included... - Group sequential methods for cluster randomization trials with binary outcomesGuang Yong Zou
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Clin Trials 2:479-87. 2005.... - Current and future challenges in the design and analysis of cluster randomization trialsN Klar
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada
Stat Med 20:3729-40. 2001..Brief mention is also made of issues related to economic analysis and to the planning and conduct of meta-analyses for cluster randomization trials. Recommendations for reporting are also discussed... - Statistical implications of the choice between a dichotomous or continuous trait in studies of interobserver agreementA Donner
Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario N6A 5C1, Canada
Biometrics 50:550-5. 1994..In both cases, and particularly in the second, the loss of power associated with measuring the trait on a dichotomous scale is shown to be always severe and frequently prohibitive... - The effect of collapsing multinomial data when assessing agreementE Bartfay
Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, Canada
Int J Epidemiol 29:1070-5. 2000..The effect of dichotomization on sample size requirements for testing hypotheses concerning kappa is also evaluated... - Meta-analysis of community-based cluster randomization trials with binary outcomesGerarda A Darlington
Department of Mathematics and Statistics, University of Guelph, Guelph, Ontario, Canada
Clin Trials 4:491-8. 2007..However, this task requires consideration of both the likely dependencies among cluster members (intracluster correlation) and stratification based on the studies considered... - Confidence interval estimation of the intraclass correlation coefficient for binary outcome dataGuangyong Zou
Robarts Clinical Trials, Robarts Research Institute, London, Ontario N6A 5K8, Canada
Biometrics 60:807-11. 2004..Simulation results indicate that confidence intervals based on the estimator proposed by Fleiss and Cuzick provide coverage levels close to nominal over a wide range of parameter combinations. Two examples are presented... - Responsiveness of the short form-36, disability of the arm, shoulder, and hand questionnaire, patient-rated wrist evaluation, and physical impairment measurements in evaluating recovery after a distal radius fractureJ C MacDermid
Hand and Upper Limb Centre, St Joseph s Health Centre, London, Ontario, Canada
J Hand Surg Am 25:330-40. 2000..Of the physical tests, grip strength was most responsive, followed by range of motion. Responsive patient-rating scales and physical performance evaluations can assist with outcome evaluation of patients with distal radius fracture... - Bivariate models for co-aggregation of dichotomous traits in twinsM M Shoukri
Department of Epidemiology and Biostatistics, Schulich School of Medicine, University of Western Ontario, London, Ont, Canada N6A 5C1
Stat Med 26:336-51. 2007..An example based on the Australian population-based twin registry published data is given to illustrate the methodology... - Comparison of two dependent within subject coefficients of variation to evaluate the reproducibility of measurement devicesMohamed M Shoukri
Department of Epidemiology and Biostatistics, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
BMC Med Res Methodol 8:24. 2008..Comparison of reproducibility or reliability of measurement devices or methods on the same set of subjects comes down to comparison of dependent reliability or reproducibility parameters... - Confidence interval construction for a difference between two dependent intraclass correlation coefficientsChinthanie F Ramasundarahettige
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont, Canada N6A 5C1
Stat Med 28:1041-53. 2009..Simulation results show that this method performs very well in terms of overall coverage percentage and tail errors. Two data sets are used to illustrate this procedure... - The merits of testing Hardy-Weinberg equilibrium in the analysis of unmatched case-control data: a cautionary noteGuang Yong Zou
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Ann Hum Genet 70:923-33. 2006..Examples from previous reports are used to illustrate the methodology... - Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practiceJ L Mahon
Department of Medicine, University of Western Ontario, Canada
Chest 115:38-48. 1999.... - Methods for the statistical analysis of binary data in split-mouth designs with baseline measurementsA Donner
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont, Canada
Stat Med 26:3476-86. 2007..The advantages and disadvantages of the different approaches are discussed in the context of an example from the published literature. The results from a limited simulation study are also presented... - The impact of patient-centered care on outcomesM Stewart
Centre for Studies in Family Medicine, The University of Western Ontario, London, Canada
J Fam Pract 49:796-804. 2000..We designed this observational cohort study to assess the association between patient-centered communication in primary care visits and subsequent health and medical care utilization... - A simple alternative confidence interval for the difference between two proportionsGuangyong Zou
Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada N6A 5K8
Control Clin Trials 25:3-12. 2004..The results of an exact evaluation study show that this new procedure performs as well as Newcombe's procedure in terms of percent coverage and expected confidence interval width. Several examples are presented... - Bivariate modeling of interobserver agreement coefficientsMohamed M Shoukri
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
Stat Med 28:430-40. 2009..In this paper, we develop the required methodology and provide an illustrative example... - A school-based program to prevent adolescent dating violence: a cluster randomized trialDavid A Wolfe
CAMH Centre for Prevention Science, 100 Collip Cir, Ste 100, London, ON N6G 4X8, Canada
Arch Pediatr Adolesc Med 163:692-9. 2009..To determine whether an interactive curriculum that integrates dating violence prevention with lessons on healthy relationships, sexual health, and substance use reduces physical dating violence (PDV)... - Intracluster correlation coefficients from the 2005 WHO Global Survey on Maternal and Perinatal Health: implications for implementation researchMonica Taljaard
Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
Paediatr Perinat Epidemiol 22:117-25. 2008..We demonstrate that ICCs generally tend to increase with higher prevalences (close to 0.5). These results can help researchers calculate the required sample size for future research studies in maternal and perinatal health... - Accounting for expected attrition in the planning of community intervention trialsMonica Taljaard
Ottawa Health Research Institute, Clinical Epidemiology Program, The Ottawa Hospital, Ottawa, Canada
Stat Med 26:2615-28. 2007..To aid in the planning of future trials, we recommend that estimates for tau be reported in published community intervention trials... - Meta-analyses of cluster randomization trials. Power considerationsAllan Donner
University of Western Ontario
Eval Health Prof 26:340-51. 2003..In this article, the authors present an approach that may be used to estimate the power of a planned meta-analysis that includes trials that are cluster randomized. Two examples are presented... - The contribution of attachment security and social support to depressive symptoms in patients with metastatic cancerGary Rodin
Department of Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, and Psychosocial Oncology and Palliative Care Research Division, Ontario Cancer Institute, University Health Network, Toronto, Canada
Psychooncology 16:1080-91. 2007.... - Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trialGeert D'Haens
Imelda Gastrointestinal Clinical Research Centre, Bonheiden, Belgium
Lancet 371:660-7. 2008..We aimed to compare the effectiveness of early use of combined immunosuppression with conventional management in patients with active Crohn's disease who had not previously received glucocorticoids, antimetabolites, or infliximab... - The feasibility of a school-based VI polysaccharide vaccine mass immunization campaign in Hue City, central Vietnam: streamlining a typhoid fever preventive strategyVu Dinh Thiem
National Institute of Hygiene and Epidemiology, Hanoi, People's Republic of Vietnam
Southeast Asian J Trop Med Public Health 37:515-22. 2006..The lessons learned, together with cost-effectiveness results to be obtained by the end of follow-up period, will hopefully accelerate the introduction of Vi typhoid fever vaccine in Vietnam... - Caesarean delivery rates and pregnancy outcomes: the 2005 WHO global survey on maternal and perinatal health in Latin AmericaJose Villar
UNDP UNFPA WHO World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, 1211 Geneva 27, Switzerland
Lancet 367:1819-29. 2006..Our aim was to assess the association between caesarean delivery and pregnancy outcome at the institutional level, adjusting for the pregnant population and institutional characteristics... - A multi-country cluster randomized controlled effectiveness evaluation to accelerate the introduction of Vi polysaccharide typhoid vaccine in developing countries in Asia: rationale and designCamilo J Acosta
International Vaccine Institute, Seoul, South Korea
Trop Med Int Health 10:1219-28. 2005..Preliminary results are presented that determined the final planning of the trial before immunization. Important methodological and practical issues regarding vaccine cluster randomized designs are illustrated... - Application of an adjusted chi2 statistic to site-specific data in observational dental studiesChul Ahn
Clinical Epidemiology, University of Texas Medical School, Houston, Texas 77030, USA
J Clin Periodontol 29:79-82. 2002..However, the required assumptions for this statistic have not yet been thoroughly addressed. These assumptions are guaranteed to hold in experimental comparisons, but may be violated in some observational studies... - Comment on 'Medication use and risk of falls' by Neutel et alAllan Donner
Pharmacoepidemiol Drug Saf 11:95-6. 2002