Timothy J Doherty

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Decomposition-based quantitative electromyography: methods and initial normative data in five muscles
    Timothy J Doherty
    Department of Physical Medicine and Rehabilitation and School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 28:204-11. 2003
  2. ncbi request reprint Invited review: Aging and sarcopenia
    Timothy J Doherty
    RM 066, St Mary s Hospital, St Joseph s Health Centre, 21 Grosvenor St, London, ON, Canada N6A 1Y6
    J Appl Physiol 95:1717-27. 2003
  3. doi request reprint Motor unit survival in lifelong runners is muscle dependent
    Geoffrey A Power
    Canadian Centre for Activity and Aging, School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada
    Med Sci Sports Exerc 44:1235-42. 2012
  4. ncbi request reprint The effect of contraction intensity on motor unit number estimates of the tibialis anterior
    Chris J McNeil
    Canadian Centre for Activity and Aging, St Joseph s Health Annex, School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, 1490 Richmond Street, London, Ont, Canada, N6G 2M3
    Clin Neurophysiol 116:1342-7. 2005
  5. doi request reprint Estimating contraction level using root mean square amplitude in control subjects and patients with neuromuscular disorders
    Shaun G Boe
    School of Kinesiology, University of Western Ontario, London, ON, Canada
    Arch Phys Med Rehabil 89:711-8. 2008
  6. doi request reprint Age-related reductions in the estimated numbers of motor units are minimal in the human soleus
    Brian H Dalton
    Canadian Centre for Activity and Aging, School of Kinesiology, University of Western Ontario, London, Ontario, N6A 5B9, Canada
    Muscle Nerve 38:1108-15. 2008
  7. doi request reprint Localization of frequency-dependent conduction block in carpal tunnel syndrome
    Bradley V Watson
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 42:120-6. 2010
  8. doi request reprint Muscle strength and fatigue in patients with generalized myasthenia gravis
    Caitlin J Symonette
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 41:362-9. 2010
  9. doi request reprint Effect of maximal voluntary contraction on the amplitude of the compound muscle action potential: implications for the interpolated twitch technique
    Michael J Berger
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 42:498-503. 2010
  10. pmc Vastus medialis motor unit properties in knee osteoarthritis
    Michael J Berger
    School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, ON, Canada
    BMC Musculoskelet Disord 12:199. 2011

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Decomposition-based quantitative electromyography: methods and initial normative data in five muscles
    Timothy J Doherty
    Department of Physical Medicine and Rehabilitation and School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 28:204-11. 2003
    ....
  2. ncbi request reprint Invited review: Aging and sarcopenia
    Timothy J Doherty
    RM 066, St Mary s Hospital, St Joseph s Health Centre, 21 Grosvenor St, London, ON, Canada N6A 1Y6
    J Appl Physiol 95:1717-27. 2003
    ....
  3. doi request reprint Motor unit survival in lifelong runners is muscle dependent
    Geoffrey A Power
    Canadian Centre for Activity and Aging, School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada
    Med Sci Sports Exerc 44:1235-42. 2012
    ..However, it is unknown if this finding is the result of long-term activation of the specifically exercised motoneuron pool (i.e., tibialis anterior) or an overall systemic neuroprotective effect of high levels of physical activity...
  4. ncbi request reprint The effect of contraction intensity on motor unit number estimates of the tibialis anterior
    Chris J McNeil
    Canadian Centre for Activity and Aging, St Joseph s Health Annex, School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, 1490 Richmond Street, London, Ont, Canada, N6G 2M3
    Clin Neurophysiol 116:1342-7. 2005
    ..To examine the effect of contractile level on motor unit number estimates (MUNEs) and establish the contraction intensity that will yield the most representative MUNE for the tibialis anterior (TA) muscle...
  5. doi request reprint Estimating contraction level using root mean square amplitude in control subjects and patients with neuromuscular disorders
    Shaun G Boe
    School of Kinesiology, University of Western Ontario, London, ON, Canada
    Arch Phys Med Rehabil 89:711-8. 2008
    ....
  6. doi request reprint Age-related reductions in the estimated numbers of motor units are minimal in the human soleus
    Brian H Dalton
    Canadian Centre for Activity and Aging, School of Kinesiology, University of Western Ontario, London, Ontario, N6A 5B9, Canada
    Muscle Nerve 38:1108-15. 2008
    ..Consequently, the ensemble MUNE was extrapolated to an intensity of approximately 15% MVC in both young and old. The results suggest that, in the soleus, the use of the same contraction intensity across age groups is a valid comparison...
  7. doi request reprint Localization of frequency-dependent conduction block in carpal tunnel syndrome
    Bradley V Watson
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 42:120-6. 2010
    ..7%). These results suggest that the safety margin for impulse transmission can be impaired distal to the presumed site of injury in CTS...
  8. doi request reprint Muscle strength and fatigue in patients with generalized myasthenia gravis
    Caitlin J Symonette
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 41:362-9. 2010
    ..The RNS decrement appears to relate best to disease severity and muscle weakness but not to objective measures of fatigue in this population...
  9. doi request reprint Effect of maximal voluntary contraction on the amplitude of the compound muscle action potential: implications for the interpolated twitch technique
    Michael J Berger
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 42:498-503. 2010
    ..18). Reduction of M(MAX) during MVC suggests that some motor axons are refractory and unable to respond to a superimposed maximal stimulus. These results have implications for the sensitivity of the interpolated twitch technique...
  10. pmc Vastus medialis motor unit properties in knee osteoarthritis
    Michael J Berger
    School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, ON, Canada
    BMC Musculoskelet Disord 12:199. 2011
    ..The purpose of this study was to measure vastus medialis motor unit (MU) properties in participants with knee OA, during submaximal isometric contractions...
  11. ncbi request reprint Motor unit number estimates and quantitative motor unit analysis in healthy subjects and patients with amyotrophic lateral sclerosis
    Shaun G Boe
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 36:62-70. 2007
    ....
  12. ncbi request reprint Frequency-dependent conduction block in carpal tunnel syndrome
    Bradley V Watson
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 33:619-26. 2006
    ..These findings may correlate with the observation of weakness in the absence of conduction block in patients with entrapment neuropathies...
  13. doi request reprint Motor unit number estimates in masters runners: use it or lose it?
    Geoffrey A Power
    Canadian Centre for Activity and Aging, School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada
    Med Sci Sports Exerc 42:1644-50. 2010
    ..This has not previously been examined in humans...
  14. doi request reprint Assessing weakness in patients with ulnar neuropathy: comparison between a custom hand muscle dynamometer and a pinch dynamometer
    Matti D Allen
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Am J Phys Med Rehabil 90:923-9. 2011
    ..The aim of this study was to compare the use of a custom intrinsic hand dynamometer (HD) with that of a standard pinch dynamometer (PD) in assessing strength in patients with ulnar neuropathy at the elbow...
  15. pmc Disease severity and knee extensor force in knee osteoarthritis: data from the Osteoarthritis Initiative
    Michael J Berger
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Arthritis Care Res (Hoboken) 64:729-34. 2012
    ..To determine whether the method of disease severity measurement influences the magnitude of knee extensor force deficits in knee osteoarthritis (OA)...
  16. doi request reprint Neck muscle responses evoked by transcranial magnetic stimulation of the human frontal eye fields
    Samanthi C Goonetilleke
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Eur J Neurosci 33:2155-67. 2011
    ..Our results also suggest that pairing neck muscle recordings with TMS-FEF provides a novel way of assaying the covert preparation of oculomotor plans...
  17. ncbi request reprint Decomposition-based quantitative electromyography: effect of force on motor unit potentials and motor unit number estimates
    Shaun G Boe
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 31:365-73. 2005
    ..These results suggest that force level is an important factor to consider when performing quantitative EMG, including MUNEs with this method...
  18. doi request reprint Frequency-dependent conduction block in ulnar neuropathy localized to the elbow
    Bradley V Watson
    School of Kinesiology, The University of Western Ontario, London, Ontario, Canada
    Clin Neurophysiol 121:2111-6. 2010
    ..To determine whether frequency-dependent conduction block (FDB) occurs in acute ulnar neuropathies localized to the elbow...
  19. doi request reprint Decomposition-based quantitative electromyography in the evaluation of muscular dystrophy severity
    Kendra L Derry
    School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, 339 Windermere Road, London, Ontario N6A 5A5, Canada
    Muscle Nerve 45:507-13. 2012
    ..In this study we aimed to determine whether decomposition-based quantitative electromyography (DQEMG) could indicate the severity of involvement in a cohort of patients with muscular dystrophies (MDs)...
  20. ncbi request reprint Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men
    Chris J McNeil
    Canadian Centre for Activity and Aging, St Joseph s Health Annex School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, 1490 Richmond Street, London, Ontario N6G 2M3, Canada
    Muscle Nerve 31:461-7. 2005
    ..Despite the smaller MUNE at age 65, strength was not reduced until beyond 80 years. This suggests that age-related MU loss in the TA does not limit function until a critical threshold is reached...
  21. doi request reprint Adaptations in capillarization and citrate synthase activity in response to endurance training in older and young men
    Juan M Murias
    School of Kinesiology, The University of Western Ontario, London, Ontario, Canada
    J Gerontol A Biol Sci Med Sci 66:957-64. 2011
    ..05). This study showed that both O and Y undertaking similar endurance training displayed capillary angiogenesis and improved mitochondrial respiratory capacity...
  22. doi request reprint Geometry of a weight-bearing and non-weight-bearing bone in the legs of young, old, and very old men
    Chris J McNeil
    Canadian Centre for Activity and Aging, School of Kinesiology, The University of Western Ontario, Arthur and Sonia Labatt Health Sciences Building, London, ON N6A 5B9, Canada
    Calcif Tissue Int 85:22-30. 2009
    ..The greater age-related differences in bone geometry in the tibia suggest the weight-bearing role of the tibia makes it more susceptible than the fibula to the reduced activity typically associated with aging...
  23. doi request reprint A within-trial measure of the stop signal reaction time in a head-unrestrained oculomotor countermanding task
    Samanthi C Goonetilleke
    CIHR Group in Action and Perception, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Neurophysiol 104:3677-90. 2010
    ..e., to cancel a gaze shift) can be achieved despite motion of other components; on such individual trials, the oculomotor stop process is expressed as an active braking pulse...
  24. doi request reprint Motor unit loss and weakness in association with diabetic neuropathy in humans
    Matti D Allen
    School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario N6G 1H1, Canada
    Muscle Nerve 48:298-300. 2013
    ..Direct quantitative assessment of MU numbers and muscle strength have not been performed in humans. We compared the estimated number of MUs of individuals with diabetic polyneuropathy (DPN) versus controls...
  25. doi request reprint Effect of demyelinating ulnar nerve injury on strength and fatigue
    Matti D Allen
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    J Clin Neuromuscul Dis 13:38-45. 2011
    ..Ulnar neuropathy at the elbow (UNE) provides an excellent model to examine the relationships between electrophysiologically defined CB and quantitative measurement of weakness and fatigue...
  26. doi request reprint Intra- and inter-rater reliability of motor unit number estimation and quantitative motor unit analysis in the upper trapezius
    Colleen T Ives
    Health and Rehabilitation Sciences, University of Western Ontario, London, Ontario, Canada
    Clin Neurophysiol 123:200-5. 2012
    ....
  27. doi request reprint Sarcopenia: prevalence, mechanisms, and functional consequences
    Michael J Berger
    School of Kinesiology, and Department of Clinical Neurological Sciences, Schulich School of Medicine, University of Western Ontario, London, Ont, Canada
    Interdiscip Top Gerontol 37:94-114. 2010
    ..Muscle power has emerged as an important indicator of function in older adults, and we discuss knee osteoarthritis as a model of accelerated limb sarcopenia...
  28. ncbi request reprint Motor unit number estimation by decomposition-enhanced spike-triggered averaging: control data, test-retest reliability, and contractile level effects
    Shaun G Boe
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Muscle Nerve 29:693-9. 2004
    ..94, P < 0.05). DE-STA thus appears to be a valid and reliable method to obtain MUNEs...
  29. ncbi request reprint Reliability of hand-held dynamometry in assessment of knee extensor strength after hip fracture
    Marc Andre Gilles Roy
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Am J Phys Med Rehabil 83:813-8. 2004
    ..To examine the reliability of hand-held dynamometry in assessing knee extensor strength in inpatients undergoing rehabilitation after hip fracture and to examine the discriminant validity of this measure...
  30. doi request reprint Prior heavy exercise elevates pyruvate dehydrogenase activity and muscle oxygenation and speeds O2 uptake kinetics during moderate exercise in older adults
    Brendon J Gurd
    Canadian Centre for Activity and Aging, School of Kinesiology, Faculty of Health Sciences, The Univ of Western Ontario, London, Ontario, Canada N6A 5B9
    Am J Physiol Regul Integr Comp Physiol 297:R877-84. 2009
    ....
  31. ncbi request reprint A moderate dose of pseudoephedrine does not alter muscle contraction strength or anaerobic power
    Kelly S Chu
    Department of Medicine Rehabilitation and Neurology, McMaster University, Hamilton, Ontario, Canada
    Clin J Sport Med 12:387-90. 2002
    ..To investigate the effect of an acute oral administration of pseudoephedrine (PSE) on muscle function, fatigue, and anaerobic power output...
  32. ncbi request reprint Within-subject reliability of motor unit number estimates and quantitative motor unit analysis in a distal and proximal upper limb muscle
    Shaun G Boe
    School of Kinesiology, The University of Western Ontario, Ont, Canada
    Clin Neurophysiol 117:596-603. 2006
    ..To establish within-subject reliability of motor unit number estimates (MUNEs) and quantitative MU analysis using decomposition-based quantitative electromyography (DQEMG)...
  33. ncbi request reprint Creatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1
    Mark Tarnopolsky
    Department of Medicine Neurology and Rehabilitation, McMaster University, Hamilton, Canada
    Muscle Nerve 29:51-8. 2004
    ....