- Loss of HLTF function promotes intestinal carcinogenesisSumit Sandhu
Department of Biochemistry and Medical Genetics, University of Manitoba, 745 Bannatyne Avenue, Winnipeg MB R3E 0J9, Canada
Mol Cancer 11:18. 2012..HLTF has also been found to be frequently inactivated by promoter hypermethylation in human colon cancers. Whether this epigenetic event is required for intestinal carcinogenesis is unknown...
- EMG1 is essential for mouse pre-implantation embryo developmentXiaoli Wu
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
BMC Dev Biol 10:99. 2010..The expression of Emg1 during mouse development was examined and mice carrying a null mutation for Emg1 were generated and characterized...
- Establishment of conditional knockout alleles for the gene encoding the regulator of telomere length (RTEL)Xiaoli Wu
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba
Genesis 45:788-92. 2007..These conditional alleles will therefore be the important genetic tools for dissecting the spatial and temporal roles of RTEL in the regulation of telomere length and genomic stability during postnatal development and tumorigenesis...