Frederick A Dick

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence
    Srikanth Talluri
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Mol Cell Biol 30:948-60. 2010
  2. doi request reprint Molecular mechanisms underlying RB protein function
    Frederick A Dick
    London Regional Cancer Program, Children s Health Research Institute, and Department of Biochemistry, Western University, London, Ontario N6A 4L6, Canada
    Nat Rev Mol Cell Biol 14:297-306. 2013
  3. pmc The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
    Shauna A Henley
    London Regional Cancer Program, Western University, London, Ontario, Canada
    Cell Div 7:10. 2012
  4. pmc Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
    Frederick A Dick
    London Regional Cancer Program, London, Ontario, Canada
    Cell Div 2:26. 2007
  5. pmc A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions
    Shauna A Henley
    London Regional Cancer Program, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada
    Cancer Cell Int 10:8. 2010
  6. pmc Sweet DREAMs for Hippo
    Frederick A Dick
    London Regional Cancer Program, London, Ontario N6A 4L6, Canada
    Genes Dev 25:889-94. 2011
  7. pmc Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo
    Srikanth Talluri
    London Regional Cancer Program, Western University, London, Ontario, Canada
    PLoS ONE 8:e72236. 2013
  8. pmc Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive
    Courtney H Coschi
    London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada
    Genes Dev 24:1351-63. 2010
  9. pmc A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice
    Matthew J Cecchini
    London Regional Cancer Program, Western University, London, Ontario, Canada
    Mol Cell Biol 34:2029-45. 2014
  10. pmc A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis
    Sarah M Francis
    London Regional Cancer Program, London, Ontario, Canada
    PLoS ONE 6:e16434. 2011

Collaborators

  • Subrata Chakrabarti
  • Joe S Mymryk
  • Nathalie G Berube
  • Ann F Chambers
  • Gary S Shaw
  • Paola Massimi
  • Lawrence Banks
  • Lea Harrington
  • Piotr Sicinski
  • Rod Bremner
  • David A Palma
  • Srikanth Talluri
  • Sarah M Francis
  • Matthew J Cecchini
  • Michael J Thwaites
  • Courtney H Coschi
  • Shauna A Henley
  • Christian E Isaac
  • Alison L Martens
  • Daniel T Passos
  • Niloufar Zarghami
  • Charles A Ishak
  • Chantal Forristal
  • James I MacDonald
  • Biljana Todorovic
  • Jasmyne Carnevale
  • Laurie A Seifried
  • Paula J Foster
  • David K Driman
  • Andrew Warner
  • Michael D Jensen
  • Eugene Wong
  • Christopher J Howlett
  • Jean Leon Chong
  • David W Holdsworth
  • Gabriel DiMattia
  • Carley Ort
  • James M Pipas
  • M Teresa Sáenz-Robles
  • James A DeCaprio
  • Frank Beier
  • Gustavo Leone
  • Ian Welch
  • Paul M Stafford
  • Larisa Litovchick
  • Paul Cantalupo
  • Chris J Norley
  • Jason R Bush
  • Oliva Palander
  • Nikita Avvakumov
  • Katherine Hung
  • Mohammad Ahmad
  • Peter Ainsworth
  • Jordan Demone
  • Kieran Ritchie
  • Jean Y J Wang
  • Carlo V Hojilla
  • Jacqueline Bergsied
  • Gabriel E DiMattia
  • Rama Khoka
  • Nicholas J Dyson
  • Lisa M Julian
  • Natalie Erdmann
  • Ulrich K Binné

Detail Information

Publications23

  1. pmc A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence
    Srikanth Talluri
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Mol Cell Biol 30:948-60. 2010
    ..Remarkably, this reveals that pRB recruits chromatin regulators primarily to engage a stress-responsive G(1) arrest program...
  2. doi request reprint Molecular mechanisms underlying RB protein function
    Frederick A Dick
    London Regional Cancer Program, Children s Health Research Institute, and Department of Biochemistry, Western University, London, Ontario N6A 4L6, Canada
    Nat Rev Mol Cell Biol 14:297-306. 2013
    ..These advances and new structural studies are combining to define the multifunctionality of RB...
  3. pmc The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
    Shauna A Henley
    London Regional Cancer Program, Western University, London, Ontario, Canada
    Cell Div 7:10. 2012
    ..This propels the cell cycle irreversibly forward leading to DNA synthesis. This review will focus on the basic biochemistry and cell biology governing the regulation and activity of mammalian RB family proteins in cell cycle control...
  4. pmc Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
    Frederick A Dick
    London Regional Cancer Program, London, Ontario, Canada
    Cell Div 2:26. 2007
    ..This article will also discuss the prospects for using this approach to further explore the unknown functions of pRB...
  5. pmc A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions
    Shauna A Henley
    London Regional Cancer Program, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada
    Cancer Cell Int 10:8. 2010
    ..CONCLUSIONS: Our work provides proof of principal that alleles encoding distinct, partial loss of function mutations in the retinoblastoma gene that specifically lose LXCXE dependent interactions, are found in human cancer...
  6. pmc Sweet DREAMs for Hippo
    Frederick A Dick
    London Regional Cancer Program, London, Ontario N6A 4L6, Canada
    Genes Dev 25:889-94. 2011
    ..Three recent studies in Genes & Development reveal how cellular proliferation is coordinated between these pathways. Here we discuss the implications of these studies and the new questions that they raise...
  7. pmc Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo
    Srikanth Talluri
    London Regional Cancer Program, Western University, London, Ontario, Canada
    PLoS ONE 8:e72236. 2013
    ..The in vivo role of chromatin regulation by pRB during senescence, and its relevance to cancer is not clear...
  8. pmc Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive
    Courtney H Coschi
    London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada
    Genes Dev 24:1351-63. 2010
    ..These data reveal a new mechanism of tumor suppression, facilitated by pRB, in which genome stability is maintained by proper condensation of mitotic chromosomes...
  9. pmc A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice
    Matthew J Cecchini
    London Regional Cancer Program, Western University, London, Ontario, Canada
    Mol Cell Biol 34:2029-45. 2014
    ..This suggests that non-E2F-, pRB-dependent pathways may have a more relevant role in proliferative control than previously identified. ..
  10. pmc A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis
    Sarah M Francis
    London Regional Cancer Program, London, Ontario, Canada
    PLoS ONE 6:e16434. 2011
    ....
  11. doi request reprint Chromosome instability and deregulated proliferation: an unavoidable duo
    Courtney H Coschi
    London Regional Cancer Program, University of Western Ontario, ON, Canada
    Cell Mol Life Sci 69:2009-24. 2012
    ....
  12. pmc Loss of the mammalian DREAM complex deregulates chondrocyte proliferation
    Chantal Forristal
    London Regional Cancer Program, Western University, London, Ontario, Canada Department of Biochemistry, Western University, London, Ontario, Canada
    Mol Cell Biol 34:2221-34. 2014
    ..This reveals that assembly of mammalian DREAM is required to induce cell cycle exit in chondrocytes. ..
  13. pmc Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor
    Biljana Todorovic
    Department of Microbiology and Immunology, Western University, London, Ontario, Canada
    J Virol 86:13313-23. 2012
    ..This demonstrates that the interaction between HPV16 E7 CR3 and pRb is functionally important for alteration of the cell cycle...
  14. pmc A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development
    Sarah M Francis
    London Regional Cancer Program, University of Western Ontario, London, Ontario N6A4L6, Canada
    Mol Cell Biol 29:4455-66. 2009
    ..Taken together, our work demonstrates a unique functional connection between pRB and TGF-beta in growth control and mammary gland development...
  15. pmc Regulation of transcription and chromatin structure by pRB: here, there and everywhere
    Srikanth Talluri
    London Regional Cancer Program, Department of Biochemistry, Western University, London, ON, Canada
    Cell Cycle 11:3189-98. 2012
    ..In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains...
  16. doi request reprint Cell Synchronization of Mouse Embryonic Fibroblasts
    Michael J Thwaites
    London Regional Cancer Program, Department of Biochemistry, Children s Health Research Institute, Western University, London, ON, Canada
    Methods Mol Biol 1342:91-9. 2016
    ..However, synchronization of these cells has often been challenging. In this chapter we outline three basic protocols for isolating mouse fibroblasts at the G1-to-S-phase transition, in S phase, and during mitosis. ..
  17. doi request reprint Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy
    Matthew J Cecchini
    London Regional Cancer Program, London, ON N6A 5W9, Canada Department of Biochemistry Western University, London, ON N6A 5C1, Canada Department of Pathology and Laboratory Medicine, London, ON N6A 5C1, Canada
    Hum Pathol 46:1922-34. 2015
    ..In summary, loss of pRB expression is associated with improved survival in patients treated with surgical resection and chemotherapy. This may be useful in classifying patients at greatest benefit for aggressive treatment regimes. ..
  18. pmc DNA damage signals through differentially modified E2F1 molecules to induce apoptosis
    Jasmyne Carnevale
    London Regional Cancer Program, London, Ontario, Canada
    Mol Cell Biol 32:900-12. 2012
    ..Our data suggest that DNA damage signals alter pRB and E2F1 to engage them in functions leading to apoptotic induction that are distinct from pRB-E2F regulation in cell cycle control...
  19. doi request reprint The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence
    Srikanth Talluri
    London Regional Cancer Program Western University London, Ontario, Canada Department of Biochemistry Western University London, Ontario, Canada
    Cell Cycle 13:641-51. 2014
    ..Binding assays show that pRB can interact with PML specifically during senescence, suggesting that signaling events in senescence regulate assembly of PML and pRB to establish heterochromatin and create a permanent cell cycle arrest. ..
  20. pmc The retinoblastoma protein regulates pericentric heterochromatin
    Christian E Isaac
    Cancer Research Labs, 790 Commissioners Road East, London, Ontario, Canada, N6A 4L6
    Mol Cell Biol 26:3659-71. 2006
    ..These results demonstrate the surprising finding that pRb uses the LXCXE binding cleft to control chromatin structure for the regulation of events beyond the G(1)-to-S-phase transition...
  21. doi request reprint Analyzing RB and E2F during the G1-S transition
    Michael J Thwaites
    London Regional Cancer Program, London, ON, Canada
    Methods Mol Biol 1170:449-61. 2014
    ..Here we describe two simple techniques used to assess pRB phosphorylation and E2F transcription during G1/S progression...
  22. doi request reprint The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein
    Matthew J Cecchini
    London Regional Cancer Program, University of Western Ontario, London, Ontario, N6A 4L6, Canada
    Biochem J 434:297-308. 2011
    ..These data reveal a mechanism by which E2F1 regulation by pRB can persist, when pRB is hyperphosphorylated and presumed to be inactive...
  23. doi request reprint Technical Note: Immunohistochemical evaluation of mouse brain irradiation targeting accuracy with 3D-printed immobilization device
    Niloufar Zarghami
    Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7, Canada
    Med Phys 42:6507-13. 2015
    ..The authors evaluate the accuracy of this device for the purpose of mouse brain irradiation...