Frederick A Dick
Affiliation: University of Western Ontario
Dick F, Li S. Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases. Cancer Discov. 2019;9:169-172 pubmed publisher
..The basis of this approach is a synthetic lethal relationship between RB1 mutations and inhibition of Aurora kinases A or B.See related article by Oser et al., p. 230.See related article by Gong et al., p. 248. ..
Kim S, Asfaha S, Dick F. CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes. Mol Cell. 2019;73:1-2 pubmed publisher
..In this issue of Molecular Cell, Jin et al. (2019) report that a phosphorylated retinoblastoma protein contacts the DNA-binding domain of p65 NF-κB, thereby blocking transcription of PD-L1. ..
Dick F, Goodrich D, Sage J, Dyson N. Non-canonical functions of the RB protein in cancer. Nat Rev Cancer. 2018;18:442-451 pubmed publisher
..These functions have implications for chemotherapy response and resistance to targeted anticancer agents. This Opinion offers a framework to guide future studies of RB in basic and clinical research. ..
Forristal C, Henley S, MacDonald J, Bush J, Ort C, Passos D, et al
. Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol Cell Biol. 2014;34:2221-34 pubmed publisher
..This reveals that assembly of mammalian DREAM is required to induce cell cycle exit in chondrocytes. ..
Cecchini M, Ishak C, Passos D, Warner A, Palma D, Howlett C, et al
. Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy. Hum Pathol. 2015;46:1922-34 pubmed publisher
..In summary, loss of pRB expression is associated with improved survival in patients treated with surgical resection and chemotherapy. This may be useful in classifying patients at greatest benefit for aggressive treatment regimes. ..
Thwaites M, Cecchini M, Passos D, Welch I, Dick F. Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression. Mol Cell Biol. 2017;37: pubmed publisher
..Our work identifies a unique relationship between pRB-E2F and p27-CDK control and offers in vivo evidence that pRB is capable of cell cycle control through E2F-independent effects. ..
Macdonald J, Ramos Valdes Y, Perampalam P, Litovchick L, DiMattia G, Dick F. A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy. Mol Cancer Res. 2017;15:371-381 pubmed publisher
..b>Implications: Loss of negative growth control mechanisms in cancer dormancy lead to cell death and not proliferation, suggesting they are an attractive therapeutic approach. Mol Cancer Res; 15(4); 371-81. ©2016 AACR. ..
Ishak C, Cecchini M, Howlett C, Dick F. Immunohistochemical Detection of the Retinoblastoma Protein. Methods Mol Biol. 2018;1726:65-75 pubmed publisher
..Importantly, these staining methods utilize broadly available reagents and equipment making them accessible to most biomedical research laboratories. ..
Dick F, Rubin S. Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol. 2013;14:297-306 pubmed publisher
..These advances and new structural studies are combining to define the multifunctionality of RB. ..