Francisco Diaz-Mitoma

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age
    Francisco Diaz-Mitoma
    Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Vaccine 29:1324-31. 2011
  2. pmc Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice
    Turaya Naas
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
    Comp Hepatol 9:7. 2010
  3. ncbi request reprint Synergistic effect of combined HIV/HCV immunogens: a combined HIV-1/HCV candidate vaccine induces a higher level of CD8+ T cell-immune responses in HLA-A2.1 mice
    Ali Azizi
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
    Curr HIV Res 5:211-9. 2007
  4. pmc Immunogenicity of a polyvalent HIV-1 candidate vaccine based on fourteen wild type gp120 proteins in golden hamsters
    Ali Azizi
    Infectious Disease and Vaccine Research Centre, Research Institute Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    BMC Immunol 7:25. 2006
  5. doi request reprint An immunological comparison between lipidated and non-lipidated multivalent HIV-1 peptides representing Gp120 and Gag hypervariable regions
    Haitham Ghunaim
    Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario, Canada K1H 8M5
    Vaccine 29:5950-8. 2011
  6. ncbi request reprint Rapid detection of anti-hepatitis A virus neutralizing antibodies in a microplate enzyme immunoassay
    Ali Azizi
    Variation Biotechnologies Inc, 1740 Woodroffe Avenue, Building 400, Ottawa, ON K2G 3R8, Canada
    J Med Microbiol 58:1433-6. 2009
  7. ncbi request reprint Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques
    Ali Azizi
    Variation Biotechnologies, Ottawa, Ontario, Canada
    J Immunol 180:2174-86. 2008
  8. doi request reprint Amplification of the signal transducer and activator of transcription I signaling pathway and its association with apoptosis in monocytes from HIV-infected patients
    Abdulkarim Alhetheel
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Canada
    AIDS 22:1137-44. 2008
  9. ncbi request reprint Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression
    Katrina Gee
    Department of Pediatrics, Research Institute, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, Canada, K1H 8L1
    J Immunol 169:5660-72. 2002
  10. doi request reprint Innovative bioinformatic approaches for developing peptide-based vaccines against hypervariable viruses
    Danylo Sirskyj
    Variation Biotechnologies Inc, Ottawa, Ontario, Canada
    Immunol Cell Biol 89:81-9. 2011

Collaborators

  • Ali Azizi
  • Ashok Kumar
  • David E Anderson
  • Ashkan Golshani
  • Jiri Mestecky
  • Rashmi Kothary
  • Jun Wu
  • Rekha Singh
  • Prakash K Bhuyan
  • Jonathan B Angel
  • Wei Ma
  • Devki Nandan
  • Danylo Sirskyj
  • Turaya Naas
  • Abdulkarim Alhetheel
  • Scott A Halperin
  • Liz Samayoa
  • Haitham Ghunaim
  • Anita Benoit
  • Nadia Sant
  • Marko Kryworuchko
  • Khaled Abdkader
  • Masoud Ghorbani
  • Catalina Soare
  • Marian P Laderoute
  • Antonio Giulivi
  • Joanne Embree
  • Paul Zickler
  • Minran Li
  • Andrew Lee
  • Bruce Tapiero
  • Earl Rubin
  • Marc Dionne
  • David Creery
  • Katrina Gee
  • Antigona Tomovici
  • William Meekison
  • Jose Torres
  • Richard Weltzin
  • Peyman Ghorbani
  • Nicole Scherling
  • Rudy Muller
  • Jasminka Bozic
  • Yuriy Yakubtsov
  • Keith Fowke
  • Hong Xing Wu
  • Louise Larocque
  • Deana Bellfoy
  • Yangxun Hou
  • Yves De Repentigny
  • Lorne Babiuk
  • Susantha Gomes
  • Ikuri Alvarez-Maya
  • Michael Lapner
  • Maya Kozlowski
  • William D Cameron
  • William Weiss
  • Wilfred Lim
  • Susan Aucoin

Detail Information

Publications23

  1. doi request reprint Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age
    Francisco Diaz-Mitoma
    Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Vaccine 29:1324-31. 2011
    ..Postdose 4 responses were adequate for all antigens in all formulations. All vaccine formulations were well-tolerated. Both PRP-OMPC formulations met prespecified immunogenicity criteria of PRP-OMPC evaluation...
  2. pmc Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice
    Turaya Naas
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
    Comp Hepatol 9:7. 2010
    ..Herein, the immune-mediated cell response to hepatitis C antigens was evaluated by adoptive transfers of carboxyfluorescein succinimidyl ester (CFSE) labelled splenocytes from HCV immunized mice into HCV transgenic mice...
  3. ncbi request reprint Synergistic effect of combined HIV/HCV immunogens: a combined HIV-1/HCV candidate vaccine induces a higher level of CD8+ T cell-immune responses in HLA-A2.1 mice
    Ali Azizi
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
    Curr HIV Res 5:211-9. 2007
    ..These results suggest a new approach to maximize vaccine efficacy against HIV and HCV...
  4. pmc Immunogenicity of a polyvalent HIV-1 candidate vaccine based on fourteen wild type gp120 proteins in golden hamsters
    Ali Azizi
    Infectious Disease and Vaccine Research Centre, Research Institute Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    BMC Immunol 7:25. 2006
    ..We compared and evaluated the immunogenicity of HIV-1 vaccines containing either gp120 protein alone or in combinations of four or fourteen gp120s from different primary HIV-1 isolates in immunized hamsters...
  5. doi request reprint An immunological comparison between lipidated and non-lipidated multivalent HIV-1 peptides representing Gp120 and Gag hypervariable regions
    Haitham Ghunaim
    Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario, Canada K1H 8M5
    Vaccine 29:5950-8. 2011
    ..A reactive HIV-1 specific immune response was detected among the immunized groups; however, mice receiving the Gag hypervariable regions demonstrated the highest frequency of cell-mediated immune responses...
  6. ncbi request reprint Rapid detection of anti-hepatitis A virus neutralizing antibodies in a microplate enzyme immunoassay
    Ali Azizi
    Variation Biotechnologies Inc, 1740 Woodroffe Avenue, Building 400, Ottawa, ON K2G 3R8, Canada
    J Med Microbiol 58:1433-6. 2009
    ..This microplate-based enzymic assay may be applicable in virological diagnostics, in evaluating the immunogenicity of HAV vaccines and in quantifying neutralizing antibodies during the course of HAV infection...
  7. ncbi request reprint Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques
    Ali Azizi
    Variation Biotechnologies, Ottawa, Ontario, Canada
    J Immunol 180:2174-86. 2008
    ..1) models. The results demonstrate strong immunogenicity with both breadth (humoral and cellular immunity) and depth (immune recognition of widely divergent viral sequences) against heterologous HIV-1 subtypes A-F...
  8. doi request reprint Amplification of the signal transducer and activator of transcription I signaling pathway and its association with apoptosis in monocytes from HIV-infected patients
    Abdulkarim Alhetheel
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Canada
    AIDS 22:1137-44. 2008
    ..As cytokine responsiveness via the signal transducer and activator of transcription (STAT1) signaling pathway is critical for these functions, we hypothesized that its activation in monocytes from HIV-positive patients may be disrupted...
  9. ncbi request reprint Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression
    Katrina Gee
    Department of Pediatrics, Research Institute, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, Canada, K1H 8L1
    J Immunol 169:5660-72. 2002
    ..Taken together, these results suggest a predominant role of JNK in LPS-induced CD44 expression in monocytic cells...
  10. doi request reprint Innovative bioinformatic approaches for developing peptide-based vaccines against hypervariable viruses
    Danylo Sirskyj
    Variation Biotechnologies Inc, Ottawa, Ontario, Canada
    Immunol Cell Biol 89:81-9. 2011
    ....
  11. pmc Nef protein of human immunodeficiency virus and lipopolysaccharide induce expression of CD14 on human monocytes through differential utilization of interleukin-10
    David Creery
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Clin Diagn Lab Immunol 9:1212-21. 2002
    ..These results suggest that HIV-Nef and IL-10 constitute biologically important modulators of CD14 expression which may influence immunobiological responses to bacterial infections in HIV disease...
  12. ncbi request reprint Mucosal HIV vaccines: a holy grail or a dud?
    Ali Azizi
    Infectious Disease and Vaccine Research Center, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth, Ottawa, Ontario, K1H 8L1, Canada
    Vaccine 28:4015-26. 2010
    ..In this article, we briefly review the function of innate and adaptive immune responses and discuss current strategies and potential adjuvants in designing and delivering HIV vaccines through mucosal routes...
  13. ncbi request reprint Augmentation of B7 expression by herpes simplex virus antigen
    Rekha Singh
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Hum Immunol 64:780-6. 2003
    ..The clinical significance of these opposing effects may be related to the pathogenesis of recurrent HSV disease in immunocompetent hosts...
  14. pmc Characterization of a branched lipopeptide candidate vaccine against influenza A/Puerto Rico 8/34 which is recognized by human B and T-cell immune responses
    Liz Samayoa
    Infectious Disease and Vaccine Research Center, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Virol J 8:309. 2011
    ..Screening the different designs with various antibody binding and cellular assays revealed that combining a branched design with the addition of lipid moieties greatly enhanced the immunoreactivity...
  15. ncbi request reprint The replicative activity of human endogenous retrovirus K102 (HERV-K102) with HIV viremia
    Marian P Laderoute
    Bloodborne Pathogens Section, Blood Safety Surveillance and Healthcare Acquired Infections Division, Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    AIDS 21:2417-24. 2007
    ..To address the activation and replicative activity of HERV-K102 in vivo associated with HIV viremia...
  16. doi request reprint Detection of influenza A and B neutralizing antibodies in vaccinated ferrets and macaques using specific biotin-streptavidin conjugated antibodies
    Danylo Sirskyj
    Variation Biotechnologies Inc, 1740 Woodroffe Ave, Building 400, Ottawa, ON, K2G 3R8, Canada
    J Virol Methods 163:459-64. 2010
    ....
  17. ncbi request reprint Inverse association of repressor growth factor independent-1 with CD8 T cell interleukin (IL)-7 receptor [alpha] expression and limited signal transducers and activators of transcription signaling in response to IL-7 among [gamma]-chain cytokines in HIV p
    Anita Benoit
    Infectious Disease and Vaccine Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    AIDS 23:1341-7. 2009
    ..As cytokine signaling through signal transducers and activators of transcription (STAT) is essential for cellular function, we hypothesized that activation of this pathway may be impaired in these cells...
  18. doi request reprint Long-term antibody persistence induced by a combined hepatitis A and B vaccine in children and adolescents
    Francisco Diaz-Mitoma
    Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Vaccine 26:1759-63. 2008
    ..The high persistence of circulating anti-HAV and anti-HBs antibodies in children and adolescents demonstrates the long-term protection offered by Twinrix in these age groups...
  19. ncbi request reprint Characterization of liver histopathology in a transgenic mouse model expressing genotype 1a hepatitis C virus core and envelope proteins 1 and 2
    Turaya Naas
    Division of Virology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada, K1H 8L1
    J Gen Virol 86:2185-96. 2005
    ..It is likely that the HCV structural proteins mediate some of the histological alterations in hepatocytes by interfering with lipid transport and liver metabolism...
  20. doi request reprint Safety and immunogenicity of a toddler dose following an infant series of a hexavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b, hepatitis B vaccine administered concurrently or at separate visits wit
    Scott A Halperin
    From the Canadian Center for Vaccinology, IWK Health Centre and Dalhousie University, Halifax, NS CHU Sainte Justine, University of Montreal, Montreal, QC CHUQ, Beauport, QC Westcoast Clinical Research, Coquitlam, BC Children s Hospital of Eastern Ontario, Ottawa, ON TASC Research, Surrey, BC Montreal Children s Hospital, Montreal, QC University of Manitoba, Winnipeg, MB, Canada Merck Research Labs, Upper Gwynedd, PA and Sanofi Pasteur Limited, Toronto, ON, Canada
    Pediatr Infect Dis J 33:73-80. 2014
    ..This study examined the effects of a booster dose at age 15 months...
  21. pmc Enhancing oral vaccine potency by targeting intestinal M cells
    Ali Azizi
    Infectious Disease and Vaccine Research Center, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    PLoS Pathog 6:e1001147. 2010
    ..In this article, we briefly review the challenges associated with current oral vaccine delivery systems and discuss strategies that might potentially target mouse and human intestinal M cells...
  22. pmc Comparison of DNA amplification, mRNA amplification, and DNA hybridization techniques for detection of cytomegalovirus in bone marrow transplant recipients
    Francisco Diaz-Mitoma
    Division of Virology, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    J Clin Microbiol 41:5159-66. 2003
    ..The earliest detection of CMV replication was provided by the RA assay (mean, 39 days posttransplantation), followed by the DG assay (mean, 48 days) and the NS assay (mean, 58 days)...
  23. ncbi request reprint Potency of cell-mediated immune responses to different combined HIV-1 immunogens in a humanized murine model
    Ali Azizi
    Infectious Disease and Vaccine Research Center, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    Hum Vaccin 1:170-6. 2005
    ..The present study reveals an optimal combination of immunogens to enhance immune responses against HIV-1...