Angela M Devlin

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Metabolic interactions of alcohol and folate
    Charles H Halsted
    Department of Internal Medicine, University of California, Davis, 95616, USA
    J Nutr 132:2367S-2372S. 2002
  2. doi request reprint Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Pathology and Laboratory Medicine, Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V5Z 4H4, Canada
    J Nutr 140:231-7. 2010
  3. pmc Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth
    Angela M Devlin
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    PLoS ONE 5:e12201. 2010
  4. ncbi request reprint Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
    Angela M Devlin
    Nutrition Research Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V6H 3N1, Canada
    J Biol Chem 282:37082-90. 2007
  5. ncbi request reprint Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
    Angela M Devlin
    Department of Internal Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 83:708-13. 2006
  6. pmc Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
    Charles H Halsted
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:10072-7. 2002
  7. pmc Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia
    Melissa B Glier
    Department of Pathology and Laboratory Medicine, University of British Columbia, Child and Family Research Institute, Vancouver, BC, Canada
    Epigenetics 8:44-53. 2013
  8. doi request reprint Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia
    Dian C Sulistyoningrum
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Epigenetics 7:514-21. 2012
  9. ncbi request reprint Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:25506-11. 2005
  10. ncbi request reprint Cerebral vascular dysfunction in methionine synthase-deficient mice
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
    Circulation 112:737-44. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Metabolic interactions of alcohol and folate
    Charles H Halsted
    Department of Internal Medicine, University of California, Davis, 95616, USA
    J Nutr 132:2367S-2372S. 2002
    ..At the same time, folate deficiency accelerates alcohol-induced changes in hepatic methionine metabolism while promoting enhanced oxidative liver injury and the histopathology of ALD...
  2. doi request reprint Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Pathology and Laboratory Medicine, Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V5Z 4H4, Canada
    J Nutr 140:231-7. 2010
    ..These findings show altered methylation and expression of Soat2/ACAT2 in liver from mice with HHcy and suggest a role for changes in liver CE in the pathology of HHcy...
  3. pmc Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth
    Angela M Devlin
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    PLoS ONE 5:e12201. 2010
    ..The methylation status of SLC6A4, which encodes the transmembrane serotonin transporter, and BDNF, which encodes brain derived neurotrophic factor, were assessed because of their potential role in behaviour...
  4. ncbi request reprint Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
    Angela M Devlin
    Nutrition Research Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V6H 3N1, Canada
    J Biol Chem 282:37082-90. 2007
    ..05), and lower Delta6-desaturase activity (p<0.001) in liver from mice with HHcy. These findings suggest that methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of HHcy...
  5. ncbi request reprint Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
    Angela M Devlin
    Department of Internal Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 83:708-13. 2006
    ..Homocysteine concentrations are influenced by vitamin status and genetics, especially several polymorphisms in folate-metabolizing genes...
  6. pmc Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
    Charles H Halsted
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:10072-7. 2002
    ..Steatohepatitis occurred in five of six pigs in FDE but not in the other groups. In summary, folate deficiency enhances perturbations in hepatic methionine metabolism and DNA damage while promoting alcoholic liver injury...
  7. pmc Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia
    Melissa B Glier
    Department of Pathology and Laboratory Medicine, University of British Columbia, Child and Family Research Institute, Vancouver, BC, Canada
    Epigenetics 8:44-53. 2013
    ..These findings suggest the relationship of AdoMet and AdoHcy to gene-specific DNA methylation is tissue-specific and that changes in DNA methylation can occur without changes in AdoMet and AdoHcy...
  8. doi request reprint Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia
    Dian C Sulistyoningrum
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Epigenetics 7:514-21. 2012
    ..These findings show methylation and silencing of vascular Nr3c1 expression and suggest a role for epigenetic regulation of gene expression in HHcy...
  9. ncbi request reprint Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:25506-11. 2005
    ..05, r = 0.620). We conclude that hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice...
  10. ncbi request reprint Cerebral vascular dysfunction in methionine synthase-deficient mice
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
    Circulation 112:737-44. 2005
    ..We tested the hypothesis that deficiency of MS impairs endothelial function in mice heterozygous for disruption of the Mtr gene, which encodes MS...
  11. ncbi request reprint Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study
    Dian C Sulistyoningrum
    Department of Pediatrics, University of British Columbia, Child and Family Research Institute, 272 950 West 28th Avenue, Vancouver, V5Z 4H4, Canada
    Cardiovasc Diabetol 12:170. 2013
    ..The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR...
  12. doi request reprint Adiposity and the relationship between vitamin D and blood pressure
    Dian C Sulistyoningrum
    Department of Pathology and Laboratory Medicine, University of British Columbia, Child and Family Research Institute, Vancouver, Canada
    Metabolism 62:1795-802. 2013
    ..The goal of this study is to investigate if the association between plasma 25OHD and BP is mediated by adiposity...
  13. ncbi request reprint Folate deficiency, methionine metabolism, and alcoholic liver disease
    Charles H Halsted
    University of California, Davis, 95616, USA
    Alcohol 27:169-72. 2002
    ..The finding of steatonecrosis and focal inflammation only in the combined diet group supports the suggestion that folate deficiency promotes and folate sufficiency protects against the early onset of methionine cycle-mediated ALD...
  14. ncbi request reprint Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations
    Timothy J Green
    Food, Nutrition, and Health, University of British Columbia, Vancouver, BC, Canada
    Br J Nutr 103:1629-34. 2010
    ..If elevated plasma AdoHcy is detrimental, this may explain why B-vitamins have generally failed to reduce vascular events in clinical trials...
  15. ncbi request reprint Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Blood 103:2624-9. 2004
    ..These findings demonstrate that the Mthfr(+/-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity and impairs endothelial function in cerebral microvessels...
  16. pmc Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice
    Sanjoy Ghosh
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada
    J Biol Chem 286:42483-93. 2011
    ..This study suggests a novel role for Cbs in maintaining the cardiac glutathione pool and protecting against cardiac lipid accumulation and oxidative stress during diet-induced obesity in mice...
  17. ncbi request reprint Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
    ....
  18. doi request reprint Childhood obesity and cardiovascular dysfunction
    Anita T Cote
    Department of Pediatrics, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 62:1309-19. 2013
    ....
  19. pmc Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig
    Charles H Halsted
    University of California, Davis, California and National Toxicological Research Center, Jefferson, Arkansas, USA
    Trans Am Clin Climatol Assoc 113:151-62; discussion 162-3. 2002
    ..Thus, the development of ALD is linked to abnormal methionine metabolism and is accelerated in the presence of folate deficiency...
  20. doi request reprint Methyl nutrients, DNA methylation, and cardiovascular disease
    Melissa B Glier
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Mol Nutr Food Res 58:172-82. 2014
    ..The focus of this review is to provide an overview on the current understanding of the relationship between methyl nutrient status and DNA methylation patterns and the potential role of this interaction in CVD pathology. ..
  21. pmc Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise
    Anita T Cote
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, Canada
    J Appl Physiol (1985) 115:1705-13. 2013
    ..Furthermore, a novel association of arterial stiffness and twist mechanics following high-intensity acute exercise illustrates the influence of vascular integrity on cardiac mechanics...
  22. pmc Ethnic-specific differences in vitamin D status is associated with adiposity
    Dian C Sulistyoningrum
    Department of Pathology and Laboratory Medicine, University of British Columbia, Child and Family Research Institute, Vancouver, Canada
    PLoS ONE 7:e43159. 2012
    ..The objective of this study is to investigate the relationship between plasma 25(OH)D, adiposity, and body fat distribution in Europeans and South Asians...
  23. ncbi request reprint Quetiapine treatment in youth is associated with decreased insulin secretion
    Ying Fai Ngai
    From the Department of Pediatrics, Faculty of Medicine, University of British Columbia Child and Family Research Institute Departments of Surgery, and Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    J Clin Psychopharmacol 34:359-64. 2014
    ..Prospective longitudinal studies are required to understand the progression of β-cell dysfunction after quetiapine initiation. ..
  24. ncbi request reprint Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
    Isabelle Morin
    Departments of Pediatrics and Human Genetics, McGill University, Montreal Children s Hospital Research Institute, 4060 Ste Catherine West, Room 200, Montreal, Canada H3Z 2Z3
    Mol Genet Metab 79:197-200. 2003
    ....
  25. ncbi request reprint ApoA-I: a missing link between homocysteine and lipid metabolism?
    Angela M Devlin
    Circ Res 98:431-3. 2006