Angela M Devlin

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. Devlin A, Brain U, Austin J, Oberlander T. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS ONE. 2010;5:e12201 pubmed publisher
    ..These findings support the concept that alterations in epigenetic processes may contribute to developmental programming of behaviour by maternal depression. ..
  2. Devlin A, Singh R, Bottiglieri T, Innis S, Green T. Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia. J Nutr. 2010;140:231-7 pubmed publisher
    ..These findings show altered methylation and expression of Soat2/ACAT2 in liver from mice with HHcy and suggest a role for changes in liver CE in the pathology of HHcy. ..
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    Devlin A, Clarke R, Birks J, Evans J, Halsted C. Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr. 2006;83:708-13 pubmed
    ..An interaction between the MTHFR 677TT and RFC1 80GG genotypes was observed whereby persons with this combination had higher serum tHcy. ..
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    Devlin A, Singh R, Wade R, Innis S, Bottiglieri T, Lentz S. Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J Biol Chem. 2007;282:37082-90 pubmed
    ..05), and lower Delta6-desaturase activity (p<0.001) in liver from mice with HHcy. These findings suggest that methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of HHcy. ..