Andrew M Demchuk

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. doi request reprint Thrombolytic therapy for acute ischaemic stroke: what can we do to improve outcomes?
    Andrew M Demchuk
    Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Calgary, AB, Canada
    Drugs 72:1833-45. 2012
  2. doi request reprint Imaging-based selection in acute ischemic stroke trials - a quest for imaging sweet spots
    Andrew M Demchuk
    Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Ann N Y Acad Sci 1268:63-71. 2012
  3. doi request reprint Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study
    Andrew M Demchuk
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Lancet Neurol 11:307-14. 2012
  4. ncbi request reprint Transcranial Doppler in acute stroke
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, AB, Canada
    Neuroimaging Clin N Am 15:473-80, ix. 2005
  5. pmc Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Cerebrovasc Dis 26:120-5. 2008
  6. doi request reprint Acute secondary stroke prevention trials in minor stroke/TIA: prime time for magnetic resonance imaging
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 1403 29 St NW, Calgary, AB, Canada
    Int J Stroke 1:91-3. 2006
  7. ncbi request reprint Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
    Stroke 36:2110-5. 2005
  8. doi request reprint Frequency and clinical course of stroke and transient ischemic attack patients with intracranial nonocclusive thrombus on computed tomographic angiography
    Volker Puetz
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Calgary, Canada
    Stroke 40:193-9. 2009
  9. ncbi request reprint Mild neurological symptoms despite middle cerebral artery occlusion
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, Alberta T2N 2T9, Canada
    Stroke 35:469-71. 2004
  10. doi request reprint Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score
    Volker Puetz
    University of Calgary, Department of Clinical Neurosciences, Calgary Stroke Program, Canada
    Int J Stroke 3:230-6. 2008

Detail Information

Publications105 found, 100 shown here

  1. doi request reprint Thrombolytic therapy for acute ischaemic stroke: what can we do to improve outcomes?
    Andrew M Demchuk
    Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Calgary, AB, Canada
    Drugs 72:1833-45. 2012
    ....
  2. doi request reprint Imaging-based selection in acute ischemic stroke trials - a quest for imaging sweet spots
    Andrew M Demchuk
    Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Ann N Y Acad Sci 1268:63-71. 2012
    ..These can be summarized as the "3C" approach of core, clot, and collateral interpretation, which together can represent an imaging sweet spot, particularly for time-efficient endovascular treatment trial design...
  3. doi request reprint Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study
    Andrew M Demchuk
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Lancet Neurol 11:307-14. 2012
    ..Proper selection of patients at high risk for haematoma expansion seems crucial to improve outcomes. In this study, we aimed to prospectively validate the CT-angiography (CTA) spot sign for prediction of haematoma expansion...
  4. ncbi request reprint Transcranial Doppler in acute stroke
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, AB, Canada
    Neuroimaging Clin N Am 15:473-80, ix. 2005
    ..TCD has shown its clinical value in thrombolysis monitoring and early emboli detection. The therapeutic effect requires confirmation and may be enhanced further by nanobubble technologies...
  5. pmc Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Cerebrovasc Dis 26:120-5. 2008
    ..We examined the relationship between small-vessel ischemic disease and symptomatic ICH within the NINDS rt-PA Stroke Study...
  6. doi request reprint Acute secondary stroke prevention trials in minor stroke/TIA: prime time for magnetic resonance imaging
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 1403 29 St NW, Calgary, AB, Canada
    Int J Stroke 1:91-3. 2006
  7. ncbi request reprint Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
    Stroke 36:2110-5. 2005
    ..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study...
  8. doi request reprint Frequency and clinical course of stroke and transient ischemic attack patients with intracranial nonocclusive thrombus on computed tomographic angiography
    Volker Puetz
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Calgary, Canada
    Stroke 40:193-9. 2009
    ..We sought to determine the frequency and clinical course of patients with acute ischemic stroke or transient ischemic attack (TIA) who had intracranial nonocclusive thrombus (iNOT) on CT angiography (CTA)...
  9. ncbi request reprint Mild neurological symptoms despite middle cerebral artery occlusion
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, Alberta T2N 2T9, Canada
    Stroke 35:469-71. 2004
    ..Only a small percentage of stroke patients are treated with thrombolytic therapy. We sought to determine whether vessel occlusion in mild strokes represented a new target population for interventional therapy...
  10. doi request reprint Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score
    Volker Puetz
    University of Calgary, Department of Clinical Neurosciences, Calgary Stroke Program, Canada
    Int J Stroke 3:230-6. 2008
    ..In ischemic stroke, functional outcomes vary depending on site of intracranial occlusion. We tested the prognostic value of a semiquantitative computed tomography angiography-based clot burden score...
  11. ncbi request reprint Reliability of assessing percentage of diffusion-perfusion mismatch
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta T2N 2T9, Canada
    Stroke 34:1681-3. 2003
    ..The present study sought to estimate the reliability of assessing the percentage of DWI-PWI mismatch...
  12. doi request reprint Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke
    Bijoy K Menon
    Calgary Stroke Program, University of Calgary, Calgary, AB, Canada
    Neuroradiology 53:261-6. 2011
    ..The Penumbra system is a newly approved mechanical device for the treatment of acute stroke designed for better and faster recanalization. We describe our initial experience with the use of this device...
  13. pmc Final 2 year results of the vascular imaging of acute stroke for identifying predictors of clinical outcome and recurrent ischemic eveNts (VISION) study
    Shelagh B Coutts
    Department of Clinical Neurosciences and Radiology, University of Calgary, Calgary, AB, T2N 2T9, Canada
    BMC Cardiovasc Disord 11:18. 2011
    ..We assessed the role of MR imaging in predicting stroke progression, recurrent stroke, and death within 2 years of symptom onset...
  14. ncbi request reprint Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry
    Imanuel Dzialowski
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, 1403 29th St NW, Calgary, Alberta, Canada
    Stroke 38:75-9. 2007
    ..We sought to study the relation between the type of hemorrhagic transformation on CT scans and functional outcome...
  15. doi request reprint Does intravenous rtPA benefit patients in the absence of CT angiographically visible intracranial occlusion?
    P N Sylaja
    Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Alberta, Canada
    Neurol India 57:739-43. 2009
    ..In patients with acute stroke receiving intravenous tissue plasminogen activator (tPA), we postulated that the presence of intracranial occlusion on CT angiography (CTA) modifies the benefit of thrombolysis...
  16. ncbi request reprint Tissue Window in Stroke Thrombolysis study (TWIST): a safety study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 40:17-20. 2013
    ....
  17. doi request reprint Outcomes in acute ischemic strokes presenting with disabling neurologic deficits without intracranial vascular occlusion
    Nandavar Shobha
    Department of Clinical Neurosciences, Calgary Stroke Program, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    Int J Stroke 6:392-7. 2011
    ..They pose diagnostic and therapeutic challenges to the physician. We sought to study these patients with an emphasis on their radiological and clinical outcomes...
  18. ncbi request reprint Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II
    Imanuel Dzialowski
    Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
    Stroke 37:973-8. 2006
    ..We hypothesized that dichotomized ASPECTS predicts response to intravenous thrombolysis and incidence of secondary hemorrhage within 6 hours of stroke onset...
  19. ncbi request reprint MR angiography compared to conventional selective angiography in acute stroke
    Anna I Tomanek
    Seaman Family MR Research Centre, University of Calgary, Calgary, AB Canada
    Can J Neurol Sci 33:58-62. 2006
    ..The purpose of this study was to determine the accuracy of MRA in evaluation of intracranial vessels in acute stroke and transient ischemic attack (TIA) patients..
  20. ncbi request reprint Derivation of power M-mode transcranial Doppler criteria for angiographic proven MCA occlusion
    Maher Saqqur
    Department of Medicine, University of Alberta, Alberta, Canada
    J Neuroimaging 16:323-8. 2006
    ..Stringent transcranial Doppler (TCD) criteria for diagnosing occlusion are needed for more reliable TCD performance at bedside in the acute stroke setting...
  21. doi request reprint Identifying lesion growth with MR imaging in acute ischemic stroke
    Michael S Bristow
    Department of Radiology, University of Calgary, Calgary, Alberta, Canada
    J Magn Reson Imaging 28:837-46. 2008
    ..To determine whether different MR diffusion- and perfusion-weighted imaging (DWI and PWI) parameters are important in distinguishing lesion growth from the acute lesion and from oligemia...
  22. ncbi request reprint MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction
    Michael S Bristow
    Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada
    J Cereb Blood Flow Metab 25:1280-7. 2005
    ..This study suggests that tissue-specific analysis of perfusion and diffusion imaging is required to accurately predict tissue at risk of infarction in acute ischemic stroke...
  23. ncbi request reprint Interobserver variation of ASPECTS in real time
    Shelagh B Coutts
    Seaman Family MR Centre, Calgary Health Region, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 35:e103-5. 2004
    ..We sought to assess the reliability of the score when performed in real time as compared with an expert rating performed at a later time point...
  24. doi request reprint Ultrashort imaging to reperfusion time interval arrests core expansion in endovascular therapy for acute ischemic stroke
    Mohammed A Almekhlafi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neurointerv Surg 5:i58-61. 2013
    ..We aimed to assess the feasibility of achieving an ultrashort imaging to reperfusion time in routine clinical practice...
  25. doi request reprint An improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor stroke
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, AB, Canada
    Int J Stroke 3:3-10. 2008
    ..Modern imaging of the brain was not included. The present study quantified the added value of magnetic resonance imaging (MRI) factors to the ABCD(2) tool...
  26. ncbi request reprint Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    Ann Neurol 57:848-54. 2005
    ....
  27. doi request reprint Malignant emboli on transcranial Doppler during carotid stenting predict postprocedure diffusion-weighted imaging lesions
    Mohammed A Almekhlafi
    Departments of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Stroke 44:1317-22. 2013
    ..We evaluated CAS safety by correlating the findings of procedural transcranial Doppler with postprocedure diffusion-weighted imaging (DWI) lesions...
  28. doi request reprint Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action
    Rohit Bhatia
    Department of Clinical Neurosciences, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada
    Stroke 41:2254-8. 2010
    ..We aimed to study acute recanalization rates of IV rt-PA in CT angiogram-proven proximal (internal carotid artery [ICA], M1 middle cerebral artery [MCA], M2-MCA, and basilar artery) occlusions and their effects on outcome. Materials and..
  29. doi request reprint Initial experience with a self-expanding retrievable stent for recanalization of large vessel occlusions in acute ischemic stroke
    Bijoy K Menon
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Neuroradiology 54:147-54. 2012
    ..Quicker recanalization results in better clinical outcomes in patients with acute ischemic strokes. We describe our experience with the use of a self-expanding, fully retrievable stent in acute intracranial occlusions...
  30. ncbi request reprint Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Stroke 38:948-54. 2007
    ..Angiographic studies with intraarterial thrombolysis suggest more proximal occlusions carry greater thrombus burden and benefit less from local therapy...
  31. doi request reprint Does current oral antiplatelet agent or subtherapeutic anticoagulation use have an effect on tissue-plasminogen-activator-mediated recanalization rate in patients with acute ischemic stroke?
    Mohamed M Ibrahim
    Department of Medicine Neurology, University of Alberta, 8440 112th Avenue, Edmonton, AB, Canada
    Cerebrovasc Dis 30:508-13. 2010
    ..Our goal is to assess if current antiplatelet (AP) use has an effect on recanalization rate and outcome in acute stroke patients...
  32. doi request reprint When to expect negative diffusion-weighted images in stroke and transient ischemic attack
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Alberta, Canada
    Stroke 39:1898-900. 2008
    ..The frequency of DWI negative cerebral ischemia and clinical factors associated with such a circumstance is not well understood...
  33. doi request reprint Perfusion MR predicts outcome in high-risk transient ischemic attack/minor stroke: a derivation-validation study
    Negar Asdaghi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 44:2486-92. 2013
    ..Transient or minor ischemic stroke is associated with an early risk of deterioration. Baseline perfusion-diffusion mismatch may predict clinical deterioration and infarct growth in this population...
  34. ncbi request reprint Role of CT angiography in thrombolysis decision-making for patients with presumed seizure at stroke onset
    P N Sylaja
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Stroke 37:915-7. 2006
    ..Currently there are no established methods of differentiating Todd's paralysis from ischemic stroke/early seizure. We sought to determine whether computed tomographic angiography (CTA) can be helpful in differentiating the 2...
  35. ncbi request reprint Derivation of transcranial Doppler criteria for rescue intra-arterial thrombolysis: multicenter experience from the Interventional Management of Stroke study
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Alberta, Canada
    Stroke 36:865-8. 2005
    ..We examined clinical utility and prognostic value of TCD flow findings in patients enrolled in an intravenous/intra-arterial rtPA pilot trial (Interventional Management of Stroke [IMS] study)...
  36. doi request reprint Does the application of X-ray contrast agents impair the clinical effect of intravenous recombinant tissue-type plasminogen activator in acute ischemic stroke patients?
    Imanuel Dzialowski
    Department of Clinical Neurosciences, University of Calgary, Calgary Stroke Program, Canada
    Stroke 43:1567-71. 2012
    ..We hypothesized that the application of a contrast agent before intravenous thrombolysis with rtPA reduces its clinical efficacy in acute ischemic stroke...
  37. doi request reprint Prognostic value of CT angiography in patients with suspected vertebrobasilar ischemia
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimaging 18:46-9. 2008
    ..The aim of our study was to analyze the CT angiography (CTA) predictors of outcome in patients with suspected vertebrobasilar ischemia...
  38. ncbi request reprint A novel method to derive separate gray and white matter cerebral blood flow measures from MR imaging of acute ischemic stroke patients
    Jessica E Simon
    1 1Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada 2 2Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    J Cereb Blood Flow Metab 25:1236-43. 2005
    ..The difference in the reversed region approached statistical significance. In core, GM and WM CBF did not differ. The results suggest separate ischemic thresholds for GM and WM in stroke penumbra...
  39. doi request reprint High rate of magnetic resonance imaging stroke recurrence in cryptogenic transient ischemic attack and minor stroke patients
    Simerpreet Bal
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, and Foothills Hospital, C1261, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada
    Stroke 43:3387-8. 2012
    ..It is likely that the imaging recurrence risk is higher than the clinical recurrence rate. We sought to determine the rate of clinical and radiographic stroke recurrence in a population of cryptogenic TIA and minor stroke...
  40. doi request reprint What causes disability after transient ischemic attack and minor stroke?: Results from the CT and MRI in the Triage of TIA and minor Cerebrovascular Events to Identify High Risk Patients (CATCH) Study
    Shelagh B Coutts
    Department of Clinical Nuerosciences, University of Calgary, Foothills Hospital, C1261, 1403 29 Street NW, Calgary, AB, T2N 2T9, Canada
    Stroke 43:3018-22. 2012
    ..We sought to assess the relative impact of these mechanisms on disability in a population of patients with transient ischemic attack and minor stroke...
  41. doi request reprint Cavitation after acute symptomatic lacunar stroke depends on time, location, and MRI sequence
    Francois Moreau
    Department of Clinical Neurosciences, Calgary, Alberta, Canada, T3C 2H8
    Stroke 43:1837-42. 2012
    ..We determined the characteristics of acute lacunar infarcts on follow-up MRI in consecutive patients participating in prospective research studies...
  42. doi request reprint CT/CT angiography and MRI findings predict recurrent stroke after transient ischemic attack and minor stroke: results of the prospective CATCH study
    Shelagh B Coutts
    Departments of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 43:1013-7. 2012
    ..MRI can identify patients at high risk for a recurrent stroke. However, MRI is not commonly available as an emergency. If similarly clinically predictive, a CT/CT angiographic (CTA) imaging strategy would be more widely applicable...
  43. ncbi request reprint Comparison of pre- and postcontrast 3D time-of-flight MR angiography for the evaluation of distal intracranial branch occlusions in acute ischemic stroke
    Janice J Yang
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 23:557-67. 2002
    ..We hypothesized that the use of contrast-enhanced MR angiography improves delineation of vessels with diminished or absent flow on precontrast MR angiograms...
  44. ncbi request reprint Perfusion MRI abnormalities in speech or motor transient ischemic attack patients
    Andrea L Krol
    Seaman Family MR Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    Stroke 36:2487-9. 2005
    ..One possible mechanism of neurological worsening is the presence of perfusion abnormalities. We sought to identify what proportion of TIA patients had evidence of perfusion abnormalities on MRI...
  45. ncbi request reprint The ICV sign as a marker of increased cerebral blood transit time
    Bijoy K Menon
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 40:187-91. 2013
    ....
  46. ncbi request reprint Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 33:279-82. 2002
    ..A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke. We sought to assess the safety and feasibility of this approach...
  47. doi request reprint Anterior temporal artery sign in CT angiography predicts reduced fatal brain edema and mortality in acute M1 middle cerebral artery occlusions
    Bijoy K Menon
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimaging 22:145-8. 2012
    ..We identify a vascular imaging sign, presence of "prominent anterior temporal artery" on computed tomography (CT) angiography (CTA) and investigate whether it predicts mortality in acute M1-MCA occlusions...
  48. ncbi request reprint Recombinant factor VIIa plus surgery for intracerebral hemorrhage
    Christina S Sutherland
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 35:567-72. 2008
    ..The peri-operative administration of rFVIIa to patients with intracerebral hemorrhage may decrease the frequency of post-operative hemorrhage, and improve outcome...
  49. doi request reprint The Intracerebral Haemorrhage Acutely Decreasing Arterial Pressure Trial: ICH ADAPT
    Kenneth Butcher
    Division of Neurology, University of Alberta, Edmonton, AB, Canada
    Int J Stroke 5:227-33. 2010
    ..A study of this type is critical to establishing the safety of early blood pressure treatment and is necessary for planning larger efficacy trials in a rational manner. This trial is registered with clinicaltrials.gov (NCT00963976)...
  50. doi request reprint Recurrent events in transient ischemic attack and minor stroke: what events are happening and to which patients?
    Shelagh B Coutts
    Department of Clinical Neurosciences, Room C1246, Foothills Medical Centre, 1403 29th St SW, Calgary, AB, T2N 2T9, Canada
    Stroke 39:2461-6. 2008
    ..Clinical trials are needed to assess acute treatment options in these patients. We sought to evaluate the type of recurrent events and to identify which subsets of patients are at risk for recurrent events...
  51. ncbi request reprint ASPECTS on CTA source images versus unenhanced CT: added value in predicting final infarct extent and clinical outcome
    Shelagh B Coutts
    Seaman Family MR Centre, Foothills Hospital, Calgary Health Region, 1403 29th St NW, Calgary, Alberta T2N 2T9, Canada
    Stroke 35:2472-6. 2004
    ..CT angiography-source images (CTA-SI) predict final infarct volume. We examined whether the final infarct ASPECTS and clinical outcome were more related to acute CTA-SI ASPECTS than to the acute noncontrast CT (NCCT) ASPECTS...
  52. ncbi request reprint Stroke imaging at 3.0 T
    M Louis Lauzon
    University of Calgary, Calgary, Alberta, Canada
    Neuroimaging Clin N Am 16:343-66, xii. 2006
    ..0 T imaging as they relate to stroke...
  53. ncbi request reprint Alberta Stroke Program Early CT Score in acute stroke triage
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada
    Neuroimaging Clin N Am 15:409-19, xii. 2005
    ..CT is likely to remain the workhorse of acute stroke imaging for some time to come...
  54. doi request reprint Measurement of Length of Hyperdense MCA Sign in Acute Ischemic Stroke Predicts Disappearance after IV tPA
    Nandavar Shobha
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimaging 24:7-10. 2014
    ..We sought to assess the hypothesis that length and volumes of middle cerebral artery (MCA) thrombus were associated with disappearance of the hyperdense middle cerebral artery sign (HMCAS) in acute ischemic stroke...
  55. doi request reprint Design of a PROspective multi-national CLOTBUST collaboration on reperfusion therapies for stroke (CLOTBUST-PRO)
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Alberta, Canada
    Int J Stroke 3:66-72. 2008
    ..The benefit of intravenous (i.v.) tissue plasminogen activator (tPA) in acute ischemic stroke (IS) is attributable to lysis of thrombus and restoration of perfusion to ischemic but not yet infarcted brain...
  56. ncbi request reprint Transcranial Doppler microembolic signal monitoring is useful in diagnosis and treatment of carotid artery dissection: two case reports
    Jayanta Roy
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimaging 17:350-2. 2007
    ..Both cases were also monitored for emboli count reduction with subsequent antiplatelet therapy...
  57. doi request reprint Acute corticospinal tract Wallerian degeneration is associated with stroke outcome
    Giselle DeVetten
    Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Alberta, Canada
    Stroke 41:751-6. 2010
    ..In this study we test the hypothesis that early diffusion changes also occur in the corticospinal tract (CST) of adults after stroke and that these lesions are associated with poor outcome...
  58. ncbi request reprint Routine CT angiography in acute stroke does not delay thrombolytic therapy
    Simerpreet Bal
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 39:499-501. 2012
    ..We compare interval times during a CTA based acute ischemic stroke protocol with an earlier non-CTA based protocol at our center...
  59. doi request reprint ASPECTS and other neuroimaging scores in the triage and prediction of outcome in acute stroke patients
    Bijoy K Menon
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, 29 Street NW, Calgary T2N2T9, Canada
    Neuroimaging Clin N Am 21:407-23, xii. 2011
    ..This review summarizes ASPECTS and other neuroimaging scores developed for risk prognostication and risk stratification with treatment in patients with acute ischemic stroke...
  60. ncbi request reprint Computed tomographic parameters predicting fatal outcome in large middle cerebral artery infarction
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 16:230-5. 2003
    ..As yet there are few guidelines to aid the selection of patients for aggressive interventional therapies, such as decompression hemicraniectomy and/or hypothermia...
  61. doi request reprint Effect of baseline CT scan appearance and time to recanalization on clinical outcomes in endovascular thrombectomy of acute ischemic strokes
    Mayank Goyal
    Department of Clinical Neuroscience, University of Calgary, Alberta, Canada
    Stroke 42:93-7. 2011
    ..We evaluated the association of a favorable initial noncontrast CT and a short time to recanalization in predicting good outcome...
  62. doi request reprint Quantomo: validation of a computer-assisted methodology for the volumetric analysis of intracerebral haemorrhage
    Jayme C Kosior
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, AB, Canada
    Int J Stroke 6:302-5. 2011
    ....
  63. ncbi request reprint Reliability of measuring lesion volumes in transient ischemic attack and minor stroke
    Nikolai Steffenhagen
    Department of Clinical Neurosciences, Foothills Medical Centre, 1403 29th Street SW, Calgary, AB, T2N 2T9, Canada
    Stroke 41:814-6. 2010
    ....
  64. ncbi request reprint Stroke prevention. MATCHing therapy to the patient with TIA
    Nicolas U Weir
    Department of Clinical Neurosciences, University of Calgary Faculty of Medicine, Foothills Medical Centre, Alberta, Canada
    Postgrad Med 117:26-30. 2005
    ..Here, the authors discuss treatment considerations, outlining the current knowledge and stressing the need for formal randomized trials to definitively establish the effectiveness of preventive therapies after minor stroke or TIA...
  65. ncbi request reprint Improved detection of microbubble signals using power M-mode Doppler
    Maher Saqqur
    Department of Medicine Neurology, University of Calgary, Calgary, Alberta, Canada
    Stroke 35:e14-7. 2004
    ..We developed criteria for emboli detection using PMD. Then, we performed a blinded comparison of transcranial PMD with single-gate spectral TCD in TCD bubble study patients...
  66. doi request reprint Treatment of stroke after carotid endarterectomy using intravenous abciximab
    P N Sylaja
    Calgary Stroke Program, Division of Neurosurgery and Department of Clinical, Neurosciences, University of Calgary, Alberta, Canada
    Neurol India 57:780-2. 2009
    ..Transcranial Doppler ultrasonography revealed very frequent microembolization in the left middle cerebral artery territory. The patient was successfully treated with intravenous abciximab with complete neurological recovery...
  67. ncbi request reprint What is causing crescendo transient ischemic attacks?
    Shelagh B Coutts
    Seaman Family MR Centre, Foothills Medical Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 30:171-3. 2003
    ..We discuss a case report from a patient who had symptoms of transient neurological deficits in the presence of a chronic subdural hematoma and severe carotid stenosis. Multi-modality imaging was used to guide management...
  68. doi request reprint Impact of a stroke unit on length of hospital stay and in-hospital case fatality
    Hai Feng Zhu
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm 1242A, 1403 29 Street NW, Calgary, Alberta, T2N 2T9, Canada
    Stroke 40:18-23. 2009
    ..In 2001, a multidisciplinary stroke unit was opened at our institution. We observed whether a stroke unit reduces length of stay and in-hospital case fatality when compared to admission to a general neurology/medical ward...
  69. pmc Do all ischemic stroke subtypes benefit from organized inpatient stroke care?
    E E Smith
    Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 2T9
    Neurology 75:456-62. 2010
    ..We analyzed the effect of organized stroke care in all stroke subtypes in a longitudinal cohort study using data from the Registry of the Canadian Stroke Network...
  70. doi request reprint A dynamic view of depressive symptoms and neurocognitive change among patients with coronary artery disease
    Elizabeth A Freiheit
    Department of Community Health Sciences, University of Calgary, Third Floor Teaching Research and Wellness, Calgary
    Arch Gen Psychiatry 69:244-55. 2012
    ..Older patients with coronary artery disease often experience depressive symptoms and are vulnerable to developing cognitive impairment. Whether depressive symptoms increase their risk of cognitive decline is unknown...
  71. pmc Multimodal imaging tools for diagnosis of fat embolism
    Nandavar Shobha
    Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Canada
    J Emerg Trauma Shock 4:306-8. 2011
    ..We discuss a patient who presented with an incomplete triad of the FES, where the diagnosis was supported by transcranial doppler monitoring of microembolic signals and magnetic resonance imaging...
  72. ncbi request reprint Biochemistry of ischemic stroke
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada
    Adv Neurol 92:151-64. 2003
  73. ncbi request reprint Arm levitation sign in acute right frontoparietal infarct
    Mohammed H Alanazy
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29 St N W Calgary, AB T2N 2T9, Canada
    Neurosciences (Riyadh) 16:66-7. 2011
    ..We also discuss in brief, the possibility of neuronal misconnections causing the sign and the resultant problems with rehabilitation when patients have this sign...
  74. doi request reprint Aphemia as a presenting symptom in acute stroke
    Pawan K Ojha
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Neurol India 59:432-4. 2011
    ..All had apraxia of speech due to acute infarct in the left motor cortex near face M1 area. Understanding the underlying speech disorder is crucial in planning the appropriate rehabilitation strategy...
  75. ncbi request reprint "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Stroke 36:1695-9. 2005
    ..We explored this hypothesis using a combined database including 4 major clinical trials of intravenous (IV) thrombolytic therapy...
  76. ncbi request reprint Bedside emergency transcranial Doppler diagnosis of severe carotid disease using orbital window examination
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Canada
    J Neuroimaging 15:138-43. 2005
    ..The authors sought to evaluate the TCD orbital window for predicting cervical ICA (cICA) stenosis in the setting of acute stroke and TIA...
  77. ncbi request reprint Postcontrast time-of-flight MR angiography demonstrating collateral flow in acute stroke
    Chul Ho Sohn
    Stroke 38:1132-3; author reply 1134. 2007
  78. ncbi request reprint Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack
    Jean Martin Boulanger
    Clinique Neuro Rive Sud, 4896 Blvd Taschereau 250, Greenfield Park, Provinvr of Quebec, Canada, J4V 2J2
    Stroke 37:911-4. 2006
    ..Cerebral microhemorrhages (MHs) are common among patients presenting with acute ischemic stroke and may predict both subsequent ischemic and hemorrhagic strokes...
  79. ncbi request reprint Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator
    Carlos A Molina
    Neurovascular Unit, Department of Neurology, Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 35:151-6. 2004
    ..Therefore, we sought to investigate whether the predictive accuracy of early recanalization on stroke outcome is improved when combined with clinical and radiological information...
  80. ncbi request reprint Comparison of MRI and CT for detection of acute intracerebral hemorrhage
    Chelsea S Kidwell
    UCLA Stroke Center, Los Angeles, Calif, USA
    JAMA 292:1823-30. 2004
    ..However, the accuracy of MRI relative to CT for the detection of hyperacute intracerebral hemorrhage has not been demonstrated...
  81. ncbi request reprint Improving delivery of acute stroke therapy: The TLL Temple Foundation Stroke Project
    Lewis B Morgenstern
    Stroke Program, Department of Neurology, University of Texas Medical School, Houston 77030, USA
    Stroke 33:160-6. 2002
    ..We performed a community and professional behavioral intervention project to increase the proportion of stroke patients treated with approved acute stroke therapy...
  82. pmc Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison
    Julio A Chalela
    Medical University of South Carolina, Charleston, SC, USA
    Lancet 369:293-8. 2007
    ..We aimed to prospectively compare CT and MRI for emergency diagnosis of acute stroke...
  83. ncbi request reprint A description of Canadian and United States physician reimbursement for thrombolytic therapy administration in acute ischemic stroke
    Dawn Kleindorfer
    Department of Neurology, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0525, Cincinnati, Ohio 45267 0525, USA
    Stroke 36:682-7. 2005
    ..We describe the physician reimbursement for thrombolytic therapy for the stroke team physicians serving the Greater Cincinnati/Northern Kentucky region (GCNK), and the Alberta region...
  84. ncbi request reprint Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey
    David Tanne
    Stroke Unit, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Circulation 105:1679-85. 2002
    ..Our aim was to identify, in a large cohort of patients, readily available baseline factors that are associated with thrombolysis-related ICH...
  85. ncbi request reprint Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston 77030, USA
    N Engl J Med 351:2170-8. 2004
    ..Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA...
  86. ncbi request reprint Clinical deterioration after intravenous recombinant tissue plasminogen activator treatment: a multicenter transcranial Doppler study
    Maher Saqqur
    University of Alberta, Department of Medicine, Division of Neurology, 2 E3 Walter Mckenzie Center, 8440 112 Ave, Edmonton, Alberta T6G 2B7, Canada
    Stroke 38:69-74. 2007
    ..We evaluated the ability of flow findings on transcranial Doppler to predict CD and outcomes on modified Rankin Scale...
  87. ncbi request reprint Hyperacute stroke: experience essential when reading unenhanced CT scans
    J H Warwick Pexman
    AJNR Am J Neuroradiol 25:516; author reply 516-8. 2004
  88. ncbi request reprint CT-NIHSS mismatch does not correlate with MRI diffusion-perfusion mismatch
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 38:2079-84. 2007
    ..However, MRI has limited availability in many hospitals. We investigated whether mismatch between the Alberta Stroke Program Early CT Score (ASPECTS) and the NIH Stroke Scale (NIHSS) correlates with MRI diffusion-perfusion mismatch...
  89. ncbi request reprint Can rt-PA be administered to the wrong patient? Two patients with somatoform disorder
    Mikael S Mouradian
    Division of Neurology, Department of Medicine, Queens University, Kingston, Ontario, Canada
    Can J Neurol Sci 31:99-101. 2004
    ..Diagnosis of the somatoform disorder is often delayed, and thrombolytics in these patients for their stroke-like presentation subjects them to risk for hemorrhage...
  90. pmc Methodology of the Interventional Management of Stroke III Trial
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Int J Stroke 3:130-7. 2008
    ..a.) approach to recanalization may be more effective than standard i.v. rt-PA (Activase) alone for moderate-to-large National Institutes of Health Stroke Scale (NIHSS>or=10) strokes, and with a similar safety profile...
  91. ncbi request reprint Prediction of hospital disposition after thrombolysis for acute ischemic stroke using the National Institutes of Health Stroke Scale
    Daniel J Schlegel
    Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, 3W Gates Building, Philadelphia, PA 19104, USA
    Arch Neurol 61:1061-4. 2004
    ..Early determination of discharge destination after acute stroke may promote earlier rehabilitation and reduce costs by shortening the duration of hospitalization...
  92. doi request reprint Transient ischemic attack etiologic subtype and early risk of stroke
    Alexandre Y Poppe
    Stroke 39:e108; author reply e109-10. 2008
  93. doi request reprint White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study
    Blake D Murphy
    Department of Imaging, Lawson Health Research Institute, London, Ontario, Canada
    Radiology 247:818-25. 2008
    ....
  94. ncbi request reprint Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial
    James Kennedy
    Acute Stroke Programme, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Lancet Neurol 6:961-9. 2007
    ..Patients with transient ischaemic attack (TIA) or minor stroke are at high immediate risk of stroke. The optimum early treatment options for these patients are not known...
  95. ncbi request reprint Diffusion-weighted imaging-negative patients with transient ischemic attack are at risk of recurrent transient events
    Jean Martin Boulanger
    Stroke 38:2367-9. 2007
    ..We assessed the implication of negative diffusion-weighted imaging on a baseline MRI in predicting subsequent TIA...
  96. ncbi request reprint Incidence of radiocontrast nephropathy in patients undergoing acute stroke computed tomography angiography
    Andrea L Krol
    Stroke 38:2364-6. 2007
    ..We investigated the incidence of contrast-induced renal impairment in these populations...
  97. ncbi request reprint Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion
    Ioannis Christou
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, MSB 7 044, Houston, TX 77030, USA
    J Neuroimaging 12:119-23. 2002
    ..Vascular imaging, safety, and outcome of TPA therapy for ICA occlusion is not well described. Our goal was to determine the site of occlusion, early recanalization after TPA infusion, and its relationship to outcome...
  98. ncbi request reprint Safety of tissue plasminogen activator for acute stroke in menstruating women
    Theodore H Wein
    Stroke Program, Department of Neurology, University of Texas at Houston Medical School, USA
    Stroke 33:2506-8. 2002
    ..Menses is a theoretical contraindication to intravenous tissue plasminogen activator (tPA) treatment. We sought to establish the safety of intravenous tPA in the treatment of acute ischemic stroke in women who are actively menstruating...
  99. doi request reprint Extent of hypoattenuation on CT angiography source images predicts functional outcome in patients with basilar artery occlusion
    Volker Puetz
    University of Technology Dresden, Department of Neurology, Dresden University Stroke Center, Fetscherstrasse 74, 01307 Dresden, Germany
    Stroke 39:2485-90. 2008
    ..We tested the validity of a novel CT score, the posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS)...
  100. ncbi request reprint Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke: a systematic review
    Ting Yim Lee
    Stroke 37:2201; author reply 2203. 2006
  101. ncbi request reprint Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the CLOTBUST trial
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:113-7. 2004
    ..The authors present Phase I data of the CLOTBUST (Combined Lysis of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic TPA)...