Marc de Perrot

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Use of the posterior pericardium to cover the bronchial stump after right extrapleural pneumonectomy
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 96:706-8. 2013
  2. doi request reprint Surgical approaches to apical thoracic malignancies
    Marc de Perrot
    Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:72-80. 2012
  3. doi request reprint Outcome of patients with pulmonary arterial hypertension referred for lung transplantation: a 14-year single-center experience
    Marc de Perrot
    Toronto Lung Transplant Program and Pulmonary Hypertension Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 143:910-8. 2012
  4. doi request reprint Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: the Toronto experience
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:692-7. 2011
  5. doi request reprint Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 85:1206-10. 2008
  6. doi request reprint Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma
    Marc de Perrot
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 27:1413-8. 2009
  7. ncbi request reprint Anterior transclavicular approach to malignant tumors of the thoracic inlet: importance of the scapulothoracic articulation
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital and Toronto Western Hospital, University of Toronto, Canada
    J Thorac Cardiovasc Surg 134:801-3. 2007
  8. doi request reprint Early postoperative pulmonary vascular compliance predicts outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
    Chest 140:34-41. 2011
  9. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: donor-related risk factors and markers
    Marc de Perrot
    Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:1460-7. 2005
  10. ncbi request reprint Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Canada
    J Thorac Cardiovasc Surg 133:111-6. 2007

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Use of the posterior pericardium to cover the bronchial stump after right extrapleural pneumonectomy
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 96:706-8. 2013
    ..The length and mobility from the posterior pericardium can then provide excellent coverage for the right bronchial stump. This technique has the advantage of being easy to perform and requiring limited time and dissection. ..
  2. doi request reprint Surgical approaches to apical thoracic malignancies
    Marc de Perrot
    Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:72-80. 2012
    ..In the present analysis, we divided the thoracic inlet into 5 different zones requiring specific surgical considerations to identify the best approach for each zone...
  3. doi request reprint Outcome of patients with pulmonary arterial hypertension referred for lung transplantation: a 14-year single-center experience
    Marc de Perrot
    Toronto Lung Transplant Program and Pulmonary Hypertension Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 143:910-8. 2012
    ..To analyze the outcomes of patients with pulmonary arterial hypertension referred for lung transplantation and determine the changes over time...
  4. doi request reprint Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: the Toronto experience
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:692-7. 2011
    ..However, this surgery remains performed in few experienced centres only. The goal of the study is to review our overall experience since the implementation of our program in August 2005...
  5. doi request reprint Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 85:1206-10. 2008
    ....
  6. doi request reprint Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma
    Marc de Perrot
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 27:1413-8. 2009
    ..We examined the results of trimodality therapy with cisplatin-based chemotherapy followed by extrapleural pneumonectomy (EPP) and adjuvant high-dose (50 to 60 Gy) hemithoracic radiation therapy for MPM...
  7. ncbi request reprint Anterior transclavicular approach to malignant tumors of the thoracic inlet: importance of the scapulothoracic articulation
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital and Toronto Western Hospital, University of Toronto, Canada
    J Thorac Cardiovasc Surg 134:801-3. 2007
  8. doi request reprint Early postoperative pulmonary vascular compliance predicts outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
    Chest 140:34-41. 2011
    ..We hypothesized that residual abnormal compliance (Cp) after PEA is associated with incomplete functional recovery despite major improvement in PVR...
  9. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: donor-related risk factors and markers
    Marc de Perrot
    Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:1460-7. 2005
  10. ncbi request reprint Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Canada
    J Thorac Cardiovasc Surg 133:111-6. 2007
    ..The impact of lymph node metastasis on the site of recurrence and the role of mediastinoscopy in the selection of patients for extrapleural pneumonectomy, however, remain unclear...
  11. ncbi request reprint Impact of extracorporeal life support on outcome in patients with idiopathic pulmonary arterial hypertension awaiting lung transplantation
    Marc de Perrot
    Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 30:997-1002. 2011
    ....
  12. ncbi request reprint Evaluation of persistent pulmonary hypertension after acute pulmonary embolism
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, 9N 961, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada
    Chest 132:780-5. 2007
    ..Better knowledge of the evolution of persistent pulmonary hypertension after acute pulmonary embolism (PE) is required to optimize the indication and timing of pulmonary endarterectomy (PEA)...
  13. ncbi request reprint Impact of donors aged 60 years or more on outcome after lung transplantation: results of an 11-year single-center experience
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Canada
    J Thorac Cardiovasc Surg 133:525-31. 2007
    ..We examined the outcome of lung transplantation with the use of donors aged 60 years or more...
  14. doi request reprint Experience with the first 50 ex vivo lung perfusions in clinical transplantation
    Marcelo Cypel
    Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:1200-6. 2012
    ..Normothermic ex vivo lung perfusion is a novel method to evaluate and improve the function of injured donor lungs. We reviewed our experience with 50 consecutive transplants after ex vivo lung perfusion...
  15. doi request reprint Induction chemoradiation therapy followed by surgical resection for non-small cell lung cancer (NSCLC) invading the thoracic inlet
    Stefan Fischer
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, University Health Network, 200 Elizabeth Street, 9th Floor, Toronto, Ontario, Canada M5G 2C4
    Eur J Cardiothorac Surg 33:1129-34. 2008
    ..The role of induction therapy for non-small cell lung cancer (NSCLC) invading the thoracic inlet is unclear. We reviewed our experience with induction chemoradiation followed by surgical resection for NSCLC invading the thoracic inlet...
  16. doi request reprint Induction chemoradiotherapy facilitates radical resection of T4 non-small cell lung cancer invading the spine
    Masaki Anraku
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 137:441-447.e1. 2009
    ..We evaluated the outcome, long-term results, and factors affecting outcome of induction chemoradiotherapy followed by surgical resection for T4 non-small cell lung cancer invading the spine...
  17. doi request reprint Functional repair of human donor lungs by IL-10 gene therapy
    Marcelo Cypel
    Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada
    Sci Transl Med 1:4ra9. 2009
    ..Thus, treatment of injured human donor lungs with the cytokine IL-10 can improve lung function, potentially rendering injured lungs suitable for transplantation into patients...
  18. doi request reprint Venous thromboembolism in patients receiving multimodality therapy for thoracic malignancies
    Apurva Patel
    Toronto General Hospital and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 138:843-8. 2009
    ..The rate of venous thromboembolism in patients undergoing multimodality therapy for lung malignancy and the impact of preoperative venous thromboembolism on postoperative outcome have not been analyzed systematically...
  19. doi request reprint Gene expression profiling in the lungs of patients with pulmonary hypertension associated with pulmonary fibrosis
    Marco Mura
    Toronto General Hospital, Toronto, ON, Canada
    Chest 141:661-73. 2012
    ..We sought to determine if different gene expression signatures in PF could be determined based on pulmonary arterial pressures (PAPs) and to provide new insights into the pathobiology of APH...
  20. ncbi request reprint Improved results of induction chemoradiation before surgical intervention for selected patients with stage IIIA-N2 non-small cell lung cancer
    Karl L Uy
    Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 134:188-93. 2007
    ..The surgical arm of the North American Intergroup 0139 trial was adopted as the standard treatment for patients with resectable N2 disease at the University Health Network. Results after 7 years of experience are reported...
  21. ncbi request reprint Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry
    Stefan Fischer
    The Toronto Lung Transplant Program, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 26:472-7. 2007
    ..A few single-center experiences have been reported with relatively few cases of ECMO after LTx...
  22. doi request reprint Increased levels of interleukin-1β and tumor necrosis factor-α in donor lungs rejected for transplantation
    Marcelo Cypel
    Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, Toronto General Research Institute, University Health Network, Toronto General Hospital, Ontario, Canada
    J Heart Lung Transplant 30:452-9. 2011
    ..This study compared gene expression levels of inflammatory cytokines between clinically rejected and transplanted donor lungs...
  23. doi request reprint Feasibility of blood conservation strategies in pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Karen McRae
    Department of Anesthesia and Pain Management, Toronto General Hospital, University of Toronto, Toronto, Ont, Canada
    Interact Cardiovasc Thorac Surg 13:35-8. 2011
    ..In conclusion, a conservative blood transfusion strategy allows PEA to be safely performed with no or minimal blood product transfusions in a majority of patients despite deep hypothermic circulatory arrest...
  24. doi request reprint Normothermic ex vivo lung perfusion in clinical lung transplantation
    Marcelo Cypel
    Toronto Lung Transplant Program, University of Toronto, ON, Canada
    N Engl J Med 364:1431-40. 2011
    ..In this study, we examined the feasibility of transplanting high-risk donor lungs that have undergone EVLP...
  25. ncbi request reprint Accommodation after lung xenografting from hamster to rat
    Toshiharu Tabata
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transplantation 75:607-12. 2003
    ..We examined whether accommodation could be induced in hamster-to-rat lung xenografts and whether the pattern of protective genes is similar to cardiac xenografts...
  26. doi request reprint Is video-assisted lobectomy for non-small-cell lung cancer oncologically equivalent to open lobectomy?
    Wael C Hanna
    Department of Thoracic Surgery, University of Toronto, Toronto, ON, Canada
    Eur J Cardiothorac Surg 43:1121-5. 2013
    ..The purpose of this study was to compare overall and disease-free survival after VATS and open lobectomy for clinical Stage I and II non-small-cell lung cancer (NSCLC)...
  27. doi request reprint Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma
    Masaki Anraku
    Latner Thoracic Surgery Research Laboratories, University Health Network, University of Toronto, Ontario, Canada
    J Immunol 185:956-66. 2010
    ..This study also validates a new intrathoracic tumor model of pleural effusion to explore the role of antitumor immunity in murine MM...
  28. ncbi request reprint 15 years single center experience with surgical resection of the superior vena cava for non-small cell lung cancer
    Yaron Shargall
    Division of Thoracic Surgery, University Health Network Princess Margaret Hospital and Toronto General Hospital and the University of Toronto, 10EN 233, Toronto, ON M5G 2C4, Canada
    Lung Cancer 45:357-63. 2004
    ..To examine our results with surgery for locally advanced non-small cell lung cancer (NSCLC) invading the superior vena cava (SVC)...
  29. doi request reprint A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer
    Kazuhiro Yasufuku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:1393-400.e1. 2011
    ..The study objective was to compare endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with mediastinoscopy for mediastinal lymph node staging of potentially resectable non-small cell lung cancer...
  30. doi request reprint Endobronchial ultrasound-guided transbronchial needle aspiration in the management of previously treated lung cancer
    Masaki Anraku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 92:251-5; discussion 255. 2011
    ..This study evaluated the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the assessment of newly developed mediastinal/hilar abnormalities in patients with previously treated lung cancer...
  31. doi request reprint Treatment of the elderly when cure is the goal: the influence of age on treatment selection and efficacy for stage III non-small cell lung cancer
    Linda E Coate
    Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Thorac Oncol 6:537-44. 2011
    ..Treatment of elderly patients with stage III NSCLC is controversial. Limited data exist, as the elderly are underrepresented in clinical trials...
  32. ncbi request reprint Impact of human interleukin-10 on vector-induced inflammation and early graft function in rat lung transplantation
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Ontario, Canada
    Am J Respir Cell Mol Biol 28:616-25. 2003
    ..The period between delivery of AdhIL-10 and lung retrieval can be reduced if the early inflammatory response is suppressed with methylprednisolone...
  33. doi request reprint Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis
    Chang Hyun Kang
    Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, Toronto General Research Institute, Toronto Lung Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada
    J Heart Lung Transplant 30:289-98. 2011
    ..We aimed to study the differential gene expression profiles in lungs of DCD and DBD patients and interpreted the differences using functional pathway analysis...
  34. ncbi request reprint Recipient T cells mediate reperfusion injury after lung transplantation in the rat
    Marc de Perrot
    Thoracic Surgery Research Laboratory and Department of Laboratory Medicine, Toronto General Hospital Research Institute, University of Toronto, Toronto, Canada
    J Immunol 171:4995-5002. 2003
    ..The effect of T cells was independent of neutrophil recruitment and activation in the transplanted lung. These results demonstrate that recipient T cells are activated and mediate IR injury during lung transplantation in rats...
  35. ncbi request reprint Twenty-year experience of lung transplantation at a single center: Influence of recipient diagnosis on long-term survival
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 127:1493-501. 2004
    ..The objective of this study was to examine the long-term patient outcomes of lung transplantation in a single center...
  36. doi request reprint Impact of tumor-infiltrating T cells on survival in patients with malignant pleural mesothelioma
    Masaki Anraku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 135:823-9. 2008
    ..The aim of the study was to determine the impact of tumor-infiltrating lymphocytes on survival in patients with malignant pleural mesothelioma treated with induction chemotherapy followed by extrapleural pneumonectomy...
  37. ncbi request reprint Technique for prolonged normothermic ex vivo lung perfusion
    Marcelo Cypel
    Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 27:1319-25. 2008
    ..The aim of this study was to develop a technique of extended (12-hour) ex vivo lung perfusion (EVLP) at normothermia for assessment and protective maintenance of the donor lung...
  38. ncbi request reprint Role of lung transplantation in the treatment of bronchogenic carcinomas for patients with end-stage pulmonary disease
    Marc de Perrot
    Toronto Lung Transplant Program, University of Toronto, Canada
    J Clin Oncol 22:4351-6. 2004
    ..To determine the role of lung transplantation in the treatment of patients presenting with bronchogenic carcinoma and end-stage lung disease...
  39. ncbi request reprint Antitumor impact of interferon-γ producing CD1d-restricted NKT cells in murine malignant mesothelioma
    Tetsuzo Tagawa
    Toronto Mesothelioma Research Program, Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, ON, Canada Department of Thoracic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunother 36:391-9. 2013
    ..Furthermore, in vivo administration of α-GalCer could suppress mesothelioma growth by activating iNKT cells. ..
  40. ncbi request reprint Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
    Yumiko Imai
    Department of Critical Care, St Michael s Hospital, University of Toronto, Toronto, Ontario
    JAMA 289:2104-12. 2003
    ..Recent clinical trials have demonstrated a decrease in multiple organ dysfunction syndrome (MODS) and mortality in patients with acute respiratory distress syndrome (ARDS) treated with a protective ventilatory strategy...
  41. ncbi request reprint Lung transplantation. Lung preservation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, EN 10 224, Toronto, Ontario M5G 2C4, Canada
    Chest Surg Clin N Am 13:443-62. 2003
    ..Hopefully, this information will provide new insights into the mechanisms of injury and reveal potential new strategies and targets for therapies to improve lung preservation...
  42. ncbi request reprint Risk quantification of early outcome after lung transplantation: donor, recipient, operative, and post-transplant parameters
    Yasuo Sekine
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:96-104. 2004
    ..The purpose of our study was to identify risk factors for 30-day mortality and prolonged intensive care unit stay and to develop a scoring system to evaluate the severity of impairment and to predict surgical outcomes...
  43. ncbi request reprint Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis
    Stefan Fischer
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 126:1174-80. 2003
    ..The objective was to determine whether donor lung transfection with the interleukin-10 gene ameliorates lung dysfunction by decreasing cell death after transplantation...
  44. ncbi request reprint Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant
    Frank D'Ovidio
    Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1254-60. 2005
    ..It is not clear whether gastroesophageal reflux is a preexisting condition or secondary to intraoperative vagal injury or drug-induced prolonged gastric emptying...
  45. ncbi request reprint Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation
    Marc de Perrot
    Division of Thoracic Surgery, Thoracic Surgery Research Laboratory and The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 165:211-5. 2002
    ..In addition, we showed that donor age and ischemic time may influence release of specific cytokines during ischemia-reperfusion...
  46. doi request reprint CTLA-4 blockade expands infiltrating T cells and inhibits cancer cell repopulation during the intervals of chemotherapy in murine mesothelioma
    Licun Wu
    Toronto Mesothelioma Research Program, Division of Thoracic Surgery, Toronto General Hospital, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada
    Mol Cancer Ther 11:1809-19. 2012
    ....
  47. ncbi request reprint Activation of mitogen-activated protein kinases during human lung transplantation
    Shoji Sakiyama
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Hospital and Department of Surgery and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:2079-85. 2005
    ..The intracellular signal transduction mechanisms of these events are largely unknown. We hypothesize that activation of mitogen-activated protein kinases (MAPKs) is one of the important signaling events during human lung transplantation...
  48. ncbi request reprint A simplified model for en bloc double lung xenotransplantation from hamster to rat
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 21:286-9. 2002
    ..This technique provides a technically easier and more reliable model to study xenotransplantation of the lung...
  49. ncbi request reprint Independent ventilation of the graft and native lungs in vivo after rat lung transplantation
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 79:2169-71. 2005
    ....
  50. ncbi request reprint Thoracic aortic endografting facilitates the resection of tumors infiltrating the aorta
    Stéphane Collaud
    Division of Thoracic Surgery, Sprott Department of Surgery, Toronto General Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 147:1178-82; discussion 1182. 2014
    ..We describe our extended experience and long-term outcome using this innovative approach...
  51. ncbi request reprint Long-term outcome after en bloc resection of non-small-cell lung cancer invading the pulmonary sulcus and spine
    Stéphane Collaud
    Divisions of Thoracic Surgery, Orthopedic Surgery, Medical Oncology, Radiation Oncology, and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Oncol 8:1538-44. 2013
    ..Nevertheless, considerable surgical progress has been made since the 1990s potentially allowing for curative resection. Here, we describe our surgical experience and long-term results...
  52. ncbi request reprint Bilateral lung transplantation using a donor with a tracheal right upper lobe bronchus
    Yasuo Sekine
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Thorac Surg 73:308-10. 2002
    ..The anastomosis was completed using a telescoping technique without any complication. This case demonstrates the possibility of successfully using donor lungs with such anatomic abnormality for transplantation...
  53. ncbi request reprint Tumor cell repopulation between cycles of chemotherapy is inhibited by regulatory T-cell depletion in a murine mesothelioma model
    Licun Wu
    Latner Thoracic Surgery Research Laboratories and Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Oncol 6:1578-86. 2011
    ..The aim of this study is to analyze the impact of Treg depletion on tumor cell repopulation during cycles of chemotherapy in a murine mesothelioma model...
  54. ncbi request reprint Prognostic significance of thymomas in patients with myasthenia gravis
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, Ontario, Canada
    Ann Thorac Surg 74:1658-62. 2002
    ..The presence of thymoma may be a negative prognostic factor with respect to the outcome of myasthenia gravis (MG)...
  55. ncbi request reprint Solitary fibrous tumors of the pleura
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Ontario, Canada
    Ann Thorac Surg 74:285-93. 2002
    ..A staging system and an algorithm for the management and follow-up of these patients are proposed...
  56. pmc Pulmonary hypertension after pulmonary emboli: an underrecognized condition
    Marc de Perrot
    Pulmonary Hypertension Program, Toronto General Hospital, University of Toronto, Toronto, Ont
    CMAJ 174:1706. 2006
  57. ncbi request reprint Caspase inhibition improves ischemia-reperfusion injury after lung transplantation
    Syed M Quadri
    Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network Toronto General Hospital, Toronto, Ontario, Canada
    Am J Transplant 5:292-9. 2005
    ..Clearly, this needs to be investigated further with more experiments to validate the potential role of caspase inhibition as a therapeutic modality in ischemia-reperfusion-induced lung injury...
  58. ncbi request reprint Ischemia-reperfusion-induced lung injury
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 167:490-511. 2003
    ....
  59. ncbi request reprint Lung preservation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Canada
    Semin Thorac Cardiovasc Surg 16:300-8. 2004
    ..In this review, we have focused our attention on the experimental and clinical work performed to optimize the methods of lung preservation from the time of retrieval to the period of reperfusion after graft implantation...
  60. ncbi request reprint Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 124:1137-44. 2002
    ..This study was undertaken to examine the effect of 2 ventilatory strategies on the development of ischemia-reperfusion injury after lung transplantation...
  61. ncbi request reprint Bronchogenic carcinoma after solid organ transplantation
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 75:367-71. 2003
    ..Although the overall incidence of malignancy is increased after solid organ transplantation, the risk of bronchogenic carcinoma in the transplant population has not been systematically studied...
  62. ncbi request reprint De novo pulmonary capillary hemangiomatosis occurring rapidly after bilateral lung transplantation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 22:698-700. 2003
    ..This case supports the theory that persistent infection or inflammation may be an inciting factor in uncontrolled angiogenesis, leading ultimately to diffuse pulmonary capillary hemangiomatosis...
  63. ncbi request reprint Strategies to optimize the use of currently available lung donors
    Marc de Perrot
    University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:1127-34. 2004
  64. doi request reprint Soluble mesothelin-related Peptide and osteopontin as markers of response in malignant mesothelioma
    Paul Wheatley-Price
    Princess Margaret Hospital, Toronto, Ontario, Canada
    J Clin Oncol 28:3316-22. 2010
    ..Both soluble mesothelin-related peptide (SMRP) and osteopontin (OP) have utility in distinguishing MM from benign pleural disease. We evaluated whether SMRP and OP also correlated with the disease course of MM...
  65. ncbi request reprint Impact of minimally invasive trans-cervical thymectomy on outcome in patients with myasthenia gravis
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Toronto, Canada
    Eur J Cardiothorac Surg 24:677-83. 2003
    ..To study the impact of minimally invasive trans-cervical thymectomy on the incidence of remission of patients with myasthenia gravis (MG) in a single institution over a 10-year period...
  66. ncbi request reprint Everting mattress running suture: an improved technique of atrial anastomosis in human lung transplantation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Thorac Surg 73:1663-4. 2002
    ..This technique should help reduce the risk of venous anastomotic complications...
  67. doi request reprint Dynamic hyperinflation and cardiac arrest during one-lung ventilation: a case report
    Katherine Marseu
    Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada
    Can J Anaesth 58:396-400. 2011
    ..It is associated with significant hemodynamic instability and may precipitate cardiac arrest. This report describes a case of hemodynamic collapse secondary to dynamic hyperinflation in a patient during one-lung ventilation...
  68. ncbi request reprint Lung preservation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Ontario, Canada
    Ann Thorac Surg 74:629-31. 2002
  69. ncbi request reprint Neuroendocrine carcinoma (carcinoid) of the thymus associated with Cushing's syndrome
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, Ontario, Canada
    Ann Thorac Surg 73:675-81. 2002
    ..In the future, the advent of radiologic and nuclear imaging as well as more accurate workup should help to diagnose these tumors at an earlier stage and improve the long-term outcome...
  70. ncbi request reprint A review of lung transplant donor acceptability criteria
    Jonathan B Orens
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 22:1183-200. 2003
  71. ncbi request reprint Risk factors for reperfusion injury after lung transplantation
    Silvia R Cottini
    Division of Surgical Intensive Care, Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Intensive Care Med 32:557-63. 2006
    ..To assess the influence of recipient's and donor's factors as well as surgical events on the occurrence of reperfusion injury after lung transplantation...
  72. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methods
    Jason D Christie
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1451-3. 2005
  73. ncbi request reprint Risk factors for acute lung injury after thoracic surgery for lung cancer
    Marc Licker
    Department of Anaesthesiology, University Hospital of Geneva, Switzerland
    Anesth Analg 97:1558-65. 2003
    ..delayed-onset ALI triggered by intercurrent complications and 2). an early form of ALI amenable to risk-reducing strategies, including preoperative alcohol abstinence, lung-protective ventilatory modes, and limited fluid intake...
  74. ncbi request reprint Long-term results after carinal resection for carcinoma: does the benefit warrant the risk?
    Marc de Perrot
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 131:81-9. 2006
    ..We sought to determine whether the benefit warrants the risk in patients undergoing carinal resection for carcinoma...
  75. pmc Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
    Edouard Sage
    UPRES EA2705, Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Respir Res 9:19. 2008
    ..We hypothesized that endothelial dysfunction is related to increased endothelial-cell (EC) death...
  76. ncbi request reprint Selective monoclonal versus polyclonal antibodies for induction of immunosuppression in lung recipients
    Margaret W Gerbase
    Clin Pharmacol Ther 72:103. 2002
  77. ncbi request reprint Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease
    John Robert
    Clinic of Thoracic Surgery, University Hospital, Geneva, Switzerland
    Eur J Cardiothorac Surg 22:708-11. 2002
    ..Identification of clinical features suggestive of pulmonary blastoma (PB) through a retrospective comparison with cases of non-small cell lung cancer (NSCLC) operated during the same period...
  78. ncbi request reprint Surgical treatment of solitary adrenal metastasis from non-small cell lung cancer
    Olaf Mercier
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Marie Lannelongue Hospital, 133 avenue de la Resistance, 92350 Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 130:136-40. 2005
    ..The aim of this study was to review our experience and to identify factors that could affect survival...
  79. ncbi request reprint Risk factors for early mortality and major complications following pneumonectomy for non-small cell carcinoma of the lung
    Marc Licker
    Department of Anesthesiology, Pharmacology, and Surgical Intensive Care, the University Hospital of Geneva, Geneva, Switzerland
    Chest 121:1890-7. 2002
    ..To assess the mortality rate and the incidence of cardiopulmonary complications after pneumonectomy for non-small cell lung carcinoma (NSCLC) and to identify possible associated risk factors...