J G de Boer

Summary

Affiliation: University of Victoria
Country: Canada

Publications

  1. pmc Regulation and expression of sexual differentiation factors in embryonic and extragonadal tissues of Atlantic salmon
    Kristian R von Schalburg
    Department of Biology, Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, Canada
    BMC Genomics 12:31. 2011
  2. pmc Isolation, characterization and comparison of Atlantic and Chinook salmon growth hormone 1 and 2
    Kristian R von Schalburg
    Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, V8W 3N5, Canada
    BMC Genomics 9:522. 2008
  3. pmc Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar
    Motoshige Yasuike
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    BMC Genomics 11:486. 2010
  4. ncbi request reprint Protection by dietary compounds against mutation in a transgenic rodent
    J G de Boer
    Centre for Environmental Health, University of Victoria, Victoria, British Columbia, Canada
    J Nutr 131:3082S-6S. 2001
  5. ncbi request reprint On the origin of unusual mutations recovered from the lacI transgenic assay
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, P O Box 3020 STN CSC, Victoria BC, Canada V8W 3N5
    Mutat Res 536:1-6. 2003
  6. ncbi request reprint Chemoprotection against N-nitrosomethylbenzylamine-induced mutation in the rat esophagus
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, Victoria BC, Canada
    Nutr Cancer 50:168-73. 2004
  7. ncbi request reprint Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, P O Box 3020 STN CSC, Victoria, BC, Canada V8W 3N5
    Mutat Res 578:15-22. 2005
  8. pmc Bursts and horizontal evolution of DNA transposons in the speciation of pseudotetraploid salmonids
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, Victoria, BC V8W 2Y2 Canada
    BMC Genomics 8:422. 2007
  9. ncbi request reprint Tris(2,3-dibromopropyl)phosphate causes a gradient of mutations in the cortex and outer and inner medullas of the kidney of lacI transgenic rats
    J G de Boer
    Centre for Environmental Health, University of Victoria, Victoria, British Columbia, Canada
    Environ Mol Mutagen 36:1-4. 2000
  10. ncbi request reprint Polymorphisms in DNA repair and environmental interactions
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, PO Box 3020, STC CSC, Victoria, Canada, BC V8W 3N5
    Mutat Res 509:201-10. 2002

Collaborators

Detail Information

Publications31

  1. pmc Regulation and expression of sexual differentiation factors in embryonic and extragonadal tissues of Atlantic salmon
    Kristian R von Schalburg
    Department of Biology, Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, Canada
    BMC Genomics 12:31. 2011
    ..Although the function of these factors in sexual differentiation have been defined, their roles in early development before sexual fate decisions and in tissues beyond the brain or gonad are essentially unknown...
  2. pmc Isolation, characterization and comparison of Atlantic and Chinook salmon growth hormone 1 and 2
    Kristian R von Schalburg
    Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, V8W 3N5, Canada
    BMC Genomics 9:522. 2008
    ....
  3. pmc Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar
    Motoshige Yasuike
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    BMC Genomics 11:486. 2010
    ..1 Mb) and IGH-B (0.9 Mb) loci. In addition, over 7,000 cDNA clones from the IgH variable (VH) region have been sequenced and analyzed...
  4. ncbi request reprint Protection by dietary compounds against mutation in a transgenic rodent
    J G de Boer
    Centre for Environmental Health, University of Victoria, Victoria, British Columbia, Canada
    J Nutr 131:3082S-6S. 2001
    ..These results demonstrate that the lacI transgenic rodent is a useful model for the study of chemoprevention in vivo...
  5. ncbi request reprint On the origin of unusual mutations recovered from the lacI transgenic assay
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, P O Box 3020 STN CSC, Victoria BC, Canada V8W 3N5
    Mutat Res 536:1-6. 2003
    ..These mutants demonstrate that mutations resulting from diverse mechanisms, in addition to the normal point mutations, can be recovered. In addition, the data indicate that such mutations may often not be of animal origin...
  6. ncbi request reprint Chemoprotection against N-nitrosomethylbenzylamine-induced mutation in the rat esophagus
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, Victoria BC, Canada
    Nutr Cancer 50:168-73. 2004
    ..In contrast, the addition of 5% ethanol to the drinking water increased the mutagenicity of NMBA. This is consistent with findings that these compounds modulate NMBA-induced carcinogenesis in the rat...
  7. ncbi request reprint Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, P O Box 3020 STN CSC, Victoria, BC, Canada V8W 3N5
    Mutat Res 578:15-22. 2005
    ..This study demonstrates how a combination of generating and analysis of plant varieties together with a mammalian assay for efficacy may improve the search for better plant-based prevention of cancer initiation...
  8. pmc Bursts and horizontal evolution of DNA transposons in the speciation of pseudotetraploid salmonids
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, Victoria, BC V8W 2Y2 Canada
    BMC Genomics 8:422. 2007
    ..We analyzed the DNA sequence of several large loci in Salmo salar and other species for the presence of DNA transposon families...
  9. ncbi request reprint Tris(2,3-dibromopropyl)phosphate causes a gradient of mutations in the cortex and outer and inner medullas of the kidney of lacI transgenic rats
    J G de Boer
    Centre for Environmental Health, University of Victoria, Victoria, British Columbia, Canada
    Environ Mol Mutagen 36:1-4. 2000
    ..This is also the first known case when transgenic animals have been used to study mutation at the suborgan level...
  10. ncbi request reprint Polymorphisms in DNA repair and environmental interactions
    Johan G de Boer
    Centre for Biomedical Research, University of Victoria, PO Box 3020, STC CSC, Victoria, Canada, BC V8W 3N5
    Mutat Res 509:201-10. 2002
    ..This review will concentrate on the mismatch repair, nucleotide repair, base excision repair, strand break repair, and direct alkyl repair pathways...
  11. ncbi request reprint Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice
    J G de Boer
    Centre for Environmental Health, Department of Biology, University of Victoria, Victoria BC, Canada
    Environ Mol Mutagen 34:80-3. 1999
    ..No changes from the spontaneous spectrum were detected. The comparison of the outcome of DMN treatment at 3 and 6 weeks confirms a change in metabolic activation, adduct removal, or mutation fixation between 3 and 6 weeks of age...
  12. ncbi request reprint Spontaneous mutation in lacI transgenic mice: a comparison of tissues
    J G de Boer
    Centre for Environmental Health, University of Victoria, BC, Canada
    Mutagenesis 13:109-14. 1998
    ....
  13. pmc The lacI gene as a target for mutation in transgenic rodents and Escherichia coli
    J G de Boer
    Centre for Environmental Health, University of Victoria, British Columbia, Canada
    Genetics 148:1441-51. 1998
    ..In addition, we compare the nature of deletion mutations between bacteria and animals. Based on the nature of deletions in the animals, we conclude that each deletion occurs in a single copy of the gene...
  14. ncbi request reprint Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice
    J G de Boer
    Department of Biology, University of Victoria, British Columbia, Canada
    Environ Mol Mutagen 30:273-86. 1997
    ..The establishment of this substantial database of spontaneous mutations in the liver of Big Blue mice is intended to serve as a reference against which mutations recovered after treatment can be compared...
  15. ncbi request reprint Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue rats
    G R Stuart
    Centre for Environmental Health and the Department of Biology, University of Victoria, Canada
    Mutat Res 452:101-21. 2000
    ..The evaluation of PhIP-induced mutational responses in these two transgenes serves as a model for intergenic mutational analyses...
  16. ncbi request reprint Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats
    J G de Boer
    Center for Environmental Health, University of Victoria, BC, Canada
    Mutat Res 352:73-8. 1996
    ..This study represents the first interspecies look into the molecular nature of mutations in the lacI transgenic rodents...
  17. ncbi request reprint Mutations induced by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in cecum and proximal and distal colon of lacI transgenic rats
    G R Stuart
    Centre for Environmental Health and Department of Biology, University of Victoria, PO Box 3020 STN CSC, Victoria, British Columbia, Canada V8W 3N5
    Mutagenesis 16:431-7. 2001
    ..Therefore, we surmise that following induction of mutations by PhIP in male and female colons, non-mutagenic factors, possibly hormonal, preferentially influence the formation of tumors in the colon of male rats...
  18. ncbi request reprint Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione
    H Yang
    Centre for Environmental Health, University of Victoria, Victoria, BC, Canada V8W 3N5
    Nutr Cancer 39:259-66. 2001
    ..In conclusion, CLA and DTT modulate PhIP-induced mutagenesis in a tissue-specific manner, and different modulation pathways are employed by CLA and DTT...
  19. ncbi request reprint Mutagenicity of TCDD in Big Blue transgenic rats
    A S Thornton
    Centre for Environmental Health, University of Victoria, P.O. Box 3020, Victoria, BC, Canada V8W 3N5
    Mutat Res 478:45-50. 2001
    ..After 6 weeks of exposure to 2 microg/kg TCDD neither an increase in mutation frequency nor any change in mutation spectrum was observed in either male or female animals...
  20. ncbi request reprint Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon
    S Zhang
    Centre for Environmental Health, Department of Biology, University of Victoria, Victoria, BC, V8W 3N5, Canada
    Oncogene 20:6066-72. 2001
    ..It also provides insight into interaction between genetic and environmental factors in human carcinogenesis...
  21. pmc Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice
    G R Stuart
    Centre for Environmental Health, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
    Genetics 154:1291-300. 2000
    ..Hence, no evidence was found to support hypotheses that predict that oxidative damage or accumulation of errors in nuclear DNA contributes significantly to the aging process, at least in these three somatic tissues...
  22. ncbi request reprint Use of log-linear analysis to construct explanatory models for TDBP- and AFB1-induced mutation spectra in lacI transgenic animals
    M E Brackley
    Centre for Environmental Health, University of Victoria, P O Box 3020 STN CSC, Victoria, B C, Canada
    Mutat Res 425:55-69. 1999
    ..The resulting statistical models are consistent with previous analyses of these data and with biological explanations for causes of the observed spectra...
  23. ncbi request reprint The dioxin TCDD protects against aflatoxin-induced mutation in female rats, but not in male rats
    A S Thornton
    Centre for Biomedical Research, University of Victoria, Victoria, BC, Canada V8W 3N5
    Mutat Res 561:147-52. 2004
    ..However, the TCDD treatment completely prevented the aflatoxin-induced transversion mutations in female animals...
  24. ncbi request reprint Spontaneous mutation of the lacI transgene in rodents: absence of species, strain, and insertion-site influence
    S Zhang
    Centre for Environmental Health, Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    Environ Mol Mutagen 37:141-6. 2001
    ..In addition to insights into spontaneous mutation, this study also provides essential data for comparison with and interpretation of induced mutations...
  25. ncbi request reprint Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum
    Shulin Zhang
    Department of Biology, Centre for Environmental Health, University of Victoria, Victoria, BC, Canada V8W 3N5
    Mutat Res 500:67-74. 2002
    ..We conclude that thymic lymphomas arising in Msh2 deficient genetic background are hypermutable and the altered mutational spectrum might be an indication of infidelity of DNA replication during tumorigenesis...
  26. ncbi request reprint Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue rats
    Haiyan Yang
    Department of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada
    Mutagenesis 18:195-200. 2003
    ..The inhibitory effect of CLA against PhIP-induced mutagenicity suggests a possibility for its application in human chemoprevention studies...
  27. ncbi request reprint The effect of dietary restriction on PhIP-induced mutation in the distal colon and B[a]P- and ENU-induced mutation in the liver of the rat
    Gordon T Cooney
    Centre for Biomedical Research, University of Victoria, BC, Canada
    Nutr Cancer 50:63-70. 2004
    ..These results indicate that a reduction in dietary intake has no preventive effect against PhIP-induced mutation in the colon, but has sex-dependent protective effects against B[a]P- and ENU-induced mutation in the liver...
  28. ncbi request reprint Sex-specific induction of mutations by PhIP in the kidney of male and female rats and its modulation by conjugated linoleic acid
    Haiyan Yang
    Centre for Biomedical Research, Department of Biology, University of Victoria, British Columbia, Canada
    Environ Mol Mutagen 40:116-21. 2002
    ..Our data indicate that the kidney of the rats responds in a sex-dependent way to mutagenesis and antimutagenesis by PhIP and CLA. These differences may be related to hormonally regulated induction of P450 enzymes or cell proliferation...
  29. ncbi request reprint Msh2 deficiency increases the mutation frequency in all parts of the mouse colon
    Shulin Zhang
    Centre for Biomedical Research, Department of Biology, University of Victoria, Victoria, BC, Canada
    Environ Mol Mutagen 40:243-50. 2002
    ..Due to the prevalence of frameshift mutations in HNPCC patients, this haploinsufficiency effect of the Msh2 gene in safeguarding genomic integrity may have important implications for human carrier status...
  30. ncbi request reprint Effect of conjugated linoleic acid on the formation of spontaneous and PhIP-induced mutation in the colon and cecum of rats
    Haiyan Yang
    Department of Biology, Center for Environmental Health, University of Victoria, Victoria, BC, Canada V8W 3N5
    Mutat Res 500:157-68. 2002
    ..75 ACF/rat, with 1.7 aberrant crypts /ACF in the colon of male rats, all located in the distal colon. This induction was completely inhibited by the addition of CLA...
  31. pmc A new mutator phenotype in breast cancer?
    Johan G de Boer
    Centre for Biomedical Research, Department of Biology, University of Victoria, Victoria, BC, Canada
    Proc Natl Acad Sci U S A 99:3368-9. 2002