Research Topics
Species | J G de BoerSummaryAffiliation: University of Victoria Country: Canada Publications
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Detail Information
Publications
Regulation and expression of sexual differentiation factors in embryonic and extragonadal tissues of Atlantic salmonKristian R von Schalburg
Department of Biology, Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, Canada
BMC Genomics 12:31. 2011..Although the function of these factors in sexual differentiation have been defined, their roles in early development before sexual fate decisions and in tissues beyond the brain or gonad are essentially unknown...- Isolation, characterization and comparison of Atlantic and Chinook salmon growth hormone 1 and 2Kristian R von Schalburg
Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, V8W 3N5, Canada
BMC Genomics 9:522. 2008.... - Evolution of duplicated IgH loci in Atlantic salmon, Salmo salarMotoshige Yasuike
Department of Biology, University of Victoria, Victoria, British Columbia, Canada
BMC Genomics 11:486. 2010..1 Mb) and IGH-B (0.9 Mb) loci. In addition, over 7,000 cDNA clones from the IgH variable (VH) region have been sequenced and analyzed... 
Protection by dietary compounds against mutation in a transgenic rodentJ G de Boer
Centre for Environmental Health, University of Victoria, Victoria, British Columbia, Canada
J Nutr 131:3082S-6S. 2001..These results demonstrate that the lacI transgenic rodent is a useful model for the study of chemoprevention in vivo...- On the origin of unusual mutations recovered from the lacI transgenic assayJohan G de Boer
Centre for Biomedical Research, University of Victoria, P O Box 3020 STN CSC, Victoria BC, Canada V8W 3N5
Mutat Res 536:1-6. 2003..These mutants demonstrate that mutations resulting from diverse mechanisms, in addition to the normal point mutations, can be recovered. In addition, the data indicate that such mutations may often not be of animal origin... - Chemoprotection against N-nitrosomethylbenzylamine-induced mutation in the rat esophagusJohan G de Boer
Centre for Biomedical Research, University of Victoria, Victoria BC, Canada
Nutr Cancer 50:168-73. 2004..In contrast, the addition of 5% ethanol to the drinking water increased the mutagenicity of NMBA. This is consistent with findings that these compounds modulate NMBA-induced carcinogenesis in the rat... - Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensisJohan G de Boer
Centre for Biomedical Research, University of Victoria, P O Box 3020 STN CSC, Victoria, BC, Canada V8W 3N5
Mutat Res 578:15-22. 2005..This study demonstrates how a combination of generating and analysis of plant varieties together with a mammalian assay for efficacy may improve the search for better plant-based prevention of cancer initiation... 
Bursts and horizontal evolution of DNA transposons in the speciation of pseudotetraploid salmonidsJohan G de Boer
Centre for Biomedical Research, University of Victoria, Victoria, BC V8W 2Y2 Canada
BMC Genomics 8:422. 2007..We analyzed the DNA sequence of several large loci in Salmo salar and other species for the presence of DNA transposon families...- Tris(2,3-dibromopropyl)phosphate causes a gradient of mutations in the cortex and outer and inner medullas of the kidney of lacI transgenic ratsJ G de Boer
Centre for Environmental Health, University of Victoria, Victoria, British Columbia, Canada
Environ Mol Mutagen 36:1-4. 2000..This is also the first known case when transgenic animals have been used to study mutation at the suborgan level... - Polymorphisms in DNA repair and environmental interactionsJohan G de Boer
Centre for Biomedical Research, University of Victoria, PO Box 3020, STC CSC, Victoria, Canada, BC V8W 3N5
Mutat Res 509:201-10. 2002..This review will concentrate on the mismatch repair, nucleotide repair, base excision repair, strand break repair, and direct alkyl repair pathways... - Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic miceJ G de Boer
Centre for Environmental Health, Department of Biology, University of Victoria, Victoria BC, Canada
Environ Mol Mutagen 34:80-3. 1999..No changes from the spontaneous spectrum were detected. The comparison of the outcome of DMN treatment at 3 and 6 weeks confirms a change in metabolic activation, adduct removal, or mutation fixation between 3 and 6 weeks of age... - Spontaneous mutation in lacI transgenic mice: a comparison of tissuesJ G de Boer
Centre for Environmental Health, University of Victoria, BC, Canada
Mutagenesis 13:109-14. 1998.... - The lacI gene as a target for mutation in transgenic rodents and Escherichia coliJ G de Boer
Centre for Environmental Health, University of Victoria, British Columbia, Canada
Genetics 148:1441-51. 1998..In addition, we compare the nature of deletion mutations between bacteria and animals. Based on the nature of deletions in the animals, we conclude that each deletion occurs in a single copy of the gene... - Spectrum of spontaneous mutations in liver tissue of lacI transgenic miceJ G de Boer
Department of Biology, University of Victoria, British Columbia, Canada
Environ Mol Mutagen 30:273-86. 1997..The establishment of this substantial database of spontaneous mutations in the liver of Big Blue mice is intended to serve as a reference against which mutations recovered after treatment can be compared... - Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue ratsG R Stuart
Centre for Environmental Health and the Department of Biology, University of Victoria, Canada
Mutat Res 452:101-21. 2000..The evaluation of PhIP-induced mutational responses in these two transgenes serves as a model for intergenic mutational analyses... - Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic ratsJ G de Boer
Center for Environmental Health, University of Victoria, BC, Canada
Mutat Res 352:73-8. 1996..This study represents the first interspecies look into the molecular nature of mutations in the lacI transgenic rodents... - Mutations induced by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in cecum and proximal and distal colon of lacI transgenic ratsG R Stuart
Centre for Environmental Health and Department of Biology, University of Victoria, PO Box 3020 STN CSC, Victoria, British Columbia, Canada V8W 3N5
Mutagenesis 16:431-7. 2001..Therefore, we surmise that following induction of mutations by PhIP in male and female colons, non-mutagenic factors, possibly hormonal, preferentially influence the formation of tumors in the colon of male rats... - Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thioneH Yang
Centre for Environmental Health, University of Victoria, Victoria, BC, Canada V8W 3N5
Nutr Cancer 39:259-66. 2001..In conclusion, CLA and DTT modulate PhIP-induced mutagenesis in a tissue-specific manner, and different modulation pathways are employed by CLA and DTT... - Mutagenicity of TCDD in Big Blue transgenic ratsA S Thornton
Centre for Environmental Health, University of Victoria, P.O. Box 3020, Victoria, BC, Canada V8W 3N5
Mutat Res 478:45-50. 2001..After 6 weeks of exposure to 2 microg/kg TCDD neither an increase in mutation frequency nor any change in mutation spectrum was observed in either male or female animals... - Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colonS Zhang
Centre for Environmental Health, Department of Biology, University of Victoria, Victoria, BC, V8W 3N5, Canada
Oncogene 20:6066-72. 2001..It also provides insight into interaction between genetic and environmental factors in human carcinogenesis... - Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic miceG R Stuart
Centre for Environmental Health, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
Genetics 154:1291-300. 2000..Hence, no evidence was found to support hypotheses that predict that oxidative damage or accumulation of errors in nuclear DNA contributes significantly to the aging process, at least in these three somatic tissues... - Use of log-linear analysis to construct explanatory models for TDBP- and AFB1-induced mutation spectra in lacI transgenic animalsM E Brackley
Centre for Environmental Health, University of Victoria, P O Box 3020 STN CSC, Victoria, B C, Canada
Mutat Res 425:55-69. 1999..The resulting statistical models are consistent with previous analyses of these data and with biological explanations for causes of the observed spectra... - The dioxin TCDD protects against aflatoxin-induced mutation in female rats, but not in male ratsA S Thornton
Centre for Biomedical Research, University of Victoria, Victoria, BC, Canada V8W 3N5
Mutat Res 561:147-52. 2004..However, the TCDD treatment completely prevented the aflatoxin-induced transversion mutations in female animals... - Spontaneous mutation of the lacI transgene in rodents: absence of species, strain, and insertion-site influenceS Zhang
Centre for Environmental Health, Department of Biology, University of Victoria, Victoria, British Columbia, Canada
Environ Mol Mutagen 37:141-6. 2001..In addition to insights into spontaneous mutation, this study also provides essential data for comparison with and interpretation of induced mutations... - Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrumShulin Zhang
Department of Biology, Centre for Environmental Health, University of Victoria, Victoria, BC, Canada V8W 3N5
Mutat Res 500:67-74. 2002..We conclude that thymic lymphomas arising in Msh2 deficient genetic background are hypermutable and the altered mutational spectrum might be an indication of infidelity of DNA replication during tumorigenesis... - Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue ratsHaiyan Yang
Department of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada
Mutagenesis 18:195-200. 2003..The inhibitory effect of CLA against PhIP-induced mutagenicity suggests a possibility for its application in human chemoprevention studies... - The effect of dietary restriction on PhIP-induced mutation in the distal colon and B[a]P- and ENU-induced mutation in the liver of the ratGordon T Cooney
Centre for Biomedical Research, University of Victoria, BC, Canada
Nutr Cancer 50:63-70. 2004..These results indicate that a reduction in dietary intake has no preventive effect against PhIP-induced mutation in the colon, but has sex-dependent protective effects against B[a]P- and ENU-induced mutation in the liver... - Sex-specific induction of mutations by PhIP in the kidney of male and female rats and its modulation by conjugated linoleic acidHaiyan Yang
Centre for Biomedical Research, Department of Biology, University of Victoria, British Columbia, Canada
Environ Mol Mutagen 40:116-21. 2002..Our data indicate that the kidney of the rats responds in a sex-dependent way to mutagenesis and antimutagenesis by PhIP and CLA. These differences may be related to hormonally regulated induction of P450 enzymes or cell proliferation... - Msh2 deficiency increases the mutation frequency in all parts of the mouse colonShulin Zhang
Centre for Biomedical Research, Department of Biology, University of Victoria, Victoria, BC, Canada
Environ Mol Mutagen 40:243-50. 2002..Due to the prevalence of frameshift mutations in HNPCC patients, this haploinsufficiency effect of the Msh2 gene in safeguarding genomic integrity may have important implications for human carrier status... - Effect of conjugated linoleic acid on the formation of spontaneous and PhIP-induced mutation in the colon and cecum of ratsHaiyan Yang
Department of Biology, Center for Environmental Health, University of Victoria, Victoria, BC, Canada V8W 3N5
Mutat Res 500:157-68. 2002..75 ACF/rat, with 1.7 aberrant crypts /ACF in the colon of male rats, all located in the distal colon. This induction was completely inhibited by the addition of CLA... - A new mutator phenotype in breast cancer?Johan G de Boer
Centre for Biomedical Research, Department of Biology, University of Victoria, Victoria, BC, Canada
Proc Natl Acad Sci U S A 99:3368-9. 2002