Jean N DaSilva

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. doi request reprint Insulin restores myocardial presynaptic sympathetic neuronal integrity in insulin-resistant diabetic rats
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada
    J Nucl Cardiol 20:845-56. 2013
  2. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
  3. ncbi request reprint Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography
    Jean N DaSilva
    PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Eur J Nucl Med Mol Imaging 29:1680-3. 2002
  4. doi request reprint Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model
    Stephanie L Thorn
    Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 54:1637-44. 2013
  5. ncbi request reprint In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues
    Miran Kenk
    Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Nucl Med Biol 34:71-7. 2007
  6. doi request reprint Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PET
    Marc Lamoureux
    National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Nucl Med Commun 33:917-25. 2012
  7. doi request reprint Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[(11)C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues
    Miran Kenk
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Nucl Med Biol 35:515-21. 2008
  8. doi request reprint PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart
    Adam J Thomas
    Cardiovascular PET Molecular Function and Imaging Program, National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 52:263-9. 2011
  9. doi request reprint Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity
    Miran Kenk
    National Cardiac PET Centre, Division of Cardiology Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada
    J Nucl Cardiol 17:254-63. 2010
  10. ncbi request reprint Presence of specific 11C-meta-Hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue
    James T Thackeray
    Cardiovascular PET Molecular Imaging Program, National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 48:1733-40. 2007

Collaborators

Detail Information

Publications39

  1. doi request reprint Insulin restores myocardial presynaptic sympathetic neuronal integrity in insulin-resistant diabetic rats
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada
    J Nucl Cardiol 20:845-56. 2013
    ..The temporal development of sympathetic neuronal dysfunction, response to therapy, and relation to ventricular function is not well characterized...
  2. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
    ....
  3. ncbi request reprint Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography
    Jean N DaSilva
    PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Eur J Nucl Med Mol Imaging 29:1680-3. 2002
    ..R-[(11)C]Rolipram is thus suitable for imaging PDE4 and possibly cAMP signal transduction in the living human brain with PET...
  4. doi request reprint Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model
    Stephanie L Thorn
    Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 54:1637-44. 2013
    ..A noninvasive and repeatable method for assessing mouse myocardial glucose uptake with (18)F-FDG PET and Patlak kinetic analysis was systematically assessed using the vena cava image-derived blood input function (IDIF)...
  5. ncbi request reprint In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues
    Miran Kenk
    Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Nucl Med Biol 34:71-7. 2007
    ..PDE4 activity and expression are regulated by cAMP levels, suggesting that measurement of PDE4 provides an index of intracellular cAMP signaling...
  6. doi request reprint Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PET
    Marc Lamoureux
    National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Nucl Med Commun 33:917-25. 2012
    ..This study aimed to quantitatively evaluate population variability, regional uniformity and repeatability of myocardial blood flow measurements using [13N]-ammonia and small animal PET...
  7. doi request reprint Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[(11)C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues
    Miran Kenk
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Nucl Med Biol 35:515-21. 2008
    ....
  8. doi request reprint PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart
    Adam J Thomas
    Cardiovascular PET Molecular Function and Imaging Program, National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 52:263-9. 2011
    ..The aim of this study was to characterize (R)-(11)C-rolipram binding in the rat myocardium in vivo, using small-animal PET...
  9. doi request reprint Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity
    Miran Kenk
    National Cardiac PET Centre, Division of Cardiology Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada
    J Nucl Cardiol 17:254-63. 2010
    ..Altered sympathetic nervous system signaling is known to play a role in the cardiotoxicity of the anthracycline chemotherapeutic agents, but the interaction of pre- and postsynaptic function is not well understood...
  10. ncbi request reprint Presence of specific 11C-meta-Hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue
    James T Thackeray
    Cardiovascular PET Molecular Imaging Program, National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 48:1733-40. 2007
    ....
  11. doi request reprint Test-retest repeatability of quantitative cardiac 11C-meta-hydroxyephedrine measurements in rats by small animal positron emission tomography
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y4W7
    Nucl Med Biol 40:676-81. 2013
    ..This study evaluated the repeatability of multiple quantitative cardiac measurements of HED retention and washout and the pharmacological response to reuptake blockade and enhanced norepinephrine levels...
  12. doi request reprint (18)F-FDG cell labeling may underestimate transplanted cell homing: more accurate, efficient, and stable cell labeling with hexadecyl-4-[(18)F]fluorobenzoate for in vivo tracking of transplanted human progenitor cells by positron emission tomography
    Yan Zhang
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Cell Transplant 21:1821-35. 2012
    ..18)F-HFB cell labeling with PET imaging offers a better modality to enhance our understanding of early retention, homing, and engraftment with cardiac cell therapy...
  13. doi request reprint Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET
    Mireille Lortie
    Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada, K1Y 4W7
    Mol Imaging Biol 14:225-36. 2012
    ..R)-[(11)C]rolipram and (S)-[(11)C]rolipram have been proposed to investigate phosphodiesterase-4 and, indirectly, cAMP-mediated signaling with PET. This study assessed binding of these tracers to phosphodiesterase-4 in canine myocardium...
  14. doi request reprint Single-phase CT aligned to gated PET for respiratory motion correction in cardiac PET/CT
    R Glenn Wells
    Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 51:1182-90. 2010
    ....
  15. doi request reprint Analysis of [11C]methyl-candesartan kinetics in the rat kidney for the assessment of angiotensin II type 1 receptor density in vivo with PET
    Mireille Lortie
    Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Nucl Med Biol 40:252-61. 2013
    ..The aim of this study was to assess binding of the novel radioligand [(11)C]methyl-candesartan to AT(1) receptors in the rat kidney in vivo with PET...
  16. doi request reprint Characterizing the normal range of myocardial blood flow with ⁸²rubidium and ¹³N-ammonia PET imaging
    Jennifer M Renaud
    Department of Physics, University of Ottawa Carleton University Institute of Physics, Ottawa, ON, Canada
    J Nucl Cardiol 20:578-91. 2013
    ..The goal of this study was to investigate the trade-off between noise and accuracy in both (82)Rb and (13)N-ammonia normal databases formed using a net retention model...
  17. ncbi request reprint Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart
    Celia M Lourenco
    PET Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Life Sci 79:356-64. 2006
    ..Use of (R)-[(11)C]rolipram and positron emission tomography as an index of PDE4 activity could provide insight into understanding disease states with altered NA, 5HT and HA concentrations...
  18. ncbi request reprint PET measurements of cAMP-mediated phosphodiesterase-4 with (R)-[11C]rolipram
    Miran Kenk
    National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Radiopharm 4:44-58. 2011
    ....
  19. doi request reprint Relation between right ventricular function and increased right ventricular [18F]fluorodeoxyglucose accumulation in patients with heart failure
    Lisa M Mielniczuk
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada
    Circ Cardiovasc Imaging 4:59-66. 2011
    ....
  20. doi request reprint Reduced septal glucose metabolism predicts response to cardiac resynchronization therapy
    David Birnie
    University of Ottawa Heart Institute, 40 Ruskin Road, Ottawa, ON K1Y 4W7, Canada
    J Nucl Cardiol 19:73-83. 2012
    ..Therefore, this study's objective was to assess whether greater septal R-MM pattern predicts response to CRT...
  21. pmc Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, K1Y 4W7, Canada
    Cardiovasc Diabetol 10:75. 2011
    ....
  22. doi request reprint Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats
    Michael Greene
    National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y4W7, Canada and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Can J Physiol Pharmacol 87:196-202. 2009
    ..Lean DR rats maintained PDE4 responsiveness indicative of a normal NA signal transduction...
  23. ncbi request reprint Tracking stem cell therapy in the myocardium: applications of positron emission tomography
    Yan Zhang
    National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    Curr Pharm Des 14:3835-53. 2008
    ..These two cell tracking approaches used for PET imaging are reviewed here and compared against other imaging modalities...
  24. doi request reprint Reduced CGP12177 binding to cardiac β-adrenoceptors in hyperglycemic high-fat-diet-fed, streptozotocin-induced diabetic rats
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y4W7
    Nucl Med Biol 38:1059-66. 2011
    ..The aim of this study was to examine the suitability of this tracer for evaluation of altered β-AR expression in diabetic rat hearts...
  25. doi request reprint Collagen-based matrices improve the delivery of transplanted circulating progenitor cells: development and demonstration by ex vivo radionuclide cell labeling and in vivo tracking with positron-emission tomography
    Yan Zhang
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Canada
    Circ Cardiovasc Imaging 1:197-204. 2008
    ....
  26. doi request reprint Preclinical evaluation of biopolymer-delivered circulating angiogenic cells in a swine model of hibernating myocardium
    Celine Giordano
    Division of Cardiac Surgery, Molecular Function and Imaging Program at the Cardiac PET Centre, Division of Cardiology, and Department of Cellular and Molecular Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ Cardiovasc Imaging 6:982-91. 2013
    ..However, to date, no experimental data have been available in this context; we therefore examined the biopolymer-supported delivery of circulating angiogenic cells using a clinically relevant swine model of hibernating myocardium...
  27. ncbi request reprint Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography
    Benjamin J W Chow
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 47:411-6. 2006
    ..The aim of this study was to compare treadmill exercise (TEX) and dipyridamole stress on the uptake and retention of N-13 ammonia...
  28. ncbi request reprint Is septal glucose metabolism altered in patients with left bundle branch block and ischemic cardiomyopathy?
    Kerry Thompson
    Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Nucl Med 47:1763-8. 2006
    ..The aim of this study was to determine the effect of LBBB on septal metabolism in patients with ICM, LV dysfunction, and LBBB...
  29. ncbi request reprint Quantification of myocardial blood flow with 82Rb dynamic PET imaging
    Mireille Lortie
    Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada
    Eur J Nucl Med Mol Imaging 34:1765-74. 2007
    ..The goal of this study was to investigate the use of a one-compartment model of (82)Rb kinetics for the quantification of myocardial blood flow...
  30. doi request reprint Novel O-[(11)C]methylated derivatives of candesartan as angiotensin II AT(1) receptor imaging ligands: radiosynthesis and ex vivo evaluation in rats
    Tayebeh Hadizad
    National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Canada ON K1Y 4W7
    Bioorg Med Chem 17:7971-7. 2009
    ..This study indicates that [(11)C]methyl-candesartan has potential for in vivo imaging renal AT(1) receptors selectively using positron emission tomography...
  31. ncbi request reprint The effects of continuous positive airway pressure on myocardial energetics in patients with heart failure and obstructive sleep apnea
    Keiichiro Yoshinaga
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada
    J Am Coll Cardiol 49:450-8. 2007
    ..We sought to examine the short-term and longer term (6-week) effects of continuous positive airway pressure (CPAP) on myocardial energetics...
  32. doi request reprint The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
    Ali Ahmadi
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada Molecular Function and Imaging Program, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada
    Biomaterials 35:4749-58. 2014
    ..These findings indicate that the synergistic therapeutic effect of CACs + matrix therapy in MI requires the matrix to enhance CAC function via α2β1 and α5 integrin signaling mechanisms, rather than simply delivering the cells. ..
  33. ncbi request reprint Current and future clinical applications of cardiac positron emission tomography
    Hiroshi Ohira
    National Cardiac PET Centre, in the Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ J 77:836-48. 2013
    ..The scope of this review is to summarize the state-of-the-art advances in PET imaging methodology, clinical utility and potential future application...
  34. doi request reprint Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 135:762-70, 770.e1. 2008
    ....
  35. doi request reprint Radiosynthesis of N-[(11)C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)
    Ana C Valdivia
    National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ont, Canada K1Y 4W7
    Appl Radiat Isot 68:325-8. 2010
    ..The radiochemical and chemical purities of N-[(11)C]-methyl-hydroxyfasudil were >95% and specific radioactivity was 1565-2565mCi/mumol at the end of the synthesis...
  36. pmc Altered sympathetic nervous system signaling in the diabetic heart: emerging targets for molecular imaging
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, University of Ottawa Heart Institute Canada Department of Cellular and Molecular Medicine, Faculty of Graduate and Postdoctoral Studies, University of Ottawa Canada
    Am J Nucl Med Mol Imaging 2:314-34. 2012
    ..Finally, the review will attempt to define the future role of these non-invasive nuclear imaging techniques in diabetes research and clinical care...
  37. ncbi request reprint Up-regulated dopamine D1 receptor binding can be detected in vivo following repeated SCH 23390, but not SKF 81297 or 6-hydroxydopamine, treatments
    Robert A Schwartz
    PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Eur J Pharmacol 459:195-201. 2003
    ..The present study has implications for studies imaging dopamine D1 receptors in neuropsychiatric disorders with abnormal dopamine stimulation using positron emission tomography...
  38. ncbi request reprint Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada
    Am J Psychiatry 160:90-9. 2003
    ....
  39. ncbi request reprint Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders
    Keiichiro Yoshinaga
    National Cardiac PET Centre, University of Ottawa Heart Institute, Ontario, Canada
    Curr Pharm Des 11:903-32. 2005
    ..This paper will also review the application of receptor ligand imaging and the principles of using surrogate physiological end-points in early drug development and evaluation...