Shyamala Dakshinamurti

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn
    S Dakshinamurti
    Department of Pediatrics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, Canada
    Pediatr Pulmonol 39:492-503. 2005
  2. ncbi Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17
    S Dakshinamurti
    Department of Pediatrics, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada
    Pediatr Pulmonol 40:398-407. 2005
  3. ncbi Regulation of myosin light chain phosphatase and pulmonary arterial relaxation
    Shyamala Dakshinamurti
    Department of Pediatrics, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 83:893-8. 2005
  4. doi Palmitoylation of Gαq determines its association with the thromboxane receptor in hypoxic pulmonary hypertension
    Anuraq S Sikarwar
    1 Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba Canada and
    Am J Respir Cell Mol Biol 50:135-43. 2014
  5. pmc New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Cell Biol 33:184-93. 2013
  6. doi Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho
    Jena Fediuk
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Physiol Lung Cell Mol Physiol 302:L13-26. 2012
  7. ncbi Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes
    M Hinton
    Department of Physiology, University of Manitoba, and Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Canada R3A 1R9
    Am J Physiol Lung Cell Mol Physiol 290:L375-84. 2006
  8. ncbi Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics
    Martha Hinton
    Department of Physiology, University of Manitoba, Manitoba Institute of Child Health, Manitoba, Canada
    Am J Physiol Lung Cell Mol Physiol 292:L654-63. 2007
  9. doi Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada Biology of Breathing Group Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada
    PLoS ONE 9:e85937. 2014
  10. doi Persistent pulmonary hypertension results in reduced tetralinoleoyl-cardiolipin and mitochondrial complex II + III during the development of right ventricular hypertrophy in the neonatal pig heart
    Harjot K Saini-Chohan
    Department of Pharmacology and Therapeutics, Manitoba Institute of Child Health, Winnepeg, Manitoba, Canada
    Am J Physiol Heart Circ Physiol 301:H1415-24. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn
    S Dakshinamurti
    Department of Pediatrics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, Canada
    Pediatr Pulmonol 39:492-503. 2005
    ....
  2. ncbi Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17
    S Dakshinamurti
    Department of Pediatrics, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada
    Pediatr Pulmonol 40:398-407. 2005
    ..We speculate that CPI-17 may play a role in myosin phosphatase upregulation during neonatal circulatory transition, and in hypoxic inhibition of pulmonary phosphatase activity in PPHN...
  3. ncbi Regulation of myosin light chain phosphatase and pulmonary arterial relaxation
    Shyamala Dakshinamurti
    Department of Pediatrics, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 83:893-8. 2005
    ..In light of the reviewed literature, further speculation is proposed on the potential contributions of these mechanisms to the pathophysiology of the perinatal pulmonary arterial relaxation defect in PPHN...
  4. doi Palmitoylation of Gαq determines its association with the thromboxane receptor in hypoxic pulmonary hypertension
    Anuraq S Sikarwar
    1 Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba Canada and
    Am J Respir Cell Mol Biol 50:135-43. 2014
    ..Palmitoylation of both cysteines is required for Gαq membrane localization and Ca(2+) mobilization. Depalmitoylation of any one Gαq cysteine reduces the hypoxic response to thromboxane challenge to equal that of normoxic cells. ..
  5. pmc New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Cell Biol 33:184-93. 2013
    ....
  6. doi Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho
    Jena Fediuk
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Physiol Lung Cell Mol Physiol 302:L13-26. 2012
    ..Both basal APM and the APM response to U46619 are increased in PPHN PA. APM corresponds with increased force generation to U46619 challenge in PPHN PA but not renal arteries...
  7. ncbi Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes
    M Hinton
    Department of Physiology, University of Manitoba, and Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Canada R3A 1R9
    Am J Physiol Lung Cell Mol Physiol 290:L375-84. 2006
    ..We postulate that hypoxia increases agonist-induced TP-R-linked IP3 pathway activation. Myocyte thromboxane hyperresponsiveness persists in culture after removal from the initiating hypoxic stimulus, suggesting altered gene expression...
  8. ncbi Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics
    Martha Hinton
    Department of Physiology, University of Manitoba, Manitoba Institute of Child Health, Manitoba, Canada
    Am J Physiol Lung Cell Mol Physiol 292:L654-63. 2007
    ..Also, the appearance of TP-R in resistance arteries after development of hypoxic PPHN may contribute to increased pulmonary arterial pressure...
  9. doi Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada Biology of Breathing Group Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada
    PLoS ONE 9:e85937. 2014
    ..Our findings have important therapeutic applications in the treatment of TP mediated pathophysiological conditions. ..
  10. doi Persistent pulmonary hypertension results in reduced tetralinoleoyl-cardiolipin and mitochondrial complex II + III during the development of right ventricular hypertrophy in the neonatal pig heart
    Harjot K Saini-Chohan
    Department of Pharmacology and Therapeutics, Manitoba Institute of Child Health, Winnepeg, Manitoba, Canada
    Am J Physiol Heart Circ Physiol 301:H1415-24. 2011
    ..These defects in cardiolipin may play an important role in the rapid development of RV dysfunction and right heart failure in PPHN...
  11. ncbi Transumbilical catheter intervention of ductus arteriosus in neonatal swine
    Abhay Divekar
    Pediatric Cardiology and Manitoba Institute of Child Health, Department of Pediatric and Child Health, Health Sciences Center, University of Manitoba, Winnipeg, Manitoba, Canada
    J Invest Surg 20:313-7. 2007
    ..Advantages over traditional methods include avoiding technical problems inherent with traversing right heart structures and surgical wounds. Access to the DA along its natural orientation facilitates intervention...
  12. pmc High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant
    Bing Xu
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 8:e76481. 2013
    ..This is the first study to report on the successful high-level expression, purification, and biophysical characterization of a naturally occurring, diffusible ligand activated GPCR CAM...
  13. ncbi Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, John Buhler Research Centre, Winnipeg, Manitoba, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L1406-18. 2007
    ..These results indicate caveolae and caveolin-1 facilitate [Ca(2+)](i) mobilization leading to ASM contraction induced by submaximal concentrations of ACh...
  14. pmc Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 7:e29996. 2012
    ..Naturally occurring mutations in conjunction with site-directed replacements can serve as powerful tools in assessing the importance of regional helix-helix interactions...
  15. doi Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation
    Vasantha Atmuri
    Department of Biochemistry and Medical Genetics, The University of Manitoba, Winnipeg, MB, Canada
    Matrix Biol 27:653-60. 2008
    ..We conclude that HYAL3 does not play a major role in constitutive HA degradation...
  16. doi Hypoxic neonatal pulmonary arterial myocytes are sensitized to ROS-generated 8-isoprostane
    Y Gong
    Manitoba Institute of Child Health, University of Manitoba, Winnipeg, Man, Canada
    Free Radic Biol Med 48:882-94. 2010
    ..8-Isoprostane binds to sensitized TP receptors, causing receptor internalization and signaling to calcium release in hypoxic myocytes. 8-Isoprostane may be an important pulmonary vasoconstrictor during neonatal hypoxia...