M I Cybulsky

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions
    Su Ning Zhu
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 206:2141-9. 2009
  2. pmc Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis
    Jenny Jongstra-Bilen
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 203:2073-83. 2006
  3. pmc Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration
    J R Chan
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Toronto General Research Institute, Toronto, Ontario, M5G 2C4, Canada
    J Exp Med 193:1149-58. 2001
  4. ncbi request reprint Leukocyte adhesion molecules in atherogenesis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Toronto General Hospital Research Institute, ON, Canada
    Clin Chim Acta 286:207-18. 1999
  5. doi request reprint Resident intimal dendritic cells and the initiation of atherosclerosis
    Myron I Cybulsky
    Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 21:397-403. 2010
  6. ncbi request reprint Leukocyte recruitment to atherosclerotic lesions
    Myron I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, University Health Network, Toronto, Canada
    Can J Cardiol 20:24B-28B. 2004
  7. pmc The fractalkine receptor CX3CR1 is a key mediator of atherogenesis
    Myron I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, UHN, 200 Elizabeth Street, Eaton 4, Toronto, Ontario, Canada M5G 2C4
    J Clin Invest 111:1118-20. 2003
  8. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
  9. ncbi request reprint Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage
    H M Dansky
    Rockefeller University, New York, NY, and the Toronto General Research Institute M I C, University of Toronto, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 21:1662-7. 2001
  10. ncbi request reprint Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
    E K Griffiths
    Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1
    Science 293:2260-3. 2001

Collaborators

Detail Information

Publications34

  1. pmc GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions
    Su Ning Zhu
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 206:2141-9. 2009
    ..These findings establish GM-CSF as a key regulator of intimal cell proliferation in lesions, and demonstrate that both proliferation and monocyte recruitment contribute to the inception of atherosclerosis...
  2. pmc Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis
    Jenny Jongstra-Bilen
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 203:2073-83. 2006
    ..Intimal CD68+ leukocytes were reduced in VCAM-1-deficient mice, suggesting that mechanisms of leukocyte accumulation in the intima of normal aorta are analogous to those in atherosclerosis...
  3. pmc Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration
    J R Chan
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Toronto General Research Institute, Toronto, Ontario, M5G 2C4, Canada
    J Exp Med 193:1149-58. 2001
    ....
  4. ncbi request reprint Leukocyte adhesion molecules in atherogenesis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Toronto General Hospital Research Institute, ON, Canada
    Clin Chim Acta 286:207-18. 1999
    ..Finally, ongoing studies are summarized which utilize transgenic mice to assess the roles of individual adhesion molecules in atherosclerotic lesion formation...
  5. doi request reprint Resident intimal dendritic cells and the initiation of atherosclerosis
    Myron I Cybulsky
    Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 21:397-403. 2010
    ..To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors...
  6. ncbi request reprint Leukocyte recruitment to atherosclerotic lesions
    Myron I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, University Health Network, Toronto, Canada
    Can J Cardiol 20:24B-28B. 2004
    ..For example, insights may be gained to distinguish the contribution of chemokines, chemokine receptors and adhesion molecules to the recruitment, survival or proliferation of different leukocyte types in atherosclerotic lesions...
  7. pmc The fractalkine receptor CX3CR1 is a key mediator of atherogenesis
    Myron I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, UHN, 200 Elizabeth Street, Eaton 4, Toronto, Ontario, Canada M5G 2C4
    J Clin Invest 111:1118-20. 2003
  8. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis...
  9. ncbi request reprint Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage
    H M Dansky
    Rockefeller University, New York, NY, and the Toronto General Research Institute M I C, University of Toronto, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 21:1662-7. 2001
    ..Our data demonstrate that VCAM-1 plays a pivotal role in the initiation of atherosclerosis in Apoe(-/-) mice...
  10. ncbi request reprint Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
    E K Griffiths
    Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1
    Science 293:2260-3. 2001
    ..Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion...
  11. ncbi request reprint Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation
    Mark D Peterson
    Division of Cardiac Surgery, Department of Surgery, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Immunol 174:8072-81. 2005
    ..Thus, activation of monocyte beta(2) integrins by alpha-gal expressed on xenogeneic endothelium provides a mechanism that may explain the dramatic accumulation of monocytes in vivo...
  12. ncbi request reprint Alpha 4 beta 1 integrin/VCAM-1 interaction activates alpha L beta 2 integrin-mediated adhesion to ICAM-1 in human T cells
    J R Chan
    Department of Laboratory Medicine, University of Toronto, Toronto General Hospital Research Institute, Toronto, Canada
    J Immunol 164:746-53. 2000
    ..A role for the cytoskeleton is implicated in this process...
  13. pmc The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
    L Hajra
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, M5G 2C4, Canada
    Proc Natl Acad Sci U S A 97:9052-7. 2000
    ....
  14. ncbi request reprint Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis
    Jenny Jongstra-Bilen
    Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 181:288-98. 2008
    ....
  15. ncbi request reprint Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants
    Sharon J Hyduk
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Blood 109:176-84. 2007
    ..A critical role for PLC and calmodulin was also established for leukocyte arrest and adhesion strengthening...
  16. ncbi request reprint Alpha 4 integrin signaling activates phosphatidylinositol 3-kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but induces a distinct rearrangement of the actin cytoskeleton
    Sharon J Hyduk
    Toronto General Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 168:696-704. 2002
    ..Qualitatively similar morphological and adhesive changes to those observed with Jurkat cells were observed following alpha(4) integrin or CD3 stimulation of human peripheral blood T cells...
  17. ncbi request reprint Paxillin selectively associates with constitutive and chemoattractant-induced high-affinity alpha4beta1 integrins: implications for integrin signaling
    Sharon J Hyduk
    Toronto General Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Blood 104:2818-24. 2004
    ..These data suggest that ligand binding to high-affinity alpha4beta1 integrins may initiate outside-in signaling cascades through paxillin that regulate leukocyte maturation and emigration...
  18. ncbi request reprint Detecting rapid and transient upregulation of leukocyte integrin affinity induced by chemokines and chemoattractants
    Jason R Chan
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Toronto General Research Institute, Toronto, ON, Canada
    J Immunol Methods 273:43-52. 2003
    ....
  19. doi request reprint Aortic regurgitation dramatically alters the distribution of atherosclerotic lesions and enhances atherogenesis in mice
    Yu Qing Zhou
    Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 30:1181-8. 2010
    ..We developed a mouse model of aortic valve regurgitation (AR) to change the aortic flow pattern and observed the effects on plaque formation...
  20. ncbi request reprint Monocyte-induced endothelial calcium signaling mediates early xenogeneic endothelial activation
    Mark D Peterson
    Division of Cardiac Surgery, The Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Transplant 5:237-47. 2005
    ..Taken together, these data suggest that human monocytes are capable of activating xenogeneic endothelial cells through calcium transients, as well as other distinct pathways...
  21. ncbi request reprint Detection of high-affinity alpha4-integrin upon leukocyte stimulation by chemoattractants or chemokines
    Jason R Chan
    Department of Laboratory Medicine and Pathobiology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Methods Mol Biol 239:261-8. 2004
  22. doi request reprint Role of alpha4beta1 integrins in chemokine-induced monocyte arrest under conditions of shear stress
    Sharon J Hyduk
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Microcirculation 16:17-30. 2009
    ....
  23. doi request reprint The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression
    Hao Liu
    Multi Organ Transplant Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada
    Eur J Immunol 38:3114-26. 2008
    ..The identification of specific receptor binding has important implications for the pathogenesis of immune-mediated disease and suggests a potential for targeted FGL2 therapy...
  24. ncbi request reprint Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis
    Itay Shalev
    Multi Organ Transplant Program, Department of Immunology, University of Toronto, Ontario, Canada
    J Immunol 180:249-60. 2008
    ..Collectively, these data suggest that FGL2 contributes to Treg cell activity and inhibits the development of autoimmune disease...
  25. pmc Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow
    Doyon Won
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Am J Pathol 171:1691-704. 2007
    ....
  26. ncbi request reprint Role of double-negative regulatory T cells in long-term cardiac xenograft survival
    Wenhao Chen
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2C4 Canada
    J Immunol 170:1846-53. 2003
    ....
  27. ncbi request reprint Tracking of leukocyte recruitment into tissues of mice by in situ labeling of blood cells with the fluorescent dye CFDA SE
    Henry M Becker
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto General Hospital, 200 Elizabeth Street, Eaton 4, Toronto, Ontario, Canada M5G 2C4
    J Immunol Methods 286:69-78. 2004
    ..Labeled leukocytes can be tracked as they accumulate in lymphoid tissues and sites of inflammation and then be immunophenotyped for analysis by flow cytometry. This method is rapid, reproducible and simple to perform...
  28. ncbi request reprint Region-specific patterns of vascular remodelling occur early in atherosclerosis and without loss of smooth muscle cell markers
    Shivalika Handa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
    Atherosclerosis 196:617-23. 2008
    ..Here we sought to determine if regions of the mouse aorta with varying susceptibilities for atherosclerosis display differential vascular remodelling and SMC gene expression at the earliest stages of disease...
  29. ncbi request reprint Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line
    Rachel G Khadaroo
    Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Biol Chem 278:47834-41. 2003
    ....
  30. ncbi request reprint Getting to the site of inflammation: the leukocyte adhesion cascade updated
    Klaus Ley
    Robert M Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 7:678-89. 2007
    ..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade...
  31. doi request reprint Morphing the topography of atherosclerosis: an unexpected role for PECAM-1
    Myron I Cybulsky
    Arterioscler Thromb Vasc Biol 28:1887-9. 2008
  32. ncbi request reprint Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis
    Chunjie Wang
    Cellular and Molecular Biology Division, Toronto Western Research Institute, Canada
    J Immunol 169:415-23. 2002
    ....
  33. ncbi request reprint Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
    Romeo Ricci
    Cardiovascular Research, Institute of Physiology, and Division of Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Science 306:1558-61. 2004
    ..Thus, JNK2-dependent phosphorylation of SR-A promotes uptake of lipids in macrophages, thereby regulating foam cell formation, a critical step in atherogenesis...
  34. doi request reprint Endothelial nitric oxide synthase gene expression during murine embryogenesis: commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system
    Anouk Martine Teichert
    Renal Division and Department of Medicine, St Michael s Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Circ Res 103:24-33. 2008
    ..In summary, transcriptional activity of the eNOS gene in the murine circulatory system occurred following the establishment of embryonic blood flow. Thus, the eNOS gene is a late-onset gene in endothelial ontogeny...