Asher D Cutter

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Integrating phylogenetics, phylogeography and population genetics through genomes and evolutionary theory
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks St, Toronto, ON M5S 3B2, Canada Electronic address
    Mol Phylogenet Evol 69:1172-85. 2013
  2. pmc Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest
    Marie Anne Felix
    Institut de Biologie Valrose, CNRS, UMR7277, Parc Valrose, Nice Cedex 02, 06108, France
    BMC Evol Biol 13:10. 2013
  3. doi request reprint Molecular hyperdiversity and evolution in very large populations
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Mol Ecol 22:2074-95. 2013
  4. doi request reprint Genomic signatures of selection at linked sites: unifying the disparity among species
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Nat Rev Genet 14:262-74. 2013
  5. doi request reprint The polymorphic prelude to Bateson-Dobzhansky-Muller incompatibilities
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
    Trends Ecol Evol 27:209-18. 2012
  6. doi request reprint Influence of finite-sites mutation, population subdivision and sampling schemes on patterns of nucleotide polymorphism for species with molecular hyperdiversity
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Mol Ecol 21:1345-59. 2012
  7. pmc Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genome Res 20:1103-11. 2010
  8. pmc Patterns of molecular evolution in Caenorhabditis preclude ancient origins of selfing
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Genetics 178:2093-104. 2008
  9. pmc Multilocus patterns of polymorphism and selection across the X chromosome of Caenorhabditis remanei
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Genetics 178:1661-72. 2008
  10. doi request reprint Divergence times in Caenorhabditis and Drosophila inferred from direct estimates of the neutral mutation rate
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Canada
    Mol Biol Evol 25:778-86. 2008

Collaborators

Detail Information

Publications44

  1. doi request reprint Integrating phylogenetics, phylogeography and population genetics through genomes and evolutionary theory
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks St, Toronto, ON M5S 3B2, Canada Electronic address
    Mol Phylogenet Evol 69:1172-85. 2013
    ....
  2. pmc Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest
    Marie Anne Felix
    Institut de Biologie Valrose, CNRS, UMR7277, Parc Valrose, Nice Cedex 02, 06108, France
    BMC Evol Biol 13:10. 2013
    ..elegans developmental biology and molecular genetics, biologists lack basic data for understanding the abundance and distribution of Caenorhabditis species in natural areas that are unperturbed by human influence...
  3. doi request reprint Molecular hyperdiversity and evolution in very large populations
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Mol Ecol 22:2074-95. 2013
    ....
  4. doi request reprint Genomic signatures of selection at linked sites: unifying the disparity among species
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Nat Rev Genet 14:262-74. 2013
    ..We advocate targeted studies of closely related species to unify our understanding of how selection and linkage interact to shape genome evolution...
  5. doi request reprint The polymorphic prelude to Bateson-Dobzhansky-Muller incompatibilities
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
    Trends Ecol Evol 27:209-18. 2012
    ..Explicit integration of VRI into speciation theory will help to quantify the relative roles of genetic drift and selection in speciation, but this synthesis requires substantial new contributions from both theory and empirical studies...
  6. doi request reprint Influence of finite-sites mutation, population subdivision and sampling schemes on patterns of nucleotide polymorphism for species with molecular hyperdiversity
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Mol Ecol 21:1345-59. 2012
    ....
  7. pmc Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genome Res 20:1103-11. 2010
    ..briggsae, Arabidopsis thaliana, Lycopersicon, human). These results illustrate how recombination, mutation, selection, and population history interact in important ways to shape molecular heterogeneity within and between genomes...
  8. pmc Patterns of molecular evolution in Caenorhabditis preclude ancient origins of selfing
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Genetics 178:2093-104. 2008
    ....
  9. pmc Multilocus patterns of polymorphism and selection across the X chromosome of Caenorhabditis remanei
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Genetics 178:1661-72. 2008
    ..remanei for detecting natural selection from genomic scans of polymorphism...
  10. doi request reprint Divergence times in Caenorhabditis and Drosophila inferred from direct estimates of the neutral mutation rate
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Canada
    Mol Biol Evol 25:778-86. 2008
    ..These revised dates have important implications for rates of genome evolution and the origin of self-fertilization in Caenorhabditis...
  11. doi request reprint Reproductive evolution: symptom of a selfing syndrome
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada
    Curr Biol 18:R1056-8. 2008
    ..Naturally occurring loss of plg-1 function results in males that fail to deposit mating plugs - a manifestation of relaxed sexual selection since the evolution of self-fertilization in this species...
  12. doi request reprint Polymorphism, divergence, and the role of recombination in Saccharomyces cerevisiae genome evolution
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada
    Mol Biol Evol 28:1745-54. 2011
    ..We conclude that widespread natural selection across the yeast genome has left its imprint on segregating genetic variation, but that this signature is much weaker than in Drosophila and Caenorhabditis...
  13. ncbi request reprint Selection intensity on preferred codons correlates with overall codon usage bias in Caenorhabditis remanei
    Asher D Cutter
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Curr Biol 16:2053-7. 2006
    ..We therefore conclude that coincident patterns of current and ancient selection are responsible for shaping biased codon usage in the C. remanei genome...
  14. pmc High nucleotide polymorphism and rapid decay of linkage disequilibrium in wild populations of Caenorhabditis remanei
    Asher D Cutter
    Institute of Evolutionary Biology, University of Edinburgh, United Kingdom
    Genetics 174:901-13. 2006
    ..This will be especially important if self-fertilization evolved recently in C. elegans history, because most of the evolutionary time separating C. elegans from its known relatives would have occurred in a state of obligate outcrossing...
  15. ncbi request reprint The evolution of biased codon and amino acid usage in nematode genomes
    Asher D Cutter
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 23:2303-15. 2006
    ....
  16. doi request reprint Evolution of the Caenorhabditis elegans genome
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada
    Mol Biol Evol 26:1199-234. 2009
    ..We also emphasize the potential importance of evolution in the gonochoristic (female and male) ancestors of the androdioecious (hermaphrodite and male) C. elegans as the source for many of its genomic and developmental patterns...
  17. doi request reprint Molecular population genetics and phenotypic sensitivity to ethanol for a globally diverse sample of the nematode Caenorhabditis briggsae
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks St, Toronto, ON, Canada M5S 3B2
    Mol Ecol 19:798-809. 2010
    ..briggsae's natural history and natural genetic variation greatly expand the potential of this organism as an emerging model for studies in molecular and quantitative genetics, the evolution of development, and ecological genetics...
  18. pmc The evolutionary dynamics of operon distributions in eukaryote genomes
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genetics 185:685-93. 2010
    ..This theory, and applications to C. elegans and Ciona, motivates several new and testable hypotheses about eukaryote operon evolution...
  19. pmc Patterns of nucleotide polymorphism distinguish temperate and tropical wild isolates of Caenorhabditis briggsae
    Asher D Cutter
    Institute of Evolutionary Biology, University of Edinburgh, UK
    Genetics 173:2021-31. 2006
    ..briggsae into northern latitudes. We discuss these findings in relation to their implications for selection, demographic history, and the persistence of self-fertilization...
  20. doi request reprint Population frequencies of transposable elements in selfing and outcrossing Caenorhabditis nematodes
    Elie S Dolgin
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, Edinburgh, UK
    Genet Res (Camb) 90:317-29. 2008
    ..elegans, but subject to purifying selection in C. remanei. These results are consistent with a reduced efficacy of natural selection against TEs in selfing populations, but may in part be explained by non-equilibrium TE dynamics...
  21. ncbi request reprint Inbreeding and outbreeding depression in Caenorhabditis nematodes
    Elie S Dolgin
    Institute of Evolutionary Biology, University of Edinburgh, King s Buildings, Edinburgh, UK
    Evolution 61:1339-52. 2007
    ..elegans performed better than crosses between strains, indicating outbreeding depression. The results are discussed in relation to the evolution of androdioecy and the effect of mating system on the level of inbreeding depression...
  22. pmc Global population genetic structure of Caenorhabditis remanei reveals incipient speciation
    Alivia Dey
    Department of Ecology and Evolutionary Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada
    Genetics 191:1257-69. 2012
    ....
  23. pmc On the potential for extinction by Muller's ratchet in Caenorhabditis elegans
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:125. 2008
    ..The potential for such a process to occur would inform our understanding of the time since the origin of self-fertilization in C. elegans history...
  24. doi request reprint Experimental evolution of sperm count in protandrous self-fertilizing hermaphrodites
    Rosalind L Murray
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S3B2, Canada
    J Exp Biol 214:1740-7. 2011
    ..These findings demonstrate how developmental trajectories can shape the fitness landscape for the evolution of reproduction and sperm traits, even without sexual selection...
  25. pmc Nucleotide polymorphism and linkage disequilibrium in wild populations of the partial selfer Caenorhabditis elegans
    Asher D Cutter
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 172:171-84. 2006
    ..I propose that genetic variation in this species is shaped largely by population subdivision due to self-fertilization coupled with long- and short-range migration between subpopulations...
  26. doi request reprint Temperature-dependent behaviours are genetically variable in the nematode Caenorhabditis briggsae
    Gregory W Stegeman
    University of Toronto, Department of Ecology and Evolutionary Biology, 25 Willcocks Street, Toronto, ON, Canada, M5S 3B2
    J Exp Biol 216:850-8. 2013
    ..These patterns of temperature-dependent behaviour motivate further development of C. briggsae as a model system for dissecting the genetic underpinnings of complex behavioural traits...
  27. pmc MicroRNA sequence variation potentially contributes to within-species functional divergence in the nematode Caenorhabditis briggsae
    Richard Jovelin
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genetics 189:967-76. 2011
    ..These findings demonstrate the potential for miRNA polymorphisms to contribute to phenotypic variation within a species. Sequences were deposited in GenBank under accession nos. JN251323-JN251744...
  28. pmc Molecular hyperdiversity defines populations of the nematode Caenorhabditis brenneri
    Alivia Dey
    Department of Ecology and Evolutionary Biology, University of Toronto, ON, Canada M5S 3B2
    Proc Natl Acad Sci U S A 110:11056-60. 2013
    ..These findings in an animal galvanize tests of theory about the evolution of complexity in genomes and phenotypes and enable molecular population genetics methods to finely resolve uncharacterized functional noncoding elements. ..
  29. doi request reprint Temperature-dependent fecundity associates with latitude in Caenorhabditis briggsae
    Anisha Prasad
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Evolution 65:52-63. 2011
    ..Available and emerging genetic tools for this organism will permit the characterization of the evolutionary genetic basis to this putative example of adaptation in latitudinally separated populations...
  30. pmc Fine-scale signatures of molecular evolution reconcile models of indel-associated mutation
    Richard Jovelin
    Department of Ecology and Evolutionary Biology, University of Toronto, Ontario, Canada
    Genome Biol Evol 5:978-86. 2013
    ..The striking influence of indel variants on the molecular evolution of flanking sequences strengthens the emerging general view that mutations can induce further mutations...
  31. doi request reprint Gene duplication in the evolution of sexual dimorphism
    Minyoung J Wyman
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada
    Evolution 66:1556-66. 2012
    ..We conclude that the data are consistent with a role of gene duplication in fostering male-biased, but not female-biased, gene expression, thereby aiding the evolution of sexual dimorphism...
  32. pmc Heritable determinants of male fertilization success in the nematode Caenorhabditis elegans
    Rosalind L Murray
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, M5S 3B2 Ontario, Canada
    BMC Evol Biol 11:99. 2011
    ..We also quantified male mating ability in assays for rates of courtship and successful copulation, and then assessed the roles of these pre- and post-mating traits in first- and second-male fertilization success...
  33. doi request reprint Genetic variation for postzygotic reproductive isolation between Caenorhabditis briggsae and Caenorhabditis sp. 9
    Joanna L Kozlowska
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada
    Evolution 66:1180-95. 2012
    ..briggsae serves as maternal parent. These findings highlight Caenorhabditis as an emerging system for understanding the genetics of general patterns of reproductive isolation...
  34. doi request reprint Specialist versus generalist life histories and nucleotide diversity in Caenorhabditis nematodes
    Shuning Li
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada, M5S 3B2, Department of Applied Biological Sciences, Saga University, Saga 840 8502, Japan
    Proc Biol Sci 281:20132858. 2014
    ..A literature survey of diverse organisms provides broader support for the SGVH. These findings encourage further testing of ecological and evolutionary hypotheses with comparative population genetics in Caenorhabditis and other taxa. ..
  35. ncbi request reprint Integrating patterns of polymorphism at SNPs and STRs
    Bret A Payseur
    Laboratory of Genetics, University of Wisconsin, Genetics Biotechnology 2428, 425 G Henry Mall, Madison, WI 53706, USA
    Trends Genet 22:424-9. 2006
    ..Examples illustrate how knowledge of these relationships could aid population genetic inference, indicating the need for thorough theoretical studies...
  36. ncbi request reprint Searching for evidence of positive selection in the human genome using patterns of microsatellite variability
    Bret A Payseur
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, Arizona 85721, USA
    Mol Biol Evol 19:1143-53. 2002
    ..These results also suggest that the effects of positive selection may be more pronounced on the X chromosome than on the autosomes in humans...
  37. ncbi request reprint Selection at linked sites in the partial selfer Caenorhabditis elegans
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 20:665-73. 2003
    ..Clarification of the relative roles of genetic hitchhiking and background selection in C. elegans awaits the development of specific theoretical predictions that account for partial self-fertilization and biased sex ratios...
  38. pmc Molecular correlates of genes exhibiting RNAi phenotypes in Caenorhabditis elegans
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genome Res 13:2651-7. 2003
    ..This approach also allows prediction of a set of heretofore-uncharacterized loci for which we expect future RNAi studies to reveal phenotypic effects (i.e., false negatives in present screens)...
  39. ncbi request reprint Clustered organization of reproductive genes in the C. elegans genome
    Michael A Miller
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Curr Biol 14:1284-90. 2004
    ..elegans genome in clustering. Because clustered genes have a direct role in reproduction and thus fitness, their aggregated pattern might have been shaped by natural selection, perhaps as hermaphroditism evolved...
  40. ncbi request reprint Sexual and temporal dynamics of molecular evolution in C. elegans development
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, USA
    Mol Biol Evol 22:178-88. 2005
    ....
  41. ncbi request reprint Postcopulatory sexual selection reduces genetic diversity in experimental populations of Caenorhabditis elegans
    Craig W LaMunyon
    Department of Biological Sciences, California State Polytechnic University, Pomona, CA 91768, USA
    J Hered 98:67-72. 2007
    ..Although sequential hermaphrodites like C. elegans probably experience little sexual selection in nature, these data suggest that sexual selection can profoundly affect diversity in outcrossing taxa...
  42. ncbi request reprint The proximate determinants of sex ratio in C. elegans populations
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genet Res 81:91-102. 2003
    ..Finally, we discuss the short-term and long-term factors that are likely to affect sex ratio and breeding system evolution in species like C. elegans...
  43. ncbi request reprint Transposable element orientation bias in the Drosophila melanogaster genome
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    J Mol Evol 61:733-41. 2005
    ..We therefore conclude that premature termination of host gene transcription due to the presence of poly(A) signal motifs in retroelements might only partially explain strand-specific detrimental effects in the D. melanogaster genome...
  44. ncbi request reprint Sperm-limited fecundity in nematodes: how many sperm are enough?
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 8571, USA
    Evolution 58:651-5. 2004
    ..Several testable hypotheses follow from the model regarding how natural selection and environmental variation may influence patterns of sperm production among populations or species with a similar mode of reproduction...