S C Cunnane

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Beta-oxidation of linoleate in obese men undergoing weight loss
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Am J Clin Nutr 73:709-14. 2001
  2. ncbi request reprint Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?
    Stephen C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    Lipids 38:477-84. 2003
  3. ncbi request reprint Survival of the fattest: fat babies were the key to evolution of the large human brain
    Stephen C Cunnane
    Department of Nutritional Sciences, University of Toronto, M5S 3E2, Toronto, Canada
    Comp Biochem Physiol A Mol Integr Physiol 136:17-26. 2003
  4. ncbi request reprint Application of new methods and analytical approaches to research on polyunsaturated fatty acid homeostasis
    S C Cunnane
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Lipids 36:975-9. 2001
  5. ncbi request reprint NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain
    S C Cunnane
    Department of Nutritional Sciences, University of Toronto, Canada
    J Mol Neurosci 16:173-80; discussion 215-21. 2001
  6. ncbi request reprint Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Prostaglandins Leukot Essent Fatty Acids 67:131-5. 2002
  7. ncbi request reprint Problems with essential fatty acids: time for a new paradigm?
    Stephen C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, M5S 3E2, Toronto, Canada
    Prog Lipid Res 42:544-68. 2003
  8. ncbi request reprint Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate
    S C Cunnane
    Department of Nutritional Sciences, University of Toronto, Canada
    Lipids 35:105-11. 2000
  9. ncbi request reprint Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Prostaglandins Leukot Essent Fatty Acids 60:387-92. 1999
  10. ncbi request reprint Utilization of carbon from dietary polyunsaturates for brain cholesterol synthesis during early postnatal development in the rat: a 13C NMR study
    S S Likhodii
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Magn Reson Med 34:803-13. 1995

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Beta-oxidation of linoleate in obese men undergoing weight loss
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Am J Clin Nutr 73:709-14. 2001
    ..This method can also provide quantitative information about the beta-oxidation of linoleate in humans...
  2. ncbi request reprint Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?
    Stephen C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    Lipids 38:477-84. 2003
    ....
  3. ncbi request reprint Survival of the fattest: fat babies were the key to evolution of the large human brain
    Stephen C Cunnane
    Department of Nutritional Sciences, University of Toronto, M5S 3E2, Toronto, Canada
    Comp Biochem Physiol A Mol Integr Physiol 136:17-26. 2003
    ..We believe that fresh- and salt-water shorelines provided a uniquely rich, abundant and accessible food supply, and the only viable environment for evolving both body fat and larger brains in human infants...
  4. ncbi request reprint Application of new methods and analytical approaches to research on polyunsaturated fatty acid homeostasis
    S C Cunnane
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Lipids 36:975-9. 2001
    ..Further application of these recently developed methods in different models should clarify the emerging importance of beta-oxidation and carbon recycling in PUFA homeostasis in mammals including humans...
  5. ncbi request reprint NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain
    S C Cunnane
    Department of Nutritional Sciences, University of Toronto, Canada
    J Mol Neurosci 16:173-80; discussion 215-21. 2001
    ....
  6. ncbi request reprint Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Prostaglandins Leukot Essent Fatty Acids 67:131-5. 2002
    ....
  7. ncbi request reprint Problems with essential fatty acids: time for a new paradigm?
    Stephen C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, M5S 3E2, Toronto, Canada
    Prog Lipid Res 42:544-68. 2003
    ....
  8. ncbi request reprint Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate
    S C Cunnane
    Department of Nutritional Sciences, University of Toronto, Canada
    Lipids 35:105-11. 2000
    ..2% of alpha-LnA intake to DHA to match the DHA accumulation of breast-fed infants. We conclude that dietary DHA should likely be provided during at least the first 6 mon of life...
  9. ncbi request reprint Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Prostaglandins Leukot Essent Fatty Acids 60:387-92. 1999
    ....
  10. ncbi request reprint Utilization of carbon from dietary polyunsaturates for brain cholesterol synthesis during early postnatal development in the rat: a 13C NMR study
    S S Likhodii
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Magn Reson Med 34:803-13. 1995
    ..Comparison of 13C-13C unit arrangements in both cholesterol and desmosterol allowed carbons 26 and 27 of desmosterol to be unambiguously assigned...
  11. ncbi request reprint Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet
    S S Likhodii
    Departments of Nutritional Sciences and Pharmacology and Bloorview Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Canada
    Epilepsia 41:1400-10. 2000
    ..The purpose of the present experiments was to compare the efficiency of different fats in inducing ketosis and affording seizure resistance...
  12. ncbi request reprint Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    Metabolism 54:1127-32. 2005
    ..In the absence of sustained ketosis, changes in fatty acid metabolism resulting in an increase in brain polyunsaturates, particularly docosahexaenoic acid may, nevertheless, contribute to the seizure protection by the ketogenic diet...
  13. ncbi request reprint Lipid and fatty acid profiles in rats consuming different high-fat ketogenic diets
    C A Dell
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Lipids 36:373-8. 2001
    ..In combination with our present data from the same seizure study, it appears that ketogenic diets with widely differing effects on tissue lipids and fatty acid profiles can confer a similar amount of seizure protection...
  14. ncbi request reprint Breath acetone predicts plasma ketone bodies in children with epilepsy on a ketogenic diet
    Kathy Musa-Veloso
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutrition 22:1-8. 2006
    ....
  15. ncbi request reprint Metabolic and health implications of moderate ketosis and the ketogenic diet
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada, ON MSS 3E2
    Prostaglandins Leukot Essent Fatty Acids 70:233-4. 2004
  16. ncbi request reprint Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Lipids 41:933-5. 2006
    ..05). We conclude that carbon recycling into saturated and monounsaturated fatty acids persists when the main end products of ALA recycling are provided in excess, using a ketogenic diet...
  17. ncbi request reprint Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant
    Richard P Bazinet
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Immunol Lett 95:85-90. 2004
    ..Thus, a high 18:3omega3 intake in pigs modulates immune function and tissue fatty acids in response to immunization...
  18. ncbi request reprint A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women
    U McCloy
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    J Lipid Res 45:474-85. 2004
    ..Conversion of [(13)C]linoleate and [(13)C]alpha-linolenate to longer chain polyunsaturates was a quantitatively minor route of utilization...
  19. ncbi request reprint Intramuscular injection of antigens and adjuvant preferentially decreases 18:2n-6 and 18:3n-3 in pig neck muscle
    Richard P Bazinet
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Lipids 38:1221-6. 2003
    ..It appears that 18:2n-6 and 18:3n-3 are preferentially metabolized (possibly beta-oxidized) in response to antigens...
  20. ncbi request reprint Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals
    Kathy Musa-Veloso
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Am J Clin Nutr 76:65-70. 2002
    ..To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed...
  21. ncbi request reprint Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet
    Sergei S Likhodii
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, M5S 1A8 Canada
    Clin Chem 48:115-20. 2002
    ....
  22. ncbi request reprint Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats
    Richard P Bazinet
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario MS 3E2, Canada
    Lipids 38:187-9. 2003
    ..Despite adequate 18:3n-3 intake, n-6 PUFA deficiency decreased the accumulation of 18:3n-3 and total n-3 PUFA...
  23. ncbi request reprint Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3
    Richard P Bazinet
    Department of Nutritional Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Lipid Res 44:314-9. 2003
    ..The high 18:3omega3 diet decreased the whole-body oxidation of 18:2omega6 by 73% and of 18:3omega3 by 63% in NSW pigs. We conclude that moderately cleaner housing SEW significantly decreases 18:2omega6 and 18:3omega3 oxidation in pigs...
  24. pmc Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis
    David J A Jenkins
    Department of Medicine, Division of Endocrinology, St Michael s Hospital, Toronto, Ont
    CMAJ 178:157-64. 2008
    ....
  25. ncbi request reprint Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 76:365-72. 2002
    ..Many of the benefits of soy have been attributed to soy isoflavones...
  26. ncbi request reprint The conditional nature of the dietary need for polyunsaturates: a proposal to reclassify 'essential fatty acids' as 'conditionally-indispensable' or 'conditionally-dispensable' fatty acids
    S C Cunnane
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Br J Nutr 84:803-12. 2000
    ....
  27. ncbi request reprint Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet
    Richard P Bazinet
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 3E2, Canada
    Lipids 38:1045-9. 2003
    ..A high 18:3n-3 intake in the sow increases not only the 18:3n-3 but also the 22:6n-3 content of sow's milk and the tissues of the suckling piglet...
  28. ncbi request reprint Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center, J Alick Little Core Lipid Laboratory, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 65:1524-33. 1997
    ..We conclude that psyllium lowered LDL- and HDL-cholesterol concentrations similarly at both MUFA intakes. However, there may be some advantage in combining soluble fiber and MUFA to reduce the ratio of LDL to HDL cholesterol...
  29. ncbi request reprint Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    J Am Coll Nutr 27:367-78. 2008
    ..Due to significant heterogeneity in the response to fish oils, further studies are required before making widespread recommendations for all groups to increase consumption of fish and fish oil...
  30. ncbi request reprint Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols
    Irina Serbanescu
    Division of Neurology, Brain and Behavior Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Lipid Res 45:2038-43. 2004
    ..Either lovastatin has a different mechanism of action than these late-stage cholesterol inhibitors or the brain sterol changes are not directly responsible for seizures in this model...
  31. ncbi request reprint Brain sterols in the AY-9944 rat model of atypical absence seizures
    Miguel A Cortez
    Division of Neurology, The Brain and Behavior Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 43:3-8. 2002
    ..AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined...
  32. ncbi request reprint Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements
    Mélanie Plourde
    Research Center on Aging, Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, 1036 Belvedere St, South, Sherbrooke, QC J1H 4C4, Canada
    Appl Physiol Nutr Metab 32:619-34. 2007
    ..Despite this inefficient conversion, there are potential roles in human health for ALA and EPA that could be independent of their metabolism to DHA through the desaturation - chain elongation pathway...
  33. ncbi request reprint Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates
    Stephen C Cunnane
    Research Center on Aging, Sherbrooke University Geriatric Institute, Quebec, Canada
    Pediatr Res 59:107-10. 2006
    ..8-fold more in the brain. We conclude that carbon recycling is an integral part of neonatal metabolism of alpha-linolenate and is not simply an overflow pathway arising from excess availability of preformed docosahexaenoate...
  34. ncbi request reprint alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk
    Eddie Vos
    Am J Clin Nutr 85:920-1; author reply 921-2. 2007
  35. ncbi request reprint Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal
    Stephen C Cunnane
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Hum Biol 19:578-81. 2007
    ..Hence, we reject Carlson and Kingston's position and reiterate support for the concept that access to shore-based diets containing docosahexaenoic acid was necessary for hominin encephalization beyond the level seen in the great apes...
  36. ncbi request reprint Claims to identify detrimental effects of the ketogenic diet (KD) on cognitive function in rats
    Stephen C Cunnane
    Pediatr Res 56:663-4; author reply 664. 2004
  37. ncbi request reprint Metabolism of polyunsaturated fatty acids and ketogenesis: an emerging connection
    Stephen C Cunnane
    Research Center on Aging, Sherbrooke University Geriatric Institute, Sherbrooke QC, Canada J1H 4C4
    Prostaglandins Leukot Essent Fatty Acids 70:237-41. 2004
    ..Both the molecular controls on these pathways and their clinical significance still need elucidation...
  38. ncbi request reprint Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens
    C Leigh Broadhurst
    US Department of Agriculture, Environmental Chemistry Laboratory, Agricultural Research Service, Beltsville, MD 20705, USA
    Comp Biochem Physiol B Biochem Mol Biol 131:653-73. 2002
    ....
  39. ncbi request reprint Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael sHospital, Toronto
    Am J Clin Nutr 75:834-9. 2002
    ..The US Food and Drug Administration (FDA) approved health claims for 2 dietary fibers, beta-glucan (0.75 g/serving) and psyllium (1.78 g/serving), on the assumption that 4 servings/d would reduce cardiovascular disease risk...
  40. ncbi request reprint Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain
    Stephen C Cunnane
    Am J Clin Nutr 82:483; author reply 483-4. 2005
  41. doi request reprint Conjugated linoleic acids: why the discrepancy between animal and human studies?
    Mélanie Plourde
    Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Nutr Rev 66:415-21. 2008
    ..The relatively unknown metabolic fate of CLA in humans may also be a contributing factor that helps explain the lack of consistency for CLA efficacy across studies...
  42. ncbi request reprint Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial
    LeAnne T Bloedon
    Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    J Am Coll Nutr 27:65-74. 2008
    ..We studied the effects of flaxseed on markers of cardiovascular risk in hypercholesterolemic adults...
  43. doi request reprint [11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice
    Simon Authier
    Sherbrooke Molecular Imaging Center, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue N, Sherbrooke, QC, Canada, J1H 5N4
    Mol Imaging Biol 10:217-23. 2008
    ..Our objective was to evaluate [11C]acetoacetate as a potential tracer of ketone body utilization by breast and prostate tumors and to compare it with [11C]acetate...
  44. ncbi request reprint Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial
    Sylvie Dodin
    Department of Obstetrics and Gynecology, Research Center, St François d Assise Hospital CHUQ, Quebec, Quebec, Canada
    Nutrition 24:23-30. 2008
    ..The present study evaluated the effect of flaxseed on markers of cardiovascular disease risk in healthy menopausal women...
  45. ncbi request reprint Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality
    Eddie Vos
    Am J Clin Nutr 77:521-2. 2003
  46. ncbi request reprint Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose
    Sebastien Tremblay
    Research Center on Aging, Sherbrooke University Geriatric Institute, 1036 Belvedere Street South, Sherbrooke, Quebec, Canada J1H 4C4
    Appl Radiat Isot 65:934-40. 2007
    ..HPLC analysis showed < or =3% impurities while residual THF (< or =200 ppm) and ethanol (< or =500 ppm) were well under the tolerable limits for human studies...
  47. ncbi request reprint Biosynthetic production of universally (13)C-labelled polyunsaturated fatty acids as reference materials for natural health product research
    Phuong Mai Le
    Institute for National Measurement Standards, National Research Council, Building M 12, 1200 Montreal Rd, Ottawa, ON, K1A 0R6, Canada
    Anal Bioanal Chem 389:241-9. 2007
    ..Finally, U-(13)C-DHA was enzymatically re-esterified to glycerol to yield a (13)C-labelled tridocosahexaenoin...
  48. ncbi request reprint Docosahexaenoic acid and human brain evolution: missing the forest for the trees--comments by Cunnane
    Stephen C Cunnane
    Research Center on Aging, Department of Medicine, Universite de Sherbrooke, QC, Canada
    Br J Nutr 97:1021-2; discussion 1025. 2007
  49. ncbi request reprint Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers (dietary portfolio) on circulating sterol levels and red cell fragility in hypercholesterolemic subjects
    Peter J Jones
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec
    Lipids 40:169-74. 2005
    ..We conclude that plant sterols had a minimal impact on serum sterol concentrations or red cell fragility in hyperlipidemic subjects on diets that greatly reduced their serum lipids...
  50. ncbi request reprint Omega-3 fatty acids, energy substrates, and brain function during aging
    Erika Freemantle
    Research Centre on Aging, 1036 Belvedere Street South, Universite de Sherbrooke, Sherbrooke, Que, Canada J1H 4C4
    Prostaglandins Leukot Essent Fatty Acids 75:213-20. 2006
    ..Hence, it may be time to consider whether the main omega-3 fatty acids have distinct but complementary roles in brain function...
  51. ncbi request reprint [Survival of the fattest: the key to human brain evolution]
    Stephen C Cunnane
    Centre de recherche sur le vieillissement, Departement de Medecine, physiologie et biophysiques, Faculté de médecine et sciences de la santé, Universite de Sherbrooke, 1036, Belvedere sud, Sherbrooke, Quebec, J1H 4C4, Canada
    Med Sci (Paris) 22:659-63. 2006
    ..Hence, survival of the fattest (babies) was the key to human brain evolution...
  52. ncbi request reprint Comparison of composition and absorption of sugarcane policosanols
    Christopher P F Marinangeli
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, H9X 3V9 Canada
    Br J Nutr 97:381-8. 2007
    ..05) than hamsters receiving APC1. If the cholesterol-lowering efficacy of PC mixtures is dependent on their purity and composition, then sugarcane-derived APC products should possess similar therapeutic properties as the OPC supplement...