B A Croy

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. ncbi Characterization of the cells that migrate from metrial glands of the pregnant mouse uterus during explant culture
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 32:241-63. 1997
  2. ncbi Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors
    E Gallo-Hendrikx
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    APMIS 107:245-56. 1999
  3. pmc Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Exp Med 187:217-23. 1998
  4. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
  5. ncbi Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells
    J D Greenwood
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 21:693-702. 2000
  6. ncbi Primer for non-immunologists on immune-deficient mice and their applications in research
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, ON, Canada
    Comp Med 51:300-13. 2001
  7. ncbi Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy--a review
    B A Croy
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Placenta 21:S77-80. 2000
  8. ncbi Mechanisms regulating immune cell contributions to spiral artery modification -- facts and hypotheses -- a review
    S Leonard
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Placenta 27:S40-6. 2006
  9. ncbi Granulated metrial gland cells: a natural killer cell subset of the pregnant murine uterus
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Microsc Res Tech 25:189-200. 1993
  10. ncbi Demonstration of YAC target cell lysis by murine granulated metrial gland cells
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Cell Immunol 133:116-26. 1991

Collaborators

Detail Information

Publications47

  1. ncbi Characterization of the cells that migrate from metrial glands of the pregnant mouse uterus during explant culture
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 32:241-63. 1997
    ..Thus, the optimal culture conditions for uNK cells remain undefined...
  2. ncbi Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors
    E Gallo-Hendrikx
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    APMIS 107:245-56. 1999
    ..The data suggest that SCID and beige immunodeficiencies may not always have the same value for the modeling of spontaneous tumors as they do for the study of xenografts...
  3. pmc Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Exp Med 187:217-23. 1998
    ..Thus, uNK cells appear to have critical functions in pregnancy that promote decidual health, the appropriate vascularization of implantation sites, and placental size...
  4. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
    ....
  5. ncbi Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells
    J D Greenwood
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 21:693-702. 2000
    ..These studies add strength to the hypothesis that uNK cells may have specialized physiological, rather than classically immune, functions in the pregnant mammalian uterus...
  6. ncbi Primer for non-immunologists on immune-deficient mice and their applications in research
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, ON, Canada
    Comp Med 51:300-13. 2001
    ..Two illustrations on developing appropriate immune deficient animal models for a new research application conclude the review...
  7. ncbi Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy--a review
    B A Croy
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Placenta 21:S77-80. 2000
    ....
  8. ncbi Mechanisms regulating immune cell contributions to spiral artery modification -- facts and hypotheses -- a review
    S Leonard
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Placenta 27:S40-6. 2006
    ..Further, this work suggests that the pro-inflammatory endometrial cytokine response seen when peri-implantation conceptuses arrest has, as its target for destruction, newly developed endometrial vasculature rather than fetal trophoblast...
  9. ncbi Granulated metrial gland cells: a natural killer cell subset of the pregnant murine uterus
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Microsc Res Tech 25:189-200. 1993
    ....
  10. ncbi Demonstration of YAC target cell lysis by murine granulated metrial gland cells
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Cell Immunol 133:116-26. 1991
    ....
  11. ncbi Induction of murine spiral artery modification by recombinant human interferon-gamma
    J M Monk
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    Placenta 26:835-8. 2005
    ..These findings are key in building humanized murine models of pregnancy since they suggest Rag2 null/gammac null mice provide a bioassay system that would detect the functioning of human uNK cells under in vivo conditions...
  12. ncbi Cellular and molecular events in early and mid gestation porcine implantation sites: a review
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
    Soc Reprod Fertil Suppl 66:233-44. 2009
    ..These data provide new insights into the roles of the endometrial immune environment in the regulation of the success and failure of porcine conceptuses...
  13. ncbi Functions of alpha 2 macroglobulins in pregnancy
    Chandrakant Tayade
    Department of Biomedical Sciences, University of Guelph, Guelph, Ont, Canada NIG 2W1
    Mol Cell Endocrinol 245:60-6. 2005
    ..Here, we review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy...
  14. ncbi Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice
    M J Guimond
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Biol Reprod 56:169-79. 1997
    ..These studies are the first to suggest a vital role for large granulated lymphocytes in the promotion of fetal survival and pregnancy success...
  15. ncbi Evaluation of the murine metrial gland for immunological function
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 15:51-69. 1989
    ..Alternatively, differential regulation of cell proliferation might be a function of the MG, within the pregnant uterus. The latter mechanism could also account for the apparent observation of non-specific immunosuppression...
  16. ncbi Preliminary characterization of lymphoid hybridoma cell lines derived from the pregnant mouse uterus
    M van den Heuvel
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 27:13-36. 1994
    ..Because these hybridomas may represent fusion to an early progenitor cell of the NK/GMG cell lineage, their continued characterization is of merit...
  17. ncbi Prolonged gestation does not extend survival of uterine natural killer lymphocytes in mice deleted in the receptor for prostaglandin F2alpha
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
    J Reprod Immunol 46:125-9. 2000
    ....
  18. ncbi Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites
    S Esadeg
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Building 40, Room 2604, Guelph, ON, Canada N1G 2W1
    Placenta 24:912-21. 2003
    ..These findings demonstrate that alpha 2M, and thereby proteinases and/or cytokines whose bio-availability is regulated by alpha 2M, exert significant decidual regulation on trophoblast invasion...
  19. ncbi A study on the relationship between parity and differentiation of granulated metrial gland cells
    J A Luross
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Placenta 17:521-5. 1996
    ....
  20. ncbi Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy
    B A Croy
    Department of Biomedical Sciences, University of Guelph, Ont, Canada
    J Reprod Immunol 35:111-33. 1997
    ....
  21. ncbi Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells
    J H Zhang
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Biol Reprod 69:404-11. 2003
    ..The four genes were induced by gd6, and uNK cells isolated from midgestation transcribed IL-23alpha and IL-27R. This study advances the understanding of uNK cell activation during normal pregnancy...
  22. ncbi Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Am J Reprod Immunol 35:501-9. 1996
    ..Pregnancy-specific functions have been postulated for GMG cells, but no successful depletion of these cells has been achieved that would permit assessment of any critical roles that might influence gestational outcome...
  23. ncbi A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha
    S Chantakru
    Department of Biomedical Sciences, Building 40 Room 2604, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada, N1G 2W1
    J Reprod Immunol 49:33-47. 2001
    ..Thus, migration, distribution and activation of NK cells within the pregnant uterus are independent of CCR2, CCR5 and MIP-1 alpha...
  24. ncbi Granulated metrial gland cells in the pregnant uterus of mice expressing the collagen mutation tight-skin (Tsk/+)
    Y Kiso
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Cell Tissue Res 268:393-6. 1992
    ..5 of gestation. Loss of GMG cells from these regions normally occurs by day 6.5 of gestation. These data suggest that alterations to the ECM change the migration properties or life span of GMG cells...
  25. ncbi Immune competence involving the natural killer cell lineage promotes placental growth
    M Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 20:441-50. 1999
    ....
  26. ncbi Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Semin Immunol 13:235-41. 2001
    ..Grafts from IFN- gamma(-/-)mice are restored uNK cells, but the uNK cells did not reverse the phenotypes. This review focuses on the functions of uNK cell-derived IFN- gamma and the genes that it may regulate in the pregnant uterus...
  27. ncbi Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia?
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Soc Gynecol Investig 7:12-20. 2000
    ..If so, changes in numbers or levels of activity of human uterine NK cells or mutations in genes regulated by uterine interferon-gamma could contribute to initiation of preeclampsia...
  28. ncbi Granulated metrial gland cells: hypotheses concerning possible functions during murine gestation
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 27:85-94. 1994
    ..A broader range of potential functions is discussed and shifts in functional roles played by GMG cells are proposed over the course of gestation...
  29. ncbi Assessment of expression of the receptor for colony-stimulating factor-1 (fms) in bovine trophoblast
    J L Beauchamp
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Biol Reprod 45:811-7. 1991
    ..The data do support a universal role for this protein during mammalian placental development...
  30. ncbi Interferon-gamma contributes to the normalcy of murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 61:493-502. 1999
    ..Furthermore, evidence is presented that IFN-gamma-producing cells exist in mesometrial regions of implantation sites that are neither NK nor T cells...
  31. pmc Experimental sialodacryoadenitis virus infection in severe combined immunodeficient mice
    D H Percy
    Department of Pathology, Ontario Veterinary College, University of Guelph
    Can J Vet Res 55:89-90. 1991
    ..Based on these criteria, there was no evidence that these immunodeficient mice were susceptible to infection with SDA virus...
  32. ncbi What are scid mice and why is it timely to devote a special topic issue to them?
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Lab Anim Sci 43:120-2. 1993
  33. ncbi Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice
    D H Percy
    Department of Pathology, University of Guelph, Ontario, Canada
    Vet Pathol 31:67-73. 1994
    ..B-17 mice. These studies indicate that the genetic differences in susceptibility of two strains of immunocompetent mice to Sendai virus infection are eliminated by expression of the mutations scid and beige...
  34. ncbi Production of capsular material by equine trophoblast transplanted into immunodeficient mice
    A Albihn
    Department of Biomedical Sciences, Ontario Veterinary College, Canada
    Reproduction 125:855-63. 2003
    ..In addition, they demonstrate that xenogeneic grafting is a useful means of culturing endometrium and conceptus tissues outside the mare when in vitro techniques do not suffice...
  35. ncbi A study of granulated metrial gland cell differentiation in pregnant, macrophage-deficient, osteopetrotic (op/op) mice
    Y Kiso
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Experientia 48:973-5. 1992
    ..Thus, the growth factor CSF-1 is not required for differentiation of the uterine NK cell subset known as GMG cells and probably GMG cells do not differentiate from macrophage precursor cells which are deficient in op/op mice...
  36. ncbi Enhancement of pancreatic tumor metastasis in transgenic immunodeficient mice
    E Gallo-Hendrikx
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Oncogene 9:2983-90. 1994
    ..The tissue distribution of metastases was similar to that recorded from human patients with pancreatic cancer, suggesting that mechanisms underlying metastasis in these mice could be similar to those involved in human disease...
  37. ncbi Vascular addressins in the uterus and pancreas of type 1 diabetic mice in early pregnancy
    H Dong
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON K7L 3N6, Canada
    Placenta 29:201-9. 2008
    ..Thus, in type 1 diabetic gestations in mice, signals for the recruitment of circulating cells are reduced in uterus and elevated in pancreas...
  38. ncbi Uterine NK cells in murine pregnancy
    M J Bilinski
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada K7L 3N6
    Reprod Biomed Online 16:218-26. 2008
    ....
  39. doi A map of relationships between uterine natural killer cells and progesterone receptor expressing cells during mouse pregnancy
    M J Oh
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada K7L 3N6
    Placenta 29:317-23. 2008
    ..5. uNK cells had limited, apparently random contact with PR(+) cells throughout pregnancy and never themselves expressed PR. Thus, uNK cell differentiation does not appear to require contact with PR(+) cells...
  40. ncbi Expression of the inducible nitric oxide synthase gene in mouse uterine leukocytes and potential relationships with uterine function during pregnancy
    J S Hunt
    Department of Anatomy, University of Kansas Medical Center, Kansas City 66160 7400, USA
    Biol Reprod 57:827-36. 1997
    ..These findings are consistent with the postulate that leukocyte NO contributes importantly to events associated with successful pregnancy that are likely to include relaxation of vascular smooth muscle...
  41. ncbi Advanced techniques in placental biology -- workshop report
    D M Nelson
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MI, USA
    Placenta 27:S87-90. 2006
    ..Finally, G. Rice presented an overview methods on profiling of complex protein mixtures within tissue and/or fluid samples that, when refined, will offer databases that will underpin a systems approach to modern trophoblast biology...
  42. ncbi Functional analysis of murine uterine natural killer cells genetically devoid of oestrogen receptors
    A M Borzychowski
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institute of Health, P O Box 12233, Research Triangle Park, NC 27709, USA
    Placenta 24:403-11. 2003
    ..Expression of alpha- and beta-ER was absent by RT-PCR from NK cells isolated from the uterus, supporting the conclusions from the in vivo study...
  43. ncbi Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report
    R E Harkness
    Connaught Centre for Biotechnology Research, Willowdale, Ontario, Canada
    APMIS 101:805-10. 1993
    ..SCID/beige mice were more affected than SCID mice both clinically and pathologically, suggesting that natural killer cell and polymorphonuclear cell functions may be important in resolving B. catarrhalis challenge...
  44. ncbi Expression of TJ6 during pregnancy
    J A Kang
    Department of Microbiology and Immunology, Finch University of Health Sciences, Chicago Medical School, IL 60064, USA
    Am J Reprod Immunol 38:183-8. 1997
    ..TJ6 will be one of the molecules involved in fetal-specific immune suppression during pregnancy. In the mouse and human decidua, the regulation of uterine natural killer (uNK) cells is important during pregnancy...
  45. ncbi Comparative aspects of placental evolution: a workshop report
    A M Carter
    Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
    Placenta 28:S129-32. 2007
  46. ncbi The study of human neoplastic disease in severe combined immunodeficient mice
    S S Williams
    Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
    Lab Anim Sci 43:139-46. 1993
    ..Characteristics which distinguish scid mice from nude mice are emphasized and a discussion of future prospects is included...
  47. ncbi There are many approaches to the culture of human trophoblast but few that facilitate study of complex interactions between fetal and maternal tissues
    T Poehlmann
    Placenta 25:357-8. 2004