B A Croy

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. pmc Trafficking of peripheral blood CD56(bright) cells to the decidualizing uterus--new tricks for old dogmas?
    Marianne van den Heuvel
    Department of Pediatrics, University of Western Ontario, Child Health Research Institute, London, Ontario, Canada N6C 2V5
    J Reprod Immunol 67:21-34. 2005
  2. ncbi Prolonged gestation does not extend survival of uterine natural killer lymphocytes in mice deleted in the receptor for prostaglandin F2alpha
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
    J Reprod Immunol 46:125-9. 2000
  3. pmc Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Reproduction 126:149-60. 2003
  4. ncbi Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia?
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Soc Gynecol Investig 7:12-20. 2000
  5. ncbi Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ont N1G 2W1, Guelph, Canada
    J Reprod Immunol 59:175-91. 2003
  6. ncbi Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy--a review
    B A Croy
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Placenta 21:S77-80. 2000
  7. ncbi Decidual natural killer cells: key regulators of placental development (a review)
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ont, Canada
    J Reprod Immunol 57:151-68. 2002
  8. ncbi Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors
    E Gallo-Hendrikx
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    APMIS 107:245-56. 1999
  9. ncbi Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells
    J D Greenwood
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 21:693-702. 2000
  10. pmc Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Exp Med 187:217-23. 1998

Collaborators

Detail Information

Publications69

  1. pmc Trafficking of peripheral blood CD56(bright) cells to the decidualizing uterus--new tricks for old dogmas?
    Marianne van den Heuvel
    Department of Pediatrics, University of Western Ontario, Child Health Research Institute, London, Ontario, Canada N6C 2V5
    J Reprod Immunol 67:21-34. 2005
    ..Thus, we conclude that the actions of LH, E(2,) and P(4) on NK cells that promote interactions with endothelium and potential uterine homing are indirectly mediated through the responsiveness of other cell types...
  2. ncbi Prolonged gestation does not extend survival of uterine natural killer lymphocytes in mice deleted in the receptor for prostaglandin F2alpha
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
    J Reprod Immunol 46:125-9. 2000
    ....
  3. pmc Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Reproduction 126:149-60. 2003
    ..Decidual maintenance and uNK cell death are additional effects of uNK cell-derived IFN-gamma. Thus, during the first half of gestation, uNK cells contribute to and sustain important changes in the maternal placental bed...
  4. ncbi Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia?
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Soc Gynecol Investig 7:12-20. 2000
    ..If so, changes in numbers or levels of activity of human uterine NK cells or mutations in genes regulated by uterine interferon-gamma could contribute to initiation of preeclampsia...
  5. ncbi Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ont N1G 2W1, Guelph, Canada
    J Reprod Immunol 59:175-91. 2003
    ..These approaches maybe applicable to studies in women. Our studies show that complex immuno-physiological events contribute to spiral artery modification by mid-gestation in mice...
  6. ncbi Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy--a review
    B A Croy
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Placenta 21:S77-80. 2000
    ....
  7. ncbi Decidual natural killer cells: key regulators of placental development (a review)
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ont, Canada
    J Reprod Immunol 57:151-68. 2002
    ..Here, we summarize the key studies in lymphocyte-, cytokine- and cytokine receptor-deficient mice and in four enhanced models of gestation in these mice that incorporate transplantation or therapy with biologically active molecules...
  8. ncbi Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors
    E Gallo-Hendrikx
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    APMIS 107:245-56. 1999
    ..The data suggest that SCID and beige immunodeficiencies may not always have the same value for the modeling of spontaneous tumors as they do for the study of xenografts...
  9. ncbi Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells
    J D Greenwood
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 21:693-702. 2000
    ..These studies add strength to the hypothesis that uNK cells may have specialized physiological, rather than classically immune, functions in the pregnant mammalian uterus...
  10. pmc Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Exp Med 187:217-23. 1998
    ..Thus, uNK cells appear to have critical functions in pregnancy that promote decidual health, the appropriate vascularization of implantation sites, and placental size...
  11. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
    ....
  12. ncbi Primer for non-immunologists on immune-deficient mice and their applications in research
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, ON, Canada
    Comp Med 51:300-13. 2001
    ..Two illustrations on developing appropriate immune deficient animal models for a new research application conclude the review...
  13. ncbi Characterization of the cells that migrate from metrial glands of the pregnant mouse uterus during explant culture
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 32:241-63. 1997
    ..Thus, the optimal culture conditions for uNK cells remain undefined...
  14. ncbi Mechanisms regulating immune cell contributions to spiral artery modification -- facts and hypotheses -- a review
    S Leonard
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Placenta 27:S40-6. 2006
    ..Further, this work suggests that the pro-inflammatory endometrial cytokine response seen when peri-implantation conceptuses arrest has, as its target for destruction, newly developed endometrial vasculature rather than fetal trophoblast...
  15. ncbi Granulated metrial gland cells: a natural killer cell subset of the pregnant murine uterus
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Microsc Res Tech 25:189-200. 1993
    ....
  16. ncbi Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites
    S Esadeg
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Building 40, Room 2604, Guelph, ON, Canada N1G 2W1
    Placenta 24:912-21. 2003
    ..These findings demonstrate that alpha 2M, and thereby proteinases and/or cytokines whose bio-availability is regulated by alpha 2M, exert significant decidual regulation on trophoblast invasion...
  17. ncbi Functions of alpha 2 macroglobulins in pregnancy
    Chandrakant Tayade
    Department of Biomedical Sciences, University of Guelph, Guelph, Ont, Canada NIG 2W1
    Mol Cell Endocrinol 245:60-6. 2005
    ..Here, we review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy...
  18. ncbi Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy
    B A Croy
    Department of Biomedical Sciences, University of Guelph, Ont, Canada
    J Reprod Immunol 35:111-33. 1997
    ....
  19. ncbi Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells
    J H Zhang
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Biol Reprod 69:404-11. 2003
    ..The four genes were induced by gd6, and uNK cells isolated from midgestation transcribed IL-23alpha and IL-27R. This study advances the understanding of uNK cell activation during normal pregnancy...
  20. ncbi Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice
    M J Guimond
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Biol Reprod 56:169-79. 1997
    ..These studies are the first to suggest a vital role for large granulated lymphocytes in the promotion of fetal survival and pregnancy success...
  21. ncbi Demonstration of YAC target cell lysis by murine granulated metrial gland cells
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Cell Immunol 133:116-26. 1991
    ....
  22. ncbi Cellular and molecular events in early and mid gestation porcine implantation sites: a review
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
    Soc Reprod Fertil Suppl 66:233-44. 2009
    ..These data provide new insights into the roles of the endometrial immune environment in the regulation of the success and failure of porcine conceptuses...
  23. ncbi Evaluation of the murine metrial gland for immunological function
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 15:51-69. 1989
    ..Alternatively, differential regulation of cell proliferation might be a function of the MG, within the pregnant uterus. The latter mechanism could also account for the apparent observation of non-specific immunosuppression...
  24. ncbi Preliminary characterization of lymphoid hybridoma cell lines derived from the pregnant mouse uterus
    M van den Heuvel
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 27:13-36. 1994
    ..Because these hybridomas may represent fusion to an early progenitor cell of the NK/GMG cell lineage, their continued characterization is of merit...
  25. ncbi Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report
    R E Harkness
    Connaught Centre for Biotechnology Research, Willowdale, Ontario, Canada
    APMIS 101:805-10. 1993
    ..SCID/beige mice were more affected than SCID mice both clinically and pathologically, suggesting that natural killer cell and polymorphonuclear cell functions may be important in resolving B. catarrhalis challenge...
  26. ncbi Induction of murine spiral artery modification by recombinant human interferon-gamma
    J M Monk
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    Placenta 26:835-8. 2005
    ..These findings are key in building humanized murine models of pregnancy since they suggest Rag2 null/gammac null mice provide a bioassay system that would detect the functioning of human uNK cells under in vivo conditions...
  27. ncbi Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Am J Reprod Immunol 35:501-9. 1996
    ..Pregnancy-specific functions have been postulated for GMG cells, but no successful depletion of these cells has been achieved that would permit assessment of any critical roles that might influence gestational outcome...
  28. ncbi A study on the relationship between parity and differentiation of granulated metrial gland cells
    J A Luross
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Placenta 17:521-5. 1996
    ....
  29. ncbi A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha
    S Chantakru
    Department of Biomedical Sciences, Building 40 Room 2604, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada, N1G 2W1
    J Reprod Immunol 49:33-47. 2001
    ..Thus, migration, distribution and activation of NK cells within the pregnant uterus are independent of CCR2, CCR5 and MIP-1 alpha...
  30. ncbi Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Semin Immunol 13:235-41. 2001
    ..Grafts from IFN- gamma(-/-)mice are restored uNK cells, but the uNK cells did not reverse the phenotypes. This review focuses on the functions of uNK cell-derived IFN- gamma and the genes that it may regulate in the pregnant uterus...
  31. ncbi Granulated metrial gland cells in the pregnant uterus of mice expressing the collagen mutation tight-skin (Tsk/+)
    Y Kiso
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Cell Tissue Res 268:393-6. 1992
    ..5 of gestation. Loss of GMG cells from these regions normally occurs by day 6.5 of gestation. These data suggest that alterations to the ECM change the migration properties or life span of GMG cells...
  32. ncbi Immune competence involving the natural killer cell lineage promotes placental growth
    M Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 20:441-50. 1999
    ....
  33. ncbi Granulated metrial gland cells: hypotheses concerning possible functions during murine gestation
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 27:85-94. 1994
    ..A broader range of potential functions is discussed and shifts in functional roles played by GMG cells are proposed over the course of gestation...
  34. ncbi Stress triggered abortions are associated with alterations of granulated cells into the decidua
    U R Markert
    McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 37:94-100. 1997
    ..Substance P release by nerves in endometrium/decidua has been found to be the key neurotransmitter in this pathway. It is still unclear which cells are stimulated by substance P to produce the increased TNF-alpha level...
  35. doi Fetal-placental hypoxia does not result from failure of spiral arterial modification in mice
    E Leno-Durán
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
    Placenta 31:731-7. 2010
    ..To determine if fetal-placental hypoxia is a primary outcome of defective spiral artery remodeling...
  36. pmc Interferon gamma contributes to preimplantation embryonic development and to implantation site structure in NOD mice
    A V C Seaward
    Department of Anatomy and Cell Biology, Queen s University, Room 915, Botterell Hall, Kingston, ON, Canada
    Hum Reprod 25:2829-39. 2010
    ..Pregnancies in NOD.Ifng(-/-) mice were assessed to investigate this issue...
  37. ncbi Production of capsular material by equine trophoblast transplanted into immunodeficient mice
    A Albihn
    Department of Biomedical Sciences, Ontario Veterinary College, Canada
    Reproduction 125:855-63. 2003
    ..In addition, they demonstrate that xenogeneic grafting is a useful means of culturing endometrium and conceptus tissues outside the mare when in vitro techniques do not suffice...
  38. ncbi Interferon-gamma contributes to the normalcy of murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 61:493-502. 1999
    ..Furthermore, evidence is presented that IFN-gamma-producing cells exist in mesometrial regions of implantation sites that are neither NK nor T cells...
  39. ncbi A study of granulated metrial gland cell differentiation in pregnant, macrophage-deficient, osteopetrotic (op/op) mice
    Y Kiso
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Experientia 48:973-5. 1992
    ..Thus, the growth factor CSF-1 is not required for differentiation of the uterine NK cell subset known as GMG cells and probably GMG cells do not differentiate from macrophage precursor cells which are deficient in op/op mice...
  40. ncbi What are scid mice and why is it timely to devote a special topic issue to them?
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Lab Anim Sci 43:120-2. 1993
  41. pmc Circulating CD56+ cells of diabetic women show deviated homing potential for specific tissues during and following pregnancy
    A V C Seaward
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    Hum Reprod 26:1675-84. 2011
    ....
  42. ncbi Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice
    D H Percy
    Department of Pathology, University of Guelph, Ontario, Canada
    Vet Pathol 31:67-73. 1994
    ..B-17 mice. These studies indicate that the genetic differences in susceptibility of two strains of immunocompetent mice to Sendai virus infection are eliminated by expression of the mutations scid and beige...
  43. ncbi Assessment of expression of the receptor for colony-stimulating factor-1 (fms) in bovine trophoblast
    J L Beauchamp
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Biol Reprod 45:811-7. 1991
    ..The data do support a universal role for this protein during mammalian placental development...
  44. pmc Experimental sialodacryoadenitis virus infection in severe combined immunodeficient mice
    D H Percy
    Department of Pathology, Ontario Veterinary College, University of Guelph
    Can J Vet Res 55:89-90. 1991
    ..Based on these criteria, there was no evidence that these immunodeficient mice were susceptible to infection with SDA virus...
  45. ncbi Enhancement of pancreatic tumor metastasis in transgenic immunodeficient mice
    E Gallo-Hendrikx
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Oncogene 9:2983-90. 1994
    ..The tissue distribution of metastases was similar to that recorded from human patients with pancreatic cancer, suggesting that mechanisms underlying metastasis in these mice could be similar to those involved in human disease...
  46. doi Immunological mechanisms affecting angiogenesis and their relation to porcine pregnancy success
    Nicola F Linton
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    Immunol Invest 37:611-29. 2008
    ..Together, these components of the immune system could regulate lymphocyte- and non-lymphocyte-promoted endometrial angiogenesis to determine conceptus survival...
  47. ncbi Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation
    Chandrakant Tayade
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    J Immunol 176:148-56. 2006
    ....
  48. ncbi In vivo models for studying homing and function of murine uterine natural killer cells
    B Anne Croy
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
    Methods Mol Med 122:77-92. 2006
    ..Quantitative histological techniques for identification, localization, and enumeration of uNK cells, as well as for assessment of spiral artery modification and microdomain size within mouse implantation sites are also included...
  49. ncbi Genetic deletion of placenta growth factor in mice alters uterine NK cells
    Chandrakant Tayade
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Immunol 178:4267-75. 2007
    ..Thus, in mice, PlGF plays an important role in successful uNK cell proliferation and/or differentiation...
  50. ncbi Lymphocyte contributions to altered endometrial angiogenesis during early and midgestation fetal loss
    Chandrakant Tayade
    Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada, N1G2W1
    J Leukoc Biol 82:877-86. 2007
    ..At gd50, this was reversed. Endometrial, vascular pathology was evident only at gd50. These data suggest the critical importance for lymphocyte-driven endometrial angiogenesis, which extends to midgestation...
  51. pmc Aberrant endometrial features of pregnancy in diabetic NOD mice
    Suzanne D Burke
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
    Diabetes 56:2919-26. 2007
    ..We studied mid- to late gestations in spontaneously type 1 diabetic NOD mice to investigate whether diabetes alters uNK cell homing and/or function...
  52. doi CD56bright cells increase expression of {alpha}4 integrin at ovulation in fertile cycles
    Crystal G Peralta
    Department of Pediatrics, University of Western Ontario, Stratford, ON, Canada N5A 6S6
    J Leukoc Biol 84:1065-74. 2008
    ....
  53. doi Maternal-fetal immunology
    B Anne Croy
    Immunol Invest 37:389-94. 2008
  54. ncbi A review of molecular contrasts between arresting and viable porcine attachment sites
    Jocelyn M Wessels
    Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada
    Am J Reprod Immunol 58:470-80. 2007
    ..Further characterization of spontaneous fetal loss in pigs will identify targets for modification by hog producers and may provide a model for identification of antecedents to fetal loss in humans...
  55. pmc Neither lymphotoxin alpha nor lymphotoxin beta receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant mouse uterus
    Angela Kather
    Departments of Biomedical Sciences and Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Immunology 108:338-45. 2003
    ..This indicates that the stromally derived molecules supporting NK cell differentiation in the uterus differ from those used in secondary lymphoid organs...
  56. ncbi Chimerism of murine fetal bone marrow by maternal cells occurs in late gestation and persists into adulthood
    Annette M Marleau
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Lab Invest 83:673-81. 2003
    ..The normalcy of maternal cell transfer to genetically immune competent progeny and their long-term engraftment is suggestive of a functional role for maternal cells in offspring...
  57. ncbi Conceptus influences the distribution of uterine leukocytes during early porcine pregnancy
    Heidi Engelhardt
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 66:1875-80. 2002
    ..The ability of an individual porcine conceptus to recruit maternal leukocytes to the adjacent stroma may be a vital step in early placental development and embryo survival...
  58. ncbi Evaluation of natural killer cell recruitment to embryonic attachment sites during early porcine pregnancy
    Heidi Engelhardt
    Departments of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 66:1185-92. 2002
    ..These results raise the possibility that uNK cells resembling those in blood may be transformed into larger, more granulated forms in the uterine microenvironment...
  59. ncbi Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy
    Ali A Ashkar
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 171:2937-44. 2003
    ..These studies indicate that uNK cell development and maturation share some aspects with NK cell development in other tissues, but also display distinctive tissue-specific regulation...
  60. pmc Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones
    Sirirak Chantakru
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    J Immunol 171:4011-9. 2003
    ..These results provide the first evidence for coordinated, organ-specific, steroid hormone-induced changes in lymphocyte homing mechanisms that could contribute to local and systemic immune responses during pregnancy...
  61. ncbi Contributions from self-renewal and trafficking to the uterine NK cell population of early pregnancy
    Sirirak Chantakru
    Department of Biomedical Sciences, Building No 40, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Immunol 168:22-8. 2002
    ..These data support a model that attributes the dramatic increases in human and murine uNK cells during decidualization to precursor cell recruitment...
  62. ncbi Characterization of a murine alpha 2 macroglobulin gene expressed in reproductive and cardiovascular tissue
    Hong He
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    Biol Reprod 72:266-75. 2005
    ..Identification of cytokines, growth factors, or other molecules bound to A2MP should provide new insights into decidualization, spiral artery modification, and cardiovascular adaptation to pregnancy...
  63. pmc Menstrual cycle hormones induce changes in functional interactions between lymphocytes and decidual vascular endothelial cells
    Marianne J van den Heuvel
    Department of Pediatrics, Child Health Research Institute, 800 Commissioner s Road East, University of Western Ontario, London, Ontario, Canada, N6C 2V5
    J Clin Endocrinol Metab 90:2835-42. 2005
    ....
  64. pmc Periovulatory increases in tissue homing potential of circulating CD56(bright) cells are associated with fertile menstrual cycles
    Marianne J van den Heuvel
    Department of Pediatrics, Child Health Research Institute, 800 Commissioner s Road East, University of Western Ontario, London, Ontario, Canada N6C 2V5
    J Clin Endocrinol Metab 90:3606-13. 2005
    ..These results support the idea that temporal control of NK cell homing to the uterine microenvironment is a prerequisite to pregnancy...
  65. ncbi Pathways participating in activation of mouse uterine natural killer cells during pregnancy
    Xuemei Xie
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 73:510-8. 2005
    ..These data reveal key importance of FcRgamma-/-/CD3zeta-/- and thus maternal IgG during activation of mouse uNK cells and assign DAP12 but not DAP10 signaling contributions...
  66. pmc Trafficking of circulating pro-NK cells to the decidualizing uterus: regulatory mechanisms in the mouse and human
    Marianne J van den Heuvel
    Department of Pediatrics, University of Western Ontario, London, Ontario, Canada
    Immunol Invest 34:273-93. 2005
    ..Here, we review factors influencing NK cell trafficking to decidualizing murine and human uteri and the differentiation and functions of these cells within the uterus...
  67. ncbi Uterine natural killer cells: their choices, their missions
    Jianhong Zhang
    School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Cell Mol Immunol 2:123-9. 2005
    ..An improved knowledge of mechanisms regulating uNK cells development and the cytokine network at the maternal-fetal interface of mice and humans might be useful to harness the power of these cells for maintenance of pregnancy...
  68. ncbi Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells
    Chandrakant Tayade
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Leukoc Biol 78:1347-55. 2005
    ..Thus, Eomes dominance to T-bet discriminates regulation of the uNK cell subset from that observed for peripheral NK cells...
  69. ncbi Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells
    Angela M Borzychowski
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 35:3054-63. 2005
    ..001 and p <0.01, respectively) and pre-eclamptic women (p <0.05). These results confirm that immunoregulation occurs in pregnancy, but suggest a dominant role of the innate rather than the adaptive immune system...